{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:12:42Z","timestamp":1790172762531,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","resuscitationjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Resuscitation"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.resuscitation.2016.06.031","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T19:37:34Z","timestamp":1469129854000},"page":"108-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Safety of glycoprotein IIb\/IIIa inhibitors in patients under therapeutic hypothermia admitted for an acute coronary syndrome"],"prefix":"10.1016","volume":"106","author":[{"given":"Gustavo","family":"Jim\u00e9nez-Br\u00edtez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Freixa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Penela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Hernandez-Enr\u00edquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"San Antonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gala","family":"Caixal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e9","family":"Roqu\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Brugaletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Masotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Sabat\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.resuscitation.2016.06.031_bib0130","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/CIRCINTERVENTIONS.109.913665","article-title":"Immediate percutaneous coronary intervention is associated with better survival after out-of-hospital cardiac arrest: insights from the PROCAT (Parisian Region Out of hospital Cardiac Arrest) registry","volume":"3","author":"Dumas","year":"2010","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0135","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.resuscitation.2015.07.030","article-title":"European resuscitation council guidelines for resuscitation 2015 section 5. Management of acute coronary syndrome","volume":"95","author":"Nikolau","year":"2015","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0140","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jacc.2012.03.036","article-title":"Long-term prognosis following resuscitation from out of hospital cardiac arrest: role of percutaneous coronary intervention and therapeutic hypothermia","volume":"60","author":"Dumas","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0145","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1097\/01.TA.0000064328.97941.FC","article-title":"A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function","volume":"56","author":"Wolberg","year":"2004","journal-title":"J Trauma"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0150","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1097\/CCM.0b013e3181962cb9","article-title":"Pronounced platelet hyperfunction in patients with cardiac arrest achieving restoration of spontaneous circulation","volume":"37","author":"Spiel","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0155","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.resuscitation.2014.06.009","article-title":"A minimal effects on ex vivo coagulation during mild therapeutic hypothermia post cardiac arrest patients","volume":"85","author":"Brinkman","year":"2014","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0160","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.thromres.2015.04.029","article-title":"The impact of therapeutic hypothermia on on-treatment platelet reactivity and clinical outcome in cardiogenic shock patients undergoing primary PCI for acute myocardial infarction: results from the ISAR-SHOCK registry","volume":"136","author":"Orban","year":"2015","journal-title":"Thromb Res"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0165","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0170","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.resuscitation.2015.11.006","article-title":"Stent thrombosis after primary percutaneous coronary intervention in comatose survivors of out-of-hospital cardiac arrest: are the new P2Y12 inhibitors really more effective than clopidogrel?","volume":"98","author":"Gouffran","year":"2016","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0175","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1093\/eurheartj\/ehu278","volume":"35","author":"Windecker","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0180","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0140-6736(02)07442-1","article-title":"Platelet glycoprotein IIb\/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials","volume":"359","author":"Boersma","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0185","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jacc.2012.10.029","article-title":"Hypothermia in acute coronary syndrome: brain salvage versus stent thrombosis?","volume":"61","author":"Penela","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0190","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.resuscitation.2014.02.013","article-title":"Stent thrombosis: an increased adverse event after angioplasty following resuscitated cardiac arrest","volume":"85","author":"Joffre","year":"2014","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0195","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.4244\/EIJY14M05_02","article-title":"Platelet reactivity in comatose survivors of cardiac arrest undergoing percutaneous coronary intervention and hypothermia","volume":"10","author":"Steblovnik","year":"2015","journal-title":"EuroIntervention: J Eur Collab Work Group Interv Cardiol Eur Soc Cardiol"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0200","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1161\/CIRCULATIONAHA.106.685313","article-title":"Academic research consortium, clinical end points in coronary stent trials: a case for standardized definitions","volume":"115","author":"Cutlip","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0205","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1161\/01.CIR.103.21.2550","article-title":"Combination therapy with abciximab reduces angiographically evident thrombus in acute myocardial infarction: a TIMI 14 substudy","volume":"103","author":"Gibson","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0210","first-page":"6B","article-title":"Angiographic thrombus burden classification in patients with ST-segment elevation myocardial infarction treated with percutaneous coronary intervention","volume":"22","author":"Sianos","year":"2010","journal-title":"J Invasive Cardiol"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0215","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.jacc.2013.09.028","article-title":"Is therapeutic hypothermia a risk factor for stent thrombosis?","volume":"63","author":"Rosillo","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0220","first-page":"137","article-title":"Outcome, timing and adverse events in therapeutic hypothermia after out-of-hospital cardiac arrest","volume":"51","author":"Nielsen","year":"2007","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0225","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00228-012-1360-0","article-title":"Impaired bioavailability and antiplatelet effect of high-dose clopidogrel in patients after cardiopulmonary resuscitation (CPR)","volume":"69","author":"Sou\u010dkov\u00e1","year":"2013","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0230","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.resuscitation.2015.11.007","article-title":"Changes in coagulation during therapeutic hypothermia in cardiac arrest patients","volume":"98","author":"Nielsen","year":"2016","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0235","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.resuscitation.2015.08.018","article-title":"The effect of targeted temperature management on coagulation parameters and bleeding events after out-of-hospital cardiac arrest of presumed cardiac cause","volume":"96","author":"Jacob","year":"2015","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0240","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1757-7241-19-64","article-title":"Thrombelastography and biomarker profiles in acute coagulopathy of trauma: a prospective study","volume":"19","author":"Ostrowski","year":"2011","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0245","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.mehy.2010.07.031","article-title":"Acute coagulopathy of trauma: balancing progressive catecholamine induced endothelial activation and damage by fluid phase anticoagulation","volume":"75","author":"Johansson","year":"2010","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.resuscitation.2016.06.031_bib0250","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1161\/01.CIR.0000023891.80661.AD","article-title":"Successful cardiopulmonary resuscitation after cardiac arrest as a sepsis-like syndrome","volume":"106","author":"Adrie","year":"2002","journal-title":"Circulation"}],"container-title":["Resuscitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300957216301381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300957216301381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T16:20:07Z","timestamp":1556382007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300957216301381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":25,"alternative-id":["S0300957216301381"],"URL":"https:\/\/doi.org\/10.1016\/j.resuscitation.2016.06.031","relation":{},"ISSN":["0300-9572"],"issn-type":[{"value":"0300-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of glycoprotein IIb\/IIIa inhibitors in patients under therapeutic hypothermia admitted for an acute coronary syndrome","name":"articletitle","label":"Article Title"},{"value":"Resuscitation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resuscitation.2016.06.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}