{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T03:27:50Z","timestamp":1772594870150,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100009542","name":"Limburg Sterk Merk","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009542","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009550","name":"Hasselt University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009550","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ziekenhuis Oost \u2013 Limburg"},{"name":"Jessa Hospital"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","resuscitationjournal.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Resuscitation"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.resuscitation.2018.01.042","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T12:34:24Z","timestamp":1517488464000},"page":"179-184","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["The validation of simplified EEG derived from the bispectral index monitor in post-cardiac arrest patients"],"prefix":"10.1016","volume":"126","author":[{"given":"Jolien","family":"Haesen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ward","family":"Eertmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Genbrugge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Meex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelle","family":"Demeestere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Vander Laenen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem","family":"Boer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Mesotten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Dens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Jans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovic","family":"Ernon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"De Deyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.resuscitation.2018.01.042_bib0005","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1212\/01.WNL.0000125184.88797.62","article-title":"Detection of electrographic seizures with continuous EEG monitoring in critically ill patients","volume":"62","author":"Claassen","year":"2004","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.resuscitation.2018.01.042_bib0010","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.eplepsyres.2013.06.018","article-title":"The incidence of seizures in patients undergoing therapeutic hypothermia after resuscitation from cardiac arrest","volume":"106","author":"Knight","year":"2013","journal-title":"Epilepsy Res"},{"issue":"3","key":"10.1016\/j.resuscitation.2018.01.042_bib0015","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.resuscitation.2012.11.001","article-title":"Prognostic value of electrographic postanoxic status epilepticus in comatose cardiac-arrest survivors in the therapeutic hypothermia era","volume":"84","author":"Legriel","year":"2013","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2018.01.042_bib0020","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.resuscitation.2017.01.017","article-title":"Prognostic significance of clinical seizures after cardiac arrest and target temperature management","volume":"114","author":"Lybeck","year":"2017","journal-title":"Resuscitation"},{"issue":"3","key":"10.1016\/j.resuscitation.2018.01.042_bib0025","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s12028-009-9246-4","article-title":"Early EEG monitoring for detecting postanoxic status epilepticus during therapeutic hypothermia: a pilot study","volume":"11","author":"Legriel","year":"2009","journal-title":"Neurocrit Care"},{"issue":"1","key":"10.1016\/j.resuscitation.2018.01.042_bib0030","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1528-1157.1994.tb02908.x","article-title":"Determinants of mortality in status epilepticus","volume":"35","author":"Towne","year":"1994","journal-title":"Epilepsia"},{"issue":"1","key":"10.1016\/j.resuscitation.2018.01.042_bib0035","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s12028-011-9565-0","article-title":"Frequency and timing of nonconvulsive status epilepticus in comatose post-cardiac arrest subjects treated with hypothermia","volume":"16","author":"Rittenberger","year":"2012","journal-title":"Neurocrit Care"},{"issue":"7","key":"10.1016\/j.resuscitation.2018.01.042_bib0040","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.resuscitation.2012.02.015","article-title":"The frequency and timing of epileptiform activity on continuous electroencephalogram in comatose post-cardiac arrest syndrome patients treated with therapeutic hypothermia","volume":"83","author":"Mani","year":"2012","journal-title":"Resuscitation"},{"issue":"4","key":"10.1016\/j.resuscitation.2018.01.042_bib0045","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11910-002-0010-9","article-title":"The current state of treatment of status epilepticus","volume":"2","author":"Hirsch","year":"2002","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"Suppl 3","key":"10.1016\/j.resuscitation.2018.01.042_bib0050","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.yebeh.2005.08.003","article-title":"Prolonged seizures and cellular injury: understanding the connection","volume":"7","author":"Fujikawa","year":"2005","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.resuscitation.2018.01.042_bib0055","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/1745-6215-15-433","article-title":"Treatment of electroencephalographic status epilepticus after cardiopulmonary resuscitation (TELSTAR): study protocol for a randomized controlled trial","volume":"15","author":"Ruijter","year":"2014","journal-title":"Trials"},{"issue":"8","key":"10.1016\/j.resuscitation.2018.01.042_bib0060","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1212\/01.wnl.0000343006.60851.62","article-title":"Predictors of awakening from postanoxic status epilepticus after therapeutic hypothermia","volume":"72","author":"Rossetti","year":"2009","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.resuscitation.2018.01.042_bib0065","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bpa.2005.08.004","article-title":"Update on bispectral index monitoring","volume":"20","author":"Johansen","year":"2006","journal-title":"Best Pract Res Clin Anaesthesiol"},{"issue":"8","key":"10.1016\/j.resuscitation.2018.01.042_bib0070","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.resuscitation.2014.04.016","article-title":"Feasibility of bispectral index monitoring to guide early post-resuscitation cardiac arrest triage","volume":"85","author":"Seder","year":"2014","journal-title":"Resuscitation"},{"issue":"12","key":"10.1016\/j.resuscitation.2018.01.042_bib0075","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1016\/j.resuscitation.2014.09.009","article-title":"Bispectral index to predict neurological outcome early after cardiac arrest","volume":"85","author":"Stammet","year":"2014","journal-title":"Resuscitation"},{"issue":"6","key":"10.1016\/j.resuscitation.2018.01.042_bib0080","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.resuscitation.2013.01.003","article-title":"Cerebral tissue oxygen saturation during therapeutic hypothermia in post-cardiac arrest patients","volume":"84","author":"Meex","year":"2013","journal-title":"Resuscitation"},{"issue":"1","key":"10.1016\/j.resuscitation.2018.01.042_bib0085","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s13054-016-1509-9","article-title":"What is the value of regional cerebral saturation in post-cardiac arrest patients? A prospective observational study","volume":"20","author":"Genbrugge","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.resuscitation.2018.01.042_bib0090","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.resuscitation.2015.07.018","article-title":"European resuscitation council and European society of intensive care medicine guidelines for post-resuscitation care 2015: section 5 of the European resuscitation council guidelines for resuscitation 2015","volume":"95","author":"Nolan","year":"2015","journal-title":"Resuscitation"},{"issue":"6","key":"10.1016\/j.resuscitation.2018.01.042_bib0095","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1007\/s00134-006-0178-6","article-title":"Amplitude-integrated EEG (aEEG) predicts outcome after cardiac arrest and induced hypothermia","volume":"32","author":"Rundgren","year":"2006","journal-title":"Intensive Care Med"},{"issue":"9","key":"10.1016\/j.resuscitation.2018.01.042_bib0100","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1097\/CCM.0b013e3181eaa1e7","article-title":"Continuous amplitude-integrated electroencephalogram predicts outcome in hypothermia-treated cardiac arrest patients","volume":"38","author":"Rundgren","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1016\/j.resuscitation.2018.01.042_bib0105","series-title":"Brain failure and resuscitation","author":"Grenvik","year":"1981"},{"issue":"8","key":"10.1016\/j.resuscitation.2018.01.042_bib0110","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s00134-013-2938-4","article-title":"Recommendations on the use of EEG monitoring in critically ill patients: consensus statement from the neurointensive care section of the ESICM","volume":"39","author":"Claassen","year":"2013","journal-title":"Intensive Care Med"},{"issue":"4","key":"10.1016\/j.resuscitation.2018.01.042_bib0115","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/cc12699","article-title":"Clinical review: continuous and simplified electroencephalography to monitor brain recovery after cardiac arrest","volume":"17","author":"Friberg","year":"2013","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.resuscitation.2018.01.042_bib0120","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1213\/ane.0b013e3181a9d8b5","article-title":"Continuous electroencephalogram monitoring in the intensive care unit","volume":"109","author":"Friedman","year":"2009","journal-title":"Anesth Analg"},{"issue":"6","key":"10.1016\/j.resuscitation.2018.01.042_bib0125","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.resuscitation.2014.01.019","article-title":"Value analysis of continuous EEG in patients during therapeutic hypothermia after cardiac arrest","volume":"85","author":"Crepeau","year":"2014","journal-title":"Resuscitation"},{"issue":"1","key":"10.1016\/j.resuscitation.2018.01.042_bib0130","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s13054-017-1806-y","article-title":"Recorded time periods of bispectral index values equal to zero predict neurological outcome after out-of-hospital cardiac arrest","volume":"21","author":"Eertmans","year":"2017","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.resuscitation.2018.01.042_bib0135","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.seizure.2011.09.001","article-title":"Utility of bilateral Bispectral index (BIS) monitoring in a comatose patient with focal nonconvulsive status epilepticus","volume":"21","author":"Fernandez-Torre","year":"2012","journal-title":"Seizure"},{"issue":"4","key":"10.1016\/j.resuscitation.2018.01.042_bib0140","first-page":"298","article-title":"Bispectral index (BIS) monitoring of acute encephalitis with refractory, repetitive partial seizures (AERRPS)","volume":"76","author":"Dahaba","year":"2010","journal-title":"Minerva Anestesiol"},{"issue":"7","key":"10.1016\/j.resuscitation.2018.01.042_bib0145","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1097\/CCM.0b013e31817c473c","article-title":"Nonconvulsive status and bispectral index","volume":"36","author":"Chamorro","year":"2008","journal-title":"Crit Care Med"},{"key":"10.1016\/j.resuscitation.2018.01.042_bib0150","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.resuscitation.2017.03.011","article-title":"Increasing or fluctuating bispectral index values during post-resuscitation targeted temperature management can predict clinical seizures after rewarming","volume":"114","author":"Ochiai","year":"2017","journal-title":"Resuscitation"},{"issue":"2","key":"10.1016\/j.resuscitation.2018.01.042_bib0155","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/WNP.0b013e3181d649e4","article-title":"A quick and reliable EEG montage for the detection of seizures in the critical care setting","volume":"27","author":"Karakis","year":"2010","journal-title":"J Clin Neurophysiol"},{"issue":"5","key":"10.1016\/j.resuscitation.2018.01.042_bib0160","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1528-1167.2007.01078.x","article-title":"Assessment of hairline EEG as a screening tool for nonconvulsive status epilepticus","volume":"48","author":"Kolls","year":"2007","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.resuscitation.2018.01.042_bib0165","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s12028-009-9248-2","article-title":"Seizure detection with a commercially available bedside EEG monitor and the subhairline montage","volume":"11","author":"Young","year":"2009","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.resuscitation.2018.01.042_bib0170","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.resuscitation.2017.05.016","article-title":"Epileptiform discharge detection with the 4-channel frontal electroencephalography during post-resuscitation care","volume":"117","author":"You","year":"2017","journal-title":"Resuscitation"},{"issue":"16","key":"10.1016\/j.resuscitation.2018.01.042_bib0175","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1212\/WNL.0000000000002462","article-title":"Standardized EEG interpretation accurately predicts prognosis after cardiac arrest","volume":"86","author":"Westhall","year":"2016","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.resuscitation.2018.01.042_bib0180","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1212\/WNL.0000000000001742","article-title":"Early EEG contributes to multimodal outcome prediction of postanoxic coma","volume":"85","author":"Hofmeijer","year":"2015","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.resuscitation.2018.01.042_bib0185","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1007\/s00134-015-3834-x","article-title":"Prognostication of post-cardiac arrest coma: early clinical and electroencephalographic predictors of outcome","volume":"41","author":"Sivaraju","year":"2015","journal-title":"Intensive Care Med"},{"issue":"9","key":"10.1016\/j.resuscitation.2018.01.042_bib0190","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jacc.2013.04.039","article-title":"Modeling serum level of s100beta and bispectral index to predict outcome after cardiac arrest","volume":"62","author":"Stammet","year":"2013","journal-title":"J Am Coll Cardiol"}],"container-title":["Resuscitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300957218300522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300957218300522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T09:55:43Z","timestamp":1535104543000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300957218300522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":38,"alternative-id":["S0300957218300522"],"URL":"https:\/\/doi.org\/10.1016\/j.resuscitation.2018.01.042","relation":{},"ISSN":["0300-9572"],"issn-type":[{"value":"0300-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The validation of simplified EEG derived from the bispectral index monitor in post-cardiac arrest patients","name":"articletitle","label":"Article Title"},{"value":"Resuscitation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resuscitation.2018.01.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}