{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:20:49Z","timestamp":1772889649424,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009033","name":"NHS Blood and Transplant","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resuscitationjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Resuscitation"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.resuscitation.2020.01.028","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T11:35:48Z","timestamp":1580988948000},"page":"10-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Safe prognostication following cardiac arrest: The role of the pharmacokinetics of fentanyl in patients treated with targeted temperature management"],"prefix":"10.1016","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-3248","authenticated-orcid":false,"given":"F.","family":"Baldwin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Waxman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7124-7543","authenticated-orcid":false,"given":"G.","family":"Scutt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.resuscitation.2020.01.028_bib0005","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1007\/s00134-014-3470-x","article-title":"Prognostication in comatose survivors of cardiac arrest: an advisory statement from the European Resuscitation Council and the European Society of Intensive Care Medicine","volume":"40","author":"Sandroni","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12028-010-9412-8","article-title":"Sedation confounds outcome prediction in cardiac arrest survivors treated with hypothermia","volume":"15","author":"Samaniego","year":"2011","journal-title":"Neurocrit Care"},{"issue":"1","key":"10.1016\/j.resuscitation.2020.01.028_bib0015","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1592\/phco.28.1.102","article-title":"Practical pharmacologic aspects of therapeutic hypothermia after cardiac arrest","volume":"28","author":"Arpino","year":"2008","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0020","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1007\/s00134-016-4349-9","article-title":"Delayed awakening after cardiac arrest: prevalence and risk factors in the Parisian registry","volume":"42","author":"Paul","year":"2016","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0025","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted temperature management at 33\u202f\u00b0C versus 36\u202f\u00b0C after cardiac arrest","volume":"369","author":"Nielsen","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0030","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1213\/01.ANE.0000146517.17910.54","article-title":"The effect of mild hypothermia on plasma fentanyl concentration and biotransformation in juvenile pigs","volume":"100","author":"Fritz","year":"2005","journal-title":"Anesth Analg"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0035","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1124\/dmd.112.045567","article-title":"Effects of hypothermia on the disposition of morphine, midazolam, fentanyl, and propofol in intensive care unit patients","volume":"41","author":"Bjelland","year":"2013","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0040","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1097\/CCM.0b013e31823779f9","article-title":"Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest","volume":"40","author":"Empey","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0045","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1097\/01.CCM.0000054864.43122.52","article-title":"Moderate hypothermia may be detrimental after traumatic brain injury in fentanyl-anesthetized rats","volume":"31","author":"Statler","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0050","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/BF00543972","article-title":"The influence of hypothermia on the disposition of fentanyl\u2014Human and animal studies","volume":"32","author":"Koren","year":"1987","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0055","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/aas.12300","article-title":"Concentrations of remifentanil, propofol, fentanyl, and midazolam during rewarming from therapeutic hypothermia","volume":"58","author":"Bjelland","year":"2014","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0060","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1176\/appi.psy.50.2.169","article-title":"Pharmacokinetic drug interactions of synthetic opiate analgesics","volume":"50","author":"Armstrong","year":"2009","journal-title":"Psychosomatics"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0065","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1097\/CCM.0b013e318275d014","article-title":"Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors","volume":"41","author":"Skrobik","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0070","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.3389\/fphar.2018.01210","article-title":"Postmortem toxicology of new synthetic opioids","volume":"9","author":"Concheiro","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0075","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatinine clearance from serum creatinine","volume":"16","author":"Cockcroft","year":"1976","journal-title":"Nephron"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0080","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/00000542-199902000-00034","article-title":"A review of the use of fentanyl analgesia in the management of acute pain in adults","volume":"90","author":"Peng","year":"1999","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0085","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/clpt.1980.138","article-title":"Intravenous fentanyl kinetics","volume":"28","author":"McClain","year":"1980","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0090","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/CCM.0000000000001347","article-title":"Population pharmacokinetics of fentanyl in the critically ill","volume":"44","author":"Choi","year":"2016","journal-title":"Crit Care Med"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0095","doi-asserted-by":"crossref","first-page":"103996","DOI":"10.1016\/j.biosystems.2019.103996","article-title":"Estimating a drug\u2019s elimination rate-constant or half-life from a single blood sample: a practical approach with particular benefits for critically ill\/vulnerable patients","author":"Scutt","year":"2019","journal-title":"Biosystems"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0100","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1111\/j.1523-1755.2005.00365.x","article-title":"Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)","volume":"67","author":"Levey","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0105","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/CCM.0b013e3182783b72","article-title":"Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit","volume":"41","author":"Barr","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0110","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1378\/chest.08-2264","article-title":"Pain management principles in the critically ill","volume":"135","author":"Erstad","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0115","first-page":"245","article-title":"Use of a fentanyl infusion in the intensive care unit: Tolerance to its anesthetic effects?","volume":"59","author":"Shafer","year":"1983","journal-title":"Anesthesiology"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0120","doi-asserted-by":"crossref","first-page":"A496","DOI":"10.1186\/2197-425X-3-S1-A496","article-title":"Intox-a prospective measurement of blood concentrations of routine drugs in patients treated in the intensive care unit","volume":"3","author":"Lennborn","year":"2015","journal-title":"Intensive Care Med Exp"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0125","first-page":"34","article-title":"Opioid dosing in renal and hepatic impairment","volume":"39","author":"Gelot","year":"2014","journal-title":"U S Pharmacist"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0130","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/j.1875-9114.1997.tb03750.x","article-title":"Fentanyl pharmacokinetics in patients undergoing renal transplantation","volume":"17","author":"Koehntop","year":"1997","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0135","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.resuscitation.2018.01.027","article-title":"Time to awakening after cardiac arrest and the association with target temperature management","volume":"126","author":"Lybeck","year":"2018","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0140","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/CCM.0000000000001444","article-title":"Fentanyl pharmacokinetics in critically ill patients: a demonstration of mixed effects","volume":"44","author":"Droege","year":"2016","journal-title":"Crit Care Med"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0145","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1097\/01.CCM.0000281517.97507.6E","article-title":"Effects of hypothermia on drug disposition, metabolism, and response: a focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system","volume":"35","author":"Tortorici","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0150","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1056\/NEJMoa1906661","article-title":"Targeted temperature management for cardiac arrest with nonshockable rhythm","volume":"381","author":"Lascarrou","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0155","first-page":"e123","article-title":"The current temperature: a survey of post-resuscitation management across Australian and New Zealand intensive care units","volume":"130","author":"Bray","year":"2018","journal-title":"Austr Crit Care"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0160","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.resuscitation.2017.02.003","article-title":"Decreased use of active temperature management following publication of the TTM trial","volume":"113","author":"Millette","year":"2017","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0165","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12028-014-9998-3","article-title":"Moderate-dose sedation and analgesia during targeted temperature management after cardiac arrest","volume":"22","author":"May","year":"2015","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0170","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.resuscitation.2018.03.025","article-title":"Comparison of two sedation regimens during targeted temperature management after cardiac arrest","volume":"128","author":"Paul","year":"2018","journal-title":"Resuscitation"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0175","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00134-012-2540-1","article-title":"Propofol and remifentanil versus midazolam and fentanyl for sedation during therapeutic hypothermia after cardiac arrest: a randomized trial","volume":"38","author":"Bjelland","year":"2012","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.resuscitation.2020.01.028_bib0180","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1213\/ANE.0b013e3181d8cacf","article-title":"Anesthesia and analgesia protocol during therapeutic hypothermia after cardiac arrest: a systematic review","volume":"110","author":"Chamorro","year":"2010","journal-title":"Anesth Analg"}],"container-title":["Resuscitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300957220300526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300957220300526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T02:59:48Z","timestamp":1759546788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300957220300526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":36,"alternative-id":["S0300957220300526"],"URL":"https:\/\/doi.org\/10.1016\/j.resuscitation.2020.01.028","relation":{},"ISSN":["0300-9572"],"issn-type":[{"value":"0300-9572","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safe prognostication following cardiac arrest: The role of the pharmacokinetics of fentanyl in patients treated with targeted temperature management","name":"articletitle","label":"Article Title"},{"value":"Resuscitation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.resuscitation.2020.01.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}