{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:13:08Z","timestamp":1789067588485,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.reth.2019.10.001","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T12:17:15Z","timestamp":1571746635000},"page":"316-323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Generation of a large-scale vascular bed for the in\u00a0vitro creation of three-dimensional cardiac tissue"],"prefix":"10.1016","volume":"11","author":[{"given":"Akitoshi","family":"Inui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidekazu","family":"Sekine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Dobashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azumi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhisa","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reth.2019.10.001_bib1","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.healun.2016.08.017","article-title":"The registry of the international society for heart and lung transplantation: thirty-third adult heart transplantation report-2016; focus theme: primary diagnostic indications for transplant","volume":"35","author":"Lund","year":"2016","journal-title":"J\u00a0Heart Lung Transplant"},{"key":"10.1016\/j.reth.2019.10.001_bib2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1253\/circj.CJ-16-0976","article-title":"Registry report on heart transplantation in Japan (June 2016)","volume":"81","author":"Fukushima","year":"2017","journal-title":"Circ J"},{"key":"10.1016\/j.reth.2019.10.001_bib3","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.112.092627","article-title":"Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance","volume":"126","author":"Chugh","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.reth.2019.10.001_bib4","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1001\/jama.2012.25321","article-title":"Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial","volume":"308","author":"Hare","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.reth.2019.10.001_bib5","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S0140-6736(12)60195-0","article-title":"Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial","volume":"379","author":"Makkar","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.reth.2019.10.001_bib6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/35070587","article-title":"Bone marrow cells regenerate infarcted myocardium","volume":"410","author":"Orlic","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.reth.2019.10.001_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0140-6736(00)03617-5","article-title":"Myoblast transplantation for heart failure","volume":"357","author":"Menasch\u00e9","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.reth.2019.10.001_bib8","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.yjmcc.2008.03.009","article-title":"Systems approaches to preventing transplanted cell death in cardiac repair","volume":"45","author":"Robey","year":"2008","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.reth.2019.10.001_bib9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2174\/1574888X11308030009","article-title":"A\u00a0systematic review on preclinical and clinical studies on the use of scaffolds for bone repair in skeletal defects","volume":"8","author":"Crowley","year":"2013","journal-title":"Curr Stem Cell Res Ther"},{"key":"10.1016\/j.reth.2019.10.001_bib10","article-title":"Trends in tissue engineering for blood vessels","volume":"2012","author":"Nemeno-Guanzon","year":"2012","journal-title":"J\u00a0Biomed Biotechnol"},{"key":"10.1016\/j.reth.2019.10.001_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.5435\/JAAOS-21-05-303","article-title":"Cartilage regeneration","volume":"21","author":"Tuan","year":"2013","journal-title":"J\u00a0Am Acad Orthop Surg"},{"key":"10.1016\/j.reth.2019.10.001_bib12","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tibtech.2012.08.004","article-title":"Skin regeneration scaffolds: a multimodal bottom-up approach","volume":"30","author":"Yildirimer","year":"2012","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.reth.2019.10.001_bib13","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/jbm.820271005","article-title":"A\u00a0novel recovery system for cultured cells using plasma-treated polystyrene dishes grafted with poly(N-isopropylacrylamide)","volume":"27","author":"Okano","year":"1993","journal-title":"J\u00a0Biomed Mater Res"},{"key":"10.1016\/j.reth.2019.10.001_bib14","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1161\/hh0302.105722","article-title":"Fabrication of pulsatile cardiac tissue grafts using a novel 3-dimensional cell sheet manipulation technique and temperature-responsive cell culture surfaces","volume":"90","author":"Shimizu","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.reth.2019.10.001_bib15","first-page":"1029","article-title":"Polymeric system for dual growth factor delivery","volume":"11","author":"Richardson","year":"2011","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.reth.2019.10.001_bib16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bbrc.2005.12.217","article-title":"Bioengineered cardiac cell sheet grafts have intrinsic angiogenic potential","volume":"341","author":"Sekiya","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.reth.2019.10.001_bib17","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/bit.22477","article-title":"Design and validation of a pulsatile perfusion bioreactor for 3D high cell density cultures","volume":"104","author":"Chouinard","year":"2009","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/j.reth.2019.10.001_bib18","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nmat4570","article-title":"Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis","volume":"15","author":"Zhang","year":"2016","journal-title":"Nat Mater"},{"key":"10.1016\/j.reth.2019.10.001_bib19","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/biot.201200160","article-title":"A bioreactor system for interfacial culture and physiological perfusion of vascularized tissue equivalents","volume":"8","author":"Groeber","year":"2013","journal-title":"Biotechnol J"},{"key":"10.1016\/j.reth.2019.10.001_bib20","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1096\/fj.05-4715fje","article-title":"Polysurgery of cell sheet grafts overcomes diffusion limits to produce thick, vascularized myocardial tissues","volume":"20","author":"Shimizu","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.reth.2019.10.001_bib21","first-page":"799","article-title":"Generation of bioartificial heart tissue by combining a three-dimensional gel-based cardiac construct with decellularized small intestinal submucosa","volume":"20","author":"Vukadinovic-Nikolic","year":"2014","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.reth.2019.10.001_bib22","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/ncomms2406","article-title":"In\u00a0vitro fabrication of functional three-dimensional tissues with perfusable blood vessels","volume":"4","author":"Sekine","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.reth.2019.10.001_bib23","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/term.1995","article-title":"Three-dimensional functional human myocardial tissues fabricated from induced pluripotent stem cells","volume":"11","author":"Komae","year":"2017","journal-title":"J\u00a0Tissue Eng Regen Med"},{"key":"10.1016\/j.reth.2019.10.001_bib24","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.reth.2019.10.001_bib25","doi-asserted-by":"crossref","first-page":"45499","DOI":"10.1038\/srep45499","article-title":"Tubular cardiac tissues derived from human induced pluripotent stem cells generate pulse pressure in\u00a0vivo","volume":"7","author":"Seta","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.reth.2019.10.001_bib26","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.bbrc.2012.07.089","article-title":"Creation of human cardiac cell sheets using pluripotent stem cells","volume":"425","author":"Matsuura","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.reth.2019.10.001_bib27","doi-asserted-by":"crossref","DOI":"10.4081\/ejh.2013.e4","article-title":"Decellularized omentum as novel biologic scaffold for reconstructive surgery and regenerative medicine","volume":"57","author":"Porzionato","year":"2013","journal-title":"Eur J Histochem"},{"key":"10.1016\/j.reth.2019.10.001_bib28","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2147\/TCRM.S134869","article-title":"Omentum flap as a salvage procedure in deep sternal wound infection","volume":"13","author":"Spindler","year":"2017","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.reth.2019.10.001_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1510\/icvts.2011.270652","article-title":"Muscle flaps or omental flap in the management of deep sternal wound infection","volume":"13","author":"van Wingerden","year":"2011","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.reth.2019.10.001_bib30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jss.2017.07.034","article-title":"Laparoscopic repair of perforated peptic ulcer: simple closure versus omentopexy","volume":"220","author":"Lin","year":"2017","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.reth.2019.10.001_bib31","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1007\/s00464-009-0765-z","article-title":"Laparoscopic correction of perforated peptic ulcer: first choice? A review of literature","volume":"24","author":"Bertleff","year":"2010","journal-title":"Surg Endosc"},{"key":"10.1016\/j.reth.2019.10.001_bib32","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1016\/j.actbio.2014.08.024","article-title":"Evaluation of decellularization protocols of tubular small intestine submucosa scaffolds for use in oesophageal tissue engineering","volume":"10","author":"Syed","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1016\/j.reth.2019.10.001_bib33","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nm1684","article-title":"Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart","volume":"14","author":"Ott","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.reth.2019.10.001_bib34","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/icvts\/ivw022","article-title":"Heterotopic transplantation of a decellularized and recellularized whole porcine heart","volume":"22","author":"Kitahara","year":"2016","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.reth.2019.10.001_bib35","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1126\/science.1189345","article-title":"Tissue-engineered lungs for in\u00a0vivo implantation","volume":"329","author":"Petersen","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.reth.2019.10.001_bib36","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/nm.2170","article-title":"Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix","volume":"16","author":"Uygun","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.reth.2019.10.001_bib37","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nm.3154","article-title":"Regeneration and experimental orthotopic transplantation of a bioengineered kidney","volume":"19","author":"Song","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.reth.2019.10.001_bib38","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s13287-017-0675-2","article-title":"Transplantation of lsl1+ cardiac progenitor cells in small intestinal submucosa improves infarcted heart function","volume":"8","author":"Wang","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.reth.2019.10.001_bib39","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1021\/bi00291a023","article-title":"Nucleotide sequences of complementary deoxyribonucleic acids for the pro alpha 1 chain of human type 1 procollagen. Statistical evaluation of structures that are conserved during evolution","volume":"22","author":"Bernard","year":"1983","journal-title":"Biochemistry"},{"key":"10.1016\/j.reth.2019.10.001_bib40","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.aan4187","article-title":"Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9","volume":"357","author":"Niu","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.reth.2019.10.001_bib41","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1161\/CIRCULATIONAHA.107.757286","article-title":"Endothelial cell coculture within tissue-engineered cardiomyocyte sheets enhances neovascularization and improves cardiac function of ischemic hearts","volume":"118","author":"Sekine","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.reth.2019.10.001_bib42","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.biomaterials.2009.11.036","article-title":"Design of prevascularized three-dimensional cell-dense tissue using a cell sheet stacking manipulation technology","volume":"31","author":"Sasagawa","year":"2010","journal-title":"Biomaterials"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320419300823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320419300823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:37:47Z","timestamp":1762450667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352320419300823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":42,"alternative-id":["S2352320419300823"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2019.10.001","relation":{},"ISSN":["2352-3204"],"issn-type":[{"value":"2352-3204","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of a large-scale vascular bed for the in\u00a0vitro creation of three-dimensional cardiac tissue","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2019.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}