{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:34:01Z","timestamp":1790703241755,"version":"4.1.0"},"reference-count":103,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.reth.2020.07.002","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T06:28:27Z","timestamp":1596522507000},"page":"129-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Regenerative medicine for the upper gastrointestinal tract"],"prefix":"10.1016","volume":"15","author":[{"given":"Kengo","family":"Kanetaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reth.2020.07.002_bib1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00595-017-1610-y","article-title":"Regenerative medicine for the esophagus","volume":"48","author":"Kanetaka","year":"2018","journal-title":"Surg Today"},{"key":"10.1016\/j.reth.2020.07.002_bib2","article-title":"Tubular organ epithelialisation","volume":"7","author":"Saksena","year":"2016","journal-title":"J\u00a0Tissue Eng"},{"key":"10.1016\/j.reth.2020.07.002_bib3","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1053\/jpsu.2002.35402","article-title":"Application of collagen sponge scaffold to muscular defects of the esophagus: an experimental study in piglets","volume":"37","author":"Komuro","year":"2002","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.reth.2020.07.002_bib4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3181\/0901-RM-5","article-title":"Grafts of porcine small intestinal submucosa with cultured autologous oral mucosal epithelial cells for esophageal repair in a canine model","volume":"234","author":"Wei","year":"2009","journal-title":"Exp Biol Med"},{"key":"10.1016\/j.reth.2020.07.002_bib5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.surg.2015.01.020","article-title":"Circumferential esophageal replacement using a tube-shaped tissue-engineered substitute: an experimental study in minipigs","volume":"158","author":"Poghosyan","year":"2015","journal-title":"Surgery"},{"key":"10.1016\/j.reth.2020.07.002_bib6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/00002480-200105000-00008","article-title":"Experimental study on in situ tissue engineering of the stomach by an acellular collagen sponge scaffold graft","volume":"47","author":"Hori","year":"2001","journal-title":"Am Soc Artif Intern Organs J"},{"key":"10.1016\/j.reth.2020.07.002_bib7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jss.2012.07.054","article-title":"Tissue engineered esophagus by mesenchymal stem cell seeding for esophageal repair in a canine model","volume":"182","author":"Tan","year":"2013","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.reth.2020.07.002_bib8","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1038\/ncomms4562","article-title":"Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats","volume":"5","author":"Sjoqvist","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.reth.2020.07.002_bib9","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/icvts\/ivw048","article-title":"Tissue-engineered artificial oesophagus patch using three-dimensionally printed polycaprolactone with mesenchymal stem cells: a preliminary report","volume":"22","author":"Park","year":"2016","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.reth.2020.07.002_bib10","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.gie.2018.06.032","article-title":"Repairing the human esophagus with tissue engineering","volume":"88","author":"Dua","year":"2018","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.reth.2020.07.002_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcmgh.2017.09.004","article-title":"Extracellular matrix bioscaffolds for building gastrointestinal tissue","volume":"5","author":"Hussey","year":"2018","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.reth.2020.07.002_bib12","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/(SICI)1097-4644(19971215)67:4<478::AID-JCB6>3.0.CO;2-P","article-title":"Identification of extractable growth factors from small intestinal submucosa","volume":"67","author":"Voytik-Harbin","year":"1997","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.reth.2020.07.002_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/10623320109063154","article-title":"Vascular endothelial growth factor in porcine-derived extracellular matrix","volume":"8","author":"Hodde","year":"2001","journal-title":"Endothelium"},{"key":"10.1016\/j.reth.2020.07.002_bib14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/0192623313512431","article-title":"Regenerative medicine of the gastrointestinal tract","volume":"42","author":"Basu","year":"2014","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.reth.2020.07.002_bib15","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0022-5223(03)00032-1","article-title":"Tissue-engineered esophagus: experimental substitution by onlay patch or interposition","volume":"126","author":"Grikscheit","year":"2003","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.reth.2020.07.002_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00383-006-1799-0","article-title":"Regeneration of the esophagus using gastric acellular matrix: an experimental study in a rat model","volume":"23","author":"Urita","year":"2007","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.reth.2020.07.002_bib17","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.jtcvs.2008.05.027","article-title":"Intrathoracic esophageal replacement by in situ tissue-engineered esophagus","volume":"136","author":"Nakase","year":"2008","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.reth.2020.07.002_bib18","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1016\/S1470-2045(14)70410-3","article-title":"Regenerative medicine for oesophageal reconstruction after cancer treatment","volume":"16","author":"Chian","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.reth.2020.07.002_bib19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jss.2005.03.002","article-title":"Esophageal reconstruction with ECM and muscle tissue in a dog model","volume":"128","author":"Badylak","year":"2005","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.reth.2020.07.002_bib20","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1136\/gut.2005.088518","article-title":"Treatment of oesophageal ulcerations using endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets in a canine model","volume":"55","author":"Ohki","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.reth.2020.07.002_bib21","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.gie.2006.12.062","article-title":"Autologous buccal keratinocyte implantation for the prevention of stenosis after EMR of the esophagus","volume":"66","author":"Sakurai","year":"2007","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.reth.2020.07.002_bib22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.gie.2008.04.022","article-title":"An extracellular matrix scaffold for esophageal stricture prevention after circumferential EMR","volume":"69","author":"Nieponice","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.reth.2020.07.002_bib23","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.gie.2010.11.008","article-title":"Use of adipose tissue-derived stromal cells for prevention of esophageal stricture after circumferential EMR in a canine model","volume":"73","author":"Honda","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.reth.2020.07.002_bib24","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jss.2012.09.029","article-title":"Bone marrow-derived cells participate in the long-term remodeling in a mouse model of esophageal reconstruction","volume":"182","author":"Nieponice","year":"2013","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.reth.2020.07.002_bib25","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1053\/jpsu.2000.7834","article-title":"Resorbable bioscaffold for esophageal repair in a dog model","volume":"35","author":"Badylak","year":"2000","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.reth.2020.07.002_bib26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1053\/jpsu.2001.20685","article-title":"Patch esophagoplasty using AlloDerm as a tissue scaffold","volume":"36","author":"Isch","year":"2001","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.reth.2020.07.002_bib27","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000076650","article-title":"Surgical mesh as a scaffold for tissue regeneration in the esophagus","volume":"36","author":"Lynen Jansen","year":"2004","journal-title":"Eur Surg Res"},{"key":"10.1016\/j.reth.2020.07.002_bib28","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1442-2050.2006.00574.x","article-title":"Esophageal replacement in rat using porcine intestinal submucosa as a patch or a tube-shaped graft","volume":"19","author":"Lopes","year":"2006","journal-title":"Dis Esophagus"},{"key":"10.1016\/j.reth.2020.07.002_bib29","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/dote.12172","article-title":"Poly-epsilon-caprolactone mesh as a scaffold for in\u00a0vivo tissue engineering in rabbit esophagus","volume":"28","author":"Diemer","year":"2015","journal-title":"Dis Esophagus"},{"key":"10.1016\/j.reth.2020.07.002_bib30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jpedsurg.2017.11.004","article-title":"Patch esophagoplasty using an in-body-tissue-engineered collagenous connective tissue membrane","volume":"53","author":"Okuyama","year":"2018","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.reth.2020.07.002_bib31","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1007\/s005950070100","article-title":"Experimental study of an artificial esophagus using a collagen sponge, a latissimus dorsi muscle flap, and split-thickness skin","volume":"30","author":"Saito","year":"2000","journal-title":"Surg Today"},{"key":"10.1016\/j.reth.2020.07.002_bib32","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0022-3468(03)00386-5","article-title":"Tissue-engineered stomach: a preliminary report of a versatile in\u00a0vivo model with therapeutic potential","volume":"38","author":"Grikscheit","year":"2003","journal-title":"J\u00a0Pediatr Surg"},{"key":"10.1016\/j.reth.2020.07.002_bib33","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1525-1594.2009.00727.x","article-title":"Unsuccessful alloplastic esophageal replacement with porcine small intestinal submucosa","volume":"33","author":"Doede","year":"2009","journal-title":"Artif Organs"},{"key":"10.1016\/j.reth.2020.07.002_bib34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.surg.2009.12.002","article-title":"Esophageal replacement by allogenic aorta in a porcine model","volume":"148","author":"Gaujoux","year":"2010","journal-title":"Surgery"},{"key":"10.1016\/j.reth.2020.07.002_bib35","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1177\/0963689717741498","article-title":"Circumferential esophageal replacement by a tissue-engineered substitute using mesenchymal stem cells: an experimental study in mini pigs","volume":"26","author":"Catry","year":"2017","journal-title":"Cell Transplant"},{"key":"10.1016\/j.reth.2020.07.002_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2018.05.023","article-title":"Decellularized and matured esophageal scaffold for circumferential esophagus replacement: proof of concept in a pig model","volume":"175","author":"Luc","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.reth.2020.07.002_bib37","article-title":"Regeneration of esophagus using a scaffold-free biomimetic structure created with bio-three-dimensional printing","volume":"14","author":"Takeoka","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.reth.2020.07.002_bib38","doi-asserted-by":"crossref","first-page":"4286","DOI":"10.1038\/s41467-018-06385-w","article-title":"Multi-stage bioengineering of a layered oesophagus with in\u00a0vitro expanded muscle and epithelial adult progenitors","volume":"9","author":"Urbani","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.reth.2020.07.002_bib39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ncb1542","article-title":"Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells","volume":"9","author":"Dellavalle","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.reth.2020.07.002_bib40","article-title":"Scaffold-free tubular tissues created by a bio-3D printer undergo remodeling and endothelialization when implanted in rat aortae","volume":"10","author":"Itoh","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.reth.2020.07.002_bib41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/01.TP.0000068903.63554.1B","article-title":"A\u00a0tissue-engineered stomach as a replacement of the native stomach","volume":"76","author":"Maemura","year":"2003","journal-title":"Transplantation"},{"key":"10.1016\/j.reth.2020.07.002_bib42","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.transproceed.2004.05.020","article-title":"Assessment of tissue-engineered stomach derived from isolated epithelium organoid units","volume":"36","author":"Maemura","year":"2004","journal-title":"Transplant Proc"},{"key":"10.1016\/j.reth.2020.07.002_bib43","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1525-1594.2007.00528.x","article-title":"A\u00a0tissue-engineered stomach shows presence of proton pump and G-cells in a rat model, resulting in improved anemia following total gastrectomy","volume":"32","author":"Maemura","year":"2008","journal-title":"Artif Organs"},{"key":"10.1016\/j.reth.2020.07.002_bib44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jss.2009.03.062","article-title":"Tissue-engineered small intestine and stomach form from autologous tissue in a preclinical large animal model","volume":"156","author":"Sala","year":"2009","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.reth.2020.07.002_bib45","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.stem.2009.11.013","article-title":"Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in\u00a0vitro","volume":"6","author":"Barker","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.reth.2020.07.002_bib46","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jss.2011.03.062","article-title":"Murine tissue-engineered stomach demonstrates epithelial differentiation","volume":"171","author":"Speer","year":"2011","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.reth.2020.07.002_bib47","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cell.2013.09.008","article-title":"Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium","volume":"155","author":"Stange","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.reth.2020.07.002_bib48","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.bbrc.2013.02.051","article-title":"Establishment of a long-term three-dimensional primary culture of mouse glandular stomach epithelial cells within the stem cell niche","volume":"432","author":"Katano","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.reth.2020.07.002_bib49","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature13863","article-title":"Modelling human development and disease in pluripotent stem-cell-derived gastric organoids","volume":"516","author":"McCracken","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.reth.2020.07.002_bib50","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1053\/j.gastro.2014.09.042","article-title":"In\u00a0vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection","volume":"148","author":"Bartfeld","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.reth.2020.07.002_bib51","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1113\/jphysiol.2014.283028","article-title":"The use of murine-derived fundic organoids in studies of gastric physiology","volume":"593","author":"Schumacher","year":"2015","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.reth.2020.07.002_bib52","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/ncb3200","article-title":"Generation of stomach tissue from mouse embryonic stem cells","volume":"17","author":"Noguchi","year":"2015","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.reth.2020.07.002_bib53","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1136\/gutjnl-2014-307949","article-title":"A\u00a0novel human gastric primary cell culture system for modelling Helicobacter pylori infection in\u00a0vitro","volume":"65","author":"Schlaermann","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.reth.2020.07.002_bib54","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature21021","article-title":"Wnt\/beta-catenin promotes gastric fundus specification in mice and humans","volume":"541","author":"McCracken","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.reth.2020.07.002_bib55","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1089\/ten.tea.2015.0194","article-title":"Bioengineered human pyloric sphincters using autologous smooth muscle and neural progenitor cells","volume":"22","author":"Rego","year":"2016","journal-title":"Tissue Eng"},{"key":"10.1016\/j.reth.2020.07.002_bib56","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.gie.2009.05.014","article-title":"Endoscopic injection of skeletal muscle-derived cells augments gut smooth muscle sphincter function: implications for a novel therapeutic approach","volume":"70","author":"Pasricha","year":"2009","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.reth.2020.07.002_bib57","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ymeth.2015.08.014","article-title":"Bioengineering functional human sphincteric and non-sphincteric gastrointestinal smooth muscle constructs","volume":"99","author":"Rego","year":"2016","journal-title":"Methods"},{"key":"10.1016\/j.reth.2020.07.002_bib58","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1002\/term.2253","article-title":"Biomechanical properties of an implanted engineered tubular gut-sphincter complex","volume":"11","author":"Zakhem","year":"2017","journal-title":"J\u00a0Tissue Eng Regen Med"},{"key":"10.1016\/j.reth.2020.07.002_bib59","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1053\/j.gastro.2010.12.001","article-title":"Gastric epithelial stem cells","volume":"140","author":"Mills","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.reth.2020.07.002_bib60","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/S0041-1345(96)00164-9","article-title":"Preliminary studies of tissue-engineered intestine using isolated epithelial organoid units on tubular synthetic biodegradable scaffolds","volume":"29","author":"Choi","year":"1997","journal-title":"Transplant Proc"},{"key":"10.1016\/j.reth.2020.07.002_bib61","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1067\/msy.2002.125310","article-title":"Tissue-engineered colon exhibits function in\u00a0vivo","volume":"132","author":"Grikscheit","year":"2002","journal-title":"Surgery"},{"key":"10.1016\/j.reth.2020.07.002_bib62","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1101\/gad.1674008","article-title":"The intestinal stem cell","volume":"22","author":"Barker","year":"2008","journal-title":"Genes Dev"},{"key":"10.1016\/j.reth.2020.07.002_bib63","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1053\/j.gastro.2007.09.031","article-title":"Prospective identification of a multilineage progenitor in murine stomach epithelium","volume":"133","author":"Qiao","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.reth.2020.07.002_bib64","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.reth.2020.07.002_bib65","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/path.5244","article-title":"Bmi1 marks gastric stem cells located in the isthmus in mice","volume":"248","author":"Yoshioka","year":"2019","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.reth.2020.07.002_bib66","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in\u00a0vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.reth.2020.07.002_bib67","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4161\/cc.7.1.5135","article-title":"Troy binding to lymphotoxin-alpha activates NF kappa B mediated transcription","volume":"7","author":"Hashimoto","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.reth.2020.07.002_bib68","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.reth.2020.07.002_bib69","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.reth.2016.01.009","article-title":"Recent policies that support clinical application of induced pluripotent stem cell-based regenerative therapies","volume":"4","author":"Azuma","year":"2016","journal-title":"Regen Ther"},{"key":"10.1016\/j.reth.2020.07.002_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004663","article-title":"CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation","volume":"11","author":"Bertaux-Skeirik","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.reth.2020.07.002_bib71","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1136\/gutjnl-2014-307650","article-title":"Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells","volume":"64","author":"Wroblewski","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.reth.2020.07.002_bib72","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ni1131","article-title":"Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island","volume":"5","author":"Viala","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.reth.2020.07.002_bib73","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2121-11-21","article-title":"High-throughput and single-cell imaging of NF-kappaB oscillations using monoclonal cell lines","volume":"11","author":"Bartfeld","year":"2010","journal-title":"BMC Cell Biol"},{"key":"10.1016\/j.reth.2020.07.002_bib74","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.molimm.2004.12.001","article-title":"Innate immune recognition of the extracellular mucosal pathogen, Helicobacter pylori","volume":"42","author":"Ferrero","year":"2005","journal-title":"Mol Immunol"},{"key":"10.1016\/j.reth.2020.07.002_bib75","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1083\/jcb.200208039","article-title":"Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response","volume":"161","author":"Churin","year":"2003","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.reth.2020.07.002_bib76","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.surg.2007.04.019","article-title":"Functional evaluation of the grafted wall with porcine-derived small intestinal submucosa (SIS) to a stomach defect in rats","volume":"142","author":"Ueno","year":"2007","journal-title":"Surgery"},{"key":"10.1016\/j.reth.2020.07.002_bib77","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/j.1525-1594.2009.00808.x","article-title":"Development of a new tissue-engineered sheet for reconstruction of the stomach","volume":"33","author":"Araki","year":"2009","journal-title":"Artif Organs"},{"key":"10.1016\/j.reth.2020.07.002_bib78","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1525-1594.2011.01360.x","article-title":"Assessment of a tissue-engineered gastric wall patch in a rat model","volume":"36","author":"Maemura","year":"2012","journal-title":"Artif Organs"},{"key":"10.1016\/j.reth.2020.07.002_bib79","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/term.1794","article-title":"Influence of mesenchymal stem cells on stomach tissue engineering using small intestinal submucosa","volume":"9","author":"Nakatsu","year":"2015","journal-title":"J\u00a0Tissue Eng Regen Med"},{"key":"10.1016\/j.reth.2020.07.002_bib80","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00595-016-1360-2","article-title":"Cell sheet technology for the regeneration of gastrointestinal tissue using a novel gastric perforation rat model","volume":"47","author":"Tanaka","year":"2017","journal-title":"Surg Today"},{"key":"10.1016\/j.reth.2020.07.002_bib81","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/00002480-199905000-00005","article-title":"Replacement of the tracheobronchial bifurcation by a newly developed Y-shaped artificial trachea","volume":"45","author":"Sekine","year":"1999","journal-title":"Am Soc Artif Intern Organs J"},{"key":"10.1016\/j.reth.2020.07.002_bib82","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00002480-199907000-00011","article-title":"Experimental replacement of the thoracic esophagus with a bioabsorbable collagen sponge scaffold supported by a silicone stent in dogs","volume":"45","author":"Yamamoto","year":"1999","journal-title":"Am Soc Artif Intern Organs J"},{"key":"10.1016\/j.reth.2020.07.002_bib83","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1089\/ten.tea.2010.0739","article-title":"Esophageal preservation in five male patients after endoscopic inner-layer circumferential resection in the setting of superficial cancer: a regenerative medicine approach with a biologic scaffold","volume":"17","author":"Badylak","year":"2011","journal-title":"Tissue Eng"},{"key":"10.1016\/j.reth.2020.07.002_bib84","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1053\/j.gastro.2012.04.050","article-title":"Prevention of esophageal stricture after endoscopic submucosal dissection using tissue-engineered cell sheets","volume":"143","author":"Ohki","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.reth.2020.07.002_bib85","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.athoracsur.2013.08.011","article-title":"Patch esophagoplasty: esophageal reconstruction using biologic scaffolds","volume":"97","author":"Nieponice","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.reth.2020.07.002_bib86","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0140-6736(15)01036-3","article-title":"In-vivo oesophageal regeneration in a human being by use of a non-biological scaffold and extracellular matrix","volume":"388","author":"Dua","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.reth.2020.07.002_bib87","doi-asserted-by":"crossref","first-page":"17460","DOI":"10.1038\/s41598-017-17663-w","article-title":"Oral epithelial cell sheets engraftment for esophageal strictures after endoscopic submucosal dissection of squamous cell carcinoma and airplane transportation","volume":"7","author":"Yamaguchi","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.reth.2020.07.002_bib88","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0016-5107(02)70043-6","article-title":"Long-term outcome after endoscopic mucosal resection in patients with esophageal squamous cell carcinoma invading the muscularis mucosae or deeper","volume":"56","author":"Shimizu","year":"2002","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.reth.2020.07.002_bib89","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/S1542-3565(05)00291-0","article-title":"Endoscopic submucosal dissection of early esophageal cancer","volume":"3","author":"Oyama","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.reth.2020.07.002_bib90","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1055\/s-2007-966761","article-title":"Clinical outcome after endoscopic mucosal resection for esophageal squamous cell carcinoma invading the muscularis mucosae--a multicenter retrospective cohort study","volume":"39","author":"Katada","year":"2007","journal-title":"Endoscopy"},{"key":"10.1016\/j.reth.2020.07.002_bib91","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.gie.2011.05.031","article-title":"Factors associated with esophageal stricture formation after endoscopic mucosal resection for neoplastic Barrett's esophagus","volume":"74","author":"Lewis","year":"2011","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.reth.2020.07.002_bib92","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10047-006-0342-3","article-title":"Fabrication of transplantable human oral mucosal epithelial cell sheets using temperature-responsive culture inserts without feeder layer cells","volume":"9","author":"Murakami","year":"2006","journal-title":"J\u00a0Artif Organs"},{"key":"10.1016\/j.reth.2020.07.002_bib93","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.gie.2010.08.007","article-title":"Fabrication of human oral mucosal epithelial cell sheets for treatment of esophageal ulceration by endoscopic submucosal dissection","volume":"72","author":"Takagi","year":"2010","journal-title":"Gastrointest Endosc"},{"key":"10.1016\/j.reth.2020.07.002_bib94","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1253\/circj.CJ-15-0243","article-title":"Safety and efficacy of autologous skeletal myoblast sheets (TCD-51073) for the treatment of severe chronic heart failure due to ischemic heart disease","volume":"79","author":"Sawa","year":"2015","journal-title":"Circ J"},{"key":"10.1016\/j.reth.2020.07.002_bib95","article-title":"Phase I clinical trial of autologous stem cell-sheet transplantation therapy for treating cardiomyopathy","volume":"6","author":"Miyagawa","year":"2017","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.reth.2020.07.002_bib96","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1056\/NEJMc1706274","article-title":"Autologous induced stem-cell-derived retinal cells for macular degeneration","volume":"377","author":"Mandai","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.reth.2020.07.002_bib97","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.biomaterials.2018.12.006","article-title":"Intestinal organoids: a new paradigm for engineering intestinal epithelium in\u00a0vitro","volume":"194","author":"Rahmani","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.reth.2020.07.002_bib98","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature12271","article-title":"Vascularized and functional human liver from an iPSC-derived organ bud transplant","volume":"499","author":"Takebe","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.reth.2020.07.002_bib99","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.biomaterials.2015.06.046","article-title":"Vascularized subcutaneous human liver tissue from engineered hepatocyte\/fibroblast sheets in mice","volume":"65","author":"Sakai","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.reth.2020.07.002_bib100","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1002\/term.2761","article-title":"Time-dependent structural and functional characterization of subcutaneous human liver tissue","volume":"12","author":"Sakai","year":"2018","journal-title":"J\u00a0Tissue Eng Regen Med"},{"key":"10.1016\/j.reth.2020.07.002_bib101","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1002\/term.2968","article-title":"Fabrication of tissue-engineered cell sheets by automated cell culture equipment","volume":"13","author":"Nishimura","year":"2019","journal-title":"J\u00a0Tissue Eng Regen Med"},{"key":"10.1016\/j.reth.2020.07.002_bib102","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.reth.2018.08.004","article-title":"A\u00a0novel, flexible and automated manufacturing facility for cell-based health care products: tissue Factory","volume":"9","author":"Kikuchi","year":"2018","journal-title":"Regen Ther"},{"key":"10.1016\/j.reth.2020.07.002_bib103","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.athoracsur.2007.10.106","article-title":"Franz John A. Torek","volume":"85","author":"Dubecz","year":"2008","journal-title":"Ann Thorac Surg"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320420300560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320420300560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:38:45Z","timestamp":1762450725000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352320420300560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":103,"alternative-id":["S2352320420300560"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2020.07.002","relation":{},"ISSN":["2352-3204"],"issn-type":[{"value":"2352-3204","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regenerative medicine for the upper gastrointestinal tract","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2020.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}