{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:14:02Z","timestamp":1768320842050,"version":"3.49.0"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.reth.2022.01.004","type":"journal-article","created":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T11:32:24Z","timestamp":1643542344000},"page":"107-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Effects of fluoride on the proliferation and activation of osteoblasts by regulating methylation of the DNA repair genes MGMT and MLH1"],"prefix":"10.1016","volume":"19","author":[{"given":"Long","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Jie","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4310-6350","authenticated-orcid":false,"given":"Shu-Mei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"41","key":"10.1016\/j.reth.2022.01.004_bib1","first-page":"162","article-title":"Endothelial cell endurance to various courses of focal brain ischemia-reperfusional injury in rats","volume":"9","author":"Chu","year":"2005","journal-title":"Chin J Clin Rehabil"},{"issue":"3","key":"10.1016\/j.reth.2022.01.004_bib2","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s12011-013-9752-2","article-title":"Role of endoplasmic reticulum stress in aberrant activation of fluoride-treated osteoblasts","volume":"154","author":"Zhou","year":"2013","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.reth.2022.01.004_bib3","doi-asserted-by":"crossref","first-page":"108875","DOI":"10.1016\/j.cbi.2019.108875","article-title":"Aberrant DNA methylation of Cyclind-CDK4-p21 is associated with chronic fluoride poisoning","volume":"315","author":"Pan","year":"2019","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.reth.2022.01.004_bib4","series-title":"Comparing activated alumina with indigenous laterite and bauxite as potential sorbents for removing fluoride from drinking water in Ghana","author":"Craig","year":"2015"},{"issue":"5","key":"10.1016\/j.reth.2022.01.004_bib5","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1177\/0022034510384626","article-title":"Fluoride's effects on the formation of teeth and bones, and the influence of genetics","volume":"90","author":"Everett","year":"2011","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.reth.2022.01.004_bib6","series-title":"Aberrant methylation-induced dysfunction of p16 is associated with osteoblast activation caused by fluoride","author":"Shouli","year":"2018"},{"issue":"10","key":"10.1016\/j.reth.2022.01.004_bib7","first-page":"3741","article-title":"p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor","volume":"29","author":"Bocangel","year":"2009","journal-title":"Anticancer Res"},{"issue":"3","key":"10.1016\/j.reth.2022.01.004_bib8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/ijc.2910610308","article-title":"O6-methylguanine-DNA methyltransferase activity in breast and brain tumors","volume":"61","author":"Preuss","year":"2010","journal-title":"Int J Cancer"},{"key":"10.1016\/j.reth.2022.01.004_bib9","series-title":"Aberrantly methylated MGMT, hMLH1 and hMSH2 in tumor and serum DNA of gliomas patients","author":"Zheng","year":"2009"},{"key":"10.1016\/j.reth.2022.01.004_bib10","article-title":"Changes of DNA repair gene methylation in blood of chronic fluorosis patients and rats","volume":"50","author":"Wu","year":"2018","journal-title":"J\u00a0Trace Elem Med Biol"},{"issue":"4","key":"10.1016\/j.reth.2022.01.004_bib11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1139\/o11-034","article-title":"Effects of fluoride on expression of bone-specific genes in developing Xenopus laevis larvae","volume":"89","author":"Manoj Nair","year":"2011","journal-title":"Biochemistry & Cell Biology-biochimie Et Biologie Cellulaire"},{"key":"10.1016\/j.reth.2022.01.004_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.etap.2016.08.001","article-title":"Relationship between fluoride exposure and osteoclast markers during RANKL-induced osteoclast differentiation","volume":"46","author":"Junrui","year":"2016","journal-title":"Environ Toxicol Pharmacol"},{"issue":"1\u20133","key":"10.1016\/j.reth.2022.01.004_bib13","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s12011-011-9059-0","article-title":"Sodium fluoride affects proliferation and apoptosis through insulin-like growth factor I receptor in primary cultured mouse osteoblasts","volume":"144","author":"Ren","year":"2011","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"10.1016\/j.reth.2022.01.004_bib14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbrc.2013.01.075","article-title":"5-Aza-dC treatment induces mesenchymal-to-epithelial transition in 1st trimester trophoblast cell line HTR8\/SVneo","volume":"432","author":"Chen","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.reth.2022.01.004_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.pedneo.2015.11.009","article-title":"5-aza-2'-deoxycytidine inhibits the proliferation of lung fibroblasts in neonatal rats exposed to hyperoxia","volume":"58","author":"Zhao","year":"2016","journal-title":"Pediatrics & Neonatology"},{"issue":"21","key":"10.1016\/j.reth.2022.01.004_bib16","first-page":"984","article-title":"[Correlation between histone H3-K9 methylation, DNA methylation and expression of gene MGMT in Hep-2 cell line]","volume":"26","author":"Jing","year":"2012","journal-title":"Journal of Clinical Otorhinolaryngology Head and Neck Surgery"},{"issue":"1","key":"10.1016\/j.reth.2022.01.004_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/1476-4598-7-68","article-title":"Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study","volume":"7","author":"Brim","year":"2008","journal-title":"Mol Cancer"},{"issue":"5","key":"10.1016\/j.reth.2022.01.004_bib18","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/his.12220","article-title":"Protein expression and methylation of DNA repair geneshMLH1,hMSH2,MGMTandBRCA1and their correlation with clinicopathological parameters and prognosis in basal-like breast cancer","volume":"63","author":"Yimit","year":"2013","journal-title":"Histopathology"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320422000049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320422000049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:37:59Z","timestamp":1762450679000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352320422000049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":18,"alternative-id":["S2352320422000049"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2022.01.004","relation":{},"ISSN":["2352-3204"],"issn-type":[{"value":"2352-3204","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of fluoride on the proliferation and activation of osteoblasts by regulating methylation of the DNA repair genes MGMT and MLH1","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2022.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}