{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:39:00Z","timestamp":1770277140373,"version":"3.49.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K16609"],"award-info":[{"award-number":["17K16609"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.reth.2023.09.006","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:58:56Z","timestamp":1694757536000},"page":"426-433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Lung regeneration with rat fetal lung implantation and promotion of alveolar stem cell differentiation by corticosteroids"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4061-167X","authenticated-orcid":false,"given":"Daisuke","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Toba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Kenzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Sakiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9288-7478","authenticated-orcid":false,"given":"Naoya","family":"Kawakita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromitsu","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reth.2023.09.006_bib1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1513\/pats.200802-022AW","article-title":"Engineering of a complex organ: progress toward development of a tissue-engineered lung","volume":"5","author":"Nichols","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.reth.2023.09.006_bib2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.stem.2014.07.012","article-title":"Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function","volume":"15","author":"Hogan","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.reth.2023.09.006_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1700521","article-title":"Functional vascularized lung grafts for lung bioengineering","volume":"3","author":"Dorrello","year":"2017","journal-title":"Sci Adv"},{"key":"10.1016\/j.reth.2023.09.006_bib4","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.stem.2020.03.009","article-title":"The cellular and physiological basis for lung repair and regeneration: past, present, and future","volume":"26","author":"Basil","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.reth.2023.09.006_bib5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nbt.2754","article-title":"Efficient generation of lung and airway epithelial cells from human pluripotent stem cells","volume":"32","author":"Huang","year":"2014","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.reth.2023.09.006_bib6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.stemcr.2014.07.005","article-title":"Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells","volume":"3","author":"Gotoh","year":"2014","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.reth.2023.09.006_bib7","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nmeth.4448","article-title":"Long-term expansion of alveolar stem cells derived from human iPS cells in organoids","volume":"14","author":"Yamamoto","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.reth.2023.09.006_bib8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stemcr.2017.11.012","article-title":"In\u00a0vitro induction and in\u00a0vivo engraftment of lung bud tip progenitor cells derived from human pluripotent stem cells","volume":"10","author":"Miller","year":"2018","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.reth.2023.09.006_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121031","article-title":"Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in\u00a0vivo","volume":"276","author":"Ikeo","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.reth.2023.09.006_bib10","doi-asserted-by":"crossref","first-page":"4950","DOI":"10.1172\/JCI68793","article-title":"Human iPS cell-derived alveolar epithelium repopulates lung extracellular matrix","volume":"123","author":"Ghaedi","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.reth.2023.09.006_bib11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.stemcr.2015.11.010","article-title":"Directed induction of functional multi-ciliated cells in proximal airway epithelial spheroids from human pluripotent stem cells","volume":"6","author":"Konishi","year":"2016","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.reth.2023.09.006_bib12","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.jtcvs.2005.11.041","article-title":"Lung regeneration: implantation of fetal rat lung fragments into adult rat lung parenchyma","volume":"131","author":"Kenzaki","year":"2006","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.reth.2023.09.006_bib13","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.jtcvs.2012.01.002","article-title":"Implantation of fetal rat lung fragments into bleomycin-induced pulmonary fibrosis","volume":"143","author":"Toba","year":"2012","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"key":"10.1016\/j.reth.2023.09.006_bib14","first-page":"182","article-title":"Lung regeneration by fetal lung tissue implantation in a mouse pulmonary emphysema model","volume":"63","author":"Uyama","year":"2016","journal-title":"J\u00a0Med Invest"},{"key":"10.1016\/j.reth.2023.09.006_bib15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nature12930","article-title":"Alveolar progenitor and stem cells in lung development, renewal and cancer","volume":"507","author":"Desai","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.reth.2023.09.006_bib16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature13173","article-title":"Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq","volume":"509","author":"Treutlein","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.reth.2023.09.006_bib17","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","volume":"25","author":"McGoldrick","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.reth.2023.09.006_bib18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1001\/jama.1995.03520290065031","article-title":"Effect of corticosteroids for fetal maturation on perinatal outcomes: nih consensus development panel on the effect of corticosteroids for fetal maturation on perinatal outcomes","volume":"273","author":"Gilstrap","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.reth.2023.09.006_bib19","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00441-016-2545-0","article-title":"Development of lung","volume":"367","author":"Schittny","year":"2017","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.reth.2023.09.006_bib20","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3892\/etm.2016.2992","article-title":"Early and late effects of prenatal corticosteroid treatment on the microRNA profiles of lung tissue in rats","volume":"11","author":"Yu","year":"2016","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.reth.2023.09.006_bib21","doi-asserted-by":"crossref","first-page":"L814","DOI":"10.1152\/ajplung.00484.2020","article-title":"Stretch increases alveolar type 1 cell number in fetal lungs through ROCK-Yap\/Taz pathway","volume":"321","author":"Nguyen","year":"2021","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.reth.2023.09.006_bib22","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1513\/pats.200710-162DR","article-title":"Epithelial progenitor cells of the embryonic lung and the role of microRNAs in their proliferation","volume":"5","author":"Lu","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.reth.2023.09.006_bib23","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1038\/onc.2016.499","article-title":"The miR-487b-3p\/GRM3\/TGF\u03b2 signaling axis is an important regulator of colon cancer tumorigenesis","volume":"36","author":"Yi","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.reth.2023.09.006_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2015.02.002","article-title":"miR-487b promotes human umbilical vein endothelial cell proliferation, migration, invasion and tube formation through regulating THBS1","volume":"591","author":"Feng","year":"2015","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.reth.2023.09.006_bib25","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1165\/rcmb.2011-0377OC","article-title":"Profibrotic role of miR-154 in pulmonary fibrosis","volume":"47","author":"Milosevic","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.reth.2023.09.006_bib26","doi-asserted-by":"crossref","first-page":"20816","DOI":"10.1002\/jcp.28687","article-title":"Long noncoding RNA MALAT1 mediates stem cell-like properties in human colorectal cancer cells\u00a0by regulating miR-20b-5p\/Oct 4 axis","volume":"234","author":"Tang","year":"2019","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.reth.2023.09.006_bib27","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1152\/physiolgenomics.00077.2010","article-title":"Combined mRNA and microRNA profiling reveals that miR-148a and miR-20b control human mesenchymal stem cell phenotype via EPAS1","volume":"43","author":"Giraud-Triboult","year":"2011","journal-title":"Physiol Genom"},{"key":"10.1016\/j.reth.2023.09.006_bib28","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1111\/jcmm.14219","article-title":"The latest progress on miR-374 and its functional implications in physiological and pathological processes","volume":"23","author":"Bian","year":"2019","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.reth.2023.09.006_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax5941","article-title":"Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents","volume":"13","author":"Antounians","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.reth.2023.09.006_bib30","doi-asserted-by":"crossref","first-page":"22","DOI":"10.21037\/sci.2019.06.09","article-title":"Cell-based therapy for idiopathic pulmonary fibrosis","volume":"6","author":"Lu","year":"2019","journal-title":"Stem Cell Invest"},{"key":"10.1016\/j.reth.2023.09.006_bib31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s12931-020-01423-y","article-title":"Extracellular vesicles: novel communicators in lung diseases","volume":"21","author":"Mohan","year":"2020","journal-title":"Respir Res"},{"key":"10.1016\/j.reth.2023.09.006_bib32","article-title":"Systematic review of extracellular vesicle-based treatments for lung injury: are EVs a potential therapy for COVID-19?","volume":"9","author":"Khalaj","year":"2020","journal-title":"J\u00a0Extracell Vesicles"},{"key":"10.1016\/j.reth.2023.09.006_bib33","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s13287-020-01726-3","article-title":"Induced pluripotent stem cell-derived lung alveolar epithelial type II cells reduce damage in bleomycin-induced lung fibrosis","volume":"11","author":"Alvarez-Palomo","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.reth.2023.09.006_bib34","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/cvr\/cvw054","article-title":"Exosomes induce and reverse monocrotaline-induced pulmonary hypertension in mice","volume":"110","author":"Aliotta","year":"2016","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.reth.2023.09.006_bib35","article-title":"Small extracellular vesicles derived from human mesenchymal stromal cells prevent group 2 innate lymphoid cell-dominant allergic airway inflammation through delivery of miR-146a-5p","volume":"9","author":"Fang","year":"2020","journal-title":"J\u00a0Extracell Vesicles"},{"key":"10.1016\/j.reth.2023.09.006_bib36","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/dvdy.21047","article-title":"Maternally imprinted microRNAs are differentially expressed during mouse and human lung development","volume":"236","author":"Williams","year":"2007","journal-title":"Dev Dynam"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320423000871?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320423000871?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:44:16Z","timestamp":1762451056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352320423000871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":36,"alternative-id":["S2352320423000871"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2023.09.006","relation":{},"ISSN":["2352-3204"],"issn-type":[{"value":"2352-3204","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lung regeneration with rat fetal lung implantation and promotion of alveolar stem cell differentiation by corticosteroids","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2023.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}