{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:27:58Z","timestamp":1791361678741,"version":"4.3.1"},"reference-count":122,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203588"],"award-info":[{"award-number":["82203588"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272489"],"award-info":[{"award-number":["82272489"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.reth.2023.12.010","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T13:32:05Z","timestamp":1703770325000},"page":"174-185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Advancements in drug-loaded hydrogel systems for bone defect repair"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1471-2784","authenticated-orcid":false,"given":"Weipeng","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reth.2023.12.010_bib1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3389\/fphar.2020.00622","article-title":"Advancements in hydrogel-based drug sustained release systems for bone tissue engineering","volume":"11","author":"Zhang","year":"2020","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.reth.2023.12.010_bib2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1302\/0301-620X.87B2.15874","article-title":"The management of fractures with bone loss","volume":"87","author":"Keating","year":"2005","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.reth.2023.12.010_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.biomaterials.2016.07.011","article-title":"Self-healing supramolecular bioelastomers with shape memory property as a multifunctional platform for biomedical applications via modular assembly","volume":"104","author":"Wu","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.reth.2023.12.010_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201900520","article-title":"Adaptable microporous hydrogels of propagating NGF-gradient by injectable building blocks for accelerated axonal outgrowth","volume":"6","author":"Hsu","year":"2019","journal-title":"Adv Sci"},{"key":"10.1016\/j.reth.2023.12.010_bib5","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.1214804","article-title":"Designing cell-compatible hydrogels for biomedical applications","volume":"336","author":"Seliktar","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.reth.2023.12.010_bib6","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.2174\/0929867326666190903113004","article-title":"Natural polymers based hydrogels for cell culture applications","volume":"27","author":"Jose","year":"2020","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.reth.2023.12.010_bib7","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1039\/D1TB00412C","article-title":"Injectable poly(gamma-glutamic acid)-based biodegradable hydrogels with tunable gelation rate and mechanical strength","volume":"9","author":"Wei","year":"2021","journal-title":"J\u00a0Mater Chem B"},{"key":"10.1016\/j.reth.2023.12.010_bib8","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1007\/s10529-015-1907-0","article-title":"Recent advances in the use of gelatin in biomedical research","volume":"37","author":"Su","year":"2015","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.reth.2023.12.010_bib9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1089\/ten.teb.2019.0256","article-title":"Engineering and functionalization of gelatin biomaterials: from cell culture to medical applications","volume":"26","author":"Bello","year":"2020","journal-title":"Tissue Eng Part B"},{"key":"10.1016\/j.reth.2023.12.010_bib10","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.foodhyd.2011.02.007","article-title":"Functional and bioactive properties of collagen and gelatin from alternative sources: a review","volume":"25","author":"Gomez-Guillen","year":"2011","journal-title":"Food Hydrocolloids"},{"key":"10.1016\/j.reth.2023.12.010_bib11","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jconrel.2021.08.055","article-title":"The role of natural polymers in bone tissue engineering","volume":"338","author":"Guo","year":"2021","journal-title":"J\u00a0Contr Release"},{"key":"10.1016\/j.reth.2023.12.010_bib12","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1002\/adfm.201401110","article-title":"In situ crosslinkable gelatin hydrogels for vasculogenic induction and delivery of mesenchymal stem cells","volume":"24","author":"Lee","year":"2014","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.reth.2023.12.010_bib13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","article-title":"Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels","volume":"73","author":"Yue","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.reth.2023.12.010_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123813","article-title":"Cerium oxide nanoparticles disseminated chitosan gelatin scaffold for bone tissue engineering applications","volume":"236","author":"Bhushan","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.reth.2023.12.010_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ma14020396","article-title":"Comparative study of gelatin hydrogels modified by various cross-linking agents","volume":"14","author":"Skopinska-Wisniewska","year":"2021","journal-title":"Materials"},{"key":"10.1016\/j.reth.2023.12.010_bib16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.4103\/0973-029X.185932","article-title":"Enigmatic insight into collagen","volume":"20","author":"Deshmukh","year":"2016","journal-title":"J\u00a0Oral Maxillofac Pathol"},{"key":"10.1016\/j.reth.2023.12.010_bib17","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/jcp.29029","article-title":"Improved osteogenic differentiation of human induced pluripotent stem cells cultured on polyvinylidene fluoride\/collagen\/platelet-rich plasma composite nanofibers","volume":"235","author":"Abazari","year":"2020","journal-title":"J\u00a0Cell Physiol"},{"key":"10.1016\/j.reth.2023.12.010_bib18","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1016\/j.actbio.2012.06.014","article-title":"Collagen for bone tissue regeneration","volume":"8","author":"Ferreira","year":"2012","journal-title":"Acta Biomater"},{"key":"10.1016\/j.reth.2023.12.010_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122500","article-title":"Tunable collagen I hydrogels for engineered physiological tissue micro-environments","volume":"10","author":"Antoine","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.reth.2023.12.010_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123864","article-title":"Injectable TG-linked recombinant human collagen hydrogel loaded with bFGF for rat cranial defect repair","volume":"236","author":"Guo","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.reth.2023.12.010_bib21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijbiomac.2021.05.019","article-title":"Chitin-hydroxyapatite-collagen composite scaffolds for bone regeneration","volume":"184","author":"Xing","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.reth.2023.12.010_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41598-022-24424-x","article-title":"Collagen-chitosan-hydroxyapatite composite scaffolds for bone repair in ovariectomized rats","volume":"13","author":"Chacon","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.reth.2023.12.010_bib23","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/9\/6\/065004","article-title":"Evaluation of novel in situ synthesized nano-hydroxyapatite\/collagen\/alginate hydrogels for osteochondral tissue engineering","volume":"9","author":"Zheng","year":"2014","journal-title":"Biomed Mater"},{"key":"10.1016\/j.reth.2023.12.010_bib24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jconrel.2014.11.021","article-title":"Development of collagen-hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering","volume":"198","author":"Quinlan","year":"2015","journal-title":"J\u00a0Contr Release"},{"key":"10.1016\/j.reth.2023.12.010_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/polym14224906","article-title":"Application of hydrogels as sustained-release drug carriers in bone defect repair","volume":"14","author":"Feng","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.reth.2023.12.010_bib26","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.biomaterials.2017.02.010","article-title":"Elastin-like protein-hyaluronic acid (ELP-HA) hydrogels with decoupled mechanical and biochemical cues for cartilage regeneration","volume":"127","author":"Zhu","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.reth.2023.12.010_bib27","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ijbiomac.2020.09.107","article-title":"Hyaluronic acid containing scaffolds ameliorate stem cell function for tissue repair and regeneration","volume":"165","author":"Agarwal","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.reth.2023.12.010_bib28","doi-asserted-by":"crossref","first-page":"7081","DOI":"10.1016\/j.actbio.2013.03.005","article-title":"Applications and emerging trends of hyaluronic acid in tissue engineering, as a dermal filler and in osteoarthritis treatment","volume":"9","author":"Fakhari","year":"2013","journal-title":"Acta Biomater"},{"key":"10.1016\/j.reth.2023.12.010_bib29","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.actbio.2013.12.019","article-title":"Hyaluronan: a simple polysaccharide with diverse biological functions","volume":"10","author":"Dicker","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1016\/j.reth.2023.12.010_bib30","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1021\/acsbiomaterials.9b01363","article-title":"Integration of human umbilical cord mesenchymal stem cells-derived exosomes with hydroxyapatite-embedded hyaluronic acid-alginate hydrogel for bone regeneration","volume":"6","author":"Yang","year":"2020","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.reth.2023.12.010_bib31","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.carbpol.2014.05.097","article-title":"Influence of both cation and alginate nature on the rheological behavior of transition metal alginate gels","volume":"112","author":"Agulhon","year":"2014","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.reth.2023.12.010_bib32","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1002\/adhm.201600461","article-title":"Bone morphogenetic protein-2 promotes human mesenchymal stem cell survival and resultant bone formation when entrapped in photocrosslinked alginate hydrogels","volume":"5","author":"Ho","year":"2016","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.reth.2023.12.010_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120473","article-title":"Injectable remodeling hydrogels derived from alendronate-tethered alginate calcium complex for enhanced osteogenesis","volume":"303","author":"Kim","year":"2023","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.reth.2023.12.010_bib34","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.ijbiomac.2012.08.027","article-title":"In\u00a0vivo evaluation of porous hydroxyapatite\/chitosan-alginate composite scaffolds for bone tissue engineering","volume":"51","author":"Jin","year":"2012","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.reth.2023.12.010_bib35","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3390\/md13010312","article-title":"Recent modifications of chitosan for adsorption applications: a critical and systematic review","volume":"13","author":"Kyzas","year":"2015","journal-title":"Mar Drugs"},{"key":"10.1016\/j.reth.2023.12.010_bib36","doi-asserted-by":"crossref","first-page":"110890","DOI":"10.18632\/oncotarget.22917","article-title":"Chitosan composite scaffold combined with bone marrow-derived mesenchymal stem cells for bone regeneration: in\u00a0vitro and in\u00a0vivo evaluation","volume":"8","author":"Zang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.reth.2023.12.010_bib37","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1128\/AEM.00453-08","article-title":"Insights into the mode of action of chitosan as an antibacterial compound","volume":"74","author":"Raafat","year":"2008","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.reth.2023.12.010_bib38","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejpb.2012.04.007","article-title":"Chitosan-based drug delivery systems","volume":"81","author":"Bernkop-Schnurch","year":"2012","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.reth.2023.12.010_bib39","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ijbiomac.2022.09.058","article-title":"Chitosan-based scaffolds as drug delivery systems in bone tissue engineering","volume":"222","author":"Bharathi","year":"2022","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.reth.2023.12.010_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202206545","article-title":"A\u00a0MgFe-ldh nanosheet-incorporated smart thermo-responsive hydrogel with controllable growth factor releasing capability for bone regeneration","volume":"35","author":"Lv","year":"2023","journal-title":"Adv Mater"},{"key":"10.1016\/j.reth.2023.12.010_bib41","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1038\/nprot.2011.379","article-title":"Materials fabrication from Bombyx mori silk fibroin","volume":"6","author":"Rockwood","year":"2011","journal-title":"Nat Protoc"},{"key":"10.1016\/j.reth.2023.12.010_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2015.09.005","article-title":"Silk fibroin as biomaterial for bone tissue engineering","volume":"31","author":"Melke","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.reth.2023.12.010_bib43","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1021\/bm0345460","article-title":"Structure and properties of silk hydrogels","volume":"5","author":"Kim","year":"2004","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.reth.2023.12.010_bib44","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1016\/j.actbio.2011.02.032","article-title":"Silk fibroin electrogelation mechanisms","volume":"7","author":"Lu","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.reth.2023.12.010_bib45","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201908381","article-title":"Bioinspired mineral-organic bone adhesives for stable fracture fixation and accelerated bone regeneration","volume":"30","author":"Bai","year":"2020","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.reth.2023.12.010_bib46","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s11095-008-9801-2","article-title":"PEG hydrogels for the controlled release of biomolecules in regenerative medicine","volume":"26","author":"Lin","year":"2009","journal-title":"Pharm Res (N Y)"},{"key":"10.1016\/j.reth.2023.12.010_bib47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1615\/JLongTermEffMedImplants.2013006244","article-title":"Long-term in\u00a0vivo effect of PEG bone tissue engineering scaffolds","volume":"22","author":"Engebretson","year":"2012","journal-title":"J\u00a0Long Term Eff Med Implants"},{"key":"10.1016\/j.reth.2023.12.010_bib48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jiec.2020.06.017","article-title":"A\u00a0comprehensive review on polymeric hydrogel and its composite: matrices of choice for bone and cartilage tissue engineering","volume":"89","author":"Tran","year":"2020","journal-title":"J\u00a0Ind Eng Chem"},{"key":"10.1016\/j.reth.2023.12.010_bib49","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.actbio.2018.06.007","article-title":"RNA interfering molecule delivery from in situ forming biodegradable hydrogels for enhancement of bone formation in rat calvarial bone defects","volume":"75","author":"Nguyen","year":"2018","journal-title":"Acta Biomater"},{"key":"10.1016\/j.reth.2023.12.010_bib50","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1097\/00006534-199909020-00018","article-title":"Transdermal photopolymerization of poly(ethylene oxide)-based injectable hydrogels for tissue-engineered cartilage","volume":"104","author":"Elisseeff","year":"1999","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.reth.2023.12.010_bib51","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.msec.2012.04.030","article-title":"Development and characterization of Poly (vinyl alcohol) based hydrogels for potential use as an articular cartilage replacement","volume":"32","author":"Maiolo","year":"2012","journal-title":"Mater Sci Eng C"},{"key":"10.1016\/j.reth.2023.12.010_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118881","article-title":"Poly (vinyl alcohol)-alginate as potential matrix for various applications: a focused review","volume":"277","author":"Kumar","year":"2022","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.reth.2023.12.010_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2019.115176","article-title":"Construction of physical-crosslink chitosan\/PVA double-network hydrogel with surface mineralization for bone repair","volume":"224","author":"Bi","year":"2019","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.reth.2023.12.010_bib54","article-title":"The combination of multi-functional ingredients-loaded hydrogels and three-dimensional printed porous titanium alloys for infective bone defect treatment","volume":"11","author":"Qiao","year":"2020","journal-title":"J\u00a0Tissue Eng"},{"issue":"Suppl 1","key":"10.1016\/j.reth.2023.12.010_bib55","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1016\/j.injury.2008.01.036","article-title":"Smart biomaterials for tissue engineering of cartilage","volume":"39","author":"Stoop","year":"2008","journal-title":"Injury"},{"key":"10.1016\/j.reth.2023.12.010_bib56","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10275","article-title":"LINC00473-modified bone marrow mesenchymal stem cells incorporated thermosensitive PLGA hydrogel transplantation for steroid-induced osteonecrosis of femoral head: a detailed mechanistic study and validity evaluation","volume":"7","author":"Xu","year":"2022","journal-title":"Bioeng Transl Med"},{"key":"10.1016\/j.reth.2023.12.010_bib57","doi-asserted-by":"crossref","first-page":"19006","DOI":"10.1021\/acsami.5b02821","article-title":"Effective bone regeneration using thermosensitive poly(N-Isopropylacrylamide) grafted gelatin as injectable carrier for bone mesenchymal stem cells","volume":"7","author":"Ren","year":"2015","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.reth.2023.12.010_bib58","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1002\/adma.201400323","article-title":"A\u00a0novel poly(amido amine)-dendrimer-based hydrogel as a mimic for the extracellular matrix","volume":"26","author":"Wang","year":"2014","journal-title":"Adv Mater"},{"key":"10.1016\/j.reth.2023.12.010_bib59","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/jor.20359","article-title":"Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells","volume":"25","author":"Luu","year":"2007","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.reth.2023.12.010_bib60","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/ng1916","article-title":"BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing","volume":"38","author":"Tsuji","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.reth.2023.12.010_bib61","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.bone.2004.01.028","article-title":"Ex\u00a0vivo gene therapy-induced endochondral bone formation: comparison of muscle-derived stem cells and different subpopulations of primary muscle-derived cells","volume":"34","author":"Shen","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.reth.2023.12.010_bib62","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/(SICI)1520-6408(1998)22:4<321::AID-DVG3>3.0.CO;2-8","article-title":"Mice lacking Bmp6 function","volume":"22","author":"Solloway","year":"1998","journal-title":"Dev Genet"},{"key":"10.1016\/j.reth.2023.12.010_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111748","article-title":"Osteogenic differentiation cues of the bone morphogenetic protein-9 (BMP-9) and its recent advances in bone tissue regeneration","volume":"120","author":"Bharadwaz","year":"2021","journal-title":"Mater Sci Eng C"},{"key":"10.1016\/j.reth.2023.12.010_bib64","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/83810","article-title":"Bone morphogenetic protein-3 is a negative regulator of bone density","volume":"27","author":"Daluiski","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.reth.2023.12.010_bib65","article-title":"Application of BMP in bone tissue engineering","volume":"10","author":"Zhu","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.reth.2023.12.010_bib66","doi-asserted-by":"crossref","first-page":"7156","DOI":"10.1038\/sj.onc.1205937","article-title":"Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-beta and bone morphogenetic protein","volume":"21","author":"Lee","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.reth.2023.12.010_bib67","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/jcb.10369","article-title":"Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways","volume":"88","author":"Franceschi","year":"2003","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.reth.2023.12.010_bib68","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.1016\/j.biomaterials.2014.03.055","article-title":"Bone regeneration using an alpha 2 beta 1 integrin-specific hydrogel as a BMP-2 delivery vehicle","volume":"35","author":"Shekaran","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.reth.2023.12.010_bib69","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/term.74","article-title":"Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)","volume":"2","author":"Bessa","year":"2008","journal-title":"J\u00a0Tissue Eng Regen Med"},{"key":"10.1016\/j.reth.2023.12.010_bib70","first-page":"4276","article-title":"Injectable chitosan microparticles incorporating bone morphogenetic protein-7 for bone tissue regeneration","volume":"102","author":"Mantripragada","year":"2014","journal-title":"J\u00a0Biomed Mater Res"},{"key":"10.1016\/j.reth.2023.12.010_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.832727","article-title":"Bioinspired protein\/peptide loaded 3D printed PLGA scaffold promotes bone regeneration","volume":"10","author":"Song","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.reth.2023.12.010_bib72","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/03008208909002415","article-title":"Further characterization of osteogenic-cell growth promoting activity derived from healing bone marrow","volume":"23","author":"Gazit","year":"1989","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.reth.2023.12.010_bib73","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1210\/endo-123-1-345","article-title":"Regenerating bone marrow produces a potent growth-promoting activity to osteogenic cells","volume":"123","author":"Bab","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/j.reth.2023.12.010_bib74","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/wnan.1376","article-title":"Osteogenic growth peptide and its use as a bio-conjugate in regenerative medicine applications","volume":"8","author":"Policastro","year":"2016","journal-title":"Wiley Interdiscip Rev Nanomed Nanobiotechnol"},{"key":"10.1016\/j.reth.2023.12.010_bib75","doi-asserted-by":"crossref","first-page":"11722","DOI":"10.1039\/C8RA08828D","article-title":"Polydopamine-modified poly(l-lactic acid) nanofiber scaffolds immobilized with an osteogenic growth peptide for bone tissue regeneration","volume":"9","author":"Liu","year":"2019","journal-title":"RSC Adv"},{"key":"10.1016\/j.reth.2023.12.010_bib76","doi-asserted-by":"crossref","first-page":"11395","DOI":"10.1021\/acsomega.2c00501","article-title":"Supramolecular hydrogel based on an osteogenic growth peptide promotes bone defect repair","volume":"7","author":"Zhao","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.reth.2023.12.010_bib77","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0006-291X(89)92678-8","article-title":"Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells","volume":"161","author":"Ferrara","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.reth.2023.12.010_bib78","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.injury.2007.05.017","article-title":"The periosteum. Part 1: anatomy, histology and molecular biology","volume":"38","author":"Augustin","year":"2007","journal-title":"Injury"},{"key":"10.1016\/j.reth.2023.12.010_bib79","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bbrc.2005.12.175","article-title":"TNP-470 blockage of VEGF synthesis is dependent on MAPK\/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells","volume":"341","author":"Wang","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"Suppl 1","key":"10.1016\/j.reth.2023.12.010_bib80","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.injury.2006.02.036","article-title":"Transcriptomics and proteomics: advancing the understanding of genetic basis of fracture healing","volume":"37","author":"Tsiridis","year":"2006","journal-title":"Injury"},{"key":"10.1016\/j.reth.2023.12.010_bib81","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1359\/JBMR.050701","article-title":"Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects","volume":"20","author":"Geiger","year":"2005","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.reth.2023.12.010_bib82","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/00000637-200044050-00011","article-title":"Expression of adenovirally delivered gene products in healing osseous tissues","volume":"44","author":"Spector","year":"2000","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.reth.2023.12.010_bib83","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1016\/j.biomaterials.2007.12.031","article-title":"The effect of mesenchymal populations and vascular endothelial growth factor delivered from biodegradable polymer scaffolds on bone formation","volume":"29","author":"Kanczler","year":"2008","journal-title":"Biomaterials"},{"key":"10.1016\/j.reth.2023.12.010_bib84","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/jbm.a.35626","article-title":"Integrin-specific hydrogels functionalized with\u00a0VEGF for vascularization and bone regeneration of critical-size bone defects","volume":"104","author":"Garcia","year":"2016","journal-title":"J\u00a0Biomed Mater Res"},{"key":"10.1016\/j.reth.2023.12.010_bib85","doi-asserted-by":"crossref","first-page":"35319","DOI":"10.1021\/acsami.2c06159","article-title":"Vascular endothelial growth factor mimetic peptide and parathyroid hormone (1-34) delivered via a blue-light-curable hydrogel synergistically accelerate bone regeneration","volume":"14","author":"Wang","year":"2022","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.reth.2023.12.010_bib86","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.1210\/endo.142.9.8356","article-title":"Catabolic effects of continuous human PTH (1--38) in\u00a0vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation","volume":"142","author":"Ma","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.reth.2023.12.010_bib87","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.joms.2009.09.045","article-title":"Effect of intermittent systemic administration of recombinant parathyroid hormone (1-34) on mandibular fracture healing in rats","volume":"68","author":"Rowshan","year":"2010","journal-title":"J\u00a0Oral Maxillofac Surg"},{"key":"10.1016\/j.reth.2023.12.010_bib88","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1210\/jc.2011-2332","article-title":"Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives","volume":"97","author":"Baron","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.reth.2023.12.010_bib89","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/jbmr.518","article-title":"Delayed short-course treatment with teriparatide (PTH(1-34)) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction","volume":"27","author":"Takahata","year":"2012","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.reth.2023.12.010_bib90","first-page":"1","article-title":"Engineering of a NIR-activable hydrogel-coated mesoporous bioactive glass scaffold with dual-mode parathyroid hormone derivative release property for angiogenesis and bone regeneration","volume":"26","author":"Liu","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.reth.2023.12.010_bib91","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.bone.2009.11.029","article-title":"Calcitonin-gene-related peptide stimulates stromal cell osteogenic differentiation and inhibits RANKL induced NF-kappaB activation, osteoclastogenesis and bone resorption","volume":"46","author":"Wang","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.reth.2023.12.010_bib92","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.npep.2012.12.002","article-title":"Neuropeptides stimulate human osteoblast\u00a0activity and promote gap junctional intercellular communication","volume":"47","author":"Ma","year":"2013","journal-title":"Neuropeptides"},{"key":"10.1016\/j.reth.2023.12.010_bib93","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/aps.2013.41","article-title":"Calcitonin gene-related peptide stimulates BMP-2 expression and the differentiation of human osteoblast-like cells in\u00a0vitro","volume":"34","author":"Tian","year":"2013","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.reth.2023.12.010_bib94","first-page":"1820","article-title":"[Control of bone remodeling by nervous system. Neural involvement in fracture healing and bone regeneration]","volume":"20","author":"Suzuki","year":"2010","journal-title":"Clin Calcium"},{"key":"10.1016\/j.reth.2023.12.010_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0072738","article-title":"Effect of CGRP-adenoviral vector transduction on the osteoblastic differentiation of rat adipose-derived stem cells","volume":"8","author":"Fang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.reth.2023.12.010_bib96","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10529-016-2263-4","article-title":"Gelatin microspheres containing calcitonin gene-related peptide or substance P repair bone defects in osteoporotic rabbits","volume":"39","author":"Chen","year":"2017","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.reth.2023.12.010_bib97","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1126\/science.2457950","article-title":"Effect of neuropeptides on production of inflammatory cytokines by human monocytes","volume":"241","author":"Lotz","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.reth.2023.12.010_bib98","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.neuroscience.2010.06.004","article-title":"Role of neurokinin receptors and ionic mechanisms within the respiratory network of the lamprey","volume":"169","author":"Mutolo","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.reth.2023.12.010_bib99","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bone.2009.04.203","article-title":"Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in\u00a0vitro","volume":"45","author":"Wang","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.reth.2023.12.010_bib100","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.npep.2006.11.002","article-title":"Substance P stimulates late-stage rat osteoblastic bone formation through neurokinin-1 receptors","volume":"41","author":"Goto","year":"2007","journal-title":"Neuropeptides"},{"key":"10.1016\/j.reth.2023.12.010_bib101","doi-asserted-by":"crossref","DOI":"10.1002\/biot.201700062","article-title":"In situ bone tissue engineering with an endogenous stem cell mobilizer and osteoinductive nanofibrous polymeric scaffolds","volume":"12","author":"Lee","year":"2017","journal-title":"Biotechnol J"},{"key":"10.1016\/j.reth.2023.12.010_bib102","doi-asserted-by":"crossref","first-page":"9369","DOI":"10.1039\/D2TB01684B","article-title":"Application of bioactive metal ions in the treatment of bone defects","volume":"10","author":"Li","year":"2022","journal-title":"J\u00a0Mater Chem B"},{"key":"10.1016\/j.reth.2023.12.010_bib103","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.actbio.2019.06.001","article-title":"The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway","volume":"98","author":"Hung","year":"2019","journal-title":"Acta Biomater"},{"key":"10.1016\/j.reth.2023.12.010_bib104","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1016\/j.actbio.2014.02.010","article-title":"Effects of extracellular magnesium on the differentiation and function of human osteoclasts","volume":"10","author":"Wu","year":"2014","journal-title":"Acta Biomater"},{"key":"10.1016\/j.reth.2023.12.010_bib105","doi-asserted-by":"crossref","first-page":"7592","DOI":"10.1021\/acsami.1c21260","article-title":"Magnesium oxide nanoparticle coordinated phosphate-functionalized chitosan injectable hydrogel for osteogenesis and angiogenesis in bone regeneration","volume":"14","author":"Chen","year":"2022","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.reth.2023.12.010_bib106","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.actbio.2018.12.017","article-title":"Injectable PLGA microspheres with tunable magnesium ion release for promoting bone regeneration","volume":"85","author":"Yuan","year":"2019","journal-title":"Acta Biomater"},{"key":"10.1016\/j.reth.2023.12.010_bib107","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1021\/acsbiomaterials.9b00584","article-title":"Chitosan\/dextran hydrogel constructs containing strontium-doped hydroxyapatite with enhanced osteogenic potential in rat cranium","volume":"5","author":"Ding","year":"2019","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.reth.2023.12.010_bib108","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s12951-022-01511-9","article-title":"Interaction of alginate with nano-hydroxyapatite-collagen using strontium provides suitable osteogenic platform","volume":"20","author":"Hassani","year":"2022","journal-title":"J\u00a0Nanobiotechnol"},{"key":"10.1016\/j.reth.2023.12.010_bib109","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.msec.2018.08.003","article-title":"Studies on effect of CuO addition on mechanical properties and in\u00a0vitro cytocompatibility in 1393 bioactive glass scaffold","volume":"93","author":"Ali","year":"2018","journal-title":"Mater Sci Eng C"},{"key":"10.1016\/j.reth.2023.12.010_bib110","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1021\/acsami.7b13750","article-title":"Multifunctional copper-containing carboxymethyl chitosan\/alginate scaffolds for eradicating clinical bacterial infection and promoting bone formation","volume":"10","author":"Lu","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.reth.2023.12.010_bib111","first-page":"361","article-title":"Continuously released Zn(2+) in 3D-printed PLGA\/beta-TCP\/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties","volume":"24","author":"Li","year":"2023","journal-title":"Bioact Mater"},{"key":"10.1016\/j.reth.2023.12.010_bib112","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jconrel.2022.12.031","article-title":"A\u00a0novel peptide hydrogel of metal ion clusters for accelerating bone defect regeneration","volume":"353","author":"Xu","year":"2023","journal-title":"J\u00a0Contr Release"},{"key":"10.1016\/j.reth.2023.12.010_bib113","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.actbio.2015.06.002","article-title":"Novel therapeutic core-shell hydrogel scaffolds with sequential delivery of cobalt and bone morphogenetic protein-2 for synergistic bone regeneration","volume":"23","author":"Perez","year":"2015","journal-title":"Acta Biomater"},{"key":"10.1016\/j.reth.2023.12.010_bib114","first-page":"35","article-title":"Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in\u00a0vitro osteoclastic bone resorption","volume":"65","author":"Wattel","year":"2003","journal-title":"Biochem\u00a0Pharmacol"},{"key":"10.1016\/j.reth.2023.12.010_bib115","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jbm.a.30071","article-title":"Prolonged ectopic calcification induced by BMP-2-derived synthetic peptide","volume":"70","author":"Saito","year":"2004","journal-title":"J\u00a0Biomed Mater Res"},{"key":"10.1016\/j.reth.2023.12.010_bib116","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1016\/j.febslet.2011.07.046","article-title":"Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-kappaB and ERK activation","volume":"585","author":"Ang","year":"2011","journal-title":"FEBS Lett"},{"key":"10.1016\/j.reth.2023.12.010_bib117","first-page":"1892","article-title":"Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice","volume":"133","author":"Chiba","year":"2003","journal-title":"J\u00a0Nutr"},{"key":"10.1016\/j.reth.2023.12.010_bib118","article-title":"Pyrroloquinoline quinine inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos in mouse bone marrow cells and inhibits wear particle-induced osteolysis in mice","volume":"8","author":"Kong","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.reth.2023.12.010_bib119","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/abbs\/gmx087","article-title":"Emodin promotes the osteogenesis of MC3T3-E1 cells via BMP-9\/Smad pathway and exerts a preventive effect in ovariectomized rats","volume":"49","author":"Chen","year":"2017","journal-title":"Acta Biochim Biophys Sin"},{"key":"10.1016\/j.reth.2023.12.010_bib120","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2015.5","article-title":"TGF-beta\/BMP signaling and other molecular events: regulation of osteoblastogenesis and\u00a0bone formation","volume":"3","author":"Rahman","year":"2015","journal-title":"Bone Res"},{"key":"10.1016\/j.reth.2023.12.010_bib121","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.bone.2011.11.007","article-title":"GSK-3 inhibition by an orally active small molecule increases bone mass in rats","volume":"50","author":"Marsell","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.reth.2023.12.010_bib122","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1177\/1087057109346446","article-title":"Identification of upregulators of BMP2 expression via high-throughput screening of a synthetic and natural compound library","volume":"14","author":"Li","year":"2009","journal-title":"J\u00a0Biomol Screen"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320423001438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320423001438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:43:52Z","timestamp":1762451032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352320423001438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":122,"alternative-id":["S2352320423001438"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2023.12.010","relation":{},"ISSN":["2352-3204"],"issn-type":[{"value":"2352-3204","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advancements in drug-loaded hydrogel systems for bone defect repair","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2023.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}