{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:59:19Z","timestamp":1773842359523,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010950","name":"Department of Science and Technology of Henan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011841","name":"Xinxiang Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011841","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.reth.2024.03.003","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T01:25:43Z","timestamp":1710120343000},"page":"48-62","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Biological characteristics of Muse cells derived from MenSCs and their application in acute liver injury and intracerebral hemorrhage diseases"],"prefix":"10.1016","volume":"27","author":[{"given":"Han","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangjia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juntang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reth.2024.03.003_bib1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41392-022-01134-4","article-title":"Stem cell-based therapy for human diseases","volume":"7","author":"Hoang","year":"2022","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.reth.2024.03.003_bib2","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/s13287-022-03126-1","article-title":"Muse cells: ushering in a new era of stem cell-based therapy for stroke","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.reth.2024.03.003_bib3","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1073\/pnas.1016753108","article-title":"PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia","volume":"108","author":"Tamai","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.reth.2024.03.003_bib4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/jcmm.12433","article-title":"Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease","volume":"19","author":"Wolff","year":"2015","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.reth.2024.03.003_bib5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3727\/096368916X693662","article-title":"Muse cells, nontumorigenic pluripotent-like stem cells, have liver regeneration capacity through specific homing and cell replacement in a mouse model of liver fibrosis","volume":"26","author":"Iseki","year":"2017","journal-title":"Cell Transplant"},{"key":"10.1016\/j.reth.2024.03.003_bib6","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/ana.20501","article-title":"Autologous mesenchymal stem cell transplantation in stroke patients","volume":"57","author":"Bang","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.reth.2024.03.003_bib7","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1161\/STROKEAHA.120.030618","article-title":"Cell-based therapy for stroke: musing with Muse cells","volume":"51","author":"Park","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.reth.2024.03.003_bib8","doi-asserted-by":"crossref","first-page":"8639","DOI":"10.1073\/pnas.0911647107","article-title":"Unique multipotent cells in adult human mesenchymal cell populations","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.reth.2024.03.003_bib9","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nprot.2013.076","article-title":"Isolation, culture and evaluation of multilineage-differentiating stress-enduring (Muse) cells","volume":"8","author":"Kuroda","year":"2013","journal-title":"Nat Protoc"},{"key":"10.1016\/j.reth.2024.03.003_bib10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1253\/circj.CJ-17-0552","article-title":"Mobilized muse cells after acute myocardial infarction predict cardiac function and remodeling in the chronic phase","volume":"82","author":"Tanaka","year":"2018","journal-title":"Circ J"},{"key":"10.1016\/j.reth.2024.03.003_bib11","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1177\/0963689719844260","article-title":"Quantitative analysis of SSEA3+ cells from human umbilical cord after magnetic sorting","volume":"28","author":"Leng","year":"2019","journal-title":"Cell Transplant"},{"key":"10.1016\/j.reth.2024.03.003_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/190d4d01-a63c-4adc-a123-e519ee40a03e","article-title":"Awakened by cellular stress: isolation and characterization of a novel population of pluripotent stem cells derived from human adipose tissue","volume":"8","author":"Heneidi","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.reth.2024.03.003_bib13","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1089\/scd.2013.0473","article-title":"Human adipose tissue possesses a unique population of pluripotent stem cells with nontumorigenic and low telomerase activities: potential implications in regenerative medicine","volume":"23","author":"Ogura","year":"2014","journal-title":"Stem Cell Dev"},{"key":"10.1016\/j.reth.2024.03.003_bib14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.5966\/sctm.2016-0014","article-title":"Pluripotent nontumorigenic adipose tissue-derived muse cells have immunomodulatory capacity mediated by transforming growth factor-\u03b21","volume":"6","author":"Gimeno","year":"2017","journal-title":"Stem Cells Trans Med"},{"key":"10.1016\/j.reth.2024.03.003_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1089\/cell.2015.0085","article-title":"Muse cells, a new type of pluripotent stem cell derived from human fibroblasts","volume":"18","author":"Liu","year":"2016","journal-title":"Cell Reprogr"},{"key":"10.1016\/j.reth.2024.03.003_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-4-431-56847-6_3","article-title":"Muse cells are endogenous reparative stem cells","volume":"1103","author":"Kushida","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.reth.2024.03.003_bib17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1479-5876-5-57","article-title":"Endometrial regenerative cells: a novel stem cell population","volume":"5","author":"Meng","year":"2007","journal-title":"J\u00a0Transl Med"},{"key":"10.1016\/j.reth.2024.03.003_bib18","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1091\/mbc.e06-09-0872","article-title":"Menstrual blood-derived cells confer human dystrophin expression in the murine model of Duchenne muscular dystrophy via cell fusion and myogenic transdifferentiation","volume":"18","author":"Cui","year":"2007","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.reth.2024.03.003_bib19","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fnmol.2019.00080","article-title":"Conditioned medium of human menstrual blood-derived endometrial stem cells protects against MPP(+)-induced cytotoxicity in\u00a0vitro","volume":"12","author":"Li","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.reth.2024.03.003_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.reth.2024.03.003_bib21","series-title":"The rat brain in stereotaxic coordinates","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.reth.2024.03.003_bib22","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","article-title":"Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.reth.2024.03.003_bib23","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/stem.2206","article-title":"Transplantation of unique subpopulation of fibroblasts, muse cells, ameliorates experimental stroke possibly via robust neuronal differentiation","volume":"34","author":"Uchida","year":"2016","journal-title":"Stem Cell"},{"key":"10.1016\/j.reth.2024.03.003_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-74216-4","article-title":"Therapeutic benefit of Muse cells in a mouse model of amyotrophic lateral sclerosis","volume":"10","author":"Yamashita","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.reth.2024.03.003_bib25","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1177\/0963689719863809","article-title":"Neurotrophic factor secretion and neural differentiation potential of multilineage-differentiating stress-enduring (Muse) cells derived from mouse adipose tissue","volume":"28","author":"Nitobe","year":"2019","journal-title":"Cell Transplant"},{"key":"10.1016\/j.reth.2024.03.003_bib26","doi-asserted-by":"crossref","first-page":"146","DOI":"10.5966\/sctm.2014-0181","article-title":"Therapeutic potential of adipose-derived SSEA-3-positive muse cells for treating diabetic skin ulcers","volume":"4","author":"Kinoshita","year":"2015","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.reth.2024.03.003_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13345","article-title":"Role of glycosphingolipid SSEA-3 and FGF2 in the stemness and lineage commitment of multilineage differentiating stress enduring (MUSE) cells","volume":"56","author":"Aprile","year":"2023","journal-title":"Cell Prolif"},{"key":"10.1016\/j.reth.2024.03.003_bib28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/1673-5374.343885","article-title":"Muse cells decrease the neuroinflammatory response by modulating the proportion of M1 and M2 microglia in\u00a0vitro","volume":"18","author":"Yin","year":"2023","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.reth.2024.03.003_bib29","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1002\/cbin.11834","article-title":"RNA-seq and ATAC-seq analyses of multilineage differentiating stress enduring cells: comparison with dermal fibroblasts","volume":"46","author":"Mao","year":"2022","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.reth.2024.03.003_bib30","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1186\/s13287-021-02671-5","article-title":"Multilineage-differentiating stress-enduring cells alleviate atopic dermatitis-associated behaviors in mice","volume":"12","author":"Fei","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.reth.2024.03.003_bib31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbrc.2021.06.070","article-title":"Human Muse cells-derived neural precursor cells as the novel seed cells for the repair of spinal cord injury","volume":"568","author":"Chen","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.reth.2024.03.003_bib32","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/STROKEAHA.116.014950","article-title":"Human muse cells reconstruct neuronal circuitry in subacute lacunar stroke model","volume":"48","author":"Uchida","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.reth.2024.03.003_bib33","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1089\/scd.2021.0088","article-title":"Muse cells have higher stress tolerance than adipose stem cells due to the overexpression of the CCNA2 gene","volume":"30","author":"Wang","year":"2021","journal-title":"Stem Cell Dev"},{"key":"10.1016\/j.reth.2024.03.003_bib34","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cbpa.2007.05.032","article-title":"The glycans of stem cells","volume":"11","author":"Lanctot","year":"2007","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.reth.2024.03.003_bib35","article-title":"Application of a novel population of multipotent stem cells derived from skin fibroblasts as donor cells in bovine SCNT","volume":"10","author":"Pan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.reth.2024.03.003_bib36","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/CIRCRESAHA.117.311648","article-title":"S1P-S1PR2 axis mediates homing of Muse cells into damaged heart for long-lasting tissue repair and functional recovery after acute myocardial infarction","volume":"122","author":"Yamada","year":"2018","journal-title":"Circ Res"},{"key":"10.1016\/j.reth.2024.03.003_bib37","doi-asserted-by":"crossref","first-page":"9875","DOI":"10.1073\/pnas.1100816108","article-title":"Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts","volume":"108","author":"Wakao","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.reth.2024.03.003_bib38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41575-021-00574-7","article-title":"Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease","volume":"19","author":"Verstockt","year":"2022","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.reth.2024.03.003_bib39","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0140-6736(21)00244-0","article-title":"Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions","volume":"398","author":"McGinley","year":"2021","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.reth.2024.03.003_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.105395","article-title":"Single-cell RNA sequencing reveals different signatures of mesenchymal stromal cell pluripotent-like and multipotent populations","volume":"25","author":"Oguma","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.reth.2024.03.003_bib41","doi-asserted-by":"crossref","first-page":"19328","DOI":"10.18632\/oncotarget.25039","article-title":"Stress and stem cells: adult Muse cells tolerate extensive genotoxic stimuli better than mesenchymal stromal cells","volume":"9","author":"Alessio","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.reth.2024.03.003_bib42","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev.pharmtox.40.1.617","article-title":"14-3-3 proteins: structure, function, and regulation","volume":"40","author":"Fu","year":"2000","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.reth.2024.03.003_bib43","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/sj.cr.7290291","article-title":"14-3-3 proteins--an update","volume":"15","author":"Mhawech","year":"2005","journal-title":"Cell Res"},{"key":"10.1016\/j.reth.2024.03.003_bib44","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.semcdb.2011.09.008","article-title":"14-3-3 proteins as signaling integration points for cell cycle control and apoptosis","volume":"22","author":"Gardino","year":"2011","journal-title":"Semin Cell Dev Biol"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320424000270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320424000270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T21:56:56Z","timestamp":1716328616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352320424000270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":44,"alternative-id":["S2352320424000270"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2024.03.003","relation":{},"ISSN":["2352-3204"],"issn-type":[{"value":"2352-3204","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biological characteristics of Muse cells derived from MenSCs and their application in acute liver injury and intracerebral hemorrhage diseases","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2024.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}