{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:41:28Z","timestamp":1775634088412,"version":"3.50.1"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T00:00:00Z","timestamp":1714780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.reth.2024.05.002","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T03:22:57Z","timestamp":1715916177000},"page":"27-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Heparin-binding epidermal growth factor-like growth factor (HB-EGF) activates p38 to affect pulmonary fibrosis"],"prefix":"10.1016","volume":"26","author":[{"given":"Yan","family":"An","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Yan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-Rong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing-Rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Zhen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.reth.2024.05.002_bib1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/MCP.0000000000000508","article-title":"New treatment paradigms for connective tissue disease-associated interstitial lung disease","volume":"24","author":"Kouranos","year":"2018","journal-title":"Curr Opin Pulm Med"},{"issue":"1","key":"10.1016\/j.reth.2024.05.002_bib2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12931-020-1296-3","article-title":"Progression of fibrosing interstitial lung disease","volume":"21","author":"Wong","year":"2020","journal-title":"Respir Res"},{"issue":"3","key":"10.1016\/j.reth.2024.05.002_bib3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1159\/000310903","article-title":"Intranuclear translocation signaling of HB-EGF carboxy-terminal fragment and mucosal defense through cell proliferation and migration in digestive tracts","volume":"82","author":"Tanida","year":"2010","journal-title":"Digestion"},{"issue":"6","key":"10.1016\/j.reth.2024.05.002_bib4","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/jcp.22496","article-title":"HB-EGF synthesis and release induced by cholesterol depletion of human epidermal keratinocytes is controlled by extracellular ATP and involves both p38 and ERK1\/2 signaling pathways [J]","volume":"226","author":"Giltaire","year":"2011","journal-title":"J\u00a0Cell Physiol"},{"issue":"12","key":"10.1016\/j.reth.2024.05.002_bib5","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.3390\/molecules28124665","article-title":"Vincamine Ameliorates epithelial-mesenchymal transition in bleomycin-induced pulmonary fibrosis in rats; targeting TGF-\u03b2\/MAPK\/Snai1 pathway","volume":"28","author":"Alaaeldin","year":"2023","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.reth.2024.05.002_bib6","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.joca.2015.04.019","article-title":"Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activities[J]","volume":"23","author":"Long","year":"2015","journal-title":"Osteoar Cartil"},{"issue":"2","key":"10.1016\/j.reth.2024.05.002_bib7","first-page":"5","article-title":"p38MAPK signaling pathway regulates silica-induced epithelial-mesenchymal transition in human bronchial epithelial cells[J]","volume":"37","author":"Fei-Feng","year":"2011","journal-title":"Ind Hyg Occup Dis"},{"issue":"2","key":"10.1016\/j.reth.2024.05.002_bib8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbrc.2020.05.091","article-title":"Pericyte-myofibroblast transition in the human lung","volume":"528","author":"Yamaguchi","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.reth.2024.05.002_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101509","article-title":"Mitochondria dysfunction and metabolic reprogramming as drivers of idiopathic pulmonary fibrosis","volume":"33","author":"Bueno","year":"2020","journal-title":"Redox Biol"},{"issue":"17","key":"10.1016\/j.reth.2024.05.002_bib10","doi-asserted-by":"crossref","first-page":"14370","DOI":"10.1074\/jbc.M111722200","volume":"277","author":"Robey","year":"2002","journal-title":"J\u00a0Biol Chem"},{"issue":"5","key":"10.1016\/j.reth.2024.05.002_bib11","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/jcp.22448","article-title":"Role of Smad2\/3 and p38 MAP kinase in TGF-\u03b21-induced epithelial\u2013mesenchymal transition of pulmonary epithelial cells","volume":"226","author":"Kolosova","year":"2011","journal-title":"J\u00a0Cell Physiol"},{"issue":"6","key":"10.1016\/j.reth.2024.05.002_bib12","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.chembiol.2015.05.008","article-title":"Growth factor identity is encoded by discrete coiled-coil rotamers in the EGFR juxtamembrane region","volume":"22","author":"Doerner","year":"2015","journal-title":"Chem Biol"},{"key":"10.1016\/j.reth.2024.05.002_bib13","series-title":"American College of Rheumatology (ACR) Guideline for the Screening and Monitoring of Interstitial lung disease in people with systemic autoimmune rheumatic disease","year":"2023"},{"issue":"1","key":"10.1016\/j.reth.2024.05.002_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12890-021-01726-w","article-title":"HB-EGF-induced IL-8 secretion from airway epithelium leads to lung fibroblast proliferation and migration","volume":"21","author":"Li","year":"2021","journal-title":"BMC Pulm Med"},{"issue":"6","key":"10.1016\/j.reth.2024.05.002_bib15","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1165\/rcmb.2022-0174OC","article-title":"Myeloid-and epithelial-derived heparin-binding epidermal growth factor-like growth factor promotes pulmonary fibrosis","volume":"67","author":"Hult","year":"2022","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.reth.2024.05.002_bib16","article-title":"The role of M2 macrophages and their product, HB-EGF, as regulators of lung fibrosis","author":"Hult","year":"2022","journal-title":"Diss"},{"issue":"2","key":"10.1016\/j.reth.2024.05.002_bib17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41374-018-0146-0","article-title":"Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies","volume":"99","author":"Eapen","year":"2019","journal-title":"Lab Invest"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320424000828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320424000828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T15:57:38Z","timestamp":1732982258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352320424000828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":17,"alternative-id":["S2352320424000828"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2024.05.002","relation":{},"ISSN":["2352-3204"],"issn-type":[{"value":"2352-3204","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heparin-binding epidermal growth factor-like growth factor (HB-EGF) activates p38 to affect pulmonary fibrosis","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2024.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}