{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:47:44Z","timestamp":1780483664461,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007951","name":"Tokyo Medical and Dental University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007951","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.reth.2024.05.005","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T02:32:20Z","timestamp":1720233140000},"page":"432-441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Induction of periodontal ligament-derived mesenchymal stromal cell-like cells from human induced pluripotent stem cells"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4980-0452","authenticated-orcid":false,"given":"Jiacheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7631-9841","authenticated-orcid":false,"given":"Kazuki","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.reth.2024.05.005_bib1","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat Rev Dis Prim"},{"key":"10.1016\/j.reth.2024.05.005_bib2","series-title":"Oral health 14 March","year":"2023"},{"issue":"2","key":"10.1016\/j.reth.2024.05.005_bib3","first-page":"297","article-title":"Recent advances in periodontal regeneration: a biomaterial perspective","volume":"5","author":"Liang","year":"2020","journal-title":"Bioact Mater"},{"issue":"11","key":"10.1016\/j.reth.2024.05.005_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20112796","article-title":"Application of periodontal ligament-derived multipotent mesenchymal stromal cell sheets for periodontal regeneration","volume":"20","author":"Onizuka","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.reth.2024.05.005_bib5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/prd.12250","article-title":"Cellular therapy in periodontal regeneration","volume":"79","author":"Nu\u00f1ez","year":"2000","journal-title":"Periodontology"},{"issue":"9429","key":"10.1016\/j.reth.2024.05.005_bib6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament","volume":"364","author":"Seo","year":"2004","journal-title":"Lancet"},{"issue":"24","key":"10.1016\/j.reth.2024.05.005_bib7","doi-asserted-by":"crossref","first-page":"6332","DOI":"10.1016\/j.biomaterials.2014.04.071","article-title":"Mesenchymal stem cell characteristics of dental pulp and periodontal ligament stem cells after in\u00a0vivo transplantation","volume":"35","author":"Lei","year":"2014","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.reth.2024.05.005_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1089\/biores.2015.0043","article-title":"Allogeneic transplantation of periodontal ligament-derived multipotent mesenchymal stromal cell sheets in canine critical-size supra-alveolar periodontal defect model","volume":"5","author":"Tsumanuma","year":"2016","journal-title":"Biores Open Access"},{"key":"10.1016\/j.reth.2024.05.005_bib9","article-title":"Detection, characterization, and clinical application of mesenchymal stem cells in periodontal ligament tissue","volume":"2018","author":"Tomokiyo","year":"2018","journal-title":"Stem Cell Int"},{"issue":"4","key":"10.1016\/j.reth.2024.05.005_bib10","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.stem.2020.09.014","article-title":"Pluripotent stem cell-based cell therapy-promise and challenges","volume":"27","author":"Yamanaka","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"7594","key":"10.1016\/j.reth.2024.05.005_bib11","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature17000","article-title":"Co-ordinated ocular development from human iPS cells and recovery of corneal function","volume":"531","author":"Hayashi","year":"2016","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.reth.2024.05.005_bib12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/cr.2012.171","article-title":"Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells","volume":"23","author":"Nakamura","year":"2013","journal-title":"Cell Res"},{"key":"10.1016\/j.reth.2024.05.005_bib13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.reth.2022.09.002","article-title":"Efficient reprogramming of human fibroblasts using RNA reprogramming with DAPT and iDOT1L under normoxia conditions","volume":"21","author":"Morita","year":"2022","journal-title":"Regenerative Therapy"},{"issue":"5","key":"10.1016\/j.reth.2024.05.005_bib14","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/odi.12703","article-title":"Stem cell-based tooth and periodontal regeneration","volume":"24","author":"Hu","year":"2018","journal-title":"Oral Dis"},{"issue":"2","key":"10.1016\/j.reth.2024.05.005_bib15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1089\/scd.2017.0077","article-title":"Extracellular matrix from periodontal ligament cells could induce the differentiation of induced pluripotent stem cells to periodontal ligament stem cell-like cells","volume":"27","year":"2018","journal-title":"Stem Cell Dev"},{"issue":"12","key":"10.1016\/j.reth.2024.05.005_bib16","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1600-051X.2010.01597.x","article-title":"Validation of human periodontal ligament-derived cells as a reliable source for cytotherapeutic use","volume":"37","author":"Iwata","year":"2010","journal-title":"J\u00a0Clin Periodontol"},{"issue":"12","key":"10.1016\/j.reth.2024.05.005_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112291","article-title":"Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media","volume":"9","author":"Fukuta","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.reth.2024.05.005_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41536-022-00241-8","article-title":"Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage","volume":"7","author":"Kamiya","year":"2022","journal-title":"NPJ Regenerat Med"},{"issue":"6","key":"10.1016\/j.reth.2024.05.005_bib19","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.devcel.2015.11.025","article-title":"Migration of founder epithelial cells drives proper molar tooth positioning and morphogenesis","volume":"35","author":"Prochazka","year":"2015","journal-title":"Dev Cell"},{"issue":"1","key":"10.1016\/j.reth.2024.05.005_bib20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/s12864-020-06825-2","article-title":"RNA-sequencing reveals positional memory of multipotent mesenchymal stromal cells from oral and maxillofacial tissue transcriptomes","volume":"21","author":"Onizuka","year":"2020","journal-title":"BMC Genom"},{"issue":"1","key":"10.1016\/j.reth.2024.05.005_bib21","doi-asserted-by":"crossref","first-page":"4803","DOI":"10.1038\/s41467-022-32490-y","article-title":"Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis","volume":"13","author":"Jing","year":"2022","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.reth.2024.05.005_bib22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/(SICI)1097-0177(200005)218:1<136::AID-DVDY12>3.0.CO;2-U","article-title":"Forkhead transcription factor FoxF2 is expressed in mesodermal tissues involved in epithelio-mesenchymal interactions","volume":"218","author":"Aitola","year":"2000","journal-title":"Dev Dynam"},{"issue":"7283","key":"10.1016\/j.reth.2024.05.005_bib23","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nature08733","article-title":"CHD7 cooperates with PBAF to control multipotent neural crest formation","volume":"463","author":"Bajpai","year":"2010","journal-title":"Nature"},{"issue":"30","key":"10.1016\/j.reth.2024.05.005_bib24","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1039\/D2TB01026G","article-title":"Effect of extracellular matrix proteins on the differentiation of human pluripotent stem cells into mesenchymal stem cells","volume":"10","author":"Tian","year":"2022","journal-title":"J\u00a0Mater Chem B"},{"key":"10.1016\/j.reth.2024.05.005_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.109883","article-title":"Surface potential and charges impact on cell responses on biomaterials interfaces for medical applications","volume":"104","author":"Metwally","year":"2019","journal-title":"Mater Sci Eng C"},{"issue":"12","key":"10.1016\/j.reth.2024.05.005_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003142","article-title":"Dynamic and differential regulation of stem cell factor FoxD3 in the neural crest is Encrypted in the genome","volume":"8","author":"Sim\u00f5es-Costa","year":"2012","journal-title":"PLoS Genet"},{"issue":"9","key":"10.1016\/j.reth.2024.05.005_bib27","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41419-021-04099-4","article-title":"SOX10 ablation severely impairs the generation of postmigratory neural crest from human pluripotent stem cells","volume":"12","author":"Lai","year":"2021","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.reth.2024.05.005_bib28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0012-1606(03)00277-X","article-title":"Integrin \u03b15\u03b21 supports the migration of Xenopus cranial neural crest on fibronectin","volume":"260","author":"Lai","year":"2003","journal-title":"Dev Biol"},{"issue":"10","key":"10.1016\/j.reth.2024.05.005_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10102366","article-title":"PAX9 is involved in periodontal ligament stem cell-like differentiation of human-induced pluripotent stem cells by regulating extracellular matrix","volume":"10","author":"Sugiura","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.reth.2024.05.005_bib30","doi-asserted-by":"crossref","first-page":"e1684","DOI":"10.7717\/peerj.1684","article-title":"Insight into the maintenance of odontogenic potential in mouse dental mesenchymal cells based on transcriptomic analysis","volume":"4","author":"Zheng","year":"2016","journal-title":"PeerJ"},{"issue":"2","key":"10.1016\/j.reth.2024.05.005_bib31","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0925-4773(97)00115-9","article-title":"Signalling networks regulating dental development","volume":"67","author":"Thesleff","year":"1997","journal-title":"Mech Dev"},{"issue":"11","key":"10.1016\/j.reth.2024.05.005_bib32","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1177\/0022034517725692","article-title":"The impact of the Eda pathway on tooth root development","volume":"96","author":"Fons Romero","year":"2017","journal-title":"J\u00a0Dent Res"},{"issue":"23","key":"10.1016\/j.reth.2024.05.005_bib33","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1101\/gad.13.23.3136","article-title":"Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival\u00a0and\u00a0patterning of the first branchial arch","volume":"13","author":"Trumpp","year":"1999","journal-title":"Genes Dev"},{"issue":"10","key":"10.1016\/j.reth.2024.05.005_bib34","doi-asserted-by":"crossref","first-page":"4083","DOI":"10.1096\/fj.14-267500","article-title":"Lhx6 and Lhx8: cell fate regulators and beyond","volume":"29","author":"Zhou","year":"2015","journal-title":"Faseb J"},{"issue":"8","key":"10.1016\/j.reth.2024.05.005_bib35","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.4252\/wjsc.v13.i8.1094","article-title":"Methods to produce induced pluripotent stem cell-derived mesenchymal stem cells: mesenchymal stem cells from induced pluripotent stem cells","volume":"13","author":"Dupuis","year":"2021","journal-title":"World J Stem Cell"},{"issue":"1","key":"10.1016\/j.reth.2024.05.005_bib36","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13287-020-01641-7","article-title":"Chemical-defined medium supporting the expansion of human mesenchymal stem cells","volume":"11","author":"Xu","year":"2020","journal-title":"Stem Cell Res Ther"},{"issue":"4","key":"10.1016\/j.reth.2024.05.005_bib37","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/(SICI)1097-0177(199808)212:4<533::AID-AJA6>3.0.CO;2-I","article-title":"Interactions between Bmp-4 and Msx-1 act to restrict gene expression to odontogenic mesenchyme","volume":"212","author":"Tucker","year":"1998","journal-title":"Dev Dynam"},{"issue":"2","key":"10.1016\/j.reth.2024.05.005_bib38","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1242\/dev.081927","article-title":"Roles of Bmp4 during tooth morphogenesis and sequential tooth formation","volume":"140","author":"Jia","year":"2013","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.reth.2024.05.005_bib39","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/odi.12931","article-title":"Genetic analysis: Wnt and other pathways in nonsyndromic tooth agenesis","volume":"25","author":"Yu","year":"2019","journal-title":"Oral Dis"},{"issue":"4","key":"10.1016\/j.reth.2024.05.005_bib40","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.gendis.2016.09.004","article-title":"Wnt and BMP signaling crosstalk in regulating dental stem cells: implications in dental tissue engineering","volume":"3","author":"Zhang","year":"2016","journal-title":"Genes Dis"},{"issue":"206","key":"10.1016\/j.reth.2024.05.005_bib41","article-title":"A\u00a0Wnt-Bmp Feedback Circuit controls intertissue signaling dynamics in tooth organogenesis","volume":"5","author":"O'Connell","year":"2012","journal-title":"Sci Signal"},{"key":"10.1016\/j.reth.2024.05.005_bib42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fcell.2016.00025","article-title":"Wnt\/\u03b2-Catenin regulates the activity of epiprofin\/Sp6, SHH, FGF, and BMP to coordinate the stages of odontogenesis","volume":"4","author":"Aurrekoetxea","year":"2016","journal-title":"Front Cell Dev Biol"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320424000853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320424000853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T15:57:46Z","timestamp":1732982266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352320424000853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":42,"alternative-id":["S2352320424000853"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2024.05.005","relation":{},"ISSN":["2352-3204"],"issn-type":[{"value":"2352-3204","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Induction of periodontal ligament-derived mesenchymal stromal cell-like cells from human induced pluripotent stem cells","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2024.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}