{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:20:22Z","timestamp":1792592422031,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":144,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K15993"],"award-info":[{"award-number":["21K15993"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H03055"],"award-info":[{"award-number":["22H03055"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.reth.2024.10.010","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:15:17Z","timestamp":1730852117000},"page":"1048-1057","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Platelet-rich plasma-derived extracellular vesicles improve liver cirrhosis in mice"],"prefix":"10.1016","volume":"26","author":[{"given":"Yuichirou","family":"Maeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-0409","authenticated-orcid":false,"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuki","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6544-2473","authenticated-orcid":false,"given":"Tomoaki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naruhiro","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Sakamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroteru","family":"Kamimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yokoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Kamimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsunori","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Terai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reth.2024.10.010_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.reth.2024.10.010_bib2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nrgastro.2013.88","article-title":"Liver transplantation: past, present and future","volume":"10","author":"Zarrinpar","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.reth.2024.10.010_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s41232-021-00178-3","article-title":"Transition of clinical and basic studies on liver cirrhosis treatment using cells to seek the best treatment","volume":"41","author":"Terai","year":"2021","journal-title":"Inflamm Regen"},{"key":"10.1016\/j.reth.2024.10.010_bib4","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJMra2200923","article-title":"Liver transplantation","volume":"389","author":"Lucey","year":"2023","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.reth.2024.10.010_bib5","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1111\/ctr.12629","article-title":"Sarcopenia and failure to rescue following liver transplantation","volume":"29","author":"Underwood","year":"2015","journal-title":"Clin Transplant"},{"key":"10.1016\/j.reth.2024.10.010_bib6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/trf.12874","article-title":"Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets","volume":"55","author":"Pienimaeki-Roemer","year":"2015","journal-title":"Transfusion"},{"key":"10.1016\/j.reth.2024.10.010_bib7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/tra.12558","article-title":"The biology of extracellular microvesicles","volume":"19","author":"Sedgwick","year":"2018","journal-title":"Traffic"},{"key":"10.1016\/j.reth.2024.10.010_bib8","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jhep.2015.07.002","article-title":"A\u00a0focus on the role of platelets in liver regeneration: do platelet-endothelial cell interactions initiate the regenerative process?","volume":"63","author":"Meyer","year":"2015","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.reth.2024.10.010_bib9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/trf.15655","article-title":"ABO-incompatible platelets are associated with increased transfusion reaction rates","volume":"60","author":"Malvik","year":"2020","journal-title":"Transfusion"},{"key":"10.1016\/j.reth.2024.10.010_bib10","first-page":"50","article-title":"Microvesicles as emerging biomarkers and therapeutic targets in cardiometabolic diseases","volume":"16","author":"Chen","year":"2018","journal-title":"Dev Reprod Biol"},{"key":"10.1016\/j.reth.2024.10.010_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070727","article-title":"Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis","volume":"8","author":"Doyle","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.reth.2024.10.010_bib12","article-title":"Routes and mechanisms of extracellular vesicle uptake","volume":"3","author":"Mulcahy","year":"2014","journal-title":"J\u00a0Extracell Vesicles"},{"key":"10.1016\/j.reth.2024.10.010_bib13","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1161\/CIRCRESAHA.120.317703","article-title":"Platelets can associate with SARS-cov-2 RNA and are hyperactivated in COVID-19","volume":"127","author":"Zaid","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.reth.2024.10.010_bib14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12951-022-01245-8","article-title":"Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis","volume":"20","author":"Zhang","year":"2022","journal-title":"J\u00a0Nanobiotechnol"},{"key":"10.1016\/j.reth.2024.10.010_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001874","article-title":"Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation","volume":"12","author":"Ridder","year":"2014","journal-title":"PLoS Biol"},{"key":"10.1016\/j.reth.2024.10.010_bib16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nri3622","article-title":"Regulation of immune responses by extracellular vesicles","volume":"14","author":"Robbins","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.reth.2024.10.010_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/sctm.18-0105","article-title":"Mesenchymal stem cells and induced bone marrow-derived macrophages synergistically improve liver fibrosis in mice","volume":"8","author":"Watanabe","year":"2019","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.reth.2024.10.010_bib18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/713611034","article-title":"Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model","volume":"33","author":"Weber","year":"2003","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.reth.2024.10.010_bib19","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.3748\/wjg.v11.i27.4167","article-title":"Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation","volume":"11","author":"Chang","year":"2005","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.reth.2024.10.010_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203879","article-title":"Fibrosis-associated hepatocarcinogenesis revisited: establishing standard medium-term chemically-induced male and female models","volume":"13","author":"Romualdo","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.reth.2024.10.010_bib21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s41232-021-00177-4","article-title":"Synthesized HMGB1 peptide attenuates liver inflammation and suppresses fibrosis in mice","volume":"41","author":"Nojiri","year":"2021","journal-title":"Inflamm Regen"},{"key":"10.1016\/j.reth.2024.10.010_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176010","article-title":"Candesartan cilexetil ameliorates NOSTRIN-NO dependent portal hypertension in cirrhosis and ACLF","volume":"958","author":"Vairappan","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.reth.2024.10.010_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104012","article-title":"Comprehensive proteomic profiling of plasma and serum phosphatidylserine-positive extracellular vesicles reveals tissue-specific proteins","volume":"25","author":"Muraoka","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.reth.2024.10.010_bib24","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jos.2016.07.009","article-title":"Leukocyte concentration and composition in platelet-rich plasma (PRP) influences the growth factor and protease concentrations","volume":"21","author":"Kobayashi","year":"2016","journal-title":"J\u00a0Orthop Sci"},{"key":"10.1016\/j.reth.2024.10.010_bib25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3350\/cmh.2020.0194","article-title":"The development of mesenchymal stem cell therapy in the present, and the perspective of cell-free therapy in the future","volume":"27","author":"Watanabe","year":"2021","journal-title":"Clin Mol Hepatol"},{"key":"10.1016\/j.reth.2024.10.010_bib26","article-title":"Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey","volume":"5","author":"Gardiner","year":"2016","journal-title":"J\u00a0Extracell Vesicles"},{"key":"10.1016\/j.reth.2024.10.010_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2021.122604","article-title":"Isolation of extracellular vesicles with combined enrichment methods","volume":"1169","author":"Stam","year":"2021","journal-title":"J\u00a0Chromatogr, B: Anal Technol Biomed Life Sci"},{"key":"10.1016\/j.reth.2024.10.010_bib28","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1172\/JCI200522675","article-title":"Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair","volume":"115","author":"Duffield","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.reth.2024.10.010_bib29","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in\u00a0vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.reth.2024.10.010_bib30","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/hep.24315","article-title":"Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function","volume":"53","author":"Thomas","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.reth.2024.10.010_bib31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41536-021-00132-4","article-title":"Small extracellular vesicles derived from interferon-\u03b3 pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis","volume":"6","author":"Takeuchi","year":"2021","journal-title":"NPJ Regen Med"},{"key":"10.1016\/j.reth.2024.10.010_bib32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s41232-023-00299-x","article-title":"Analysis of distribution, collection, and confirmation of capacity dependency of small extracellular vesicles toward a therapy for liver cirrhosis","volume":"43","author":"Takeda","year":"2023","journal-title":"Inflamm Regen"},{"key":"10.1016\/j.reth.2024.10.010_bib33","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jconrel.2020.09.001","article-title":"Intercellular delivery of NF-\u03baB inhibitor peptide utilizing small extracellular vesicles for the application of anti-inflammatory therapy","volume":"328","author":"Takenaka","year":"2020","journal-title":"J\u00a0Contr Release"},{"key":"10.1016\/j.reth.2024.10.010_bib34","doi-asserted-by":"crossref","first-page":"561","DOI":"10.2131\/jts.41.561","article-title":"Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis","volume":"41","author":"Dong","year":"2016","journal-title":"J\u00a0Toxicol Sci"},{"key":"10.1016\/j.reth.2024.10.010_bib35","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1136\/gutjnl-2011-300304","article-title":"Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury","volume":"61","author":"Baeck","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.reth.2024.10.010_bib36","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/nm.3282","article-title":"Targeting of \u03b1v integrin identifies a core molecular pathway that regulates fibrosis in several organs","volume":"19","author":"Henderson","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.reth.2024.10.010_bib37","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1164\/rccm.200706-806OC","article-title":"Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis","volume":"177","author":"Puthawala","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.reth.2024.10.010_bib38","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/jhbp.245","article-title":"Recent advancement of molecular mechanisms of liver fibrosis","volume":"22","author":"Seki","year":"2015","journal-title":"J\u00a0Hepatobiliary Pancreat Sci"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320424001883?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320424001883?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T16:00:51Z","timestamp":1732982451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352320424001883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":38,"alternative-id":["S2352320424001883"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2024.10.010","relation":{},"ISSN":["2352-3204"],"issn-type":[{"value":"2352-3204","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet-rich plasma-derived extracellular vesicles improve liver cirrhosis in mice","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2024.10.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier BV on behalf of The Japanese Society for Regenerative Medicine.","name":"copyright","label":"Copyright"}]}}