{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:43:43Z","timestamp":1792122223872,"version":"4.4.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["18342"],"award-info":[{"award-number":["18342"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","award":["18343"],"award-info":[{"award-number":["18343"]}],"id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.reth.2024.11.021","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T23:50:05Z","timestamp":1732924205000},"page":"30-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen therapy enhance neuroregeneration in a rat model of sciatic nerve crush injury"],"prefix":"10.1016","volume":"28","author":[{"given":"Fereshteh Talebpour","family":"Amiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aref","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahimeh","family":"Ahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Mokhtari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Raoofi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshad","family":"Moharrami Kasmaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Omran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Amin","family":"Alimohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0249-4115","authenticated-orcid":false,"given":"Davood","family":"Nasiry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.reth.2024.11.021_bib1","doi-asserted-by":"crossref","first-page":"918","DOI":"10.3390\/ijms23020918","article-title":"Peripheral nerve injury treatments and advances: one health perspective","volume":"23","author":"Lopes","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.reth.2024.11.021_bib2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.mporth.2020.03.011","article-title":"Peripheral nerve injury: an update","volume":"34","author":"Khan","year":"2020","journal-title":"Orthop Trauma"},{"key":"10.1016\/j.reth.2024.11.021_bib3","first-page":"91","article-title":"Musculoskeletal disorders in nurses and their relationship with occupation-related stress","volume":"25","author":"Nasiry Zarrin Ghabaee","year":"2016","journal-title":"J\u00a0Maz Univ Med Sci"},{"key":"10.1016\/j.reth.2024.11.021_bib4","first-page":"1","article-title":"Peripheral nerve injury: a review article","volume":"3","author":"Seddighi","year":"2016","journal-title":"Int Clin Neurosci J"},{"key":"10.1016\/j.reth.2024.11.021_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12883-017-1004-1","article-title":"Neuroprotective effects of hyperbaric oxygen (HBO) therapy on neuronal death induced by sciatic nerve transection in rat","volume":"17","author":"Shams","year":"2017","journal-title":"BMC Neurol"},{"key":"10.1016\/j.reth.2024.11.021_bib6","first-page":"1041","article-title":"Changes in nerve microcirculation following peripheral nerve compression","volume":"8","author":"Gao","year":"2013","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.reth.2024.11.021_bib7","first-page":"3215","article-title":"A\u00a0morphological and biochemical evaluation of the effects of quercetin on experimental sciatic nerve damage in rats","volume":"15","author":"T\u00fcredi","year":"2018","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.reth.2024.11.021_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11910-019-0984-1","article-title":"Modern medical management of spinal cord injury","volume":"19","author":"Karsy","year":"2019","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.reth.2024.11.021_bib9","doi-asserted-by":"crossref","first-page":"8583","DOI":"10.3390\/ijms23158583","article-title":"Human multipotent mesenchymal stromal cell\u2013derived extracellular vesicles enhance neuroregeneration in a rat model of sciatic nerve crush injury","volume":"23","author":"Demyanenko","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.reth.2024.11.021_bib10","first-page":"1","article-title":"Therapeutic effects of peripherally administrated neural crest stem cells on pain and spinal cord changes after sciatic nerve transection","volume":"12","author":"Zhang","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.reth.2024.11.021_bib11","first-page":"105","article-title":"Effect of exosomes derived from human dental pulp stem cells on peripheral nerve regeneration after crush injury","volume":"20","author":"Ying","year":"2022","journal-title":"China J Oral Maxillofac Surg"},{"key":"10.1016\/j.reth.2024.11.021_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-020-01872-8","article-title":"Dose-effect relationship and molecular mechanism by which BMSC-derived exosomes promote peripheral nerve regeneration after crush injury","volume":"11","author":"Zhao","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.reth.2024.11.021_bib13","article-title":"Stem cell-derived extracellular vesicle-based therapy for nerve injury: a review of the molecular mechanisms","volume":"19","author":"Nasiry","year":"2023","journal-title":"World Neurosurg: X"},{"key":"10.1016\/j.reth.2024.11.021_bib14","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.2174\/1570159X19666210203161559","article-title":"Exosomes as a promising therapeutic strategy for peripheral nerve injury","volume":"19","author":"Yu","year":"2021","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.reth.2024.11.021_bib15","first-page":"1","article-title":"Advances in exosome-based therapies for the repair of peripheral nerve injuries","author":"Rahimian","year":"2024","journal-title":"Neurochem Res"},{"key":"10.1016\/j.reth.2024.11.021_bib16","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cellbi.2006.03.009","article-title":"Isolation of mesenchymal stem cells from human placenta: comparison with human bone marrow mesenchymal stem cells","volume":"30","author":"Miao","year":"2006","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.reth.2024.11.021_bib17","first-page":"1","article-title":"Human placental mesenchymal stem cell-derived exosomes in combination with hyperbaric oxygen synergistically promote recovery after spinal cord injury in rats","author":"Cheshmi","year":"2023","journal-title":"Neurotox Res"},{"key":"10.1016\/j.reth.2024.11.021_bib18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.reth.2023.09.003","article-title":"Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen synergically alleviates spinal cord ischemia-reperfusion injury","volume":"24","author":"Jafari","year":"2023","journal-title":"Regen Ther"},{"key":"10.1016\/j.reth.2024.11.021_bib19","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1007\/s11064-008-9910-7","article-title":"Human amniotic fluid mesenchymal stem cells in combination with hyperbaric oxygen augment peripheral nerve regeneration","volume":"34","author":"Pan","year":"2009","journal-title":"Neurochem Res"},{"key":"10.1016\/j.reth.2024.11.021_bib20","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3390\/medicina57090864","article-title":"A\u00a0general overview on the hyperbaric oxygen therapy: applications, mechanisms and translational opportunities","volume":"57","author":"Ortega","year":"2021","journal-title":"Medicina"},{"key":"10.1016\/j.reth.2024.11.021_bib21","first-page":"1","article-title":"Synergistic effect of hyperbaric oxygen and decellularized human amniotic membrane on full-thickness diabetic wound healing in rats","volume":"32","author":"Izanlu","year":"2022","journal-title":"J\u00a0Maz Univ Med Sci"},{"key":"10.1016\/j.reth.2024.11.021_bib22","first-page":"133","article-title":"Hyperbaric oxygen therapy in crush injuries and compartment syndrome","volume":"34","author":"Ayd\u0131n","year":"2024","journal-title":"Ana J Gen Med Res"},{"key":"10.1016\/j.reth.2024.11.021_bib23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1136\/rapm-2022-104113","article-title":"The role of hyperbaric oxygen therapy in the management of perioperative peripheral nerve injury: a scoping review of the literature","volume":"48","author":"Brenna","year":"2023","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.reth.2024.11.021_bib24","series-title":"Unbiased stereology: three-dimensional measurement in microscopy","author":"Howard","year":"2004"},{"key":"10.1016\/j.reth.2024.11.021_bib25","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1007\/s12640-021-00391-5","article-title":"Bone marrow mesenchymal stem cell condition medium loaded on PCL nanofibrous scaffold promoted nerve regeneration after sciatic nerve transection in male rats","volume":"39","author":"Raoofi","year":"2021","journal-title":"Neurotox Res"},{"key":"10.1016\/j.reth.2024.11.021_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/jphp.12741","article-title":"Supplementation protects sciatic nerve injury-induced apoptotic, inflammatory and oxidative damage to muscle, blood and brain in rats","volume":"71","author":"Uslusoy","year":"2019","journal-title":"J\u00a0Pharm Pharmacol"},{"key":"10.1016\/j.reth.2024.11.021_bib27","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neuint.2012.12.018","article-title":"(\u2212)-Epigallocatechin-3-gallate (EGCG) attenuates peripheral nerve degeneration in rat sciatic nerve crush injury","volume":"62","author":"Renno","year":"2013","journal-title":"Neurochem Int"},{"key":"10.1016\/j.reth.2024.11.021_bib28","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1097\/WNR.0000000000001468","article-title":"Reduced inflammatory response and accelerated functional recovery following sciatic nerve crush lesion in CXCR3-deficient mice","volume":"31","author":"Jeub","year":"2020","journal-title":"Neuroreport"},{"key":"10.1016\/j.reth.2024.11.021_bib29","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1089\/neu.2004.21.1652","article-title":"Functional and morphological assessment of a standardized rat sciatic nerve crush injury with a non-serrated clamp","volume":"21","author":"Varej\u00e3o","year":"2004","journal-title":"J\u00a0Neurotrauma"},{"key":"10.1016\/j.reth.2024.11.021_bib30","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.3892\/mmr.2017.7605","article-title":"Placenta-derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17\/Treg balance","volume":"16","author":"Li","year":"2017","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.reth.2024.11.021_bib31","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.3390\/cells10112837","article-title":"The unique properties of placental mesenchymal stromal cells: a novel source of therapy for congenital and acquired spinal cord injury","volume":"10","author":"Kulubya","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.reth.2024.11.021_bib32","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3109\/08941939.2014.999961","article-title":"Effects of hyperbaric oxygen and preconditioning on wound healing in colonic anastomoses","volume":"28","author":"Poyrazoglu","year":"2015","journal-title":"J\u00a0Invest Surg"},{"key":"10.1016\/j.reth.2024.11.021_bib33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neuroscience.2023.07.015","article-title":"Hyperbaric oxygen in combination with epigallocatechin-3-gallate synergistically enhance recovery from spinal cord injury in rats","volume":"527","author":"Alshahrani","year":"2023","journal-title":"Neurosci"},{"key":"10.1016\/j.reth.2024.11.021_bib34","first-page":"991","article-title":"Curcumin enhances nerve regeneration and functional recovery of peripheral sciatic nerve in rats with sciatic nerve cut and crush injury","volume":"15","author":"Mehboob","year":"2023","journal-title":"J\u00a0Pharm Sci Res"},{"key":"10.1016\/j.reth.2024.11.021_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-021-02275-z","article-title":"Human placental mesenchymal stem cells ameliorate chemotherapy-induced damage in the testis by reducing apoptosis\/oxidative stress and promoting autophagy","volume":"12","author":"Lu","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.reth.2024.11.021_bib36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-0404.2010.01363.x","article-title":"Use of normobaric and hyperbaric oxygen in acute focal cerebral ischemia\u2013a preclinical and clinical review","volume":"123","author":"Michalski","year":"2011","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.reth.2024.11.021_bib37","doi-asserted-by":"crossref","first-page":"131S","DOI":"10.1097\/PRS.0b013e3181fbe2bf","article-title":"Hyperbaric oxygen: its mechanisms and efficacy","volume":"127","author":"Thom","year":"2011","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.reth.2024.11.021_bib38","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00421-009-1229-9","article-title":"Hyperbaric oxygenation alleviates MCAO-induced brain injury and reduces hydroxyl radical formation and glutamate release","volume":"108","author":"Yang","year":"2010","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.reth.2024.11.021_bib39","first-page":"1","article-title":"Synergistic neuroprotective effects of hyperbaric oxygen and methylprednisolone following contusive spinal cord injury in rat","author":"Ahmadi","year":"2021","journal-title":"J\u00a0Spinal Cord Med"},{"key":"10.1016\/j.reth.2024.11.021_bib40","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1007\/s11064-007-9354-5","article-title":"Effects of methylprednisolone and hyperbaric oxygen on oxidative status after experimental spinal cord injury: a comparative study in rats","volume":"32","author":"Kahraman","year":"2007","journal-title":"Neurochem Res"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235232042400213X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235232042400213X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:22:05Z","timestamp":1778872925000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235232042400213X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":40,"alternative-id":["S235232042400213X"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2024.11.021","relation":{},"ISSN":["2352-3204"],"issn-type":[{"value":"2352-3204","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomes derived from human placental mesenchymal stem cells in combination with hyperbaric oxygen therapy enhance neuroregeneration in a rat model of sciatic nerve crush injury","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2024.11.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier BV on behalf of The Japanese Society for Regenerative Medicine.","name":"copyright","label":"Copyright"}]}}