{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:18:27Z","timestamp":1789697907779,"version":"4.0.1"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021J01803"],"award-info":[{"award-number":["2021J01803"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970908"],"award-info":[{"award-number":["81970908"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170929"],"award-info":[{"award-number":["82170929"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["L222090"],"award-info":[{"award-number":["L222090"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7222224"],"award-info":[{"award-number":["7222224"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["BMU2024YFJHPY007"],"award-info":[{"award-number":["BMU2024YFJHPY007"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.reth.2025.03.012","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:59:31Z","timestamp":1743469171000},"page":"262-270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Apoptotic vesicles inhibit bone marrow adiposity via wnt\/\u03b2-catenin signaling"],"prefix":"10.1016","volume":"29","author":[{"given":"Yuan","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoshan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunkun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7279-2954","authenticated-orcid":false,"given":"Weiliang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranli","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8364-1898","authenticated-orcid":false,"given":"Yunsong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.reth.2025.03.012_bib1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.stem.2017.02.009","article-title":"Adipocyte accumulation in the bone marrow during obesity and aging impairs stem cell-based hematopoietic and bone regeneration","volume":"20","author":"Ambrosi","year":"2017","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.reth.2025.03.012_bib2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.metabol.2009.11.023","article-title":"Increased bone resorption and impaired bone microarchitecture in short-term and extended high-fat diet-induced obesity","volume":"60","author":"Patsch","year":"2011","journal-title":"Metabolism"},{"issue":"10169","key":"10.1016\/j.reth.2025.03.012_bib3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","article-title":"Osteoporosis","volume":"393","author":"Compston","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.reth.2025.03.012_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cytogfr.2020.02.003","article-title":"The relationship between bone marrow adipose tissue and bone metabolism in postmenopausal osteoporosis","volume":"52","author":"Li","year":"2020","journal-title":"Cytokine Growth Factor Rev"},{"issue":"2","key":"10.1016\/j.reth.2025.03.012_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19020360","article-title":"Mesenchymal stem cells: cell fate decision to osteoblast or adipocyte and application in osteoporosis treatment","volume":"19","author":"Hu","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.reth.2025.03.012_bib6","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.stem.2021.01.010","article-title":"Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging","volume":"28","author":"Deng","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.reth.2025.03.012_bib7","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1359\/jbmr.091015","article-title":"Growth hormone regulates the balance between bone formation and bone marrow adiposity","volume":"25","author":"Menagh","year":"2010","journal-title":"J Bone Miner Res"},{"issue":"9","key":"10.1016\/j.reth.2025.03.012_bib8","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrneph.2017.98","article-title":"Extracellular vesicles in renal disease","volume":"13","author":"Karpman","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.reth.2025.03.012_bib9","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.3389\/fimmu.2018.01486","article-title":"Apoptotic cell-derived extracellular vesicles: more than just debris","volume":"9","author":"Caruso","year":"2018","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.reth.2025.03.012_bib10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J Cell Biol"},{"issue":"4","key":"10.1016\/j.reth.2025.03.012_bib11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6478","key":"10.1016\/j.reth.2025.03.012_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.reth.2025.03.012_bib13","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.ccell.2016.10.009","article-title":"Extracellular vesicles in cancer: cell-to-cell mediators of metastasis","volume":"30","author":"Becker","year":"2016","journal-title":"Cancer Cell"},{"issue":"5","key":"10.1016\/j.reth.2025.03.012_bib14","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41590-021-00899-0","article-title":"Extracellular vesicles in immunomodulation and tumor progression","volume":"22","author":"Marar","year":"2021","journal-title":"Nat Immunol"},{"issue":"11","key":"10.1016\/j.reth.2025.03.012_bib15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41569-020-0389-5","article-title":"Native and bioengineered extracellular vesicles for cardiovascular therapeutics","volume":"17","author":"de Abreu","year":"2020","journal-title":"Nat Rev Cardiol"},{"issue":"5","key":"10.1016\/j.reth.2025.03.012_bib16","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12669","article-title":"Exosomes derived from miR-375-overexpressing human adipose mesenchymal stem cells promote bone regeneration","volume":"52","author":"Chen","year":"2019","journal-title":"Cell Prolif"},{"issue":"10","key":"10.1016\/j.reth.2025.03.012_bib17","doi-asserted-by":"crossref","first-page":"9135","DOI":"10.1007\/s12274-022-4554-5","article-title":"Exosomes derived from human adipose-derived stem cells ameliorate osteoporosis through miR-335-3p\/Aplnr axis","volume":"15","author":"Chunhui","year":"2022","journal-title":"Nano Res"},{"issue":"9","key":"10.1016\/j.reth.2025.03.012_bib18","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/s41422-018-0070-2","article-title":"Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors","volume":"28","author":"Liu","year":"2018","journal-title":"Cell Res"},{"issue":"1","key":"10.1016\/j.reth.2025.03.012_bib19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12951-024-02333-7","article-title":"Apoptotic extracellular vesicles derived from hypoxia-preconditioned mesenchymal stem cells within a modified gelatine hydrogel promote osteochondral regeneration by enhancing stem cell activity and regulating immunity","volume":"22","author":"Ding","year":"2024","journal-title":"J Nanobiotechnol"},{"issue":"7","key":"10.1016\/j.reth.2025.03.012_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12240","article-title":"Proteomic analysis of MSC-derived apoptotic vesicles identifies Fas inheritance to ameliorate haemophilia a via activating platelet functions","volume":"11","author":"Zhang","year":"2022","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.reth.2025.03.012_bib21","article-title":"Apoptotic vesicles regulate bone metabolism via the miR1324\/SNX14\/SMAD1\/5 signaling Axis","author":"Zhu","year":"2023","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.reth.2025.03.012_bib22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41368-024-00293-0","article-title":"Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake","volume":"16","author":"Cheng","year":"2024","journal-title":"Int J Oral Sci"},{"issue":"2","key":"10.1016\/j.reth.2025.03.012_bib23","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/jcmm.13356","article-title":"Oxidative stress induces imbalance of adipogenic\/osteoblastic lineage commitment in mesenchymal stem cells through decreasing SIRT1 functions","volume":"22","author":"Lin","year":"2018","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.reth.2025.03.012_bib24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.bone.2018.05.019","article-title":"Defining osteoblast and adipocyte lineages in the bone marrow","volume":"118","author":"Pierce","year":"2019","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.reth.2025.03.012_bib25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.exger.2008.10.004","article-title":"Age-related bone loss in the LOU\/c rat model of healthy ageing","volume":"44","author":"Duque","year":"2009","journal-title":"Exp Gerontol"},{"issue":"7","key":"10.1016\/j.reth.2025.03.012_bib26","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/cdd.2015.168","article-title":"Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?","volume":"23","author":"Chen","year":"2016","journal-title":"Cell Death Differ"},{"issue":"3","key":"10.1016\/j.reth.2025.03.012_bib27","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2174\/1574888X10666150519093429","article-title":"PPAR\u03b3 and Wnt signaling in adipogenic and osteogenic differentiation of mesenchymal stem cells","volume":"11","author":"Yuan","year":"2016","journal-title":"Curr Stem Cell Res Ther"},{"issue":"12","key":"10.1016\/j.reth.2025.03.012_bib28","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.5966\/sctm.2015-0042","article-title":"Bone morphogenetic protein-2 induces donor-dependent osteogenic and adipogenic differentiation in human adipose stem cells","volume":"4","author":"Vanhatupa","year":"2015","journal-title":"Stem cells translational medicine"},{"issue":"10","key":"10.1016\/j.reth.2025.03.012_bib29","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1002\/jcp.26592","article-title":"Notch activation promotes osteoblast mineralization by inhibition of apoptosis","volume":"233","author":"Xu","year":"2018","journal-title":"J Cell Physiol"},{"issue":"8","key":"10.1016\/j.reth.2025.03.012_bib30","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1089\/ten.tea.2010.0048","article-title":"Sonic Hedgehog influences the balance of osteogenesis and adipogenesis in mouse adipose-derived stromal cells","volume":"16","author":"James","year":"2010","journal-title":"Tissue Eng Part A"},{"issue":"1","key":"10.1016\/j.reth.2025.03.012_bib31","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1038\/s41467-018-06898-4","article-title":"Mettl3-mediated m(6)A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis","volume":"9","author":"Wu","year":"2018","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.reth.2025.03.012_bib32","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/joim.12368","article-title":"The WNT system: background and its role in bone","volume":"277","author":"Lerner","year":"2015","journal-title":"J Intern Med"},{"issue":"4","key":"10.1016\/j.reth.2025.03.012_bib33","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/jb\/mvv124","article-title":"Regulation of bone metabolism by Wnt signals","volume":"159","author":"Kobayashi","year":"2016","journal-title":"J Biochem"},{"issue":"19","key":"10.1016\/j.reth.2025.03.012_bib34","doi-asserted-by":"crossref","first-page":"14515","DOI":"10.1074\/jbc.M700030200","article-title":"Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT\/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma","volume":"282","author":"Kang","year":"2007","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.reth.2025.03.012_bib35","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bone.2011.08.010","article-title":"Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a \u03b2-catenin-dependent mechanism","volume":"50","author":"Cawthorn","year":"2012","journal-title":"Bone"},{"issue":"6402","key":"10.1016\/j.reth.2025.03.012_bib36","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1126\/science.aah4065","article-title":"Apoptosis propagates through the cytoplasm as trigger waves","volume":"361","author":"Cheng","year":"2018","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.reth.2025.03.012_bib37","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell Mol Immunol"},{"issue":"4","key":"10.1016\/j.reth.2025.03.012_bib38","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.cell.2011.10.033","article-title":"Programmed cell death in animal development and disease","volume":"147","author":"Fuchs","year":"2011","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.reth.2025.03.012_bib39","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s13287-022-03004-w","article-title":"Macrophage-derived apoptotic vesicles regulate fate commitment of mesenchymal stem cells via miR155","volume":"13","author":"Zhu","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.reth.2025.03.012_bib40","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1007\/s12274-022-4709-4","article-title":"Apoptotic vesicles rejuvenate mesenchymal stem cells via Rab7-mediated autolysosome formation and alleviate bone loss in aging mice","volume":"16","author":"Lei","year":"2023","journal-title":"Nano Res"},{"issue":"1","key":"10.1016\/j.reth.2025.03.012_bib41","doi-asserted-by":"crossref","DOI":"10.1080\/20013078.2020.1783869","article-title":"Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension","volume":"9","author":"Feng","year":"2020","journal-title":"J Extracell Vesicles"},{"issue":"8","key":"10.1016\/j.reth.2025.03.012_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12085","article-title":"Biodistribution of extracellular vesicles following administration into animals: a systematic review","volume":"10","author":"Kang","year":"2021","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.reth.2025.03.012_bib43","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ejps.2016.10.009","article-title":"Cell type-specific and common characteristics of exosomes derived from mouse cell lines: yield, physicochemical properties, and pharmacokinetics","volume":"96","author":"Charoenviriyakul","year":"2017","journal-title":"Eur J Pharmaceut Sci"},{"issue":"7","key":"10.1016\/j.reth.2025.03.012_bib44","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1007\/s00198-017-4014-3","article-title":"Reduced bone mass and preserved marrow adipose tissue in patients with inflammatory bowel diseases in long-term remission","volume":"28","author":"Bastos","year":"2017","journal-title":"Osteoporos Int"},{"issue":"11","key":"10.1016\/j.reth.2025.03.012_bib45","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1359\/jbmr.070721","article-title":"Patients with high bone mass phenotype exhibit enhanced osteoblast differentiation and inhibition of adipogenesis of human mesenchymal stem cells","volume":"22","author":"Qiu","year":"2007","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.reth.2025.03.012_bib46","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/s41467-021-22126-y","article-title":"Quantitative characterization of extracellular vesicle uptake and content delivery within mammalian cells","volume":"12","author":"Bonsergent","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.reth.2025.03.012_bib47","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jconrel.2017.09.019","article-title":"Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis","volume":"266","author":"Costa Verdera","year":"2017","journal-title":"J Contr Release"},{"issue":"10","key":"10.1016\/j.reth.2025.03.012_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21103679","article-title":"Molecular basis of bone aging","volume":"21","author":"Corrado","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.reth.2025.03.012_bib49","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/jbmr.3729","article-title":"Independent roles of estrogen deficiency and cellular senescence in the pathogenesis of osteoporosis: evidence in Young adult mice and older humans","volume":"34","author":"Farr","year":"2019","journal-title":"J Bone Miner Res"},{"issue":"4","key":"10.1016\/j.reth.2025.03.012_bib50","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1365-2796.2012.02564.x","article-title":"New insights into osteoporosis: the bone-fat connection","volume":"272","author":"Kawai","year":"2012","journal-title":"J Intern Med"},{"issue":"15","key":"10.1016\/j.reth.2025.03.012_bib51","doi-asserted-by":"crossref","first-page":"E1501","DOI":"10.1073\/pnas.1312880111","article-title":"Epidermal Wnt\/\u03b2-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors","volume":"111","author":"Donati","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.reth.2025.03.012_bib52","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.2337\/dbi20-0015","article-title":"Wnt signaling: from mesenchymal cell fate to lipogenesis and other mature adipocyte functions","volume":"70","author":"Bagchi","year":"2021","journal-title":"Diabetes"},{"issue":"41","key":"10.1016\/j.reth.2025.03.012_bib53","doi-asserted-by":"crossref","first-page":"38239","DOI":"10.1074\/jbc.M206402200","article-title":"Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors","volume":"277","author":"Longo","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.reth.2025.03.012_bib54","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.antiviral.2015.02.010","article-title":"LiCl inhibits PRRSV infection by enhancing Wnt\/\u03b2-catenin pathway and suppressing inflammatory responses","volume":"117","author":"Hao","year":"2015","journal-title":"Antivir Res"},{"issue":"2","key":"10.1016\/j.reth.2025.03.012_bib55","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/1759720X11430858","article-title":"Aging and bone loss: new insights for the clinician","volume":"4","author":"Demontiero","year":"2012","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"7155","key":"10.1016\/j.reth.2025.03.012_bib56","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nature05985","article-title":"The common biology of cancer and ageing","volume":"448","author":"Finkel","year":"2007","journal-title":"Nature"},{"issue":"7628","key":"10.1016\/j.reth.2025.03.012_bib57","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/nature20411","article-title":"Ageing, neurodegeneration and brain rejuvenation","volume":"539","author":"Wyss-Coray","year":"2016","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.reth.2025.03.012_bib58","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.reth.2025.03.012_bib59","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s13287-018-0995-x","article-title":"Osteogenesis and aging: lessons from mesenchymal stem cells","volume":"9","author":"Infante","year":"2018","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"10.1016\/j.reth.2025.03.012_bib60","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S2213-8587(14)70007-5","article-title":"The bone-fat interface: basic and clinical implications of marrow adiposity","volume":"3","author":"Devlin","year":"2015","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"3","key":"10.1016\/j.reth.2025.03.012_bib61","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.cmet.2017.01.001","article-title":"Parathyroid hormone directs bone marrow mesenchymal cell fate","volume":"25","author":"Fan","year":"2017","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.reth.2025.03.012_bib62","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s11914-018-0427-y","article-title":"Good, bad, or ugly: the biological roles of bone marrow fat","volume":"16","author":"Singh","year":"2018","journal-title":"Curr Osteoporos Rep"},{"issue":"6","key":"10.1016\/j.reth.2025.03.012_bib63","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1474-9728.2004.00127.x","article-title":"Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma\/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta\/BMP signaling pathways","volume":"3","author":"Moerman","year":"2004","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.reth.2025.03.012_bib64","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1002\/jbmr.4537","article-title":"Bone marrow adiposity in models of radiation- and aging-related bone loss is dependent on cellular senescence","volume":"37","author":"Chandra","year":"2022","journal-title":"J Bone Miner Res"},{"issue":"5","key":"10.1016\/j.reth.2025.03.012_bib65","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13602","article-title":"Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity","volume":"21","author":"Chandra","year":"2022","journal-title":"Aging Cell"},{"issue":"9","key":"10.1016\/j.reth.2025.03.012_bib66","doi-asserted-by":"crossref","first-page":"14360","DOI":"10.1021\/acsnano.1c03517","article-title":"Apoptotic extracellular vesicles ameliorate multiple myeloma by restoring fas-mediated apoptosis","volume":"15","author":"Wang","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.reth.2025.03.012_bib67","first-page":"626","article-title":"Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair","volume":"19","author":"Ma","year":"2023","journal-title":"Bioact Mater"},{"issue":"7","key":"10.1016\/j.reth.2025.03.012_bib68","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12109","article-title":"Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes","volume":"10","author":"Zheng","year":"2021","journal-title":"J Extracell Vesicles"},{"issue":"7866","key":"10.1016\/j.reth.2025.03.012_bib69","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41586-021-03624-x","article-title":"Obesity accelerates hair thinning by stem cell-centric converging mechanisms","volume":"595","author":"Morinaga","year":"2021","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.reth.2025.03.012_bib70","doi-asserted-by":"crossref","first-page":"e984","DOI":"10.1161\/CIR.0000000000000973","article-title":"Obesity and cardiovascular disease: a scientific statement from the American heart association","volume":"143","author":"Powell-Wiley","year":"2021","journal-title":"Circulation"},{"issue":"35","key":"10.1016\/j.reth.2025.03.012_bib71","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1200\/JCO.2016.67.4283","article-title":"Obesity and cancer mechanisms: tumor microenvironment and inflammation","volume":"34","author":"Iyengar","year":"2016","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.reth.2025.03.012_bib72","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13128","article-title":"Individuals with obesity and COVID-19: a global perspective on the epidemiology and biological relationships","volume":"21","author":"Popkin","year":"2020","journal-title":"Obes Rev"},{"key":"10.1016\/j.reth.2025.03.012_bib73","article-title":"Obesity-induced methylation of osteopontin contributes to adipogenic differentiation of adipose-derived mesenchymal stem cells","volume":"2019","author":"Tang","year":"2019","journal-title":"Stem Cell Int"},{"issue":"1","key":"10.1016\/j.reth.2025.03.012_bib74","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/s41467-019-09010-6","article-title":"Stem cell proliferation is induced by apoptotic bodies from dying cells during epithelial tissue maintenance","volume":"10","author":"Brock","year":"2019","journal-title":"Nat Commun"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320425000665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320425000665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T04:27:53Z","timestamp":1763699273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352320425000665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":74,"alternative-id":["S2352320425000665"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2025.03.012","relation":{},"ISSN":["2352-3204"],"issn-type":[{"value":"2352-3204","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apoptotic vesicles inhibit bone marrow adiposity via wnt\/\u03b2-catenin signaling","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2025.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier BV on behalf of The Japanese Society for Regenerative Medicine.","name":"copyright","label":"Copyright"}]}}