{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T16:33:59Z","timestamp":1764693239647,"version":"3.46.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.reth.2025.05.016","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T07:17:56Z","timestamp":1751354276000},"page":"299-308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Transplantation of adipose-derived stem cell aggregates via hydrogel microspheres that incorporate growth factors increases muscle strength"],"prefix":"10.1016","volume":"30","author":[{"given":"Tomohiro","family":"Abe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Tanaka Isomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshie","family":"Kuwahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Mitsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Matsukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoko","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-277X","authenticated-orcid":false,"given":"Yasuhiko","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reth.2025.05.016_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/107632701300062859","article-title":"Multilineage cells from human adipose tissue: implications for cell-based therapies","volume":"7","author":"Zuk","year":"2001","journal-title":"Tissue Eng"},{"key":"10.1016\/j.reth.2025.05.016_bib2","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1007\/s00264-013-2059-2","article-title":"Role of mesenchymal stem cells in bone regeneration and fracture repair: a review","volume":"37","author":"Wang","year":"2013","journal-title":"Int Orthop"},{"key":"10.1016\/j.reth.2025.05.016_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2015.06.007","article-title":"Stem cell therapies in clinical trials: progress and challenges","volume":"17","author":"Trounson","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.reth.2025.05.016_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/14712598.2019.1563069","article-title":"An updated review of adipose derived-mesenchymal stem cells and their applications in musculoskeletal disorders","volume":"19","author":"Rivera-Izquierdo","year":"2019","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.reth.2025.05.016_bib5","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.reth.2021.09.003","article-title":"Efficient cell transplantation combining injectable hydrogels with control release of growth factors","volume":"18","author":"Mitsui","year":"2021","journal-title":"Regen Ther"},{"key":"10.1016\/j.reth.2025.05.016_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fnagi.2015.00123","article-title":"Potential of adipose-derived stem cells in muscular regenerative therapies","volume":"7","author":"Forcales","year":"2015","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.reth.2025.05.016_bib7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fnmol.2020.00107","article-title":"Effects of ASC application on endplate regeneration upon glycerol-induced muscle damage","volume":"13","author":"Rigon","year":"2020","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.reth.2025.05.016_bib8","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1249\/MSS.0000000000000405","article-title":"Mesenchymal stem cells augment the adaptive response to eccentric exercise","volume":"47","author":"Zou","year":"2015","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.reth.2025.05.016_bib9","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/ana.20501","article-title":"Autologous mesenchymal stem cell transplantation in stroke patients","volume":"57","author":"Bang","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1016\/j.reth.2025.05.016_bib10","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/jcsm.12416","article-title":"Cell therapy to improve regeneration of skeletal muscle injuries","volume":"10","author":"Qazi","year":"2019","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.reth.2025.05.016_bib11","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1007\/s00167-012-2256-3","article-title":"Cartilage repair using mesenchymal stem cell (MSC) sheet and MSCs-loaded bilayer PLGA scaffold in a rabbit model","volume":"22","author":"Qi","year":"2014","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.reth.2025.05.016_bib12","doi-asserted-by":"crossref","first-page":"847","DOI":"10.5966\/sctm.2015-0245","article-title":"Adipose mesenchymal stromal cell-based therapy for severe osteoarthritis of the knee: a phase I dose-escalation trial","volume":"5","author":"Pers","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.reth.2025.05.016_bib13","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/jbm.a.35956","article-title":"Injectable uncrosslinked biomimetic hydrogels as a candidate scaffold for neural stem cell delivery","volume":"105","author":"Farrell","year":"2017","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.reth.2025.05.016_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120765","article-title":"Transplantation of 3D MSC\/HUVEC spheroids with neuroprotective and proangiogenic potentials ameliorates ischemic stroke brain injury","volume":"272","author":"Hsu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.reth.2025.05.016_bib15","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.biomaterials.2018.01.008","article-title":"Mechanically resilient injectable scaffolds for intramuscular stem cell delivery and cytokine release","volume":"159","author":"Young","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.reth.2025.05.016_bib16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s13287-020-01901-6","article-title":"A barrier against reactive oxygen species: chitosan\/acellular dermal matrix scaffold enhances stem cell retention and improves cutaneous wound healing","volume":"11","author":"Lin","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.reth.2025.05.016_bib17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s10266-015-0209-2","article-title":"Platelet-rich plasma and its derivatives as promising bioactive materials for regenerative medicine: basic principles and concepts underlying recent advances","volume":"103","author":"Kawase","year":"2015","journal-title":"Odontology"},{"key":"10.1016\/j.reth.2025.05.016_bib18","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1519\/JSC.0b013e31824f207e","article-title":"Does exercise-induced muscle damage play a role in skeletal muscle hypertrophy?","volume":"26","author":"Schoenfeld","year":"2012","journal-title":"J Strength Cond Res"},{"key":"10.1016\/j.reth.2025.05.016_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1089\/ten.1999.5.127","article-title":"Biodegradation of hydrogel carrier incorporating fibroblast growth factor","volume":"5","author":"Tabata","year":"1999","journal-title":"Tissue Eng"},{"key":"10.1016\/j.reth.2025.05.016_bib20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1006\/dbio.1997.8803","article-title":"HGF\/SF is present in normal adult skeletal muscle and is capable of activating satellite cells","volume":"194","author":"Tatsumi","year":"1998","journal-title":"Dev Biol"},{"key":"10.1016\/j.reth.2025.05.016_bib21","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019102154","article-title":"Muscle-secreted granulocyte colony-stimulating factor functions as metabolic niche factor ameliorating loss of muscle stem cells in aged mice","volume":"38","author":"Li","year":"2019","journal-title":"EMBO J"},{"key":"10.1016\/j.reth.2025.05.016_bib22","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.3390\/cells9091970","article-title":"Mechanisms of IGF-1-mediated regulation of skeletal muscle hypertrophy and atrophy","volume":"9","author":"Yoshida","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.reth.2025.05.016_bib23","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/cbin.10725","article-title":"The role of TGF-\u03b21 during skeletal muscle regeneration","volume":"41","author":"Delaney","year":"2017","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.reth.2025.05.016_bib24","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/(SICI)1097-4598(199707)20:7<815::AID-MUS5>3.0.CO;2-A","article-title":"The role of leukemia inhibitory factor in skeletal muscle regeneration","volume":"20","author":"Kurek","year":"1997","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.reth.2025.05.016_bib25","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.actbio.2012.01.016","article-title":"Enhanced angiogenesis by multiple release of platelet-rich plasma contents and basic fibroblast growth factor from gelatin hydrogels","volume":"8","author":"Matsui","year":"2012","journal-title":"Acta Biomater"},{"issue":"Supplement 1","key":"10.1016\/j.reth.2025.05.016_bib26","doi-asserted-by":"crossref","first-page":"i45","DOI":"10.1093\/ndt\/gft273","article-title":"PDGF and the progression of renal disease","volume":"29","author":"Boor","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.reth.2025.05.016_bib27","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1152\/ajplung.00315.2001","article-title":"Role of the JAK-STAT pathway in PDGF-stimulated proliferation of human airway smooth muscle cells","volume":"6","author":"Simon","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.reth.2025.05.016_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057141","article-title":"Early activation of rat skeletal muscle IL-6\/STAT1\/STAT3 dependent gene expression in resistance exercise linked to hypertrophy","volume":"8","author":"Begue","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.reth.2025.05.016_bib29","first-page":"1814","article-title":"Platelet-derived growth factor BB influences muscle regeneration in duchenne muscle dystrophy","volume":"8","author":"Patrica","year":"2017","journal-title":"Am J Pathol"},{"key":"10.1016\/j.reth.2025.05.016_bib30","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s41467-020-20289-8","article-title":"TGF\u03b2 signaling curbs cell fusion and muscle regeneration","volume":"12","author":"Girardi","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.reth.2025.05.016_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5187\/jast.2022.e114","article-title":"The roles of growth factors and hormones in the regulation of muscle satellite cells for cultured meat production","volume":"65","author":"Ahmad","year":"2023","journal-title":"J Anim Sci Technol"},{"key":"10.1016\/j.reth.2025.05.016_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13287-018-0851-z","article-title":"Platelet-rich plasma enhances the proliferation of human adipose stem cells through multiple signaling pathways","volume":"9","author":"Lai","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.reth.2025.05.016_bib33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.reth.2020.03.013","article-title":"Basic fibroblast growth factor enhances proliferation and hepatocyte growth factor expression of feline mesenchymal stem cells","volume":"15","author":"Fujimoto","year":"2020","journal-title":"Regen Ther"},{"key":"10.1016\/j.reth.2025.05.016_bib34","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1021\/bm1006344","article-title":"Mineralization, biodegradation, and drug release behavior of gelatin\/apatite composite microspheres for bone regeneration","volume":"11","author":"Leeuwenburgh","year":"2010","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.reth.2025.05.016_bib35","article-title":"Growth factors released from gelatin hydrogel microspheres increase new neurons in the adult mouse brain","volume":"2012","author":"Nakaguchi","year":"2012","journal-title":"Stem Cell Int"},{"key":"10.1016\/j.reth.2025.05.016_bib36","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/FJC.0b013e31820c9776","article-title":"Treatment of leg ischemia with biodegradable gelatin hydrogel microspheres incorporating granulocyte colony-stimulating factor","volume":"57","author":"Kawamura","year":"2011","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.reth.2025.05.016_bib37","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1016\/j.actbio.2011.04.013","article-title":"Preparation of stem cell aggregates with gelatin microspheres to enhance biological functions","volume":"7","author":"Hayashi","year":"2011","journal-title":"Acta Biomater"},{"key":"10.1016\/j.reth.2025.05.016_bib38","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/term.3076","article-title":"Preparation of cell aggregates incorporating gelatin hydrogel microspheres of sugar-responsive water solubilization","volume":"14","author":"Inoo","year":"2020","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.reth.2025.05.016_bib39","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1002\/jor.23451","article-title":"Effect of platelet-rich plasma on degeneration change of rotator cuff muscles: in vitro and in vivo evaluations","volume":"35","author":"Takase","year":"2017","journal-title":"J Orthop Res"},{"key":"10.1016\/j.reth.2025.05.016_bib40","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/0012-1606(87)90408-8","article-title":"Inhibition of myogenic differentiation by fibroblast growth factor or type \u03b2 transforming growth factor does not require c-myc expression","volume":"123","author":"Spizz","year":"1987","journal-title":"Dev Biol"},{"key":"10.1016\/j.reth.2025.05.016_bib41","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1369\/jhc.6R6995.2006","article-title":"The skeletal muscle satellite cell: the stem cell that came in from the cold","volume":"54","author":"Zammit","year":"2006","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.reth.2025.05.016_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050491","article-title":"Adult cardiac progenitor cell aggregates exhibit survival benefit both in vitro and in vivo","volume":"7","author":"Bauer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.reth.2025.05.016_bib43","doi-asserted-by":"crossref","first-page":"zqaa009","DOI":"10.1093\/function\/zqaa009","article-title":"Fusion-independent satellite cell communication to muscle fibers during load-induced hypertrophy","volume":"1","author":"Murach","year":"2020","journal-title":"Function (Oxf)"},{"key":"10.1016\/j.reth.2025.05.016_bib44","first-page":"1027","article-title":"Satellite cells and skeletal muscle regeneration","volume":"3","author":"Dumont","year":"2015","journal-title":"Compr Physiol"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320425001312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320425001312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T16:30:46Z","timestamp":1764693046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352320425001312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":44,"alternative-id":["S2352320425001312"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2025.05.016","relation":{},"ISSN":["2352-3204"],"issn-type":[{"type":"print","value":"2352-3204"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transplantation of adipose-derived stem cell aggregates via hydrogel microspheres that incorporate growth factors increases muscle strength","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2025.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier BV on behalf of The Japanese Society for Regenerative Medicine.","name":"copyright","label":"Copyright"}]}}