{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T21:46:31Z","timestamp":1776203191652,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regenerative Therapy"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.reth.2026.101081","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T13:18:00Z","timestamp":1772111880000},"page":"101081","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Anti-inflammatory and immunomodulatory effects of human induced pluripotent stem cells-derived mesenchymal stem\/stromal cells and their extracellular vesicles"],"prefix":"10.1016","volume":"31","author":[{"given":"Yusaku","family":"Komoike","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3510-282X","authenticated-orcid":false,"given":"Daisuke","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Sasaki-Ban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3930-8032","authenticated-orcid":false,"given":"Makoto","family":"Ikeya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reth.2026.101081_bib1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nri2395","article-title":"Mesenchymal stem cells in health and disease","volume":"8","author":"Uccelli","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.reth.2026.101081_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080886","article-title":"Mesenchymal stem cells for regenerative medicine","volume":"8","author":"Han","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.reth.2026.101081_bib3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.reth.2026.101081_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12016-025-09030-9","article-title":"Mesenchymal stromal cell-based therapy: a promising approach for autoimmune diseases","volume":"68","author":"Li","year":"2025","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.reth.2026.101081_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41536-022-00241-8","article-title":"Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage","volume":"7","author":"Kamiya","year":"2022","journal-title":"NPJ Regen Med"},{"key":"10.1016\/j.reth.2026.101081_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.749192","article-title":"Effects of mesenchymal stem cell-derived exosomes on autoimmune diseases","volume":"12","author":"Shen","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.reth.2026.101081_bib7","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12943-019-0990-6","article-title":"Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma","volume":"18","author":"Yang","year":"2019","journal-title":"Mol Cancer"},{"key":"10.1016\/j.reth.2026.101081_bib8","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay3051","article-title":"miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4, and CHORDC1","volume":"6","author":"Urabe","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.reth.2026.101081_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114517","article-title":"Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progression","volume":"43","author":"Yamamoto","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.reth.2026.101081_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/eji.201141651","article-title":"Suppression assays with human T regulatory cells: a technical guide","volume":"42","author":"McMurchy","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.reth.2026.101081_bib11","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1056\/NEJMhpr063086","article-title":"FDA regulation of stem-cell-based therapies","volume":"355","author":"Halme","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.reth.2026.101081_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6597815","article-title":"Xeno-free strategies for safe human mesenchymal stem\/stromal cell expansion: supplements and coatings","volume":"2017","author":"Cimino","year":"2017","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.reth.2026.101081_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.596079","article-title":"Extracellular vesicle-dependent communication between mesenchymal stromal cells and immune effector cells","volume":"8","author":"Bazzoni","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.reth.2026.101081_bib14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1248\/bpb.b13-00845","article-title":"Functional receptors and intracellular signal pathways of midkine (MK) and pleiotrophin (PTN)","volume":"37","author":"Xu","year":"2014","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.reth.2026.101081_bib15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1387\/ijdb.8507561","article-title":"Midkine (MK), the product of a retinoic acid responsive gene, and pleiotrophin constitute a new protein family regulating growth and differentiation","volume":"37","author":"Muramatsu","year":"1993","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.reth.2026.101081_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3835(03)00450-6","article-title":"Midkine and pleiotrophin in neural development and cancer","volume":"204","author":"Kadomatsu","year":"2004","journal-title":"Cancer Lett"},{"key":"10.1016\/j.reth.2026.101081_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1242\/dev.121.1.37","article-title":"Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis","volume":"121","author":"Mitsiadis","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.reth.2026.101081_bib18","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1046\/j.1471-4159.1999.02084.x","article-title":"Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons","volume":"73","author":"Owada","year":"1999","journal-title":"J Neurochem"},{"key":"10.1016\/j.reth.2026.101081_bib19","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1111\/j.1471-4159.2006.04138.x","article-title":"Midkine, a heparin-binding growth factor, is expressed in neural precursor cells and promotes their growth","volume":"99","author":"Zou","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.reth.2026.101081_bib20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/geno.1998.5439","article-title":"Molecular cloning of a human cDNA IGSF3 encoding an immunoglobulin-like membrane protein: expression and mapping to chromosome band 1p13","volume":"52","author":"Saupe","year":"1998","journal-title":"Genomics"},{"key":"10.1016\/j.reth.2026.101081_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-44093-8","article-title":"Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization","volume":"13","author":"Tanjore Ramanathan","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.reth.2026.101081_bib22","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/s41419-021-04214-5","article-title":"LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure","volume":"12","author":"Su","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.reth.2026.101081_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/genes12060795","article-title":"LTBP4 in health and disease","volume":"12","author":"Su","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.reth.2026.101081_bib24","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1172\/JCI39845","article-title":"Latent TGF-beta-binding protein 4 modifies muscular dystrophy in mice","volume":"119","author":"Heydemann","year":"2009","journal-title":"J Clin Investig"},{"key":"10.1016\/j.reth.2026.101081_bib25","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0014-5793(97)00685-6","article-title":"Sequence and expression of a novel member (LTBP-4) of the family of latent transforming growth factor-beta binding proteins","volume":"411","author":"Giltay","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.reth.2026.101081_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006019","article-title":"Overexpression of latent TGFbeta binding protein 4 in muscle ameliorates muscular dystrophy through myostatin and TGFbeta","volume":"12","author":"Lamar","year":"2016","journal-title":"PLoS Genet"},{"key":"10.1016\/j.reth.2026.101081_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.scr.2018.07.004","article-title":"Shisa2 regulates the fusion of muscle progenitors","volume":"31","author":"Liu","year":"2018","journal-title":"Stem Cell Res"},{"issue":"1","key":"10.1016\/j.reth.2026.101081_bib28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40478-023-01557-2","article-title":"IGFBP2 promotes proliferation and cell migration through STAT3 signaling in sonic hedgehog medulloblastoma","volume":"11","author":"Kunhiraman","year":"2023","journal-title":"Acta Neuropathol Commun"},{"issue":"4","key":"10.1016\/j.reth.2026.101081_bib29","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.jhep.2010.12.043","article-title":"Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations","volume":"55","author":"Chen","year":"2011","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.reth.2026.101081_bib30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41420-025-02327-w","article-title":"Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer","volume":"11","author":"Cong","year":"2025","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.reth.2026.101081_bib31","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.2147\/JIR.S345517","article-title":"The therapeutic effect of iMSC-Derived small extracellular vesicles on tendinopathy related pain through alleviating inflammation: an in vivo and in vitro study","volume":"15","author":"Zhu","year":"2022","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.reth.2026.101081_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26062827","article-title":"Extracellular vesicles in the mesenchymal stem cell\/macrophage axis: potential targets for inflammatory treatment","volume":"26","author":"Che","year":"2025","journal-title":"Int J Mol Sci"}],"container-title":["Regenerative Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320426000222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352320426000222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T20:50:10Z","timestamp":1776199810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352320426000222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":32,"alternative-id":["S2352320426000222"],"URL":"https:\/\/doi.org\/10.1016\/j.reth.2026.101081","relation":{},"ISSN":["2352-3204"],"issn-type":[{"value":"2352-3204","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory and immunomodulatory effects of human induced pluripotent stem cells-derived mesenchymal stem\/stromal cells and their extracellular vesicles","name":"articletitle","label":"Article Title"},{"value":"Regenerative Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.reth.2026.101081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier BV on behalf of The Japanese Society for Regenerative Medicine.","name":"copyright","label":"Copyright"}],"article-number":"101081"}}