{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:15:57Z","timestamp":1788488157301,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Translational Medicine"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.retram.2016.04.008","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T21:42:28Z","timestamp":1464385348000},"page":"123-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Down-regulation of tumor suppressor PDCD4 expression in endometrium of adenomyosis patients"],"prefix":"10.1016","volume":"64","author":[{"given":"Y.","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2341-5335","authenticated-orcid":false,"given":"Z.","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.retram.2016.04.008_bib0165","first-page":"36","article-title":"Adenomyosis at hysterectomy: prevalence and relationship to operative findings and reproductive and menstrual factors","volume":"24","author":"Vavilis","year":"1997","journal-title":"Clin Exp Obstet Gynecol"},{"key":"10.1016\/j.retram.2016.04.008_bib0170","first-page":"278","article-title":"Clinical significance of adenomyosis","volume":"69","author":"Nikkanen","year":"1980","journal-title":"Ann Chir Gynaecol"},{"key":"10.1016\/j.retram.2016.04.008_bib0175","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M112.017988","article-title":"Proteomics identification of annexin\u00a0A2 as a key mediator in the metastasis and proangiogenesis of endometrial cells in human adenomyosis","volume":"11","author":"Zhou","year":"2012","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.retram.2016.04.008_bib0180","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.bpobgyn.2006.01.016","article-title":"Pathology and physiopathology of adenomyosis","volume":"20","author":"Bergeron","year":"2006","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.retram.2016.04.008_bib0185","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bpobgyn.2006.01.003","article-title":"Experimental adenomyosis","volume":"20","author":"Greaves","year":"2006","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.retram.2016.04.008_bib0190","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1038\/onc.2011.202","article-title":"Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation","volume":"30","author":"Singh","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.retram.2016.04.008_bib0195","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1038\/sj.onc.1206433","article-title":"Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation","volume":"22","author":"Yang","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.retram.2016.04.008_bib0200","doi-asserted-by":"crossref","first-page":"7484","DOI":"10.1038\/sj.onc.1208064","article-title":"Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun","volume":"23","author":"Bitomsky","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.retram.2016.04.008_bib0205","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1038\/sj.onc.1210234","article-title":"Tumor suppressor Pdcd4 inhibits invasion\/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors","volume":"26","author":"Leupold","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.retram.2016.04.008_bib0210","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1038\/onc.2008.115","article-title":"siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1\/Cip1) expression","volume":"27","author":"Bitomsky","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.retram.2016.04.008_bib0215","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1128\/MCB.23.1.26-37.2003","article-title":"The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor\u00a04A binding protein that inhibits translation","volume":"23","author":"Yang","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.retram.2016.04.008_bib0220","doi-asserted-by":"crossref","first-page":"11107","DOI":"10.1093\/nar\/gku800","article-title":"An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4","volume":"42","author":"Fehler","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.retram.2016.04.008_bib0225","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.biolcel.2003.09.003","article-title":"Programmed cell death protein\u00a04 (pdcd4): a novel target for antineoplastic therapy?","volume":"95","author":"Lankat-Buttgereit","year":"2003","journal-title":"Biol Cell"},{"key":"10.1016\/j.retram.2016.04.008_bib0230","doi-asserted-by":"crossref","first-page":"8095","DOI":"10.4049\/jimmunol.177.11.8095","article-title":"Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death\u00a04","volume":"177","author":"Hilliard","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.retram.2016.04.008_bib0235","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/path.1378","article-title":"Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis","volume":"200","author":"Chen","year":"2003","journal-title":"J Pathol"},{"key":"10.1016\/j.retram.2016.04.008_bib0240","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/cncr.22983","article-title":"Loss of programmed cell death 4\u00a0expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase\u00a0B, and is an independent prognostic factor in resected colorectal cancer","volume":"110","author":"Mudduluru","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.retram.2016.04.008_bib0245","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1038\/sj.onc.1209634","article-title":"Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma","volume":"25","author":"Zhang","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.retram.2016.04.008_bib0250","doi-asserted-by":"crossref","first-page":"8135","DOI":"10.1038\/sj.onc.1207983","article-title":"Induction of PDCD4 tumor suppressor gene expression by RAR agonists, antiestrogen and HER-2\/neu antagonist in breast cancer cells. Evidence for a role in apoptosis","volume":"23","author":"Afonja","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.retram.2016.04.008_bib0255","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1124\/mi.10.2.5","article-title":"Have tumor suppressor PDCD4 and its counteragent oncogenic miR-21 gone rogue?","volume":"10","author":"Young","year":"2010","journal-title":"Mol Interv"},{"key":"10.1016\/j.retram.2016.04.008_bib0260","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1126\/science.1130276","article-title":"S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth","volume":"314","author":"Dorrello","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.retram.2016.04.008_bib0265","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1158\/0008-5472.CAN-07-1719","article-title":"Translation inhibitor Pdcd4 is targeted for degradation during tumor promotion","volume":"68","author":"Schmid","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.retram.2016.04.008_bib0270","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1111\/j.1349-7006.2009.01210.x","article-title":"PDCD4 inhibits the malignant phenotype of ovarian cancer cells","volume":"100","author":"Wei","year":"2009","journal-title":"Cancer Sci"},{"key":"10.1016\/j.retram.2016.04.008_bib0275","first-page":"2991","article-title":"Expression and prognostic significance of PDCD4 in human epithelial ovarian carcinoma","volume":"28","author":"Wang","year":"2008","journal-title":"Anticancer Res"},{"key":"10.1016\/j.retram.2016.04.008_bib0280","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jmig.2011.04.004","article-title":"Adenomyosis: review of the literature","volume":"18","author":"Garcia","year":"2011","journal-title":"J Minim Invasive Gynecol"},{"key":"10.1016\/j.retram.2016.04.008_bib0285","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/00006254-200006000-00025","article-title":"Endometrial-myometrial interface: relationship to adenomyosis and changes in pregnancy","volume":"55","author":"Uduwela","year":"2000","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.retram.2016.04.008_bib0290","first-page":"5762","article-title":"L-22 enhances the invasiveness of endometrial stromal cells of adenomyosis in an autocrine manner","volume":"7","author":"Wang","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.retram.2016.04.008_bib0295","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1093\/humrep\/det042","article-title":"The expression and functionality of stromal caveolin\u00a01 in human adenomyosis","volume":"28","author":"Zhao","year":"2013","journal-title":"Hum Reprod"},{"key":"10.1016\/j.retram.2016.04.008_bib0300","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1038\/sj.onc.1206710","article-title":"The transformation suppressor protein Pdcd4 shuttles between nucleus and cytoplasm and binds RNA","volume":"22","author":"Bohm","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.retram.2016.04.008_bib0305","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1158\/0008-5472.CAN-05-3469","article-title":"Akt phosphorylates and regulates Pdcd4 tumor suppressor protein","volume":"65","author":"Palamarchuk","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.retram.2016.04.008_bib0310","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0015-0282(02)03344-7","article-title":"Involvement of catalase in the endometrium of patients with endometriosis and adenomyosis","volume":"78","author":"Ota","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.retram.2016.04.008_bib0315","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ejogrb.2011.12.011","article-title":"Expression and possible role of interleukin-10 receptors in patients with adenomyosis","volume":"161","author":"Qin","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.retram.2016.04.008_bib0320","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.mce.2011.10.035","article-title":"Mechanisms of endometrial progesterone resistance","volume":"358","author":"Al-Sabbagh","year":"2012","journal-title":"Mol Cell Endocrinol"}],"container-title":["Current Research in Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452318616300101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452318616300101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T12:51:29Z","timestamp":1536670289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452318616300101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S2452318616300101"],"URL":"https:\/\/doi.org\/10.1016\/j.retram.2016.04.008","relation":{},"ISSN":["2452-3186"],"issn-type":[{"value":"2452-3186","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down-regulation of tumor suppressor PDCD4 expression in endometrium of adenomyosis patients","name":"articletitle","label":"Article Title"},{"value":"Current Research in Translational Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.retram.2016.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}