{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:10:46Z","timestamp":1790172646088,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Translational Medicine"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.retram.2019.06.002","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T17:27:43Z","timestamp":1567790863000},"page":"129-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Epstein-Barr virus infection in gliomas"],"prefix":"10.1016","volume":"67","author":[{"given":"S.","family":"Limam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6964-075X","authenticated-orcid":false,"given":"N.","family":"Missaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mestiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Yacoubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Krifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Selmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mokni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.retram.2019.06.002_bib0005","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1001\/jamaoncol.2018.1789","article-title":"Adult glioma incidence and survival by race or ethnicity in the United States from 2000 to 2014","volume":"4","author":"Ostrom","year":"2018","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.retram.2019.06.002_bib0010","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1001\/jama.2013.280319","article-title":"Glioblastoma and other malignant gliomas: a clinical review","volume":"310","author":"Omuro","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.retram.2019.06.002_bib0015","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/neuonc\/nou087","article-title":"The epidemiology of glioma in adults: a \u201cstate of the science\u201d review","volume":"16","author":"Ostrom","year":"2014","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.retram.2019.06.002_bib0020","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdu050","article-title":"High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"25","author":"Stupp","year":"2014","journal-title":"Ann Oncol"},{"key":"10.1016\/j.retram.2019.06.002_bib0025","first-page":"3","article-title":"Glioblastoma multiforme: a review of its epidemiology and pathogenesis through clinical presentation and treatment","volume":"18","author":"Hanif","year":"2017","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.1016\/j.retram.2019.06.002_bib0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1750-9378-8-7","article-title":"Role of infectious agents in the carcinogenesis of brain and head and neck cancers","volume":"8","author":"Alibek","year":"2013","journal-title":"Infect Agent Cancer"},{"key":"10.1016\/j.retram.2019.06.002_bib0035","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.tim.2016.03.008","article-title":"Viral carcinogenesis beyond malignant transformation: EBV in the progression of human cancers","volume":"24","author":"Elgui de Oliveira","year":"2016","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.retram.2019.06.002_bib0040","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s11060-011-0658-6","article-title":"The roles of viruses in brain tumour initiation and oncomodulation","volume":"105","author":"Kofman","year":"2011","journal-title":"J Neurooncol"},{"key":"10.1016\/j.retram.2019.06.002_bib0045","doi-asserted-by":"crossref","first-page":"E111","DOI":"10.3390\/jcm6120111","article-title":"Viral oncology: molecular biology and pathogenesis","volume":"6","author":"Mui","year":"2017","journal-title":"J Clin Med"},{"key":"10.1016\/j.retram.2019.06.002_bib0050","doi-asserted-by":"crossref","first-page":"221","DOI":"10.21873\/invivo.11049","article-title":"Prevalence of neurotropic viruses in malignant glioma and their onco-modulatory potential","volume":"31","author":"Strojnik","year":"2017","journal-title":"In Vivo"},{"key":"10.1016\/j.retram.2019.06.002_bib0055","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.prp.2016.12.006","article-title":"An overview of the infection of CMV, HSV 1\/2 and EBV in Mexican patients with glioblastoma multiforme","volume":"213","author":"Zavala-Vega","year":"2017","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.retram.2019.06.002_bib0060","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13027-016-0081-x","article-title":"Human herpesvirus multiplex ddPCR detection in brain tissue from low- and high-grade astrocytoma cases and controls","volume":"11","author":"Lin","year":"2016","journal-title":"Infect Agent Cancer"},{"key":"10.1016\/j.retram.2019.06.002_bib0065","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1590\/1516-3180.2013.1912814","article-title":"Frequency of Epstein-Barr virus DNA sequences in human gliomas","volume":"133","author":"Fonseca","year":"2015","journal-title":"Sao Paulo Med J"},{"key":"10.1016\/j.retram.2019.06.002_bib0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-9378-10-3","article-title":"Prevalence of human cytomegalovirus, polyomaviruses, and oncogenic viruses in glioblastoma among Japanese subjects","volume":"10","author":"Hashida","year":"2015","journal-title":"Infect Agent Cancer"},{"key":"10.1016\/j.retram.2019.06.002_bib0075","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.yexmp.2014.03.010","article-title":"Detection of viral pathogens in high grade gliomas from unmapped next-generation sequencing data","volume":"96","author":"Cimino","year":"2014","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.retram.2019.06.002_bib0080","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/neuonc\/not140","article-title":"Evidence of association of human papillomavirus with prognosis worsening in glioblastoma multiforme","volume":"16","author":"Vidone","year":"2014","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.retram.2019.06.002_bib0085","doi-asserted-by":"crossref","first-page":"8916","DOI":"10.1128\/JVI.00340-13","article-title":"Landscape of DNA virus associations across human malignant cancers: analysis of 3,775 cases using RNA-Seq","volume":"87","author":"Khoury","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.retram.2019.06.002_bib0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fonc.2018.00123","article-title":"Epstein\u2013Barr virus in gliomas: cause, association, or artifact?","volume":"8","author":"Akhtar","year":"2018","journal-title":"Front Oncol"},{"key":"10.1016\/j.retram.2019.06.002_bib0095","first-page":"149","article-title":"Epstein-Barr virus infection and human malignancies","volume":"82","author":"Niedobitek","year":"2001","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.retram.2019.06.002_bib0100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2169\/internalmedicine.42.33","article-title":"Epstein-Barr virus infections of the central nervous system","volume":"42","author":"Fujimoto","year":"2003","journal-title":"Intern Med"},{"key":"10.1016\/j.retram.2019.06.002_bib0105","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0140-6736(64)91524-7","article-title":"Virus particles in cultured lymphoblasts from Burkitt\u2019s lymphoma","volume":"1","author":"Epstein","year":"1964","journal-title":"Lancet"},{"key":"10.1016\/j.retram.2019.06.002_bib0110","series-title":"Fields virology","first-page":"2603","article-title":"Epstein-Barr virus and its replication","author":"Kieff","year":"2006"},{"key":"10.1016\/j.retram.2019.06.002_bib0115","article-title":"Characterization of Epstein-Barr virus miRNAome in nasopharyngeal carcinoma by deep sequencing","volume":"5","author":"Chen","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.retram.2019.06.002_bib0120","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1128\/JVI.02104-08","article-title":"Comprehensive profiling of Epstein-Barr virus microRNAs in nasopharyngeal carcinoma","volume":"83","author":"Cosmopoulos","year":"2009","journal-title":"J Virol"},{"key":"10.1016\/j.retram.2019.06.002_bib0125","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1158\/0008-5472.CAN-07-5126","article-title":"EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3","volume":"68","author":"Xia","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.retram.2019.06.002_bib0130","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1371\/journal.ppat.0020023","article-title":"Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed","volume":"2","author":"Cai","year":"2006","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.retram.2019.06.002_bib0135","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/ijc.28670","article-title":"O. Comprehensive metagenomic analysis of glioblastoma reveals absence of known virus despite antiviral-like type I interferon gene response","volume":"135","author":"Cosset","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1016\/j.retram.2019.06.002_bib0140","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.brainres.2008.05.009","article-title":"Detection and quantitative analysis of human herpesvirus in pilocytic astrocytoma","volume":"1221","author":"Neves","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.retram.2019.06.002_bib0145","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1080\/13550280600654573","article-title":"Lack of association of herpesviruses with brain tumors","volume":"12","author":"Poltermann","year":"2006","journal-title":"J Neurovirol"},{"key":"10.1016\/j.retram.2019.06.002_bib0150","doi-asserted-by":"crossref","first-page":"7722","DOI":"10.1128\/JVI.73.9.7722-7733.1999","article-title":"Epstein-Barr virus infection of human astrocyte cell lines","volume":"73","author":"Menet","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.retram.2019.06.002_bib0155","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.4049\/jimmunol.156.6.2247","article-title":"Identification and characterization of complement C3 receptors on human astrocytes","volume":"156","author":"Gasque","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.retram.2019.06.002_bib0160","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s13402-015-0242-8","article-title":"DNA methylation patterns in EBV-positive and EBV-negative Hodgkin lymphomas","volume":"38","author":"Dhiab","year":"2015","journal-title":"Cell Oncol (Dordr)"},{"key":"10.1016\/j.retram.2019.06.002_bib0165","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/0140-6736(90)91433-B","article-title":"Detection by PCR of HHV-6 and EBV DNA in blood and oropharynx of healthy adults and HIV-seropositives","volume":"335","author":"Gopal","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.retram.2019.06.002_bib0170","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/aje\/154.2.161","article-title":"Prevalence of antibodies to four herpesviruses among adults with glioma and controls","volume":"154","author":"Wrensch","year":"2001","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.retram.2019.06.002_bib0175","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1128\/JVI.02271-06","article-title":"Expression of viral microRNAs in Epstein-Barr virus-associated gastric carcinoma","volume":"81","author":"Kim","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.retram.2019.06.002_bib0180","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1038\/ncomms8353","article-title":"Epstein-Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma","volume":"6","author":"Cai","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.retram.2019.06.002_bib0185","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/path.4025","article-title":"The pathological roles of BART miRNAs in nasopharyngeal carcinoma","volume":"227","author":"Lo","year":"2012","journal-title":"J Pathol"},{"key":"10.1016\/j.retram.2019.06.002_bib0190","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/nar\/gkm1080","article-title":"Epstein-Barr virus-encoded microRNA miR-BART2 down-regulates the viral DNA polymerase BALF5","volume":"36","author":"Barth","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.retram.2019.06.002_bib0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125791","article-title":"Analysis of glioblastoma patients\u2019 plasma revealed the presence of MicroRNAs with a prognostic impact on survival and those of viral origin","volume":"10","author":"Herman","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.retram.2019.06.002_bib0200","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s40478-016-0338-z","article-title":"A comprehensive next generation sequencing-based virome assessment in brain tissue suggests no major virus-tumor association","volume":"4","author":"Strong","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.retram.2019.06.002_bib0205","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1128\/CMR.00124-13","article-title":"Viruses and human cancers: a long road of discovery of molecular paradigms","volume":"27","author":"White","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.retram.2019.06.002_bib0210","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11481-010-9204-0","article-title":"Chronic viral infection and primary central nervous system malignancy","volume":"5","author":"Saddawi-Konefka","year":"2010","journal-title":"J Neuroimmune Pharmacol"}],"container-title":["Current Research in Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452318619300285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452318619300285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:38:35Z","timestamp":1762821515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452318619300285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S2452318619300285"],"URL":"https:\/\/doi.org\/10.1016\/j.retram.2019.06.002","relation":{},"ISSN":["2452-3186"],"issn-type":[{"value":"2452-3186","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epstein-Barr virus infection in gliomas","name":"articletitle","label":"Article Title"},{"value":"Current Research in Translational Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.retram.2019.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Masson SAS.","name":"copyright","label":"Copyright"}]}}