{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T02:58:51Z","timestamp":1789009131298,"version":"build-2803163510"},"reference-count":102,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CB-2014\\u2013241840"],"award-info":[{"award-number":["CB-2014\\u2013241840"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["99097556"],"award-info":[{"award-number":["99097556"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["338440"],"award-info":[{"award-number":["338440"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004881","name":"Instituto Mexicano del Seguro Social","doi-asserted-by":"publisher","award":["FIS\/IMSS\/PROT\/PRIO\/18\/076"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/PRIO\/18\/076"]}],"id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Translational Medicine"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.retram.2021.103295","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T04:58:12Z","timestamp":1620104292000},"page":"103295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Understanding the hematopoietic microenvironment in chronic myeloid leukemia: A concise review"],"prefix":"10.1016","volume":"69","author":[{"given":"P.","family":"Torres-Barrera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2483-3782","authenticated-orcid":false,"given":"H.","family":"Mayani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4542-1023","authenticated-orcid":false,"given":"A.","family":"Ch\u00e1vez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.retram.2021.103295_bib0001","first-page":"431","article-title":"Hemopoietic stem cell differentiation","volume":"605","author":"Till","year":"1980","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"10.1016\/j.retram.2021.103295_bib0002","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/ncb2442","article-title":"Inferring rules of lineage commitment in haematopoiesis","volume":"14","author":"Pina","year":"2012","journal-title":"Nat Cell Biol"},{"issue":"5","key":"10.1016\/j.retram.2021.103295_bib0003","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-0609.1992.tb00053.x","article-title":"Biology of the hemopoietic microenvironment","volume":"49","author":"Mayani","year":"1992","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.retram.2021.103295_bib0004","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1146\/annurev-pathol-012615-044414","article-title":"Hematopoietic stem cell niche in health and disease","volume":"11","author":"Hoggatt","year":"2016","journal-title":"Annu Rev Pathol"},{"issue":"14","key":"10.1016\/j.retram.2021.103295_bib0005","doi-asserted-by":"crossref","first-page":"5306","DOI":"10.1073\/pnas.83.14.5306","article-title":"Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells","volume":"83","author":"Eaves","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"10.1016\/j.retram.2021.103295_bib0006","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/nm.3647","article-title":"Hematopoietic stem cell niche maintenance during homeostasis and regeneration","volume":"20","author":"Mendelson","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.retram.2021.103295_bib0007","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exphem.2020.07.010","article-title":"Caught in the net\": the extracellular matrix of the bone marrow in normal hematopoiesis and leukemia","volume":"89","author":"Zanetti","year":"2020","journal-title":"Exp Hematol"},{"issue":"1","key":"10.1016\/j.retram.2021.103295_bib0008","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1182\/blood.V46.1.65.65","article-title":"The relative spatial distributions of CFUs and CFUc in the normal mouse femur","volume":"46","author":"Lord","year":"1975","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0009","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1182\/blood.V87.2.518.bloodjournal872518","article-title":"Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow cultures","volume":"87","author":"Taichman","year":"1996","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.retram.2021.103295_bib0010","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.179.5.1677","article-title":"Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor","volume":"179","author":"Taichman","year":"1994","journal-title":"J Exp Med"},{"issue":"7225","key":"10.1016\/j.retram.2021.103295_bib0011","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nature07639","article-title":"Detection of functional haematopoietic stem cell niche using real-time imaging","volume":"457","author":"Xie","year":"2009","journal-title":"Nature"},{"issue":"6960","key":"10.1016\/j.retram.2021.103295_bib0012","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature02040","article-title":"Osteoblastic cells regulate the haematopoietic stem cell niche","volume":"425","author":"Calvi","year":"2003","journal-title":"Nature"},{"issue":"6960","key":"10.1016\/j.retram.2021.103295_bib0013","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nature02041","article-title":"Identification of the haematopoietic stem cell niche and control of the niche size","volume":"425","author":"Zhang","year":"2003","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0014","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.stem.2008.10.005","article-title":"Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance","volume":"4","author":"Kiel","year":"2009","journal-title":"Cell Stem Cell"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0015","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1182\/blood-2011-09-377457","article-title":"N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells","volume":"120","author":"Greenbaum","year":"2012","journal-title":"Blood"},{"issue":"7382","key":"10.1016\/j.retram.2021.103295_bib0016","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10783","article-title":"Endothelial and perivascular cells maintain haematopoietic stem cells","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.retram.2021.103295_bib0017","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","article-title":"SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells","volume":"121","author":"Kiel","year":"2005","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.retram.2021.103295_bib0018","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.immuni.2006.10.016","article-title":"Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches","volume":"25","author":"Sugiyama","year":"2006","journal-title":"Immunity"},{"issue":"7473","key":"10.1016\/j.retram.2021.103295_bib0019","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature12612","article-title":"Arteriolar niches maintain haematopoietic stem cell quiescence","volume":"502","author":"Kunisaki","year":"2013","journal-title":"Nature"},{"issue":"7589","key":"10.1016\/j.retram.2021.103295_bib0020","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature16943","article-title":"Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche","volume":"530","author":"Chen","year":"2016","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.retram.2021.103295_bib0021","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ncb2730","article-title":"Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment","volume":"15","author":"Nombela-Arrieta","year":"2013","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.retram.2021.103295_bib0022","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.devcel.2014.03.013","article-title":"Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development","volume":"29","author":"Mizoguchi","year":"2014","journal-title":"Dev Cell"},{"issue":"4","key":"10.1016\/j.retram.2021.103295_bib0023","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.bbrc.2013.07.081","article-title":"N-Cadherin is a prospective cell surface marker of human mesenchymal stem cells that have high ability for cardiomyocyte differentiation","volume":"438","author":"Ishimine","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0024","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nrc2791","article-title":"Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors","volume":"10","author":"Butler","year":"2010","journal-title":"Nat Rev Cancer"},{"issue":"7571","key":"10.1016\/j.retram.2021.103295_bib0025","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nature15250","article-title":"Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal","volume":"526","author":"Acar","year":"2015","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0026","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.stem.2013.06.015","article-title":"Regional localization within the bone marrow influences the functional capacity of human HSCs","volume":"13","author":"Guezguez","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"9","key":"10.1016\/j.retram.2021.103295_bib0027","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/labinvest.2012.93","article-title":"Distinctive contact between CD34+ hematopoietic progenitors and CXCL12+ CD271+ mesenchymal stromal cells in benign and myelodysplastic bone marrow","volume":"92","author":"Flores-Figueroa","year":"2012","journal-title":"Lab Invest"},{"issue":"3","key":"10.1016\/j.retram.2021.103295_bib0028","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.immuni.2010.08.017","article-title":"The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche","volume":"33","author":"Omatsu","year":"2010","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.retram.2021.103295_bib0029","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1084\/jem.20122252","article-title":"PDGFRalpha and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion","volume":"210","author":"Pinho","year":"2013","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.retram.2021.103295_bib0030","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.stem.2010.02.001","article-title":"Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells","volume":"6","author":"Butler","year":"2010","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.retram.2021.103295_bib0031","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1182\/blood-2011-12-398115","article-title":"Development of a vascular niche platform for expansion of repopulating human cord blood stem and progenitor cells","volume":"120","author":"Butler","year":"2012","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.retram.2021.103295_bib0032","doi-asserted-by":"crossref","first-page":"864","DOI":"10.5966\/sctm.2016-0240","article-title":"Endothelial cells promote expansion of long-term engrafting marrow hematopoietic stem and progenitor cells in primates","volume":"6","author":"Gori","year":"2017","journal-title":"Stem Cells Transl Med"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0033","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1182\/blood-2004-11-4269","article-title":"Tie2 activation contributes to hemangiogenic regeneration after myelosuppression","volume":"106","author":"Kopp","year":"2005","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.retram.2021.103295_bib0034","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1038\/nm.2969","article-title":"Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance","volume":"18","author":"Winkler","year":"2012","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.retram.2021.103295_bib0035","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.celrep.2013.07.048","article-title":"Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis","volume":"4","author":"Poulos","year":"2013","journal-title":"Cell Rep"},{"issue":"4","key":"10.1016\/j.retram.2021.103295_bib0036","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.celrep.2012.09.002","article-title":"Pleiotrophin regulates the retention and self-renewal of hematopoietic stem cells in the bone marrow vascular niche","volume":"2","author":"Himburg","year":"2012","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0037","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1084\/jem.20101688","article-title":"Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche","volume":"208","author":"Chow","year":"2011","journal-title":"J Exp Med"},{"issue":"23","key":"10.1016\/j.retram.2021.103295_bib0038","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1182\/blood-2009-11-253534","article-title":"Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs","volume":"116","author":"Winkler","year":"2010","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0039","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cell.2005.10.041","article-title":"Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow","volume":"124","author":"Katayama","year":"2006","journal-title":"Cell"},{"issue":"7308","key":"10.1016\/j.retram.2021.103295_bib0040","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"Mendez-Ferrer","year":"2010","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.retram.2021.103295_bib0041","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/nm.3707","article-title":"Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion","volume":"20","author":"Bruns","year":"2014","journal-title":"Nat Med"},{"issue":"11","key":"10.1016\/j.retram.2021.103295_bib0042","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/nm.3706","article-title":"Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells","volume":"20","author":"Zhao","year":"2014","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0043","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.bbrc.2014.10.095","article-title":"Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin","volume":"454","author":"Nakamura-Ishizu","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.retram.2021.103295_bib0044","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1089\/scd.2016.0096","article-title":"Neuropilin-1 is an important niche component and exerts context-dependent effects on hematopoietic stem cells","volume":"26","author":"Ghode","year":"2017","journal-title":"Stem Cells Dev"},{"issue":"5","key":"10.1016\/j.retram.2021.103295_bib0045","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1469-7580.2011.01423.x","article-title":"Changes in human bone marrow fat content associated with changes in hematopoietic stem cell numbers and cytokine levels with aging","volume":"219","author":"Tuljapurkar","year":"2011","journal-title":"J Anat"},{"issue":"7252","key":"10.1016\/j.retram.2021.103295_bib0046","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature08099","article-title":"Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment","volume":"460","author":"Naveiras","year":"2009","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.retram.2021.103295_bib0047","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0002-9343(77)90124-3","article-title":"Chronic myelocytic leukemia: clonal origin in a stem cell common to the granulocyte, erythrocyte, platelet and monocyte\/macrophage","volume":"63","author":"Fialkow","year":"1977","journal-title":"Am J Med"},{"issue":"17","key":"10.1016\/j.retram.2021.103295_bib0048","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1056\/NEJM199904293401706","article-title":"Chronic myeloid leukemia","volume":"340","author":"Sawyers","year":"1999","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.retram.2021.103295_bib0049","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1182\/blood.V94.6.2056","article-title":"Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia","volume":"94","author":"Holyoake","year":"1999","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.retram.2021.103295_bib0050","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.leukres.2008.11.011","article-title":"In vitro biology of human myeloid leukemia","volume":"33","author":"Mayani","year":"2009","journal-title":"Leuk Res"},{"key":"10.1016\/j.retram.2021.103295_bib0051","series-title":"Stem Cell Biology in Normal Life and Diseases","article-title":"Dafne Moreno-Lorenzana and H\u00e9ctor Mayani hematopoietic stem cells in chronic myeloid leukemia","author":"Antonieta Ch\u00e1vez-Gonz\u00e1lez","year":"2013"},{"issue":"37","key":"10.1016\/j.retram.2021.103295_bib0052","doi-asserted-by":"crossref","first-page":"16280","DOI":"10.1073\/pnas.1004408107","article-title":"Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein","volume":"107","author":"Jaras","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"23","key":"10.1016\/j.retram.2021.103295_bib0053","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1182\/blood-2015-11-679928","article-title":"Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor-treated CML stem cells","volume":"128","author":"Zhang","year":"2016","journal-title":"Blood"},{"issue":"25","key":"10.1016\/j.retram.2021.103295_bib0054","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1182\/blood-2013-10-536078","article-title":"Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia","volume":"123","author":"Herrmann","year":"2014","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.retram.2021.103295_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13402-016-0297-1","article-title":"Novel strategies for targeting leukemia stem cells: sounding the death knell for blood cancer","volume":"40","author":"Chavez-Gonzalez","year":"2017","journal-title":"Cell Oncol (Dordr)"},{"issue":"8","key":"10.1016\/j.retram.2021.103295_bib0056","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1158\/1078-0432.CCR-15-0767","article-title":"Identification of CD25 as STAT5-dependent growth regulator of leukemic stem cells in Ph+ CML","volume":"22","author":"Sadovnik","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"3","key":"10.1016\/j.retram.2021.103295_bib0057","first-page":"128","article-title":"[STI571: a new dimension in the treatment of chronic myeloid leukemia]","volume":"146","author":"Somers","year":"2002","journal-title":"Ned Tijdschr Geneeskd"},{"issue":"5","key":"10.1016\/j.retram.2021.103295_bib0058","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrc2126","article-title":"Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia","volume":"7","author":"Weisberg","year":"2007","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"10.1016\/j.retram.2021.103295_bib0059","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.leukres.2005.06.028","article-title":"Functional integrity in vitro of hematopoietic progenitor cells from patients with chronic myeloid leukemia that have achieved hematological remission after different therapeutic procedures","volume":"30","author":"Chavez-Gonzalez","year":"2006","journal-title":"Leuk Res"},{"issue":"4","key":"10.1016\/j.retram.2021.103295_bib0060","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.hoc.2017.04.007","article-title":"Mechanisms of Resistance to ABL Kinase Inhibition in Chronic Myeloid Leukemia and the Development of Next Generation ABL Kinase Inhibitors","volume":"31","author":"Patel","year":"2017","journal-title":"Hematol Oncol Clin North Am"},{"issue":"6","key":"10.1016\/j.retram.2021.103295_bib0061","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1182\/blood.V88.6.2162.bloodjournal8862162","article-title":"Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemia","volume":"88","author":"Petzer","year":"1996","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.retram.2021.103295_bib0062","first-page":"1041","article-title":"Composition and function of the hemopoietic microenvironment in human myeloid leukemia","volume":"10","author":"Mayani","year":"1996","journal-title":"Leukemia"},{"issue":"19","key":"10.1016\/j.retram.2021.103295_bib0063","first-page":"171","article-title":"Bone marrow stromal cells in the pathogenesis of acute myeloid leukemia","volume":"1","year":"2014","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"7","key":"10.1016\/j.retram.2021.103295_bib0064","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1172\/JCI41246","article-title":"Chronic myeloid leukemia: mechanisms of blastic transformation","volume":"120","author":"Perrotti","year":"2010","journal-title":"J Clin Invest"},{"key":"10.1016\/j.retram.2021.103295_bib0065","series-title":"Proceedings of the National Academy of Sciences of the United States of America","first-page":"11842","article-title":"Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?","volume":"100","author":"Passegue","year":"2003"},{"issue":"12","key":"10.1016\/j.retram.2021.103295_bib0066","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1182\/blood-2016-11-696070","article-title":"The microenvironment in human myeloid malignancies: emerging concepts and therapeutic implications","volume":"129","author":"Medyouf","year":"2017","journal-title":"Blood"},{"issue":"19","key":"10.1016\/j.retram.2021.103295_bib0067","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1182\/blood-2013-02-485607","article-title":"Autocrine TNF-alpha production supports CML stem and progenitor cell survival and enhances their proliferation","volume":"122","author":"Gallipoli","year":"2013","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.retram.2021.103295_bib0068","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ccr.2011.10.012","article-title":"IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development","volume":"20","author":"Reynaud","year":"2011","journal-title":"Cancer Cell"},{"issue":"22","key":"10.1016\/j.retram.2021.103295_bib0069","doi-asserted-by":"crossref","first-page":"12804","DOI":"10.1073\/pnas.96.22.12804","article-title":"Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia","volume":"96","author":"Jiang","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0070","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1182\/blood-2016-09-742049","article-title":"CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression","volume":"129","author":"Tarafdar","year":"2017","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.retram.2021.103295_bib0071","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1038\/s41375-020-0732-1","article-title":"SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia","volume":"34","author":"Sinnakannu","year":"2020","journal-title":"Leukemia"},{"issue":"8","key":"10.1016\/j.retram.2021.103295_bib0072","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1182\/blood-2014-06-581926","article-title":"MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors","volume":"125","author":"Wang","year":"2015","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.retram.2021.103295_bib0073","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ccr.2012.02.018","article-title":"Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia","volume":"21","author":"Zhang","year":"2012","journal-title":"Cancer Cell"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0074","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1186\/ar2391","article-title":"TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood","volume":"10","author":"Zhang","year":"2008","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"10.1016\/j.retram.2021.103295_bib0075","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1634\/stemcells.20-3-259","article-title":"Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1","volume":"20","author":"Peled","year":"2002","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/j.retram.2021.103295_bib0076","doi-asserted-by":"crossref","first-page":"9535","DOI":"10.1038\/s41598-017-10373-3","article-title":"Adhesion to stromal cells mediates imatinib resistance in chronic myeloid leukemia through ERK and BMP signaling pathways","volume":"7","author":"Kumar","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.retram.2021.103295_bib0077","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2019.02.018","article-title":"Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells","volume":"24","author":"Agarwal","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.retram.2021.103295_bib0078","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/1479-5876-11-298","article-title":"Leukemia cells induce changes in human bone marrow stromal cells","volume":"11","author":"Civini","year":"2013","journal-title":"J Transl Med"},{"issue":"3","key":"10.1016\/j.retram.2021.103295_bib0079","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.stem.2013.06.009","article-title":"Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche","volume":"13","author":"Schepers","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"19","key":"10.1016\/j.retram.2021.103295_bib0080","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1002\/cncr.31663","article-title":"Bone marrow core biopsy in 508 consecutive patients with chronic myeloid leukemia: assessment of potential value","volume":"124","author":"Hidalgo-Lomicronpez","year":"2018","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.retram.2021.103295_bib0081","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.leukres.2011.12.002","article-title":"Potentiation of Nilotinib-mediated cell death in the context of the bone marrow microenvironment requires a promiscuous JAK inhibitor in CML","volume":"36","author":"Nair","year":"2012","journal-title":"Leuk Res"},{"issue":"5","key":"10.1016\/j.retram.2021.103295_bib0082","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/leu.2011.325","article-title":"Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors","volume":"26","author":"Traer","year":"2012","journal-title":"Leukemia"},{"issue":"10","key":"10.1016\/j.retram.2021.103295_bib0083","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1158\/1535-7163.MCT-08-0314","article-title":"Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance","volume":"7","author":"Bewry","year":"2008","journal-title":"Mol Cancer Ther"},{"issue":"10","key":"10.1016\/j.retram.2021.103295_bib0084","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1182\/blood-2012-02-412890","article-title":"Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-beta-catenin signaling","volume":"121","author":"Zhang","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.retram.2021.103295_bib0085","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/sj.leu.2402769","article-title":"Clinicopathologic correlations of bone marrow angiogenesis in chronic myeloid leukemia: a morphometric study","volume":"17","author":"Korkolopoulou","year":"2003","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.retram.2021.103295_bib0086","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1309\/3JLTFNNEDQHB4A0P","article-title":"Immunohistochemical detection of VEGF in the bone marrow of patients with chronic myeloid leukemia and correlation with the phase of disease","volume":"121","author":"Krauth","year":"2004","journal-title":"Am J Clin Pathol"},{"issue":"6","key":"10.1016\/j.retram.2021.103295_bib0087","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1182\/blood.V96.6.2240","article-title":"Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes","volume":"96","author":"Aguayo","year":"2000","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.retram.2021.103295_bib0088","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.ccr.2011.05.007","article-title":"Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia","volume":"19","author":"Schmidt","year":"2011","journal-title":"Cancer Cell"},{"issue":"8","key":"10.1016\/j.retram.2021.103295_bib0089","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.leukres.2015.05.014","article-title":"Do endothelial cells belong to the primitive stem leukemic clone in CML? Role of extracellular vesicles","volume":"39","author":"Ramos","year":"2015","journal-title":"Leuk Res"},{"issue":"1","key":"10.1016\/j.retram.2021.103295_bib0090","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10456-011-9241-1","article-title":"Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a Src-dependent fashion","volume":"15","author":"Mineo","year":"2012","journal-title":"Angiogenesis"},{"issue":"4","key":"10.1016\/j.retram.2021.103295_bib0091","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nm.4499","article-title":"Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia","volume":"24","author":"Zhang","year":"2018","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.retram.2021.103295_bib0092","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3324\/haematol.2018.212365","article-title":"The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL\/TAL1 - CD44 axis","volume":"105","author":"Godavarthy","year":"2020","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.retram.2021.103295_bib0093","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/nm1489","article-title":"Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells","volume":"12","author":"Krause","year":"2006","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.retram.2021.103295_bib0094","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood-2013-11-538694","article-title":"Selectins and their ligands are required for homing and engraftment of BCR-ABL1+ leukemic stem cells in the bone marrow niche","volume":"123","author":"Krause","year":"2014","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0095","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1182\/blood-2011-04-348151","article-title":"Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia","volume":"119","author":"Frisch","year":"2012","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.retram.2021.103295_bib0096","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1158\/1535-7163.MCT-07-0042","article-title":"CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cells","volume":"7","author":"Jin","year":"2008","journal-title":"Mol Cancer Ther"},{"issue":"5","key":"10.1016\/j.retram.2021.103295_bib0097","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1158\/1535-7163.MCT-13-0410","article-title":"Combination of imatinib with CXCR4 antagonist BKT140 overcomes the protective effect of stroma and targets CML in vitro and in vivo","volume":"13","author":"Beider","year":"2014","journal-title":"Mol Cancer Ther"},{"issue":"2","key":"10.1016\/j.retram.2021.103295_bib0098","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1182\/blood.V76.2.401.401","article-title":"Diminished A-LAK cytotoxicity and proliferation accompany disease progression in chronic myelogenous leukemia","volume":"76","author":"Verfaillie","year":"1990","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.retram.2021.103295_bib0099","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/leu.2016.360","article-title":"Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia","volume":"31","author":"Ilander","year":"2017","journal-title":"Leukemia"},{"issue":"2357","key":"10.1016\/j.retram.2021.103295_bib0100","article-title":"Natural killer cells in myeloid malignancies: immune surveillance, NK cell dysfunction, and pharmacological opportunities to bolster the endogenous NK cells","volume":"10","author":"Carlsten","year":"2019","journal-title":"Front Immunol"},{"issue":"23","key":"10.1016\/j.retram.2021.103295_bib0101","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1182\/blood-2015-11-679985","article-title":"IL1RAP antibodies block IL-1\u2013induced expansion of candidate CML stem cells and mediate cell killing in xenograft models","volume":"128","author":"\u00c5gerstam","year":"2016","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.retram.2021.103295_bib0102","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1158\/0008-5472.CAN-18-1078","article-title":"CML hematopoietic stem cells expressing IL1RAP can be targeted by chimeric antigen receptor\u2013engineered T cells","volume":"79","author":"Warda","year":"2019","journal-title":"Cancer Res."}],"container-title":["Current Research in Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452318621000210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2452318621000210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:25:22Z","timestamp":1778891122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2452318621000210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":102,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S2452318621000210"],"URL":"https:\/\/doi.org\/10.1016\/j.retram.2021.103295","relation":{},"ISSN":["2452-3186"],"issn-type":[{"value":"2452-3186","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Understanding the hematopoietic microenvironment in chronic myeloid leukemia: A concise review","name":"articletitle","label":"Article Title"},{"value":"Current Research in Translational Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.retram.2021.103295","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103295"}}