{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T10:37:23Z","timestamp":1720694243694},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatolog\u00eda Cl\u00ednica"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1016\/j.reuma.2009.04.006","type":"journal-article","created":{"date-parts":[[2009,7,11]],"date-time":"2009-07-11T04:57:35Z","timestamp":1247288255000},"page":"5-8","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S2","title":["Sistemas cannabinoide y opioide en los mecanismos y el control del dolor"],"prefix":"10.1016","volume":"5","author":[{"given":"Carlos","family":"Goicoechea Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Mart\u00edn Fontelles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reuma.2009.04.006_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0531-5131(02)00600-3","article-title":"History of opium","volume":"1242","author":"Arag\u00f3n-Poce","year":"2002","journal-title":"International Congress Series"},{"key":"10.1016\/j.reuma.2009.04.006_bib2","unstructured":"Aldrich M. History of therapeutic cannabis. En: Mathre ML, editor. Cannabis in medical practice. Jefferson (NC): Editorial Mc Farland;, 1997. p. 35\u201355."},{"key":"10.1016\/j.reuma.2009.04.006_bib3","unstructured":"Gutstein HB, Akil H. Analg\u00e9sicos opioides. En: Brunton LL, Lazo JS, Parker KL, editores. Goodman & Gilman. Las bases farmacol\u00f3gicas de la terap\u00e9utica. 11 ed. M\u00e9xico DF, M\u00e9xico: Editorial Mc Graw Hill; 2007. p. 547\u201389."},{"key":"10.1016\/j.reuma.2009.04.006_bib4","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1021\/ja01062a046","article-title":"Isolation, structure, and partial synthesis of an active constituent of hashish","volume":"86","author":"Gaoni","year":"1964","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.reuma.2009.04.006_bib5","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.peptides.2008.09.007","article-title":"Endogenous opiates and behavior: 2007","volume":"29","author":"Bodnar","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.reuma.2009.04.006_bib6","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2174\/138945008785909356","article-title":"Enkephalinase inhibitors: Potential agents for the management of pain","volume":"9","author":"Thanawala","year":"2008","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.reuma.2009.04.006_bib7","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/372686a0","article-title":"Formation and inactivation of endogenous cannabinoid anandamide in central neurons","volume":"372","author":"Di Marzo","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.reuma.2009.04.006_bib8","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0163-7258(97)82001-3","article-title":"Pharmacology of cannabinoid CB1 and CB2 receptors","volume":"74","author":"Pertwee","year":"1997","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.reuma.2009.04.006_bib9","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/sj.bjp.0707481","article-title":"Novel cannabinoid receptors","volume":"152","author":"Brown","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.reuma.2009.04.006_bib10","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2174\/1381612043453081","article-title":"Oxidative metabolism of endocannabinoids by COX-2","volume":"10","author":"Kozak","year":"2004","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.reuma.2009.04.006_bib11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0169-328X(95)00165-O","article-title":"Primary astroglial cultures derived from several rat brain regions differentially express m, d and k opioid receptor mRNA","volume":"34","author":"Ruzicka","year":"1995","journal-title":"Mol Brain Res"},{"key":"10.1016\/j.reuma.2009.04.006_bib12","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.2174\/138161208785740135","article-title":"Expression and function of the endocannabinoid system in glial cells","volume":"14","author":"Massi","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.reuma.2009.04.006_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.coph.2008.12.009","article-title":"Peripheral mechanisms of opioid analgesia","volume":"9","author":"Stein","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.reuma.2009.04.006_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0304-3959(01)00321-9","article-title":"CB2 cannabinoid receptor-mediated peripheral antinociception","volume":"93","author":"Malan","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.reuma.2009.04.006_bib15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0014-2999(96)00015-5","article-title":"N-(2-hydroxyethyl)- hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation","volume":"300","author":"Mazzari","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.reuma.2009.04.006_bib16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s12035-007-8007-7","article-title":"Cannabinoid CB2 receptor-mediated antinociception in models of acute and chronic pain","volume":"36","author":"Jhaveri","year":"2007","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.reuma.2009.04.006_bib17","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1073\/pnas.0409888102","article-title":"CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids","volume":"102","author":"Ibrahim","year":"2005","journal-title":"PNAS"},{"key":"10.1016\/j.reuma.2009.04.006_bib18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pbb.2005.02.007","article-title":"Analgesic effects of loperamide in bone cancer pain in mice","volume":"81","author":"Men\u00e9ndez","year":"2005","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.reuma.2009.04.006_bib19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejphar.2008.07.052","article-title":"Analgesic activity and pharmacological characterization of N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl] propenamide, a new opioid agonist acting peripherally","volume":"595","author":"Goicoechea","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.reuma.2009.04.006_bib20","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/sj.bjp.0707531","article-title":"Cannabinoid CB2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain","volume":"153","author":"Guindon","year":"2008","journal-title":"Br J Pharmacol"}],"container-title":["Reumatolog\u00eda Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1699258X09001521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1699258X09001521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T07:24:47Z","timestamp":1545117887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1699258X09001521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":20,"alternative-id":["S1699258X09001521"],"URL":"https:\/\/doi.org\/10.1016\/j.reuma.2009.04.006","relation":{},"ISSN":["1699-258X"],"issn-type":[{"value":"1699-258X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}