{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T10:37:48Z","timestamp":1720694268261},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatolog\u00eda Cl\u00ednica"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.reuma.2010.01.002","type":"journal-article","created":{"date-parts":[[2010,2,13]],"date-time":"2010-02-13T04:41:10Z","timestamp":1266036070000},"page":"28-32","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S1","title":["Lo que el cl\u00ednico debe saber sobre los mecanismos de conexi\u00f3n entre la inflamaci\u00f3n y la formaci\u00f3n de hueso. \u00bfEs suficiente el bloqueo de la inflamaci\u00f3n para prevenir la osificaci\u00f3n?"],"prefix":"10.1016","volume":"6","author":[{"given":"Pilar","family":"Aguado Ac\u00edn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reuma.2010.01.002_bib1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1136\/ard.2007.071159","article-title":"Tumour necrosis factor blockers and structural remodelling in ankylosing spondylitis: what is reality and what is fiction?","volume":"66","author":"Schett","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.reuma.2010.01.002_bib2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.reuma.2010.01.002_bib3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1001\/jama.292.4.490","article-title":"Clinical implications of the Osteoprotegerin\/RANKL\/RANK System for bone and vascular diseases","volume":"292","author":"Hofbauer","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.reuma.2010.01.002_bib4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/01.bor.0000127824.42507.68","article-title":"Bone loss in inflammatory arthritis: mechanisms and treatment strategies","volume":"16","author":"Walsh","year":"2004","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.reuma.2010.01.002_bib5","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/art.23290","article-title":"The abundant synovial expression of the RANKL\/RANK\/ Osteoprotegerin system in peripheral spondyloarthritis is partially disconnected from inflammation","volume":"58","author":"Vandooren","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.reuma.2010.01.002_bib6","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1172\/JCI27071","article-title":"Pathogenesis of osteoporosis: concepts, conflicts and prospects","volume":"115","author":"Raisz","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.reuma.2010.01.002_bib7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nm1538","article-title":"Dickkopf-1 is a master regulator of joint remodeling","volume":"13","author":"Diarra","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.reuma.2010.01.002_bib8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1136\/ard.2003.013599","article-title":"Ankylosing enthesitis, dactylitis and onychoperiostitis in a mouse model of psoriatic arthritis","volume":"63","author":"Lories","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.reuma.2010.01.002_bib9","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/art.22372","article-title":"Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis","volume":"56","author":"Lories","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.reuma.2010.01.002_bib10","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1172\/JCI23738","article-title":"Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis","volume":"115","author":"Lories","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.reuma.2010.01.002_bib11","article-title":"Blockade of Dickkopf-1 induces fusion of sacroiliac joints","author":"Uderhardt","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.reuma.2010.01.002_bib12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/ar2642","article-title":"Mechanisms of new bone formation in spondyloarthritis","volume":"11","author":"Lories","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.reuma.2010.01.002_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.reuma.2008.02.001","article-title":"Monitorizaci\u00f3n y valor pron\u00f3stico por resonancia magn\u00e9tica de los tratamientos biol\u00f3gicos en las espondiloartritis","volume":"5","author":"Martos","year":"2009","journal-title":"Reumatol Clin"},{"key":"10.1016\/j.reuma.2010.01.002_bib14","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/art.23471","article-title":"Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept","volume":"58","author":"Van der Heijde","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.reuma.2010.01.002_bib15","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1002\/art.23755","article-title":"Distinct topography of erosion and new bone formation in achilles tendon enthesitis. Implications for understanding the link between inflammation and bone formation in spondylarthritis","volume":"58","author":"McGonagle","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.reuma.2010.01.002_bib16","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/art.23260","article-title":"Critical appraisal of assessment of structural damage in ankylosing spondylitis. Implications for treatment outcomes","volume":"58","author":"Sieper","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.reuma.2010.01.002_bib17","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/art.24132","article-title":"Inflammatory lesions of the spine on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis. Evidence of a relationship between inflammation and new bone formation","volume":"60","author":"Maksymowych","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.reuma.2010.01.002_bib18","doi-asserted-by":"crossref","first-page":"R125","DOI":"10.1186\/ar2537","article-title":"Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment","volume":"10","author":"Appel","year":"2008","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.reuma.2010.01.002_bib19","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1002\/art.24888","article-title":"Altered skeletal expression of sclerostin and its link to radiographic progression in ankylosing spondylitis","volume":"60","author":"Appel","year":"2009","journal-title":"Artritis Rheum"}],"container-title":["Reumatolog\u00eda Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1699258X10000215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1699258X10000215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T02:24:30Z","timestamp":1544667870000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1699258X10000215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":19,"alternative-id":["S1699258X10000215"],"URL":"https:\/\/doi.org\/10.1016\/j.reuma.2010.01.002","relation":{},"ISSN":["1699-258X"],"issn-type":[{"value":"1699-258X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}