{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:15:45Z","timestamp":1779351345212,"version":"3.51.4"},"reference-count":95,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Reumatolog\u00eda Cl\u00ednica"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.reuma.2013.02.008","type":"journal-article","created":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T18:46:13Z","timestamp":1383936373000},"page":"303-315","source":"Crossref","is-referenced-by-count":43,"title":["Osteoinmunolog\u00eda: el estudio de la relaci\u00f3n entre el sistema inmune y el tejido \u00f3seo"],"prefix":"10.1016","volume":"9","author":[{"given":"Luis","family":"Arboleya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santos","family":"Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.reuma.2013.02.008_bib0005","series-title":"Gray's Anatomy","first-page":"81","article-title":"Functional anatomy of the musculoskeletal system","author":"Wigley","year":"2008"},{"key":"10.1016\/j.reuma.2013.02.008_bib0010","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.2215\/CJN.04151206","article-title":"Normal bone anatomy and physiology","volume":"3","author":"Clarke","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0015","first-page":"573","article-title":"Bone metabolism during adolescence: the known, the unknown, and the controversial","volume":"19","author":"Harel","year":"2008","journal-title":"Adolesc Med State Art Rev"},{"key":"10.1016\/j.reuma.2013.02.008_bib0020","series-title":"Principles of bone biology","first-page":"3","article-title":"Modelling and remodelling","author":"Seeman","year":"2008"},{"key":"10.1016\/j.reuma.2013.02.008_bib0025","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/35046196","article-title":"Bone versus immune system","volume":"408","author":"Arron","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.reuma.2013.02.008_bib0030","series-title":"Osteoimmunology","year":"2011"},{"key":"10.1016\/j.reuma.2013.02.008_bib0035","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/ar3375","article-title":"Osteoimmunology and osteoporosis","volume":"13","author":"Geusens","year":"2011","journal-title":"Arth Res Ther"},{"key":"10.1016\/j.reuma.2013.02.008_bib0040","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature02040","article-title":"Osteoblastic cells regulate the haematopoietic stem cell niche","volume":"425","author":"Calvi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.reuma.2013.02.008_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2011.10.044","article-title":"Update on Wnt signaling in bone cell biology and bone disease","volume":"492","author":"Monroe","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.reuma.2013.02.008_bib0050","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","article-title":"Disorders of bone remodeling","volume":"6","author":"Feng","year":"2011","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0055","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.clinbiochem.2012.03.021","article-title":"An overview of the regulation of bone remodelling at the cellular level","volume":"45","author":"Kular","year":"2012","journal-title":"Clin Biochem"},{"key":"10.1016\/j.reuma.2013.02.008_bib0060","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature06907","article-title":"The Cl-\/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes","volume":"453","author":"Graves","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.reuma.2013.02.008_bib0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(01)00206-9","article-title":"Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man","volume":"104","author":"Kornak","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.reuma.2013.02.008_bib0070","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1359\/JBMR.040302","article-title":"The chloride channel inhibitor NS3736 prevents bone resorption in ovariectomized rats without changing bone formation","volume":"19","author":"Schaller","year":"2004","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.reuma.2013.02.008_bib0075","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/sj.emboj.7600576","article-title":"Loss of the chloride channel ClC-7 leads to lysosomal storage disease and neurodegeneration","volume":"24","author":"Kasper","year":"2005","journal-title":"EMBO J"},{"key":"10.1016\/j.reuma.2013.02.008_bib0080","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","article-title":"The molecular understanding of osteoclast differentiation","volume":"40","author":"Asagiri","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.reuma.2013.02.008_bib0085","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1172\/JCI45913","article-title":"OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice","volume":"121","author":"Barrow","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.reuma.2013.02.008_bib0090","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.4049\/jimmunol.1102836","article-title":"TREM-2 and \u03b2-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis","volume":"188","author":"Otero","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-11-0132","article-title":"Osteoblasts in osteoporosis: past, emerging, and future anabolic targets","volume":"165","author":"Marie","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0100","doi-asserted-by":"crossref","first-page":"126","DOI":"10.2741\/s138","article-title":"Transcriptional regulation of bone formation","volume":"3","author":"Baek","year":"2011","journal-title":"Front Biosci"},{"key":"10.1016\/j.reuma.2013.02.008_bib0105","doi-asserted-by":"crossref","first-page":"272","DOI":"10.7150\/ijbs.2929","article-title":"TGF-\u03b2 and BMP signaling in osteoblast differentiation and bone formation","volume":"8","author":"Chen","year":"2012","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.reuma.2013.02.008_bib0110","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1093\/gerona\/gls102","article-title":"Aging, atherosclerosis, and IGF-1","volume":"67","author":"Higashi","year":"2012","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.reuma.2013.02.008_bib0115","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/dvdy.20603","article-title":"Buried alive: how osteoblasts become osteocytes","volume":"235","author":"Franz-Odendaal","year":"2006","journal-title":"Dev Dyn"},{"key":"10.1016\/j.reuma.2013.02.008_bib0120","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/j.bbamem.2011.09.018","article-title":"Gap junctions and hemichannels in signal transmission, function and development of bone","volume":"1818","author":"Batra","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.reuma.2013.02.008_bib0125","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1007\/s00198-012-1915-z","article-title":"Osteocyte regulation of bone mineral: a little give and take","volume":"23","author":"Atkins","year":"2012","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.reuma.2013.02.008_bib0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1748-1716.2011.02385.x","article-title":"Osteocytes: central conductors of bone biology in normal and pathological conditions","volume":"204","author":"Neve","year":"2012","journal-title":"Acta Physiol (Oxf)"},{"key":"10.1016\/j.reuma.2013.02.008_bib0135","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/0022034510363963","article-title":"Osteocytes and WNT: the mechanical control of bone formation","volume":"89","author":"Galli","year":"2010","journal-title":"J Dent Res"},{"key":"10.1016\/j.reuma.2013.02.008_bib0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1126\/science.1222879","article-title":"Structural basis of Wnt recognition by Frizzled","volume":"337","author":"Janda","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.reuma.2013.02.008_bib0145","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1172\/JCI0215582","article-title":"Osteoclasts are essential for TNF-\u03b1-mediated joint destruction","volume":"110","author":"Redlich","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.reuma.2013.02.008_bib0150","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0002-9440(10)63016-7","article-title":"TRANCE\/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis","volume":"159","author":"Petit","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0155","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1182\/blood.V91.10.3702","article-title":"Myeloid development is selectively disrupted in PU.1 null mice","volume":"91","author":"Anderson","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.reuma.2013.02.008_bib0160","doi-asserted-by":"crossref","first-page":"6158","DOI":"10.1073\/pnas.0401602101","article-title":"The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcR-\u03b3) regulate development of functional osteoclasts through the Syk tyrosine kinase","volume":"101","author":"Mocsai","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.reuma.2013.02.008_bib0165","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.immuni.2009.05.001","article-title":"Plasticity of CD4+ T cell lineage differentiation","volume":"30","author":"Zhou","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.reuma.2013.02.008_bib0170","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/35046102","article-title":"T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-\u03b3","volume":"408","author":"Takayanagi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.reuma.2013.02.008_bib0175","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/ar3323","article-title":"Regulation of bone by the adaptive immune system in arthritis","volume":"13","author":"Okamoto","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.reuma.2013.02.008_bib0180","doi-asserted-by":"crossref","first-page":"13960","DOI":"10.1073\/pnas.251534698","article-title":"Up-regulation of TNF producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo","volume":"98","author":"Roggia","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.reuma.2013.02.008_bib0185","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI11066","article-title":"Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alfa","volume":"106","author":"Cenci","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.reuma.2013.02.008_bib0190","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1359\/jbmr.060726","article-title":"T lymphocyte-deficient mice lose trabecular bone mass with ovariectomy","volume":"21","author":"Lee","year":"2006","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.reuma.2013.02.008_bib0195","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1196\/annals.1346.030","article-title":"Estrogen regulation of immune cell bone interactions","volume":"1068","author":"Weitzmann","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.reuma.2013.02.008_bib0200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1749-6632.2012.06674.x","article-title":"The development of denosumab for the treatment of diseases of bone loss and cancer-induced bone destruction","volume":"1263","author":"Goessl","year":"2012","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.reuma.2013.02.008_bib0205","doi-asserted-by":"crossref","first-page":"29851","DOI":"10.1074\/jbc.M112.377945","article-title":"Receptor activator of nuclear factor \u03baB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss","volume":"287","author":"Onal","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.reuma.2013.02.008_bib0210","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1210\/er.2007-0014","article-title":"Receptor activator of nuclear factor kappa B ligand and osteoprotegerin regulation of bone remodeling in health and disease","volume":"29","author":"Kearns","year":"2008","journal-title":"Endocr Rev"},{"key":"10.1016\/j.reuma.2013.02.008_bib0215","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1210\/en.2003-1536","article-title":"Estrogen deficiency accelerates murine autoimmune arthritis associated with receptor activator of nuclear factor kappa B ligand-mediated osteoclastogenesis","volume":"145","author":"Yoneda","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.reuma.2013.02.008_bib0220","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00198-008-0731-y","article-title":"Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo","volume":"20","author":"Clowes","year":"2009","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.reuma.2013.02.008_bib0225","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nm.1945","article-title":"Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis","volume":"15","author":"Binder","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.reuma.2013.02.008_bib0230","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.yexcr.2009.01.014","article-title":"Estrogen inhibits RANKL-stimulated osteoclastic differentiation of human monocytes through estrogen and RANKL regulated interaction of estrogen receptor alpha with BCAR1 and TRAF6","volume":"315","author":"Robinson","year":"2009","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.reuma.2013.02.008_bib0235","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/jbmr.1500","article-title":"Role of T cells in ovariectomy induced bone loss--revisited","volume":"27","author":"Pacifici","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.reuma.2013.02.008_bib0240","doi-asserted-by":"crossref","first-page":"27091","DOI":"10.1074\/jbc.273.42.27091","article-title":"Transforming growth factor-B stimulates the production of osteoprotegerin\/osteoclastogenesis inhibitory factor by bone marrow stromal cells","volume":"273","author":"Takai","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.reuma.2013.02.008_bib0245","series-title":"Osteoimmunology","first-page":"270","article-title":"The role of the immune system in the development of osteoporosis","author":"M\u00f6dder","year":"2011"},{"key":"10.1016\/j.reuma.2013.02.008_bib0250","series-title":"Rheumatology","first-page":"841","article-title":"Rheumatoid synovitis and pannus","author":"Gravallese","year":"2008"},{"key":"10.1016\/j.reuma.2013.02.008_bib0255","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s11926-012-0253-7","article-title":"Bone loss in RA: systemic, periarticular and focal","volume":"14","author":"Deal","year":"2012","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.reuma.2013.02.008_bib0260","series-title":"Osteoimmunology","first-page":"301","article-title":"The role of the immune system in the bone loss of inflammatory artritis","author":"Goldring","year":"2011"},{"key":"10.1016\/j.reuma.2013.02.008_bib0265","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.intimp.2010.11.010","article-title":"Osteoclasts in arthritis and Th-17 cell development","volume":"11","author":"Okamoto","year":"2011","journal-title":"Intern Immunopharmacol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0270","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nrd3794","article-title":"Targeting IL-17 and TH17 cells in chronic inflammation","volume":"10","author":"Miossec","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.reuma.2013.02.008_bib0275","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.it.2012.05.004","article-title":"Defining the human T helper 17 cell phenotype","volume":"10","author":"Annunziato","year":"2012","journal-title":"Trends Immunol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0280","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1056\/NEJMra0707449","article-title":"Interleukin-17 and type 17 helper T cells","volume":"361","author":"Miossec","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.reuma.2013.02.008_bib0285","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/eji.200939566","article-title":"Treatment of collagen-induced arthritis by Natura-alpha via regulation of Th-1\/Th-17 responses","volume":"40","author":"Glatigny","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0290","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1084\/jem.20061775","article-title":"Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction","volume":"203","author":"Sato","year":"2006","journal-title":"J Exp Med"},{"key":"10.1016\/j.reuma.2013.02.008_bib0295","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrrheum.2012.167","article-title":"New developments in osteoimmunology","volume":"8","author":"Takayanagi","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0300","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/art.27334","article-title":"LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled, proof-of-concept study","volume":"62","author":"Genovese","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.reuma.2013.02.008_bib0305","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.tips.2008.11.004","article-title":"Interleukin-17 as a drug target in human disease","volume":"30","author":"Ivanov","year":"2009","journal-title":"Trends Pharmacol Sci"},{"issue":"Suppl. 5","key":"10.1016\/j.reuma.2013.02.008_bib0310","doi-asserted-by":"crossref","first-page":"v3","DOI":"10.1093\/rheumatology\/kes113","article-title":"Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis","volume":"51","author":"Choy","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.reuma.2013.02.008_bib0315","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrrheum.2012.153","article-title":"Bone erosion in RA: mechanisms, diagnosis and treatment","volume":"8","author":"Schett","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0320","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/ard.2009.119156","article-title":"Repair of erosions occurs almost exclusively in damaged joints without swelling","volume":"69","author":"Lukas","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.reuma.2013.02.008_bib0325","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1136\/ard.2008.097048","article-title":"Erosive progression is minimal, but erosion healing rare, in patients with rheumatoid arthritis treated with adalimumab. A 1-year investigator-initiated follow-up study using high-resolution computed tomography as the primary outcome measure","volume":"68","author":"M\u00f8ller D\u00f8hn","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.reuma.2013.02.008_bib0330","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/annrheumdis-2011-201075","article-title":"Interleukin 6 receptor blockade induces limited repair of bone erosions in rheumatoid arthritis: a micro CT study","volume":"72","author":"Finzel","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.reuma.2013.02.008_bib0335","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1136\/ard.2010.148395","article-title":"Repair of bone erosions in rheumatoid arthritis treated with tumour necrosis factor inhibitors is based on bone apposition at the base of the erosion","volume":"70","author":"Finzel","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.reuma.2013.02.008_bib0340","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1359\/jbmr.090320","article-title":"Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis","volume":"24","author":"Walsh","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.reuma.2013.02.008_bib0345","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.semarthrit.2011.01.006","article-title":"The emerging role of Dickkopf-1 in bone biology: is it the main switch controlling bone and joint remodeling?","volume":"41","author":"Daoussis","year":"2011","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.reuma.2013.02.008_bib0350","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11914-011-0086-8","article-title":"Potential role for therapies targeting DKK1, LRP5, and Serotonin in the treatment of osteoporosis","volume":"10","author":"Zhang","year":"2012","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.reuma.2013.02.008_bib0355","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nature05656","article-title":"Nuclear cytokine-activated IKK\u03b1 controls prostate cancer metastasis by repressing Maspin","volume":"446","author":"Luo","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.reuma.2013.02.008_bib0360","doi-asserted-by":"crossref","first-page":"15852","DOI":"10.1073\/pnas.0706728104","article-title":"IkB kinase a kinase activity is required for self-renewal of ErbB2\/Her2-transformed mammary tumor-initiating cells","volume":"104","author":"Cao","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.reuma.2013.02.008_bib0365","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nature09707","article-title":"Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL\u2013RANK signaling","volume":"470","author":"Tan","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.reuma.2013.02.008_bib0370","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1158\/0008-5472.CAN-12-0044","article-title":"RANK induces epithelial-mesenchymal transition and stemness in human mammary epithelial cells and promotes tumorigenesis and metastasis","volume":"72","author":"Palafox","year":"2012","journal-title":"Cancer Res"},{"key":"10.1016\/j.reuma.2013.02.008_bib0375","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1242\/jcs.094029","article-title":"Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells","volume":"125","author":"Beristain","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1016\/j.reuma.2013.02.008_bib0380","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1074-7613(02)00279-0","article-title":"Pancreatic lymph node-derived CD4(+) CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals","volume":"16","author":"Green","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.reuma.2013.02.008_bib0385","doi-asserted-by":"crossref","first-page":"6079","DOI":"10.4049\/jimmunol.0711823","article-title":"RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis","volume":"182","author":"Totsuka","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0390","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.tem.2012.05.005","article-title":"New insights into osteoclastogenic signaling mechanisms","volume":"23","author":"Nakashima","year":"2012","journal-title":"Trends Endoc Metab"},{"key":"10.1016\/j.reuma.2013.02.008_bib0395","doi-asserted-by":"crossref","first-page":"142","DOI":"10.5312\/wjo.v3.i9.142","article-title":"RANKL-RANK interaction in immune regulatory systems","volume":"3","author":"Akiyama","year":"2012","journal-title":"World J Orthop"},{"key":"10.1016\/j.reuma.2013.02.008_bib0400","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/eji.201141480","article-title":"Effects of RANKL on the thymic medulla","volume":"41","author":"Ohigashi","year":"2011","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0405","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.179.5.1677","article-title":"Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor","volume":"179","author":"Taichman","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.reuma.2013.02.008_bib0410","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2174\/187152812800392689","article-title":"Bone marrow niches for hematopoietic stem cells and immune cells","volume":"11","author":"Sugiyama","year":"2012","journal-title":"Inflamm Allergy Drug Targets"},{"key":"10.1016\/j.reuma.2013.02.008_bib0415","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bone.2011.09.036","article-title":"N-cadherin adherens junctions mediate osteogenesis through PI3K signaling","volume":"50","author":"Guntur","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.reuma.2013.02.008_bib0420","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nri3132","article-title":"The bone marrow at the crossroad of blood and immunity","volume":"12","author":"Mercier","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0425","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cell.2004.07.004","article-title":"Tie2\/angiopoietin-1 signaling regulates hematopoietic stemm cell quiescence in the bone marrow niche","volume":"118","author":"Arai","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.reuma.2013.02.008_bib0430","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nm1417","article-title":"Osteoclast degrade endosteal components and promote mobilization of hematopoietic progenitor cells","volume":"12","author":"Kollet","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.reuma.2013.02.008_bib0435","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1084\/jem.20101890","article-title":"Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization","volume":"208","author":"Miyamoto","year":"2011","journal-title":"J Exp Med"},{"key":"10.1016\/j.reuma.2013.02.008_bib0440","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/intimm\/dxn035","article-title":"Osteoclasts support the survival of human plasma cells in vitro","volume":"20","author":"Geffroy-Luseau","year":"2008","journal-title":"Int Immunol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0445","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/jbmr.1608","article-title":"Absence of sclerostin adversely affects B-cell survival","volume":"7","author":"Cain","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.reuma.2013.02.008_bib0450","doi-asserted-by":"crossref","first-page":"e38199","DOI":"10.1371\/journal.pone.0038199","article-title":"Osteoclast activated FoxP+ CD8+ T-cells supress bone resorption in vitro","volume":"7","author":"Buchwald","year":"2012","journal-title":"Plos One"},{"key":"10.1016\/j.reuma.2013.02.008_bib0455","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.4049\/jimmunol.0803897","article-title":"Cross-presentation by osteoclasts induces FoxP3 in CD8+ T cells","volume":"182","author":"Kiesel","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0460","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s12026-009-8130-9","article-title":"Regulating functional cell fates in CD8 T cells","volume":"46","author":"Shrikant","year":"2010","journal-title":"Immunol Res"},{"key":"10.1016\/j.reuma.2013.02.008_bib0465","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/nm.2499","article-title":"Targeting osteoclast-osteoblast communication","volume":"17","author":"Cao","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.reuma.2013.02.008_bib0470","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.it.2012.01.008","article-title":"Diverse roles for semaphoring-plexin signaling in the immune system","volume":"33","author":"Takamatsu","year":"2012","journal-title":"Trends Immunol"},{"key":"10.1016\/j.reuma.2013.02.008_bib0475","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nature11000","article-title":"Osteoprotection by semaphorin 3A","volume":"485","author":"Hayashi","year":"2012","journal-title":"Nature"}],"container-title":["Reumatolog\u00eda Cl\u00ednica"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1699258X13000855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1699258X13000855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T16:22:15Z","timestamp":1596817335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1699258X13000855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":95,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S1699258X13000855"],"URL":"https:\/\/doi.org\/10.1016\/j.reuma.2013.02.008","relation":{},"ISSN":["1699-258X"],"issn-type":[{"value":"1699-258X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}