{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:57:44Z","timestamp":1790888264838,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["La Revue de M\u00e9decine Interne"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.revmed.2004.02.025","type":"journal-article","created":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T06:22:09Z","timestamp":1081837329000},"page":"629-635","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Peptides antimicrobiens cationiques\u00a0: de l'\u00e9tude de l'immunit\u00e9 inn\u00e9e \u00e0 la production de m\u00e9dicaments"],"prefix":"10.1016","volume":"25","author":[{"given":"E.","family":"Andr\u00e8s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-L.","family":"Dimarcq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.revmed.2004.02.025_BIB1","first-page":"1165","article-title":"The new antibiotics","volume":"17","author":"Breithaupt","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.revmed.2004.02.025_BIB2","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1126\/science.291.5511.2068","article-title":"Innate immunity: ancient system gets new respect","volume":"291","author":"Gura","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.revmed.2004.02.025_BIB3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2174\/1568005024605855","article-title":"Clinical development of cationic antimicrobial peptides: from natural to novel antibiotics","volume":"2","author":"Hancock","year":"2002","journal-title":"Curr Drug Targets Infect Disord"},{"key":"10.1016\/j.revmed.2004.02.025_BIB4","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.284.5418.1313","article-title":"Phylogenetic perspectives in innate immunity","volume":"284","author":"Hoffmann","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.revmed.2004.02.025_BIB5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0952-7915(99)80005-3","article-title":"Anti-microbial peptides in mammalian and insect host defence","volume":"11","author":"Lehrer","year":"1999","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.revmed.2004.02.025_BIB6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0952-7915(98)80029-0","article-title":"Anti-microbial peptides of vertebrates","volume":"10","author":"Ganz","year":"1998","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.revmed.2004.02.025_BIB7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2165\/00003495-199957040-00002","article-title":"Host defense peptides","volume":"57","author":"Hancock","year":"1999","journal-title":"Drugs"},{"key":"10.1016\/j.revmed.2004.02.025_BIB8","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S1473-3099(01)00092-5","article-title":"Cationic peptides: effectors in innate immunity and novel antimicrobials","volume":"1","author":"Hancock","year":"2001","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.revmed.2004.02.025_BIB9","first-page":"306","article-title":"Epithelial antimicrobial peptides and proteins: their role in host defence and inflammation","volume":"2","author":"Hiemstra","year":"2001","journal-title":"Paediatr Respir Rev"},{"key":"10.1016\/j.revmed.2004.02.025_BIB10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1164\/rccm.200307-971OC","article-title":"Cathelicidin peptide sheep myeloid antimicrobial peptide-29 prevents endotoxin-induced mortality in rat models of septic shock","volume":"169","author":"Giacometti","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.revmed.2004.02.025_BIB11","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1056\/NEJMoa021481","article-title":"Endogenous antimicrobial peptides and skin infections in atopic dermatitis","volume":"347","author":"Ong","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2004.02.025_BIB12","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/S0140-6736(02)11201-3","article-title":"Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study","volume":"360","author":"Putsep","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.revmed.2004.02.025_BIB13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nature02021","article-title":"The immune response of Drosophila","volume":"426","author":"Hoffmann","year":"2003","journal-title":"Nature"},{"issue":"Suppl 2","key":"10.1016\/j.revmed.2004.02.025_BIB14","doi-asserted-by":"crossref","first-page":"S327","DOI":"10.1086\/374758","article-title":"Drosophila melanogaster antimicrobial defense","volume":"187","author":"Hetru","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.revmed.2004.02.025_BIB15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/(SICI)1097-0282(1998)47:6<465::AID-BIP5>3.0.CO;2-#","article-title":"Cysteine-rich anti-microbial peptides in invertebrates","volume":"47","author":"Dimarcq","year":"1998","journal-title":"Biopolymers"},{"key":"10.1016\/j.revmed.2004.02.025_BIB16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1046\/j.1365-2796.2003.01228.x","article-title":"Antibacterial peptides: basic facts and emerging concepts","volume":"254","author":"Boman","year":"2003","journal-title":"J Intern Med"},{"key":"10.1016\/j.revmed.2004.02.025_BIB17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1046\/j.1365-3083.1998.00343.x","article-title":"Gene-encoded peptide antibiotics and the concept of innate immunity: an update review","volume":"48","author":"Boman","year":"1998","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.revmed.2004.02.025_BIB18","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0006-2952(90)90138-B","article-title":"Magainins: a new family of membrane-active host defense peptides","volume":"39","author":"Berkowitz","year":"1990","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.revmed.2004.02.025_BIB19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1749-6632.1996.tb52963.x","article-title":"Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich anti-microbial peptides","volume":"797","author":"Lehrer","year":"1996","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.revmed.2004.02.025_BIB20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/(SICI)1097-0282(1998)47:6<479::AID-BIP6>3.0.CO;2-K","article-title":"Plant defense peptides","volume":"47","author":"Garcia-Olmedo","year":"1998","journal-title":"Biopolymers"},{"key":"10.1016\/j.revmed.2004.02.025_BIB21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1399-3011.1995.tb01055.x","article-title":"Synthesis and characterization of indolicidin, a tryptophan-rich anti-microbial peptide from bovine neutrophils","volume":"45","author":"van Abel","year":"1995","journal-title":"Int J Pept Protein Res"},{"key":"10.1016\/j.revmed.2004.02.025_BIB22","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0145-305X(99)00015-4","article-title":"Anti-microbial peptides in insects; structure and function","volume":"23","author":"Bulet","year":"1999","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.revmed.2004.02.025_BIB23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1574-6968.2002.tb11000.x","article-title":"Role of membrane in the activities of antimicrobial cationic peptides","volume":"206","author":"Hancock","year":"2002","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.revmed.2004.02.025_BIB24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/(SICI)1097-0282(1998)47:6<451::AID-BIP4>3.0.CO;2-F","article-title":"Mode of action of linear amphipathic alpha-helical anti-microbial peptides","volume":"47","author":"Oren","year":"1998","journal-title":"Biopolymers"},{"key":"10.1016\/j.revmed.2004.02.025_BIB25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1139\/o98-026","article-title":"Structure-function relationships of anti-microbial peptides","volume":"76","author":"Hwang","year":"1998","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.revmed.2004.02.025_BIB26","doi-asserted-by":"crossref","first-page":"19239","DOI":"10.1016\/S0021-9258(19)36505-6","article-title":"Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus","volume":"268","author":"Cociancich","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.revmed.2004.02.025_BIB27","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1357-4310(99)01490-2","article-title":"Antibiotic peptides from higher eukaryotes: biology and applications","volume":"5","author":"Ganz","year":"1999","journal-title":"Mol Med Today"},{"key":"10.1016\/j.revmed.2004.02.025_BIB28","doi-asserted-by":"crossref","first-page":"14150","DOI":"10.1021\/bi0012843","article-title":"Interaction between heat shock proteins and anti-microbial peptides","volume":"39","author":"Otvos","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.revmed.2004.02.025_BIB29","doi-asserted-by":"crossref","first-page":"9531","DOI":"10.1073\/pnas.160077797","article-title":"A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii)","volume":"97","author":"Thevissen","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.revmed.2004.02.025_BIB30","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.4049\/jimmunol.165.6.3358","article-title":"An alpha-helical cationic anti-microbial peptide selectively modulates macrophage responses to lipopolysaccharide and directly alters macrophage gene expression","volume":"165","author":"Scott","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.revmed.2004.02.025_BIB31","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1615\/CritRevImmunol.v20.i5.40","article-title":"Cationic anti-microbial peptides and their multifunctional role in the immune system","volume":"20","author":"Scott","year":"2000","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.revmed.2004.02.025_BIB32","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1517\/13543784.9.8.1723","article-title":"Cationic anti-microbial peptides: toward clinical application","volume":"9","author":"Hancock","year":"2000","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.revmed.2004.02.025_BIB33","first-page":"201","article-title":"Les peptides antimicrobiens cationiques et leurs applications potentielles","volume":"3","author":"Andr\u00e8s","year":"2001","journal-title":"Antibiotiques"},{"key":"10.1016\/j.revmed.2004.02.025_BIB34","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1046\/j.1365-2796.2003.01278.x","article-title":"Cationic antimicrobial peptides: update of clinical development","volume":"255","author":"Andr\u00e8s","year":"2003","journal-title":"J Intern Med"},{"key":"10.1016\/j.revmed.2004.02.025_BIB35","first-page":"197","article-title":"Potential therapeutic applications of magainins and other anti-microbial agents of animal origin","volume":"186","author":"Jacob","year":"1994","journal-title":"Ciba Found Symp"},{"key":"10.1016\/j.revmed.2004.02.025_BIB36","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2165\/00003495-199856060-00011","article-title":"Pexiganan acetate","volume":"56","author":"Lamb","year":"1998","journal-title":"Drugs"},{"key":"10.1016\/j.revmed.2004.02.025_BIB37","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S1079-2104(99)70131-9","article-title":"Effect of local application of the anti-microbial peptide IBL-367 on the incidence and severity of oral mucositis in hamsters","volume":"87","author":"Loury","year":"1999","journal-title":"Oral Surg, Oral Med, Oral Path, Oral Radiol and Endodontics"},{"key":"10.1016\/j.revmed.2004.02.025_BIB38","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1517\/13543784.9.8.1731","article-title":"Protegrins: new antibiotics of mammalian origin","volume":"9","author":"Bellm","year":"2000","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.revmed.2004.02.025_BIB39","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1034\/j.1600-051X.2002.291201.x","article-title":"Safety and clinical effects of topical histatin gels in human with experimental gingivitis","volume":"29","author":"Paquette","year":"2002","journal-title":"J Clin Periondotal"},{"key":"10.1016\/j.revmed.2004.02.025_BIB40","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0140-6736(97)06468-4","article-title":"Preliminary evaluation of recombinant amino-terminal fragment of human bactericidal\/permeability increasing protein in children with severe meningococcal sepsis","volume":"350","author":"Giroir","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.revmed.2004.02.025_BIB41","first-page":"667","article-title":"Bactericidal\/permeability increasing protein (rBPI-21) in patients with hemorrhage due to trauma: results of a multicenter phase II clinical trial","volume":"46","author":"Demetriades","year":"1999","journal-title":"Trauma"},{"key":"10.1016\/j.revmed.2004.02.025_BIB42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nature02021","article-title":"The immune system of Drosophila","volume":"426","author":"Hoffmann","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.revmed.2004.02.025_BIB43","doi-asserted-by":"crossref","first-page":"14614","DOI":"10.1073\/pnas.94.26.14614","article-title":"Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms","volume":"94","author":"Lemaitre","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.revmed.2004.02.025_BIB44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0924-8579(03)00201-2","article-title":"Thanatin activity on multidrug resistant clinical isolates of Enterobacter aerogenes and Klebsiella pneumoniae","volume":"22","author":"Pages","year":"2003","journal-title":"Int J Antimicrob Agents"}],"container-title":["La Revue de M\u00e9decine Interne"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866304000840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866304000840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:08:10Z","timestamp":1759334890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0248866304000840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":44,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0248866304000840"],"URL":"https:\/\/doi.org\/10.1016\/j.revmed.2004.02.025","relation":{},"ISSN":["0248-8663"],"issn-type":[{"value":"0248-8663","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peptides antimicrobiens cationiques\u00a0: de l'\u00e9tude de l'immunit\u00e9 inn\u00e9e \u00e0 la production de m\u00e9dicaments","name":"articletitle","label":"Article Title"},{"value":"La Revue de M\u00e9decine Interne","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.revmed.2004.02.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 \u00c9ditions scientifiques et m\u00e9dicales Elsevier SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}