{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:16:54Z","timestamp":1760782614904},"reference-count":62,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["La Revue de M\u00e9decine Interne"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.revmed.2004.07.003","type":"journal-article","created":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T14:34:09Z","timestamp":1092234849000},"page":"806-815","source":"Crossref","is-referenced-by-count":4,"title":["M\u00e9nopause en 2004\u00a0: le \u00ab\u00a0traitement hormonal substitutif\u00a0\u00bb n'est plus ce qu'il \u00e9tait"],"prefix":"10.1016","volume":"25","author":[{"given":"C.","family":"Azoulay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.revmed.2004.07.003_BIB1","first-page":"203","article-title":"L'interniste et la m\u00e9nopause","volume":"13","author":"Godeau","year":"2000","journal-title":"Reprod. Hum. Horm."},{"key":"10.1016\/j.revmed.2004.07.003_BIB2","unstructured":"AFSSAPS\u00a0: communiqu\u00e9 de presse du 08\u00a0ao\u00fbt 2003. Traitement hormonal substitutif et risque de cancer du sein."},{"key":"10.1016\/j.revmed.2004.07.003_BIB3","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1210\/jc.2003-030876","article-title":"An epidemiologist looks at hormones and heart disease in women","volume":"88","author":"Barrett-Connor","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.revmed.2004.07.003_BIB4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.7326\/0003-4819-137-4-200208200-00012","article-title":"Postmenopausal hormone replacement therapy and the primary prevention of cardiovascular disease","volume":"137","author":"Humphrey","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.revmed.2004.07.003_BIB5","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/jama.280.7.605","article-title":"Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women: Heart and Estrogen\/progestin Replacement Study (HERS) Research Group","volume":"280","author":"Hulley","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2004.07.003_BIB6","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1001\/jama.273.3.199","article-title":"Effects of estrogen or estrogen\/progestin regimens on heart disease risk factors in postmenopausal women. The Postmenopausal Estrogen\/Progestin Interventions (PEPI) Trial","volume":"273","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2004.07.003_BIB7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomised controlled trial","volume":"288","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2004.07.003_BIB8","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1067\/S0002-9378(03)00979-7","article-title":"WHI trial: it's time to be critical!","volume":"189","author":"Speroff","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.revmed.2004.07.003_BIB9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1071-5576(02)00189-2","article-title":"The impact of the Women's Health Initiative on clinical practice","volume":"9","author":"Speroff","year":"2002","journal-title":"J Soc Gynecol Investig"},{"key":"10.1016\/j.revmed.2004.07.003_BIB10","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa030808","article-title":"Estrogen plus progestin and the risk of coronary heart disease","volume":"349","author":"Manson","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2004.07.003_BIB11","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1016\/S0140-6736(02)12001-0","article-title":"Estrogen therapy for prevention of reinfarction in postmenopausal women: a randomised placebo controlled trial","volume":"360","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.revmed.2004.07.003_BIB12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1056\/NEJMoa030830","article-title":"Hormone therapy and the progression of coronary-artery atherosclerosis in postmenopausal women","volume":"349","author":"Hodis","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2004.07.003_BIB13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0378-5122(98)00060-7","article-title":"Transdermal estrogen replacement therapy and plasma lipids in 693\u00a0French women","volume":"30","author":"Bongard","year":"1998","journal-title":"Maturitas"},{"key":"10.1016\/j.revmed.2004.07.003_BIB14","first-page":"1","article-title":"Impact cardiovasculaire du THS\u00a0: une mise au point apr\u00e8s HERS, WEST et WHI","volume":"158","author":"Galand-Portier","year":"2003","journal-title":"Gyn\u00e9col Obst\u00e9t pratique"},{"key":"10.1016\/j.revmed.2004.07.003_BIB15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0248-8663(02)00812-3","article-title":"L'hormonoth\u00e9rapie substitutive de la m\u00e9nopause apporte-t-elle un b\u00e9n\u00e9fice cardiovasculaire\u00a0?","volume":"24","author":"Scarabin","year":"2003","journal-title":"Rev M\u00e9d Int"},{"key":"10.1016\/j.revmed.2004.07.003_BIB16","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1001\/jama.291.14.1701","article-title":"Effects of conjugated equine oestrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial","volume":"291","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2004.07.003_BIB17","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1056\/NEJMoa010534","article-title":"A clinical trial of estrogen-replacement therapy after ischemic stroke","volume":"345","author":"Viscoli","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2004.07.003_BIB18","doi-asserted-by":"crossref","first-page":"680","DOI":"10.7326\/0003-4819-136-9-200205070-00011","article-title":"Postmenopausal estrogen replacement and risk for venous thromboembolism: a systemic review and meta-analysis for the U.S. preventive services task force","volume":"136","author":"Miller","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.revmed.2004.07.003_BIB19","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0140-6736(03)14066-4","article-title":"Differential association of oral and transdermal estrogen-replacement therapy with venous thromboembolism risk","volume":"362","author":"Scarabin","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.revmed.2004.07.003_BIB20","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1001\/jama.289.24.3243","article-title":"Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women-The Women's Health Initiative randomized trial","volume":"289","author":"Chlebowski","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2004.07.003_BIB21","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0140-6736(03)14065-2","article-title":"Breast cancer and hormone-replacement therapy in the million women study","volume":"362","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.revmed.2004.07.003_BIB22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.maturitas.2003.08.001","article-title":"The million women study and breast cancer","volume":"46","author":"Speroff","year":"2003","journal-title":"Maturitas"},{"key":"10.1016\/j.revmed.2004.07.003_BIB23","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1001\/jama.290.13.1739","article-title":"Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures: the Women's Health Initiative randomized trial","volume":"290","author":"Anderson","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2004.07.003_BIB24","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1001\/jama.291.14.1769","article-title":"The WHI estrogen-alone trial. Do things look any better?","volume":"291","author":"Hulley","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2004.07.003_BIB25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1056\/NEJMoa022464","article-title":"Bone loss and bone size after menopause","volume":"349","author":"Ahlborg","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2004.07.003_BIB26","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1001\/jama.290.13.1729","article-title":"Effects of estrogen plus progestin on risk of fracture and bone mineral density-The Women's Health Initiative randomized trial","volume":"290","author":"Cauley","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2004.07.003_BIB27","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1001\/jama.289.20.2651","article-title":"Estrogen Plus Progestin and the Incidence of Dementia and Mild Cognitive Impairment in Postmenopausal Women: The Women's Health Initiative Memory Study (WHIMS)","volume":"289","author":"Shumaker","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2004.07.003_BIB28","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1001\/jama.289.20.2663","article-title":"Effect of estrogen plus progestin on global cognitive function in postmenopausal women: the Women's Health Initiative Memory Study: a randomized controlled trial","volume":"289","author":"Rapp","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2004.07.003_BIB29","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1001\/jama.289.20.2673","article-title":"Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial","volume":"289","author":"Wassertheil-Smoller","year":"2003","journal-title":"JAMA"},{"issue":"19","key":"10.1016\/j.revmed.2004.07.003_BIB30","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1056\/NEJMoa030311","article-title":"Effects of estrogen plus progestin on health-related quality of life","volume":"348","author":"Hays","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2004.07.003_BIB31","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0015-0282(03)00993-2","article-title":"Hormone therapy: the Women's Health Initiative has caused confusion and concern","volume":"80","author":"Reid","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.revmed.2004.07.003_BIB32","first-page":"11","article-title":"Traitement hormonal substitutif de la m\u00e9nopause\u00a0: les suites de la WHI, HERS II, et autres m\u00e9ta-analyses\u00a0: le r\u00eave est-il bris\u00e9\u00a0?","volume":"9","author":"Bouchard","year":"2002","journal-title":"R\u00e9f Gyn\u00e9col Obstet"},{"key":"10.1016\/j.revmed.2004.07.003_BIB33","series-title":"Traitements hormonaux substitutifs de la m\u00e9nopause \u2014 rapport d'orientation","year":"2004"},{"key":"10.1016\/j.revmed.2004.07.003_BIB34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0015-0282(03)01148-8","article-title":"How does the WHI study alter the risk-benefit ratio of HT?","volume":"80","author":"Collins","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.revmed.2004.07.003_BIB35","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0015-0282(03)00994-4","article-title":"Women's Health Initiative results: a glass more empty than full","volume":"80","author":"Strickler","year":"2003","journal-title":"Fertil Steril"},{"key":"10.1016\/j.revmed.2004.07.003_BIB36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0378-5122(02)00214-1","article-title":"European Menopause & Andropause Society. Results from WHI and HERS II-implications for women and the prescriber of HRT","volume":"42","author":"Neves-e-Castro","year":"2002","journal-title":"Maturitas"},{"key":"10.1016\/j.revmed.2004.07.003_BIB37","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1067\/S0002-9378(03)00778-6","article-title":"Decision analysis of hormone replacement therapy after the Women's Health Initiative","volume":"189","author":"Kim","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.revmed.2004.07.003_BIB38","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.obstetgynecol.2003.08.007","article-title":"Effect of the Women's Health Initiative on women's decisions to discontinue postmenopausal hormone therapy","volume":"102","author":"Ettinger","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.revmed.2004.07.003_BIB39","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1067\/S0002-9378(03)01097-4","article-title":"Menopausal hormone therapy informed consent","volume":"189","author":"Hendrix","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.revmed.2004.07.003_BIB40","first-page":"8","article-title":"Alternatives au traitement hormonal substitutif","author":"Graesslin","year":"2002","journal-title":"Encycl M\u00e9d Chir"},{"key":"10.1016\/j.revmed.2004.07.003_BIB41","first-page":"634","article-title":"Menopause: new therapies","volume":"178","author":"Davis","year":"2003","journal-title":"Med J Aust"},{"key":"10.1016\/j.revmed.2004.07.003_BIB42","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0960-0760(01)00044-9","article-title":"Tibolone: a steroid with a tissue-specific mode of action","volume":"76","author":"Kloosterboer","year":"2001","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.revmed.2004.07.003_BIB43","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0378-5122(00)00184-5","article-title":"Tibolone: what does tissue specific activity mean?","volume":"37","author":"Palacios","year":"2001","journal-title":"Maturitas"},{"key":"10.1016\/j.revmed.2004.07.003_BIB44","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/cmt.4.2.120.136","article-title":"Tibolone and its effects on bone: a review","volume":"4","author":"Berning","year":"2001","journal-title":"Climacteric"},{"key":"10.1016\/j.revmed.2004.07.003_BIB45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S1471-7697(02)00017-5","article-title":"Why tibolone is different?","volume":"2","author":"Rymer","year":"2002","journal-title":"Rev Gynecol Pract"},{"key":"10.1016\/j.revmed.2004.07.003_BIB46","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/ijc.20016","article-title":"Increased risk of breast cancer following different regimens of hormone replacement therapy frequently used in Europe","volume":"109","author":"Stahlberg","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1016\/j.revmed.2004.07.003_BIB47","first-page":"1","article-title":"Livial: a review of clinical studies","volume":"106","author":"Moore","year":"1999","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.revmed.2004.07.003_BIB48","first-page":"1314","article-title":"Tibolone","volume":"31","author":"Jamin","year":"2002","journal-title":"Presse Med"},{"key":"10.1016\/j.revmed.2004.07.003_BIB49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1210\/jc.87.1.16","article-title":"Tibolone for postmenopausal women: systematic review of randomized trials","volume":"87","author":"Modelska","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.revmed.2004.07.003_BIB50","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0020-7292(02)00350-8","article-title":"Selective estrogen receptor modulators","volume":"79","year":"2002","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/j.revmed.2004.07.003_BIB51","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1056\/NEJMra022219","article-title":"Selective estrogen\u2013receptor modulators \u2014 mechanisms of action and application to clinical practice","volume":"348","author":"Riggs","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2004.07.003_BIB52","first-page":"4","article-title":"Les modulateurs s\u00e9lectifs des r\u00e9cepteurs aux estrog\u00e8nes. M\u00e9canisme d'action","volume":"13","author":"Maudelonde","year":"2000","journal-title":"Reprod. Hum. Horm."},{"key":"10.1016\/j.revmed.2004.07.003_BIB53","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1210\/er.2001-4002","article-title":"Meta-analyses of therapies for postmenopausal osteoporosis. IV. Meta-analysis of raloxifene for the prevention and treatment of postmenopausal osteoporosis","volume":"23","author":"Cranney","year":"2002","journal-title":"Endocr Rev"},{"key":"10.1016\/j.revmed.2004.07.003_BIB54","first-page":"16","article-title":"Effets osseux des SERM","volume":"13","author":"Delmas","year":"2000","journal-title":"Reprod. Hum. Horm."},{"key":"10.1016\/j.revmed.2004.07.003_BIB55","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0889-8529(02)00057-9","article-title":"Selective estrogen receptors modulators in the prevention and treatment of postmenopausal osteoporosis","volume":"32","author":"Fontana","year":"2003","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.revmed.2004.07.003_BIB56","first-page":"21","article-title":"Le raloxif\u00e8ne. Principales propri\u00e9t\u00e9s, effets sur les organes cibles (extraosseux), tol\u00e9rance clinique","volume":"13","author":"Rozenbaum","year":"2000","journal-title":"Reprod. Hum. Horm."},{"key":"10.1016\/j.revmed.2004.07.003_BIB57","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1210\/jc.87.8.3609","article-title":"Efficacy of raloxifene on vertebral fracture risk reduction in postmenopausal women with osteoporosis: four-year results from a randomized clinical trial","volume":"87","author":"Delmas","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.revmed.2004.07.003_BIB58","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0149-2918(03)80114-5","article-title":"Post hoc analysis of data from the Multiple Outcomes of Raloxifene Evaluation (MORE) trial on the effects of three years of raloxifene treatment on glycemic control and cardiovascular disease risk factors in women with and without type 2\u00a0diabetes","volume":"25","author":"Barrett-Connor","year":"2003","journal-title":"Clin Ther"},{"key":"10.1016\/j.revmed.2004.07.003_BIB59","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1001\/jama.287.7.847","article-title":"MORE Investigators (Multiple Outcomes of Raloxifene Evaluation). Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial","volume":"287","author":"Barrett-Connor","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2004.07.003_BIB60","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1051\/medsci\/200319101030","article-title":"Phytoestrog\u00e8nes chez la femme m\u00e9nopaus\u00e9e","volume":"19","author":"Dodin","year":"2003","journal-title":"M\u00e9decine & Sciences"},{"key":"10.1016\/j.revmed.2004.07.003_BIB61","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0378-5122(02)00345-6","article-title":"Soy isoflavones: hope or hype?","volume":"44","author":"Fitzpatrick","year":"2003","journal-title":"Maturitas"},{"key":"10.1016\/j.revmed.2004.07.003_BIB62","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0960-0760(02)00259-5","article-title":"Phytoestrogens for hormone replacement therapy?","volume":"83","author":"Wuttke","year":"2002","journal-title":"J Steroid Biochem Mol Biol"}],"container-title":["La Revue de M\u00e9decine Interne"],"original-title":[],"language":"fr","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0248866304002632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0248866304002632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T09:27:58Z","timestamp":1497605278000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0248866304002632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0248866304002632"],"URL":"https:\/\/doi.org\/10.1016\/j.revmed.2004.07.003","relation":{},"ISSN":["0248-8663"],"issn-type":[{"value":"0248-8663","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}