{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:33:35Z","timestamp":1774438415301,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["La Revue de M\u00e9decine Interne"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.revmed.2004.11.001","type":"journal-article","created":{"date-parts":[[2004,12,10]],"date-time":"2004-12-10T09:36:13Z","timestamp":1102671373000},"page":"95-102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["D\u00e9ficit immunitaire commun variable avec manifestations auto-immunes : \u00e9tude de neuf observations ; int\u00e9r\u00eat d\u2019un immunoph\u00e9notypage sp\u00e9cifique des lymphocytes B circulants chez sept patients"],"prefix":"10.1016","volume":"26","author":[{"given":"M.","family":"Pavic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"S\u00e8ve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Malcus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Sarrot-Reynault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Peyramond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Debourdeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Andriamanantena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bouhour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Philippe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Rousset","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Broussolle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.revmed.2004.11.001_bib1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1056\/NEJM199508173330707","article-title":"The primary immunodeficiencies","volume":"333","author":"Rosen","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.revmed.2004.11.001_bib2","doi-asserted-by":"crossref","first-page":"720","DOI":"10.7326\/0003-4819-118-9-199305010-00011","article-title":"NIH conference. New insights into common variable immunodeficiency","volume":"118","author":"Sneller","year":"1993","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.revmed.2004.11.001_bib3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1054\/blre.2001.0185","article-title":"Hematologic complications of primary immune deficiencies","volume":"16","author":"Cunningham-Rundles","year":"2002","journal-title":"Blood Rev."},{"key":"10.1016\/j.revmed.2004.11.001_bib4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/00000441-200101000-00007","article-title":"Common variable immunodeficiency","volume":"321","author":"Sneller","year":"2001","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.revmed.2004.11.001_bib5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/ni902","article-title":"Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency","volume":"4","author":"Grimbacher","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.revmed.2004.11.001_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.revmed.2004.11.001_bib7","first-page":"22","article-title":"Gastrointestinal manifestations of primary immunodeficiency disorders","volume":"8","author":"Lai Ping So","year":"1997","journal-title":"Semin. Gastrointest. Dis."},{"key":"10.1016\/j.revmed.2004.11.001_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11938-002-0003-4","article-title":"Gastrointestinal Manifestations of Non-AIDS Immunodeficiency","volume":"5","author":"McCabe","year":"2002","journal-title":"Curr. Treat. Options Gastroenterol"},{"key":"10.1016\/j.revmed.2004.11.001_bib9","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1097\/00000478-199610000-00010","article-title":"Gastrointestinal pathology in patients with common variable immunodeficiency and X-linked agammaglobulinemia","volume":"20","author":"Washington","year":"1996","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.revmed.2004.11.001_bib10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00005792-199609000-00002","article-title":"Sarcoidosis and common variable immunodeficiency. Report of 8 cases and review of the literature","volume":"75","author":"Fasano","year":"1996","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.revmed.2004.11.001_bib11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.7326\/0003-4819-127-8_Part_1-199710150-00005","article-title":"Granulomatous disease in common variable immunodeficiency","volume":"127","author":"Mechanic","year":"1997","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.revmed.2004.11.001_bib12","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/713688933","article-title":"The simultaneous presentation of sarcoidosis and common variable immune deficiency","volume":"32","author":"Ameratunga","year":"2000","journal-title":"Pathology"},{"key":"10.1016\/j.revmed.2004.11.001_bib13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0140-6736(85)91037-2","article-title":"Prospective study of cancer in patients with hypogammaglobulinaemia","volume":"1","author":"Kinlen","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.revmed.2004.11.001_bib14","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/BF00915550","article-title":"Incidence of cancer in 98 patients with common varied immunodeficiency","volume":"7","author":"Cunningham-Rundles","year":"1987","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.revmed.2004.11.001_bib15","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1046\/j.1365-2249.2002.02004.x","article-title":"Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined Danish and Swedish study","volume":"130","author":"Mellemkjaer","year":"2002","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.revmed.2004.11.001_bib16","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1182\/blood.V99.5.1544","article-title":"Severe deficiency of switched memory B cells (CD27(+)IgM(\u2013)IgD(\u2013)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease","volume":"99","author":"Warnatz","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.revmed.2004.11.001_bib17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1182\/blood.V91.1.173","article-title":"Generation of plasma cells from peripheral blood memory B cells: synergistic effect of interleukin-10 and CD27\/CD70 interaction","volume":"91","author":"Agematsu","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.revmed.2004.11.001_bib18","first-page":"323","article-title":"Common variable immunodeficiency, insulin-dependent diabetes mellitus and celiac disease","volume":"28","author":"Lopez Cruz","year":"2000","journal-title":"Allergol. Immunopathol. (Madr.)"},{"key":"10.1016\/j.revmed.2004.11.001_bib19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0091-6749(89)90324-2","article-title":"Type I diabetes in an adolescent with common variable immunodeficiency","volume":"84","author":"Moffitt","year":"1989","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.revmed.2004.11.001_bib20","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2337\/diacare.21.6.1029a","article-title":"Common variable immunodeficiency in adult woman with IDDM","volume":"21","author":"Iglesias","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1016\/j.revmed.2004.11.001_bib21","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2337\/diacare.20.4.677","article-title":"IDDM in an adolescent patient with common variable immunodeficiency","volume":"20","author":"Metin","year":"1997","journal-title":"Diabetes Care"},{"key":"10.1016\/j.revmed.2004.11.001_bib22","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0248-8663(03)00189-9","article-title":"Le d\u00e9ficit immunitaire commun variable de l'adulte\u00a0: \u00e9tude clinique, biologique et immunologique chez 17 patients","volume":"24","author":"Bloch-Michel","year":"2003","journal-title":"Rev. Med. Interne"},{"key":"10.1016\/j.revmed.2004.11.001_bib23","doi-asserted-by":"crossref","first-page":"10653","DOI":"10.1073\/pnas.89.22.10653","article-title":"Shared HLA class II-associated genetic susceptibility and resistance, related to the HLA-DQB1 gene, in IgA deficiency and common variable immunodeficiency","volume":"89","author":"Olerup","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.revmed.2004.11.001_bib24","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00004836-199709000-00004","article-title":"Celiac sprue and immunodeficiency states: a 25-year review","volume":"25","author":"Heneghan","year":"1997","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/j.revmed.2004.11.001_bib25","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/S0248-8663(97)83753-8","article-title":"D\u00e9ficit immunitaire commun variable et atrophie villositaire totale r\u00e9gressive apr\u00e8s r\u00e9gime sans gluten","volume":"18","author":"Bili","year":"1997","journal-title":"Rev. Med. Interne"},{"key":"10.1016\/j.revmed.2004.11.001_bib26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/096120339600500314","article-title":"Common variable immunodeficiency in a patient with systemic lupus erythematosus","volume":"5","author":"Swaak","year":"1996","journal-title":"Lupus"},{"key":"10.1016\/j.revmed.2004.11.001_bib27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0091-6749(82)90010-0","article-title":"Panhypogammaglobulinemia in systemic lupus erythematosus: in vitro demonstration of multiple cellular defects","volume":"70","author":"Ashman","year":"1982","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.revmed.2004.11.001_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.7326\/0003-4819-99-1-32","article-title":"Transition from systemic lupus erythematosus to common variable hypogammaglobulinemia","volume":"99","author":"Sussman","year":"1983","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.revmed.2004.11.001_bib29","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/0091-6749(84)90458-5","article-title":"Immunodeficiency with hyper IgM after systemic lupus erythematosus","volume":"73","author":"Slepian","year":"1984","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.revmed.2004.11.001_bib30","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1002\/art.1780280418","article-title":"Concurrent systemic lupus erythematosus and common variable hypogammaglobulinemia","volume":"28","author":"Stein","year":"1985","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.revmed.2004.11.001_bib31","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/0002-9343(86)90413-4","article-title":"Development of hypogammaglobulinemia in a patient with systemic lupus erythematosus","volume":"81","author":"Tsokos","year":"1986","journal-title":"Am. J. Med."},{"key":"10.1016\/j.revmed.2004.11.001_bib32","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0002-9343(89)80831-9","article-title":"Conversion of systemic lupus erythematosus to common variable hypogammaglobulinemia","volume":"87","author":"Baum","year":"1989","journal-title":"Am. J. Med."},{"key":"10.1016\/j.revmed.2004.11.001_bib33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/art.1780280117","article-title":"Systemic lupus erythematosus and common variable panhypogammaglobulinemia: a patient with absence of circulating B cells","volume":"28","author":"Goldstein","year":"1985","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.revmed.2004.11.001_bib34","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0090-1229(90)90145-G","article-title":"Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2","volume":"56","author":"Bryant","year":"1990","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.revmed.2004.11.001_bib35","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1002\/1521-4141(200009)30:9<2516::AID-IMMU2516>3.0.CO;2-Z","article-title":"Study of the B cell memory compartment in common variable immunodeficiency","volume":"30","author":"Brouet","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.revmed.2004.11.001_bib36","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/intimm\/13.7.871","article-title":"B cell co-receptors regulating T cell-dependent antibody production in common variable immunodeficiency: CD27 pathway defects identify subsets of severely immuno-compromised patients","volume":"13","author":"Jacquot","year":"2001","journal-title":"Int. Immunol."},{"key":"10.1016\/j.revmed.2004.11.001_bib37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0952-7915(00)00204-1","article-title":"B1 Cells: similarities and differences with other B cell subsets","volume":"13","author":"Martin","year":"2001","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.revmed.2004.11.001_bib38","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/371389a0","article-title":"Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire","volume":"371","author":"Cyster","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.revmed.2004.11.001_bib39","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1078\/0171-2985-00198","article-title":"Expansion of CD19(hi)CD21(lo\/neg) B cells in common variable immunodeficiency (CVID) patients with auto-immune cytopenia","volume":"206","author":"Warnatz","year":"2002","journal-title":"Immunobiology"},{"key":"10.1016\/j.revmed.2004.11.001_bib40","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1023\/A:1025373601374","article-title":"Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects","volume":"23","author":"Piqueras","year":"2003","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.revmed.2004.11.001_bib41","first-page":"31","article-title":"Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications","volume":"86","author":"Hermaszewski","year":"1993","journal-title":"Q. J. Med."},{"key":"10.1016\/j.revmed.2004.11.001_bib42","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/00043426-199123000-00014","article-title":"Danazol therapy for chronic immune-mediated thrombocytopenic purpura in a patient with common variable immunodeficiency","volume":"13","author":"Saulsbury","year":"1991","journal-title":"Am. J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.revmed.2004.11.001_bib43","first-page":"36","article-title":"Management of chronic immune thrombocytopenic purpura in children and adults","volume":"35","author":"Blanchette","year":"1998","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.revmed.2004.11.001_bib44","doi-asserted-by":"crossref","first-page":"112","DOI":"10.7326\/0003-4819-140-3-200402030-00012","article-title":"Management of adult patients with persistent idiopathic thrombocytopenic purpura following splenectomy: a systematic review","volume":"140","author":"Vesely","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.revmed.2004.11.001_bib45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0002-9343(87)90398-6","article-title":"Successful treatment of auto-immune hemolytic anemia in common variable immunodeficiency with high-dose intravenous gamma globulin","volume":"82","author":"Leickly","year":"1987","journal-title":"Am. J. Med."}],"container-title":["La Revue de M\u00e9decine Interne"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866304004163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866304004163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:08:11Z","timestamp":1759334891000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0248866304004163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0248866304004163"],"URL":"https:\/\/doi.org\/10.1016\/j.revmed.2004.11.001","relation":{},"ISSN":["0248-8663"],"issn-type":[{"value":"0248-8663","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"D\u00e9ficit immunitaire commun variable avec manifestations auto-immunes : \u00e9tude de neuf observations ; int\u00e9r\u00eat d\u2019un immunoph\u00e9notypage sp\u00e9cifique des lymphocytes B circulants chez sept patients","name":"articletitle","label":"Article Title"},{"value":"La Revue de M\u00e9decine Interne","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.revmed.2004.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}