{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:29:27Z","timestamp":1761596967423,"version":"build-2065373602"},"reference-count":98,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["La Revue de M\u00e9decine Interne"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.revmed.2006.02.014","type":"journal-article","created":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T17:13:22Z","timestamp":1149700402000},"page":"843-853","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Physiopathologie de\u00a0la\u00a0maladie de\u00a0Beh\u00e7et"],"prefix":"10.1016","volume":"27","author":[{"given":"Z.","family":"Amoura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Guillaume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Caillat-Zucman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Wechsler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-C.","family":"Piette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.revmed.2006.02.014_bib1","first-page":"1152","article-title":"Uber rezidivierende Aphthose, durch ein Virus verursachte Geschwure am Mund, am Auge und an den Genitalien","volume":"105","author":"Beh\u00e7et","year":"1937","journal-title":"Dermatol. Wochenschr."},{"key":"10.1016\/j.revmed.2006.02.014_bib2","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1001\/archopht.1982.01030040433013","article-title":"Close association of HLA-Bw51 with Behcet's disease","volume":"100","author":"Ohno","year":"1982","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.revmed.2006.02.014_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1034\/j.1399-0039.1999.540301.x","article-title":"Behcet's disease, the Silk Road and HLA-B51: historical and geographical perspectives","volume":"54","author":"Verity","year":"1999","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.revmed.2006.02.014_bib4","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1056\/NEJM199910213411707","article-title":"Beh\u00e7et's disease","volume":"341","author":"Sakane","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.revmed.2006.02.014_bib5","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/art.1780380321","article-title":"Excessive function of peripheral blood neutrophils from patients with Beh\u00e7et's disease and from HLA-B51 transgenic mice","volume":"38","author":"Takeno","year":"1995","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.revmed.2006.02.014_bib6","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/art.10815","article-title":"Mapping the HLA association in Beh\u00e7et's disease: a role for tumor necrosis factor polymorphisms?","volume":"48","author":"Ahmad","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.revmed.2006.02.014_bib7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1034\/j.1399-0039.2003.610110.x","article-title":"HLA-B phenotype modifies the course of Behcet's disease in Moroccan patients","volume":"61","author":"Choukri","year":"2003","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.revmed.2006.02.014_bib8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/sj.gene.6363863","article-title":"A weak association of HLA-B*2702 with Behcet's disease","volume":"3","author":"Gul","year":"2002","journal-title":"Genes Immun."},{"key":"10.1016\/j.revmed.2006.02.014_bib9","doi-asserted-by":"crossref","first-page":"6259","DOI":"10.1073\/pnas.91.14.6259","article-title":"A second lineage of mammalian major histocompatibility complex class I genes","volume":"91","author":"Bahram","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.revmed.2006.02.014_bib10","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.285.5428.727","article-title":"Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA","volume":"285","author":"Bauer","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.revmed.2006.02.014_bib11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/85321","article-title":"Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells","volume":"2","author":"Groh","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib12","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1073\/pnas.94.4.1298","article-title":"Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behcet disease","volume":"94","author":"Mizuki","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.revmed.2006.02.014_bib13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1399-0039.2005.00465.x","article-title":"Associations of major histocompatibility complex class I chain-related molecule polymorphisms with Behcet's disease in Caucasian patients","volume":"66","author":"Hughes","year":"2005","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.revmed.2006.02.014_bib14","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1002\/art.20597","article-title":"Autoreactive CD8+ cytotoxic T lymphocytes to major histocompatibility complex class I chain-related gene A in patients with Behcet's disease","volume":"50","author":"Yasuoka","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.revmed.2006.02.014_bib15","first-page":"128","article-title":"Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Beh\u00e7et\u2019s disease: soluble TNF-75 as a biological marker of disease activity","volume":"24","author":"Turan","year":"1997","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2174\/1568010053622894","article-title":"Behcet's disease as an autoinflammatory disorder","volume":"4","author":"Gul","year":"2005","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"key":"10.1016\/j.revmed.2006.02.014_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/1098-1004(200009)16:3<271::AID-HUMU16>3.0.CO;2-A","article-title":"MEFV mutations in Behcet's disease","volume":"16","author":"Touitou","year":"2000","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.revmed.2006.02.014_bib18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/03009740510017931","article-title":"MEFV gene is a probable susceptibility gene for Behcet's disease","volume":"34","author":"Imirzalioglu","year":"2005","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib19","first-page":"S35","article-title":"MEFV mutations are increased in Behcet's disease (BD) and are associated with vascular involvement","volume":"21","author":"Atagunduz","year":"2003","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib20","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/art.20873","article-title":"Association of the R92Q TNFRSF1A mutation and extracranial deep vein thrombosis in patients with Behcet's disease","volume":"52","author":"Amoura","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.revmed.2006.02.014_bib21","first-page":"1428","article-title":"Production of TNF-alpha and IL-1 in active Behcet's disease","volume":"17","author":"Hamzaoui","year":"1990","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib22","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/rheumatology\/keg232R","article-title":"Association of specific interleukin 1 gene cluster polymorphisms with increased susceptibility for Behcet's disease","volume":"42","author":"Karasneh","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.revmed.2006.02.014_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.0906-6705.2005.00253.x","article-title":"Specific interleukin-1 gene polymorphisms in Turkish patients with Behcet's disease","volume":"14","author":"Coskun","year":"2005","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1046\/j.1365-2370.2000.00202.x","article-title":"Intercellular adhesion molecule-1 gene polymorphisms in Behcet's disease","volume":"27","author":"Verity","year":"2000","journal-title":"Eur. J. Immunogenet."},{"key":"10.1016\/j.revmed.2006.02.014_bib25","first-page":"1283","article-title":"Intercellular adhesion molecule-1 gene polymorphisms in Behcet's Disease","volume":"28","author":"Boiardi","year":"2001","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3346\/jkms.2003.18.3.415","article-title":"Intercellular adhesion molecule-1 polymorphisms in Korean patients with Behcet s disease","volume":"18","author":"Kim","year":"2003","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.revmed.2006.02.014_bib27","first-page":"179","article-title":"Soluble intercellular adhesion molecule-1 (ICAM-1), CD4, CD8 and interleukin-2 receptor in patients with Behcet's disease and Vogt-Koyanagi-Harada's disease","volume":"17","author":"Uchio","year":"1999","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib28","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/art.21060","article-title":"Whole-genome screening for susceptibility genes in multicase families with Behcet's disease","volume":"52","author":"Karasneh","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.revmed.2006.02.014_bib29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF02505221","article-title":"Polymerase chain reaction reveals herpes simplex virus DNA in saliva of patients with Behcet's disease","volume":"288","author":"Lee","year":"1996","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.revmed.2006.02.014_bib30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1080\/00015550310007472","article-title":"Detection of herpes virus genomes in skin lesions from patients with Behcet's disease and other related inflammatory diseases","volume":"83","author":"Tojo","year":"2003","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.revmed.2006.02.014_bib31","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1600-0714.1996.tb01374.x","article-title":"Human cytomegalovirus as a potential etiologic agent in recurrent aphthous ulcers and Behcet's disease","volume":"25","author":"Sun","year":"1996","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.revmed.2006.02.014_bib32","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1600-0714.1998.tb01935.x","article-title":"Preliminary evidence for an association of Epstein-Barr virus with pre-ulcerative oral lesions in patients with recurrent aphthous ulcers or Behcet's disease","volume":"27","author":"Sun","year":"1998","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.revmed.2006.02.014_bib33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1022537209948","article-title":"The seroprevalence of varicella zoster antibodies in Behcet's and other skin diseases","volume":"18","author":"Akdeniz","year":"2003","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.revmed.2006.02.014_bib34","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1086\/319681","article-title":"Expression of Th2 cytokines decreases the development of and improves Behcet's disease-like symptoms induced by herpes simplex virus in mice","volume":"183","author":"Sohn","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.revmed.2006.02.014_bib35","first-page":"1029","article-title":"Induction of Behcet's disease symptoms after dental treatment and streptococcal antigen skin test","volume":"15","author":"Mizushima","year":"1988","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib36","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1002\/art.1780391216","article-title":"The effect of prophylactic penicillin treatment on the course of arthritis episodes in patients with Beh\u00e7et's disease: a randomized clinical trial","volume":"39","author":"Calguneri","year":"1996","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.revmed.2006.02.014_bib37","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/0008-8749(92)90207-6","article-title":"Streptococcal-related antigens stimulate production of IL6 and interferon-gamma by T cells from patients with Behcet's disease","volume":"140","author":"Hirohata","year":"1992","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib38","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1002\/eji.1830240712","article-title":"Fine antigen specificity of human \u03b3\u03b4 T cell lines (V gamma 9+) established by repetitive stimulation with a serotype (KTH-1) of a Gram-positive bacterium, Streptococcus\u00a0sanguis","volume":"2","author":"Mochizuki","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib39","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1067\/mjd.2001.117728","article-title":"HSP 60 expression in mucocutaneous lesions of Behcet's disease","volume":"45","author":"Ergun","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib40","first-page":"708","article-title":"T cell responses to 60\/65\u00a0kDa heat shock protein derived peptides in Turkish patients with Beh\u00e7et's disease","volume":"27","author":"Direskeneli","year":"2000","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib41","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0165-2478(01)00280-2","article-title":"Human HSP 60 peptide responsive T cell lines are similarly present in both Behcet's disease patients and healthy controls","volume":"79","author":"Saruhan-Direskeneli","year":"2001","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.revmed.2006.02.014_bib42","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1128\/iai.59.4.1434-1441.1991","article-title":"Association between the 65-kilodalton-heat shock protein, Streptococcus\u00a0sanguis, and the corresponding antibodies in Behcet's syndrome","volume":"59","author":"Lehner","year":"1991","journal-title":"Infect. Immun."},{"key":"10.1016\/j.revmed.2006.02.014_bib43","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1006\/exer.1998.0574","article-title":"HSP-derived peptides inducing uveitis and IgG and IgA antibodies","volume":"67","author":"Uchio","year":"1998","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.revmed.2006.02.014_bib44","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1002\/(SICI)1521-4141(199808)28:08<2444::AID-IMMU2444>3.0.CO;2-N","article-title":"Experimental mucosal induction of uveitis with the 60-kDa heat shock protein-derived peptide 336-351","volume":"28","author":"Hu","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib45","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-2249.2004.02520.x","article-title":"Oral tolerization with peptide 336-351 linked to cholera toxin B subunit in preventing relapses of uveitis in Behcet's disease","volume":"137","author":"Stanford","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib46","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000267916","article-title":"Common antigenicity between Yersinia\u00a0enterocolitica-derived heat shock protein and the retina, and its role in uveitis","volume":"28","author":"Tanaka","year":"1996","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.revmed.2006.02.014_bib47","first-page":"S44","article-title":"The role of heat shock proteins in Behcet's disease","volume":"21","author":"Direskeneli","year":"2003","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib48","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2249.2005.02695.x","article-title":"Involvement of Th1 cells and heat-shock protein 60 in the pathogenesis of intestinal Behcet's disease","volume":"139","author":"Imamura","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib49","doi-asserted-by":"crossref","first-page":"12445","DOI":"10.1073\/pnas.93.22.12445","article-title":"Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium","volume":"93","author":"Groh","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.revmed.2006.02.014_bib50","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s004150070049","article-title":"Anti-\u03b1\u03b2-crystallin immunoreactivity in inflammatory nervous system diseases","volume":"247","author":"Celet","year":"2000","journal-title":"J. Neurol."},{"key":"10.1016\/j.revmed.2006.02.014_bib51","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1001\/archopht.1994.01090160124032","article-title":"The role of nitric oxide in uveitis","volume":"112","author":"Parks","year":"1994","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.revmed.2006.02.014_bib52","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1067\/mjd.2002.118338","article-title":"Increased nitric oxide production in patients with Beh\u00e7et's disease: is it a new activity marker?","volume":"46","author":"Evereklioglu","year":"2002","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib53","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/09629350310001599710","article-title":"The pathophysiological significance of red blood cell nitric oxide concentrations in inflammatory Beh\u00e7et's disease","volume":"12","author":"Evereklioglu","year":"2003","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.revmed.2006.02.014_bib54","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s10067-004-1015-3","article-title":"Synovial nitric oxide concentrations are increased and correlated with serum levels in patients with active Behcet's disease: a pilot study","volume":"24","author":"Duygulu","year":"2005","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib55","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00006982-200206000-00012","article-title":"Aqueous humor nitric oxide levels in patients with Beh\u00e7et disease","volume":"22","author":"Yilmaz","year":"2002","journal-title":"Retina"},{"key":"10.1016\/j.revmed.2006.02.014_bib56","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/rheumatology\/keh561","article-title":"Polymorphisms in the endothelial nitric oxide synthase gene are associated with Beh\u00e7et's disease","volume":"44","author":"Karasneh","year":"2005","journal-title":"Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib57","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1136\/ard.62.11.1083","article-title":"Endothelial nitric oxide synthase gene polymorphisms in Beh\u00e7et's disease and rheumatic diseases with vasculitis","volume":"62","author":"Kim","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.revmed.2006.02.014_bib58","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0008-6363(98)00228-4","article-title":"Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells","volume":"41","author":"Bouloumi\u00e9","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.revmed.2006.02.014_bib59","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1172\/JCI19284","article-title":"Antithrombotic activity of TNF-\u03b1","volume":"112","author":"Cambien","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.revmed.2006.02.014_bib60","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/bjo.86.6.653","article-title":"Serum homocysteine level is increased and correlated with endothelin-1 and nitric oxide in Behcet's disease","volume":"86","author":"Er","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.revmed.2006.02.014_bib61","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000018061","article-title":"Decreased notric oxide production in patients with Beh\u00e7et\u2019s disease","volume":"198","author":"Orem","year":"1999","journal-title":"Dermatology"},{"key":"10.1016\/j.revmed.2006.02.014_bib62","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1365-2230.2004.01488.x","article-title":"Erythrocyte superoxide dismutase, catalase activities and plasma nitrite and nitrate levels in patients with Beh\u00e7et disease and recurrent aphthous stomatitis","volume":"29","author":"G\u00fcnd\u00fcz","year":"2004","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib63","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0735-1097(00)01137-2","article-title":"Vascular endothelial function and oxidative stress mechanisms in patients with Beh\u00e7et\u2019s syndrome","volume":"37","author":"Chambers","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.revmed.2006.02.014_bib64","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/0962935031000097754","article-title":"Adenosine deaminase enzyme activity is increased and negatively correlates with catalase, superoxide dismutase and glutathione peroxidase in patients with Behcet's disease: original contributions\/clinical and laboratory investigations","volume":"12","author":"Erkilic","year":"2003","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.revmed.2006.02.014_bib65","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/rheumatology\/35.5.424","article-title":"Monocyte activity in Beh\u00e7et's disease","volume":"35","author":"Sahin","year":"1996","journal-title":"Br. J. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib66","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/ard.55.2.128","article-title":"Neutrophil adhesion to endothelial cells and factors affecting adhesion in patients with Beh\u00e7et's disease","volume":"55","author":"Sahin","year":"1996","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.revmed.2006.02.014_bib67","first-page":"S19","article-title":"Neutrophil activation in Behcet's disease","volume":"19","author":"Eksioglu-Demiralp","year":"2001","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib68","doi-asserted-by":"crossref","first-page":"7678","DOI":"10.4049\/jimmunol.175.11.7678","article-title":"T cell-regulated neutrophilic inflammation in autoinflammatory diseases","volume":"175","author":"Keller","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib69","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.femsim.2004.07.007","article-title":"Neutrophil and lymphocyte responses to oral Streptococcus in Adamantiades-Behcet's disease","volume":"43","author":"Kurauchi","year":"2005","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.revmed.2006.02.014_bib70","first-page":"S17","article-title":"The effects of nitric oxide donors and inhibitors on neutrophil functions in Behcet's disease","volume":"20","author":"Atalay","year":"2002","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib71","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1016\/j.jaad.2003.12.023","article-title":"Treatment of Behcet's disease with granulocyte and monocyte adsorption apheresis","volume":"51","author":"Kanekura","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib72","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2249.2005.02695.x","article-title":"Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease","volume":"139","author":"Imamura","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib73","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2249.2004.02688.x","article-title":"Excessive expression of Txk, a member of the Tec family of tyrosine kinases, contributes to excessive Th1 cytokine production by T lymphocytes in patients with Behcet's disease","volume":"139","author":"Nagafuchi","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib74","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1002\/art.21145","article-title":"NF-kappaB protects Behcet's disease T cells against CD95-induced apoptosis up-regulating antiapoptotic proteins","volume":"52","author":"Todaro","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.revmed.2006.02.014_bib75","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jaut.2004.07.005","article-title":"Abnormal expression of chemokine receptors in Behcet's disease: relationship to intracellular Th1\/Th2 cytokines and to clinical manifestations","volume":"23","author":"Houman","year":"2004","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.revmed.2006.02.014_bib76","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1002\/art.20334","article-title":"Involvement of chemokines and Th1 cytokines in the pathogenesis of mucocutaneous lesions of Behcet's disease","volume":"50","author":"Ben Ahmed","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.revmed.2006.02.014_bib77","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1136\/bjo.83.12.1386","article-title":"CD56+ T cells in the peripheral blood of uveitis patients","volume":"83","author":"Yato","year":"1999","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.revmed.2006.02.014_bib78","first-page":"S59","article-title":"T and NK cell subset changes with microbial extracts and human HSP60-derived peptides in Behcet's disease","volume":"22","author":"Kibaroglu","year":"2004","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib79","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2249.2004.02536.x","article-title":"The number of CD8+ T cells and NKT cells increases in the aqueous humor of patients with Behcet's uveitis","volume":"137","author":"Yu","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib80","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.4049\/jimmunol.175.9.6133","article-title":"CD8brightCD56+ T cells are cytotoxic effectors in patients with active Behcet's uveitis","volume":"175","author":"Ahn","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib81","first-page":"S45","article-title":"The level of soluble Granzyme A is elevated in the plasma and in the Vgamma9\/Vdelta2 T cell culture supernatants of patients with active Behcet's disease","volume":"22","author":"Accardo-Palumbo","year":"2004","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib82","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.4049\/jimmunol.173.3.2151","article-title":"Characterization of human T cells that regulate neutrophilic skin inflammation","volume":"173","author":"Schaerli","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib83","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1002\/art.20597","article-title":"Autoreactive CD8+ cytotoxic T lymphocytes to major histocompatibility complex class I chain-related gene A in patients with Behcet's disease","volume":"50","author":"Yasuoka","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"347","key":"10.1016\/j.revmed.2006.02.014_bib84","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0140-6736(96)90868-5","article-title":"Role of gamma delta T cells in pathogenesis and diagnosis of Behcet's disease","volume":"23","author":"Hasan","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.revmed.2006.02.014_bib85","doi-asserted-by":"crossref","first-page":"R262","DOI":"10.1186\/ar785","article-title":"Vgamma9\/Vdelta2 T lymphocytes in Italian patients with Behcet's disease: evidence for expansion, and tumor necrosis factor receptor II and interleukin-12 receptor beta1 expression in active disease","volume":"5","author":"Triolo","year":"2003","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.revmed.2006.02.014_bib86","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1076\/ocii.6.3.139.4035","article-title":"Proliferative response of CD8+ gamma delta+ T cells to Streptococcus\u00a0sanguis in patients with Behcet's disease","volume":"6","author":"Nishida","year":"1998","journal-title":"Ocul. Immunol. Inflamm."},{"key":"10.1016\/j.revmed.2006.02.014_bib87","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1067\/mlc.2003.1","article-title":"Expansion of gammadelta T-cells in Behcet's disease: role of disease activity and microbial flora in oral ulcers","volume":"141","author":"Bank","year":"2003","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.revmed.2006.02.014_bib88","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0165-5728(02)00208-4","article-title":"Vgamma9Vdelta2 T cells recovered from eyes of patients with Behcet's disease recognize non-peptide prenyl pyrophosphate antigens","volume":"130","author":"Verjans","year":"2002","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib89","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1046\/j.1365-2249.2000.01176.x","article-title":"Anti-MHC autoimmunity in Behcet's disease: T cell responses to an HLA-B-derived peptide cross-reactive with retinal-S antigen in patients with uveitis","volume":"120","author":"Kurhan-Yavuz","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib90","first-page":"3480","article-title":"Prospective determination of T-cell responses to S-antigen in Beh\u00e7et's disease patients and controls","volume":"41","author":"de Smet","year":"2000","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.revmed.2006.02.014_bib91","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0002-9394(14)71070-0","article-title":"Treatment of uveitis by oral administration of retinal antigens: results of a phase I\/II randomized masked trial","volume":"123","author":"Nussenblatt","year":"1997","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.revmed.2006.02.014_bib92","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1749-6632.1996.tb21140.x","article-title":"Intraocular inflammatory disease (uveitis) and the use of oral tolerance: a status report","volume":"778","author":"Nussenblatt","year":"1996","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.revmed.2006.02.014_bib93","first-page":"826","article-title":"Phenotypic characteristics of B cells in Behcet's disease: increased activity in B cell subsets","volume":"26","author":"Eksioglu-Demiralp","year":"1999","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib94","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1002\/1529-0131(200107)44:7<1707::AID-ART295>3.0.CO;2-P","article-title":"Oligoclonal B lymphocyte expansion in the synovium of a patient with Behcet's disease","volume":"44","author":"Suh","year":"2001","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.revmed.2006.02.014_bib95","first-page":"S27","article-title":"Anti-endothelial cell antibodies in Behcet's disease","volume":"21","author":"Dinc","year":"2003","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.revmed.2006.02.014_bib96","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1002\/art.11074","article-title":"Human alpha-enolase from endothelial cells as a target antigen of anti-endothelial cell antibody in Behcet's disease","volume":"48","author":"Lee","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.revmed.2006.02.014_bib97","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/1521-4141(200202)32:2<356::AID-IMMU356>3.0.CO;2-9","article-title":"Identification of alpha-tropomyosin as a target self-antigen in Behcet's syndrome","volume":"32","author":"Mor","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.revmed.2006.02.014_bib98","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1365-2249.2005.02760.x","article-title":"Alpha tropomyosin as a self-antigen in patients with Behcet's disease","volume":"140","author":"Mahesh","year":"2005","journal-title":"Clin. Exp. Immunol."}],"container-title":["La Revue de M\u00e9decine Interne"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866306002268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866306002268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:20:02Z","timestamp":1759335602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0248866306002268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":98,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0248866306002268"],"URL":"https:\/\/doi.org\/10.1016\/j.revmed.2006.02.014","relation":{},"ISSN":["0248-8663"],"issn-type":[{"type":"print","value":"0248-8663"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physiopathologie de\u00a0la\u00a0maladie de\u00a0Beh\u00e7et","name":"articletitle","label":"Article Title"},{"value":"La Revue de M\u00e9decine Interne","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.revmed.2006.02.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}