{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:29:28Z","timestamp":1791250168403,"version":"4.1.0"},"reference-count":87,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["La Revue de M\u00e9decine Interne"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.revmed.2015.04.015","type":"journal-article","created":{"date-parts":[[2015,7,5]],"date-time":"2015-07-05T11:34:29Z","timestamp":1436096069000},"page":"658-667","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Histiocytose langerhansienne de l\u2019adulte"],"prefix":"10.1016","volume":"36","author":[{"given":"A.","family":"N\u00e9el","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Artifoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Donadieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lorillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hamidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.revmed.2015.04.015_bib0440","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2141.2002.03232.x","article-title":"The Langerhans cell histiocytosis X files revealed","volume":"116","author":"Coppes-Zantinga","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0445","first-page":"84","article-title":"Histiocytosis X: integration of eosinophilic granuloma of bone, Letterer-Siwe disease, and Schuller-Christian disease as related manifestations of a single nosologic entity","volume":"56","author":"Lichtenstein","year":"1953","journal-title":"AMA Arch Pathol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0450","first-page":"365","article-title":"Histiocytosis X: histogenetic arguments for a Langerhans cell origin","volume":"18","author":"Nezelof","year":"1973","journal-title":"Biomedicine"},{"key":"10.1016\/j.revmed.2015.04.015_bib0455","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1182\/blood-2010-04-279083","article-title":"Recurrent BRAF mutations in Langerhans cell histiocytosis","volume":"116","author":"Badalian-Very","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.revmed.2015.04.015_bib0460","first-page":"1009","article-title":"Langerhans\u2019 cell histiocytosis: is there a role for genetics?","volume":"86","author":"Aric\u00f2","year":"2001","journal-title":"Haematologica"},{"key":"10.1016\/j.revmed.2015.04.015_bib0465","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/pbc.21498","article-title":"Descriptive epidemiology of childhood Langerhans cell histiocytosis in France, 2000\u20132004","volume":"51","author":"Guyot-Goubin","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.revmed.2015.04.015_bib0470","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1002\/(SICI)1097-0142(19990515)85:10<2278::AID-CNCR25>3.0.CO;2-U","article-title":"Langerhans cell histiocytosis: diagnosis, natural history, management, and outcome","volume":"85","author":"Howarth","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.revmed.2015.04.015_bib0475","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1016\/S0959-8049(03)00672-5","article-title":"Langerhans cell histiocytosis in adults. Report from the International Registry of the Histiocyte Society","volume":"39","author":"Aric\u00f2","year":"2003","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.revmed.2015.04.015_bib0480","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.revmed.2014.04.007","article-title":"Erdheim-Chester disease","volume":"35","author":"Haroche","year":"2014","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.revmed.2015.04.015_bib0485","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nri2455","article-title":"Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells","volume":"8","author":"Merad","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0490","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.4049\/jimmunol.0902336","article-title":"Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells","volume":"184","author":"Allen","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0495","doi-asserted-by":"crossref","first-page":"5199","DOI":"10.1182\/blood-2012-02-410241","article-title":"Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells","volume":"120","author":"Hutter","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.revmed.2015.04.015_bib0500","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1056\/NEJM199407213310303","article-title":"Langerhans\u2019 cell histiocytosis [histiocytosis X] \u2013 a clonal proliferative disease","volume":"331","author":"Willman","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2015.04.015_bib0505","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0140-6736(94)91842-2","article-title":"Clonal proliferation of Langerhans cells in Langerhans cell histiocytosis","volume":"343","author":"Yu","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.revmed.2015.04.015_bib0510","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/gcc.20634","article-title":"No genomic aberrations in Langerhans cell histiocytosis as assessed by diverse molecular technologies","volume":"48","author":"Da Costa","year":"2009","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.revmed.2015.04.015_bib0515","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1084\/jem.20030137","article-title":"Aberrant chemokine receptor expression and chemokine production by Langerhans cells underlies the pathogenesis of Langerhans cell histiocytosis","volume":"197","author":"Annels","year":"2003","journal-title":"J Exp Med"},{"key":"10.1016\/j.revmed.2015.04.015_bib0520","doi-asserted-by":"crossref","first-page":"e253","DOI":"10.1371\/journal.pmed.0040253","article-title":"Expansion of regulatory T cells in patients with Langerhans cell histiocytosis","volume":"4","author":"Senechal","year":"2007","journal-title":"PLoS Med"},{"key":"10.1016\/j.revmed.2015.04.015_bib0525","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nm1694","article-title":"Langerhans cell histiocytosis reveals a new IL-17A-dependent pathway of dendritic cell fusion","volume":"14","author":"Coury","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.revmed.2015.04.015_bib0530","doi-asserted-by":"crossref","first-page":"e3262","DOI":"10.1371\/journal.pone.0003262","article-title":"Herpes-virus infection in patients with Langerhans cell histiocytosis: a case-controlled sero-epidemiological study, and in situ analysis","volume":"3","author":"Jeziorski","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.revmed.2015.04.015_bib0535","doi-asserted-by":"crossref","first-page":"e33891","DOI":"10.1371\/journal.pone.0033891","article-title":"BRAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease","volume":"7","author":"Satoh","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.revmed.2015.04.015_bib0540","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1182\/blood-2012-06-429597","article-title":"BRAF V600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis","volume":"120","author":"Sahm","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.revmed.2015.04.015_bib0545","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nature03890","article-title":"BRAFE600-associated senescence-like cell cycle arrest of human naevi","volume":"436","author":"Michaloglou","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.revmed.2015.04.015_bib0550","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/jnci\/djp309","article-title":"Polyclonality of BRAF mutations in acquired melanocytic nevi","volume":"101","author":"Lin","year":"2009","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.revmed.2015.04.015_bib0555","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-pathol-020712-163959","article-title":"Pathogenesis of Langerhans cell histiocytosis","volume":"8","author":"Badalian-Very","year":"2013","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0560","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1182\/blood-2013-06-511139","article-title":"Somatic activating ARAF mutations in Langerhans cell histiocytosis","volume":"123","author":"Nelson","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.revmed.2015.04.015_bib0565","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1182\/blood-2014-05-577361","article-title":"High prevalence of somatic MAP2K1 mutations in BRAF V600E negative Langerhans cell histiocytosis","volume":"124","author":"Brown","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.revmed.2015.04.015_bib0570","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.20130977","article-title":"BRAF V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups","volume":"211","author":"Berres","year":"2014","journal-title":"J Exp Med"},{"key":"10.1016\/j.revmed.2015.04.015_bib0575","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1182\/blood-2012-05-430140","article-title":"High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses","volume":"120","author":"Haroche","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.revmed.2015.04.015_bib0580","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1182\/blood-2013-12-543793","article-title":"Association of both Langerhans cell histiocytosis and Erdheim-Chester disease linked to BRAF V600E mutation: a multicenter study of 23 cases","volume":"124","author":"Hervier","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.revmed.2015.04.015_bib0585","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1183\/09031936.06.00024004","article-title":"Adult pulmonary Langerhans\u2019 cell histiocytosis","volume":"27","author":"Tazi","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.revmed.2015.04.015_bib0590","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/00000478-200105000-00010","article-title":"Pulmonary Langerhans\u2019 cell histiocytosis: molecular analysis of clonality","volume":"25","author":"Yousem","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0595","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/mpo.1110","article-title":"Pulmonary abnormalities at long-term follow-up of patients with Langerhans cell histiocytosis","volume":"36","author":"Bernstrand","year":"2001","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0600","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1378\/chest.12-1917","article-title":"Pulmonary Langerhans cell histiocytosis: profiling of multifocal tumors using next-generation sequencing identifies concordant occurrence of BRAF V600E mutations","volume":"143","author":"Yousem","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.revmed.2015.04.015_bib0605","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1097\/01.tp.0000200304.64613.af","article-title":"Lung transplantation for pulmonary Langerhans\u2019 cell histiocytosis: a multicenter analysis","volume":"81","author":"Dauriat","year":"2006","journal-title":"Transplantation"},{"key":"10.1016\/j.revmed.2015.04.015_bib0610","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1182\/blood-2012-07-446286","article-title":"Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation","volume":"121","author":"Haroche","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.revmed.2015.04.015_bib0615","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/1097-0142(19930201)71:3<865::AID-CNCR2820710334>3.0.CO;2-0","article-title":"Association of Langerhans cell histiocytosis with malignant neoplasms","volume":"71","author":"Egeler","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.revmed.2015.04.015_bib0620","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0889-8588(05)70516-5","article-title":"The relation of Langerhans cell histiocytosis to acute leukemia, lymphomas, and other solid tumors. The LCH-Malignancy Study Group of the Histiocyte Society","volume":"12","author":"Egeler","year":"1998","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.revmed.2015.04.015_bib0625","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S1470-2045(05)70211-4","article-title":"Clonal relationship between precursor T-lymphoblastic leukaemia\/lymphoma and Langerhans cell histiocytosis","volume":"6","author":"Feldman","year":"2005","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0630","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2350\/09-03-0622-OA.1","article-title":"Clinicopathologic features of histiocytic lesions following ALL, with a review of the literature","volume":"13","author":"Castro","year":"2010","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0635","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1183\/09059180.00007509","article-title":"Pulmonary Langerhans cell histiocytosis associated with Hodgkin's lymphoma","volume":"19","author":"Feuillet","year":"2010","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.revmed.2015.04.015_bib0640","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/j.1365-2133.2012.11169.x","article-title":"Langerhans cell histiocytosis first presenting in the skin in adults: frequent association with a second haematological malignancy","volume":"167","author":"Edelbroek","year":"2012","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0645","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.revmed.2013.09.009","article-title":"Bone lesions","volume":"35","author":"Oehler","year":"2014","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.revmed.2015.04.015_bib0650","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00003086-200010000-00027","article-title":"Langerhans\u2019 cell histiocytosis in patients older than 21 years","volume":"379","author":"Islinger","year":"2000","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.revmed.2015.04.015_bib0655","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/(SICI)1096-911X(199701)28:1<9::AID-MPO3>3.0.CO;2-P","article-title":"Langerhans\u2019 cell histiocytosis in adults","volume":"28","author":"Baumgartner","year":"1997","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0660","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1002\/1097-0142(19951215)76:12<2471::AID-CNCR2820761211>3.0.CO;2-Z","article-title":"Langerhans\u2019 cell histiocytosis (histiocytosis X) of bone. A clinicopathologic analysis of 263 pediatric and adult cases","volume":"76","author":"Kilpatrick","year":"1995","journal-title":"Cancer"},{"key":"10.1016\/j.revmed.2015.04.015_bib0665","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.revmed.2013.06.005","article-title":"A rib lesion","volume":"35","author":"Gallay","year":"2014","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.revmed.2015.04.015_bib0670","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/pbc.20425","article-title":"Risk factors for diabetes insipidus in Langerhans cell histiocytosis","volume":"46","author":"Grois","year":"2006","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.revmed.2015.04.015_bib0675","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jpeds.2003.12.030","article-title":"Endocrine involvement in pediatric-onset Langerhans\u2019 cell histiocytosis: a population-based study","volume":"144","author":"Donadieu","year":"2004","journal-title":"J Pediatr"},{"key":"10.1016\/j.revmed.2015.04.015_bib0680","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000071786","article-title":"Adult Langerhans cell histiocytosis limited to the skin","volume":"207","author":"Singh","year":"2003","journal-title":"Dermatology"},{"key":"10.1016\/j.revmed.2015.04.015_bib0685","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1210\/jcem.85.4.6501","article-title":"Hypothalamo-pituitary abnormalities in adult patients with Langerhans cell histiocytosis: clinical, endocrinological, and radiological features and response to treatment","volume":"85","author":"Kaltsas","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.revmed.2015.04.015_bib0690","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.jpeds.2010.03.001","article-title":"Central nervous system disease in Langerhans cell histiocytosis","volume":"156","author":"Grois","year":"2010","journal-title":"J Pediatr"},{"key":"10.1016\/j.revmed.2015.04.015_bib0695","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s12022-010-9134-7","article-title":"Langerhans cell histiocytosis of the thyroid is a rare entity, but an association with a papillary thyroid carcinoma is often described","volume":"21","author":"Vergez","year":"2010","journal-title":"Endocr Pathol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0700","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1056\/NEJMoa012087","article-title":"Clinical outcomes of pulmonary Langerhans\u2019 cell histiocytosis in adults","volume":"346","author":"Vassallo","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2015.04.015_bib0705","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1183\/09031936.00210711","article-title":"Serial computed tomography and lung function testing in pulmonary Langerhans\u2019 cell histiocytosis","volume":"40","author":"Tazi","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.revmed.2015.04.015_bib0710","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1378\/chest.11-2490","article-title":"Pulmonary Langerhans cell histiocytosis associated pulmonary hypertension: clinical characteristics and impact of pulmonary arterial hypertension therapies","volume":"142","author":"Le Pavec","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.revmed.2015.04.015_bib0715","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jpeds.2011.12.035","article-title":"Pulmonary involvement in pediatric-onset multisystem Langerhans cell histiocytosis: effect on course and outcome","volume":"161","author":"Ronceray","year":"2012","journal-title":"J Pediatr"},{"key":"10.1016\/j.revmed.2015.04.015_bib0720","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/pbc.24367","article-title":"Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years","volume":"60","author":"Haupt","year":"2013","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.revmed.2015.04.015_bib0725","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.clinre.2011.03.012","article-title":"Langerhans\u2019 cell histiocytosis of the liver in adults","volume":"35","author":"Abdallah","year":"2011","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0730","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/S0022-3476(96)70027-6","article-title":"Digestive tract involvement in Langerhans cell histiocytosis. The French Langerhans Cell Histiocytosis Study Group","volume":"129","author":"Geissmann","year":"1996","journal-title":"J Pediatr"},{"key":"10.1016\/j.revmed.2015.04.015_bib0735","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/PAS.0b013e31820654e4","article-title":"Gastrointestinal tract Langerhans cell histiocytosis: a clinicopathologic study of 12 patients","volume":"35","author":"Singhi","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0740","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/adc.75.1.17","article-title":"A multicentre retrospective survey of Langerhans\u2019 cell histiocytosis: 348 cases observed between 1983 and 1993. The French Langerhans\u2019 Cell Histiocytosis Study Group","volume":"75","year":"1996","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.revmed.2015.04.015_bib0745","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1001\/archderm.143.5.626","article-title":"Crusted Norwegian scabies in an adult with Langerhans cell histiocytosis: mishaps leading to systemic chemotherapy","volume":"143","author":"Kartono","year":"2007","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0750","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.humpath.2005.08.024","article-title":"Lesions resembling Langerhans cell histiocytosis in association with other lymphoproliferative disorders: a reactive or neoplastic phenomenon?","volume":"37","author":"Christie","year":"2006","journal-title":"Hum Pathol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0755","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/ajh.20857","article-title":"Dendritic cell neoplasms: an overview","volume":"82","author":"Kairouz","year":"2007","journal-title":"Am J Hematol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0760","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1164\/rccm.200510-1620CR","article-title":"Pulmonary cystic disorder related to light chain deposition disease","volume":"173","author":"Colombat","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.revmed.2015.04.015_bib0765","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1517\/14656566.2012.688028","article-title":"Medical management of Langerhans cell histiocytosis from diagnosis to treatment","volume":"13","author":"Donadieu","year":"2012","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.revmed.2015.04.015_bib0770","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1750-1172-8-72","article-title":"Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net","volume":"8","author":"Girschikofsky","year":"2013","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.revmed.2015.04.015_bib0775","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/pbc.21782","article-title":"Comparison of FDG-PET scans to conventional radiography and bone scans in management of Langerhans cell histiocytosis","volume":"52","author":"Phillips","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.revmed.2015.04.015_bib0780","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/pbc.20160","article-title":"A new clinical score for disease activity in Langerhans cell histiocytosis","volume":"43","author":"Donadieu","year":"2004","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.revmed.2015.04.015_bib0785","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1542\/peds.76.2.286","article-title":"Healing rates of treated and untreated bone lesions in histiocytosis X","volume":"76","author":"Womer","year":"1985","journal-title":"Pediatrics"},{"key":"10.1016\/j.revmed.2015.04.015_bib0790","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/COC.0b013e318281d6ce","article-title":"Clinical outcomes of radiation therapy in the management of Langerhans cell histiocytosis","volume":"37","author":"Kotecha","year":"2014","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0795","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00066-006-1630-9","article-title":"Radiotherapy of Langerhans\u2019 cell histiocytosis: results and implications of a national patterns-of-care study","volume":"182","author":"Olschewski","year":"2006","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0800","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/pbc.20578","article-title":"A phase II trial using thalidomide for Langerhans cell histiocytosis","volume":"48","author":"McClain","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.revmed.2015.04.015_bib0805","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ejogrb.2012.03.010","article-title":"Management of adult primary vulvar Langerhans cell histiocytosis: review of the literature and a case history","volume":"163","author":"El-Safadi","year":"2012","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0810","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1046\/j.1365-2133.2001.04298.x","article-title":"Successful treatment of cutaneous Langerhans cell histiocytosis with low-dose methotrexate","volume":"145","author":"Steen","year":"2001","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0815","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/(SICI)1096-911X(199612)27:6<540::AID-MPO6>3.0.CO;2-L","article-title":"Langerhans cell histiocytosis in the adult","volume":"27","author":"Malpas","year":"1996","journal-title":"Med Pediatr Oncol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0820","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1002\/(SICI)1097-0142(19971101)80:9<1786::AID-CNCR13>3.0.CO;2-1","article-title":"Langerhans\u2019 cell histiocytosis in adults: a clinical and therapeutic analysis of 11 patients from a single institution","volume":"80","author":"Giona","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.revmed.2015.04.015_bib0825","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1182\/blood.V93.12.4125","article-title":"Cladribine activity in adult Langerhans cell histiocytosis","volume":"93","author":"Saven","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.revmed.2015.04.015_bib0830","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0025-7753(01)71821-0","article-title":"Results of treatment with 2-chlorodeoxyadenosine in refractory or relapsed Langerhans cell histiocytosis. Study of 9 patients","volume":"116","author":"Grau","year":"2001","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.revmed.2015.04.015_bib0835","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4065\/78.3.301","article-title":"2-chlorodeoxyadenosine therapy for disseminated Langerhans cell histiocytosis","volume":"78","author":"Pardanani","year":"2003","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.revmed.2015.04.015_bib0840","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1093\/annonc\/mdp455","article-title":"MACOP-B regimen in the treatment of adult Langerhans cell histiocytosis: experience on seven patients","volume":"21","author":"Derenzini","year":"2010","journal-title":"Ann Oncol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0845","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1750-1172-6-83","article-title":"Efficacy of vinblastine in central nervous system Langerhans cell histiocytosis: a nationwide retrospective study","volume":"6","author":"Ng Wing Tin","year":"2011","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.revmed.2015.04.015_bib0850","doi-asserted-by":"crossref","first-page":"e43257","DOI":"10.1371\/journal.pone.0043257","article-title":"Optimal therapy for adults with Langerhans cell histiocytosis bone lesions","volume":"7","author":"Cantu","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.revmed.2015.04.015_bib0855","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s12185-012-1245-0","article-title":"Therapeutic outcome of multifocal Langerhans cell histiocytosis in adults treated with the Special C regimen formulated by the Japan LCH Study Group","volume":"97","author":"Morimoto","year":"2013","journal-title":"Int J Hematol"},{"key":"10.1016\/j.revmed.2015.04.015_bib0860","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.3109\/10428194.2012.744454","article-title":"Cladribine therapy in adults with advanced Langerhans cell histiocytosis","volume":"54","author":"Schini","year":"2013","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.revmed.2015.04.015_bib0865","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1136\/thx.2008.108944","article-title":"Progressive diffuse pulmonary Langerhans cell histiocytosis improved by cladribine chemotherapy","volume":"64","author":"Lazor","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.revmed.2015.04.015_bib0435","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1164\/ajrccm.186.9.930","article-title":"Cladribine is effective against cystic pulmonary Langerhans cell histiocytosis","volume":"186","author":"Lorillon","year":"2012","journal-title":"Am J Respir Crit Care Med"}],"container-title":["La Revue de M\u00e9decine Interne"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866315004646?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866315004646?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:35:37Z","timestamp":1759336537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0248866315004646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":87,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S0248866315004646"],"URL":"https:\/\/doi.org\/10.1016\/j.revmed.2015.04.015","relation":{},"ISSN":["0248-8663"],"issn-type":[{"value":"0248-8663","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histiocytose langerhansienne de l\u2019adulte","name":"articletitle","label":"Article Title"},{"value":"La Revue de M\u00e9decine Interne","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.revmed.2015.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Soci\u00e9t\u00e9 nationale fran\u00e7aise de m\u00e9decine interne (SNFMI). Published by Elsevier Masson SAS","name":"copyright","label":"Copyright"}]}}