{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:50:32Z","timestamp":1779313832566,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["La Revue de M\u00e9decine Interne"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.revmed.2018.04.014","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T08:41:15Z","timestamp":1525423275000},"page":"772-776","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Int\u00e9r\u00eat de l\u2019acide tranexamique en traitement d\u2019urgence de premi\u00e8re intention des crises d\u2019angi\u0153d\u00e8me bradykinique sous IEC"],"prefix":"10.1016","volume":"39","author":[{"given":"C.","family":"Beauch\u00eane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Martins-H\u00e9richer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Denis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Maillard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.revmed.2018.04.014_bib0190","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1097\/MD.0000000000001939","article-title":"Angioedema related to angiotensin-converting enzyme inhibitors\u00a0: attack severity, treatment, and hospital admission in a prospective multicenter study","volume":"94","author":"Javaud","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.revmed.2018.04.014_bib0195","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2340\/00015555-1760","article-title":"Angiotensin-converting enzyme inhibitor-induced angioedema \u2013 a dangerous new epidemic","volume":"94","author":"Rasmussen","year":"2014","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.revmed.2018.04.014_bib0200","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11739-015-1205-9","article-title":"Treatment of ACEI-related angioedema with icatibant: a case series","volume":"10","author":"Bova","year":"2015","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.revmed.2018.04.014_bib0215","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1056\/NEJMoa1312524","article-title":"A randomized trial of icatibant in ACE-inhibitor-induced angioedema","volume":"372","author":"Ba\u015f","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2018.04.014_bib0220","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1081-1206(10)60594-7","article-title":"Multicenter study of patients with angiotensin-converting enzyme inhibitor-induced angioedema who present to the emergency department","volume":"100","author":"Banerji","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.revmed.2018.04.014_bib0225","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1001\/archinte.165.14.1637","article-title":"Incidence and characteristics of angioedema associated with enalapril","volume":"165","author":"Kostis","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.revmed.2018.04.014_bib0230","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.revmed.2012.12.017","article-title":"Prise en charge des angi\u0153d\u00e8mes induits par les inhibiteurs de l\u2019enzyme de conversion de l\u2019angiotensine: recommandations du Centre de r\u00e9f\u00e9rence national des angi\u0153d\u00e8mes","volume":"34","author":"Nosbaum","year":"2013","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.revmed.2018.04.014_bib0235","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.amjcard.2011.11.014","article-title":"Angiotensin-converting enzyme (ACE) inhibitor angioedema: the silent epidemic","volume":"109","author":"Roberts","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.revmed.2018.04.014_bib0240","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.lpm.2015.01.005","article-title":"Traitements des angi\u0153d\u00e8mes h\u00e9r\u00e9ditaires: recommandations du centre de r\u00e9f\u00e9rence national des angi\u0153d\u00e8mes","volume":"44","author":"Bouillet","year":"2015","journal-title":"Presse Med"},{"key":"10.1016\/j.revmed.2018.04.014_bib0245","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.revmed.2004.07.018","article-title":"Int\u00e9r\u00eat diagnostic et th\u00e9rapeutique de l\u2019acide tranexamique dans les angio-\u0153d\u00e8mes non-histaminiques","volume":"25","author":"Bouillet","year":"2004","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.revmed.2018.04.014_bib0250","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.revmed.2009.11.021","article-title":"Les angi\u0153d\u00e8mes bradykiniques h\u00e9r\u00e9ditaires ou acquis","volume":"32","author":"Bouillet","year":"2011","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.revmed.2018.04.014_bib0255","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/MEJ.0000000000000252","article-title":"Bradykinin-mediated angioedema: factors associated with admission to an intensive care unit, a multicenter study","volume":"23","author":"Javaud","year":"2016","journal-title":"Eur J Emerg Med"},{"key":"10.1016\/j.revmed.2018.04.014_bib0260","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1520\/JFS15129J","article-title":"Asphyxia due to angiotensin converting enzyme (ACE) inhibitor mediated angioedema of the tongue during the treatment of hypertensive heart disease","volume":"46","author":"Dean","year":"2001","journal-title":"J Forensic Sci"},{"key":"10.1016\/j.revmed.2018.04.014_bib0265","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1007\/BF03022528","article-title":"Brief review: angiotensin converting enzyme inhibitors and angioedema: anesthetic implications","volume":"53","author":"Sarkar","year":"2006","journal-title":"Can J Anaesth"},{"key":"10.1016\/j.revmed.2018.04.014_bib0270","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1365-2249.2005.02726.x","article-title":"C1\u00a0inhibitor deficiency: consensus document","volume":"139","author":"Gompels","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.revmed.2018.04.014_bib0275","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1056\/NEJMcp0803977","article-title":"Hereditary angioedema","volume":"359","author":"Zuraw","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2018.04.014_bib0280","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0002-9343(99)00123-0","article-title":"Idiopathic nonhistaminergic angioedema","volume":"106","author":"Cicardi","year":"1999","journal-title":"Am J Med"},{"key":"10.1016\/j.revmed.2018.04.014_bib0285","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1056\/NEJMoa0906393","article-title":"Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema","volume":"363","author":"Cicardi","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2018.04.014_bib0290","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/imj.12799","article-title":"Icatibant in angiotensin-converting enzyme (ACE) inhibitor-associated angioedema","volume":"45","author":"Fok","year":"2015","journal-title":"Intern Med J"},{"key":"10.1016\/j.revmed.2018.04.014_bib0295","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.jaip.2017.03.003","article-title":"Randomized trial of icatibant for angiotensin-converting enzyme inhibitor-induced upper airway angioedema","volume":"5","author":"Sinert","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.revmed.2018.04.014_bib0300","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jaci.2016.09.051","article-title":"Effect of bradykinin receptor antagonism on ACE inhibitor-associated angioedema","volume":"140","author":"Straka","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.revmed.2018.04.014_bib0305","first-page":"642","article-title":"Angiotensin converting enzyme inhibitor-related angioedema: a case of an unexpected death","volume":"14","author":"Atalay","year":"2015","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"10.1016\/j.revmed.2018.04.014_bib0310","series-title":"Analyse de leur disponibilit\u00e9 dans la vall\u00e9e du Rh\u00f4ne et des facteurs qui l\u2019influencent","article-title":"Les traitements efficaces des angi\u0153d\u00e8mes aux IEC sont-ils accessibles \u00e0 tous les patients\u00a0?","author":"Moriceau","year":"2016"},{"key":"10.1016\/j.revmed.2018.04.014_bib0315","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/MEJ.0b013e32835bb4a9","article-title":"The early treatment of bradykinin angioedema, a challenge for emergency medicine","volume":"20","author":"Javaud","year":"2013","journal-title":"Eur J Emerg Med"},{"key":"10.1016\/j.revmed.2018.04.014_bib0320","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.annder.2014.09.017","article-title":"Revising the nosology of bradykinin-mediated angioedema","volume":"142","author":"Martin","year":"2015","journal-title":"Ann Dermatol Venereol"},{"key":"10.1016\/j.revmed.2018.04.014_bib0325","first-page":"422","article-title":"Consensus statement on the diagnosis, management, and treatment of angioedema mediated by bradykinin. Part II. Treatment, follow-up, and special situations","volume":"21","author":"Caballero","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.revmed.2018.04.014_bib0330","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/all.12380","article-title":"Classification, diagnosis, and approach to treatment for angioedema: consensus report from the hereditary angioedema international working group","volume":"69","author":"Cicardi","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.revmed.2018.04.014_bib0335","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1710-1492-6-14","article-title":"Acquired angioedema","volume":"6","author":"Cicardi","year":"2010","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.revmed.2018.04.014_bib0340","unstructured":"Centre de r\u00e9f\u00e9rence sur les agents t\u00e9ratog\u00e8nes. 2018. http:\/\/lecrat.fr\/spip.php?page=article&id_article=735."},{"key":"10.1016\/j.revmed.2018.04.014_bib0345","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1398-9995.2009.02234.x","article-title":"Efficacy of tranexamic acid in sporadic idiopathic bradykinin angioedema","volume":"65","author":"Du-Thanh","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.revmed.2018.04.014_bib0350","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1567-5769(02)00162-5","article-title":"Bradykinin and the pathophysiology of angioedema","volume":"3","author":"Cugno","year":"2003","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.revmed.2018.04.014_bib0355","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1503\/cmaj.060535","article-title":"Angioedema without urticaria: a large clinical survey","volume":"175","author":"Zingale","year":"2006","journal-title":"CMAJ"},{"key":"10.1016\/j.revmed.2018.04.014_bib0360","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.revmed.2007.09.038","article-title":"Angio-\u0153d\u00e8me acquis induit par les IEC: traitement aux urgences par concentr\u00e9 de C1\u00a0inhibiteur","volume":"29","author":"Gel\u00e9e","year":"2008","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.revmed.2018.04.014_bib0365","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/cei.12379","article-title":"Tranexamic acid as maintenance treatment for non-histaminergic angioedema: analysis of efficacy and safety in 37\u00a0patients","volume":"178","author":"Wintenberger","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.revmed.2018.04.014_bib0185","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.annemergmed.2010.03.032","article-title":"Therapeutic efficacy of icatibant in angioedema induced by angiotensin-converting enzyme inhibitors: a case series","volume":"56","author":"Bas","year":"2010","journal-title":"Ann Emerg Med"}],"container-title":["La Revue de M\u00e9decine Interne"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866318305204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866318305204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:39:28Z","timestamp":1759336768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0248866318305204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0248866318305204"],"URL":"https:\/\/doi.org\/10.1016\/j.revmed.2018.04.014","relation":{},"ISSN":["0248-8663"],"issn-type":[{"value":"0248-8663","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Int\u00e9r\u00eat de l\u2019acide tranexamique en traitement d\u2019urgence de premi\u00e8re intention des crises d\u2019angi\u0153d\u00e8me bradykinique sous IEC","name":"articletitle","label":"Article Title"},{"value":"La Revue de M\u00e9decine Interne","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.revmed.2018.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Soci\u00e9t\u00e9 Nationale Fran\u00e7aise de M\u00e9decine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}