{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:48:49Z","timestamp":1785782929937,"version":"3.56.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["La Revue de M\u00e9decine Interne"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.revmed.2019.04.003","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T08:18:38Z","timestamp":1556698718000},"page":"670-676","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Benefits and risks of oxygen therapy during acute medical illness: Just a matter of dose!"],"prefix":"10.1016","volume":"40","author":[{"given":"J.","family":"Allardet-Servent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sicard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Metz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Chiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.revmed.2019.04.003_bib0195","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1136\/emj.2008.059287","article-title":"Audit of oxygen use in emergency ambulances and in a hospital emergency department","volume":"25","author":"Hale","year":"2008","journal-title":"Emerg Med J"},{"key":"10.1016\/j.revmed.2019.04.003_bib0200","first-page":"201","article-title":"Holtzapple (1862\u20131946) and oxygen therapy for lobar pneumonia: the first reported case (1887) and a review of the contemporary literature to 1899","volume":"13","author":"Shultz","year":"2005","journal-title":"J Med Biogr"},{"key":"10.1016\/j.revmed.2019.04.003_bib0205","first-page":"370","article-title":"The treatment of anoxia in clinical medicine","volume":"26","author":"Barach","year":"1950","journal-title":"Bull N Y Acad Med"},{"key":"10.1016\/j.revmed.2019.04.003_bib0210","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/joim.12139","article-title":"The medical use of oxygen: a time for critical reappraisal","volume":"274","author":"Sj\u00f6berg","year":"2013","journal-title":"J Intern Med"},{"key":"10.1016\/j.revmed.2019.04.003_bib0215","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4187\/respcare.01831","article-title":"The story of oxygen","volume":"58","author":"Heffner","year":"2013","journal-title":"Respir Care"},{"key":"10.1016\/j.revmed.2019.04.003_bib0220","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0140-6736(18)30479-3","article-title":"Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis","volume":"391","author":"Chu","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.revmed.2019.04.003_bib0225","series-title":"Nunn's applied respiratory physiology","article-title":"Oxygen","author":"Lumb","year":"2005"},{"issue":"5","key":"10.1016\/j.revmed.2019.04.003_bib0230","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1164\/ajrccm.160.5.9806006","article-title":"Arterial blood gas reference values for sea level and an altitude of 1,400 meters","volume":"160","author":"Crapo","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.revmed.2019.04.003_bib0235","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/thorax.57.2.170","article-title":"The pulmonary physician in critical care \u2022 2: oxygen delivery and consumption in the critically ill","volume":"57","author":"Leach","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.revmed.2019.04.003_bib0240","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1056\/NEJMra1011165","article-title":"Oxygen sensing, homeostasis, and disease","volume":"365","author":"Semenza","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2019.04.003_bib0245","series-title":"Nunn's applied respiratory physiology","article-title":"Hypoxia","author":"Lumb","year":"2005"},{"key":"10.1016\/j.revmed.2019.04.003_bib0250","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s13054-015-0996-4","article-title":"Bench-to-bedside review: the effects of hyperoxia during critical illness","volume":"19","author":"Helmerhorst","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.revmed.2019.04.003_bib0255","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/cc11475","article-title":"Oxygen-induced hypercapnia in COPD: myths and facts","volume":"16","author":"Abdo","year":"2012","journal-title":"Crit Care"},{"key":"10.1016\/j.revmed.2019.04.003_bib0260","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1164\/arrd.1980.122.5.747","article-title":"Effects of the administration of O2 on ventilation and blood gases in patients with chronic obstructive pulmonary disease during acute respiratory failure","volume":"122","author":"Aubier","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.revmed.2019.04.003_bib0265","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1164\/arrd.1980.122.5.747","article-title":"Central respiratory drive in acute respiratory failure of patients with chronic obstructive pulmonary disease","volume":"122","author":"Aubier","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.revmed.2019.04.003_bib0270","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1164\/ajrccm.161.5.9904119","article-title":"The role of hypoventilation and ventilation-perfusion redistribution in oxygen-induced hypercapnia during acute exacerbations of chronic obstructive pulmonary disease","volume":"161","author":"Robinson","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"10.1016\/j.revmed.2019.04.003_bib0275","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1136\/thx.2010.155259","article-title":"Randomised controlled trial of high concentration versus titrated oxygen therapy in severe exacerbations of asthma","volume":"66","author":"Perrin","year":"2011","journal-title":"Thorax"},{"issue":"4","key":"10.1016\/j.revmed.2019.04.003_bib0280","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1378\/chest.124.4.1312","article-title":"Effects of short-term 28% and 100% oxygen on PaCO2 and peak expiratory flow rate in acute asthma: a randomized trial","volume":"124","author":"Rodrigo","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.revmed.2019.04.003_bib0285","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1378\/chest.10-1280","article-title":"The effect of supplemental oxygen on hypercapnia in subjects with obesity-associated hypoventilation: a randomized, crossover, clinical study","volume":"139","author":"Wijesinghe","year":"2011","journal-title":"Chest"},{"issue":"Suppl 1","key":"10.1016\/j.revmed.2019.04.003_bib0290","doi-asserted-by":"crossref","first-page":"ii1","DOI":"10.1136\/thoraxjnl-2016-209729","article-title":"BTS guideline for oxygen use in adults in healthcare and emergency settings","volume":"72","author":"O\u2019Driscoll","year":"2017","journal-title":"Thorax"},{"key":"10.1016\/j.revmed.2019.04.003_bib0295","doi-asserted-by":"crossref","first-page":"529","DOI":"10.4187\/respcare.04577","article-title":"High-flow nasal cannula oxygen therapy in adults: physiological benefits, indication, clinical benefits, and adverse effects","volume":"61","author":"Nishimura","year":"2016","journal-title":"Respir Care"},{"key":"10.1016\/j.revmed.2019.04.003_bib0300","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s13054-015-0984-8","article-title":"Pulse oximetry","volume":"19","author":"Jubran","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.revmed.2019.04.003_bib0305","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1097\/ALN.0000000000002002","article-title":"Four types of pulse oximeters accurately detect hypoxia during low perfusion and motion","volume":"128","author":"Louie","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.revmed.2019.04.003_bib0310","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1001\/jama.2017.11463","article-title":"Effect of routine low-dose oxygen supplementation on death and disability in adults with acute stroke: the stroke oxygen study randomized clinical trial","volume":"318","author":"Roffe","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2019.04.003_bib0315","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1161\/CIRCULATIONAHA.114.014494","article-title":"Air versus oxygen in ST-segment\u2013elevation myocardial infarction","volume":"131","author":"Stub","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.revmed.2019.04.003_bib0320","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1056\/NEJMoa1706222","article-title":"Oxygen therapy in suspected acute myocardial infarction","volume":"377","author":"Hofmann","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.revmed.2019.04.003_bib0325","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.resuscitation.2005.08.010","article-title":"Comparison of 30 and the 100% inspired oxygen concentrations during early post-resuscitation period: a randomized controlled pilot study","volume":"69","author":"Kuisma","year":"2006","journal-title":"Resuscitation"},{"key":"10.1016\/j.revmed.2019.04.003_bib0330","doi-asserted-by":"crossref","first-page":"e279","DOI":"10.1097\/CCM.0000000000002935","article-title":"The cumulative partial pressure of arterial oxygen is associated with neurological outcomes after cardiac arrest treated with targeted temperature management","volume":"46","author":"Youn","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.revmed.2019.04.003_bib0335","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1161\/CIRCULATIONAHA.117.032054","article-title":"Association between early hyperoxia exposure after resuscitation from cardiac arrest and neurological disability: prospective multicenter protocol-directed cohort study","volume":"137","author":"Roberts","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.revmed.2019.04.003_bib0340","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1097\/CCM.0b013e3182656976","article-title":"Hyperoxia is associated with increased mortality in patients treated with mild therapeutic hypothermia after sudden cardiac arrest","volume":"40","author":"Janz","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.revmed.2019.04.003_bib0345","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S2213-2600(17)30046-2","article-title":"Hyperoxia and hypertonic saline in patients with septic shock (HYPERS2S): a two-by-two factorial, multicentre, randomised, clinical trial","volume":"5","author":"Asfar","year":"2017","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.revmed.2019.04.003_bib0350","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1164\/rccm.201505-1019OC","article-title":"Conservative versus liberal oxygenation targets for mechanically ventilated patients. A pilot multicenter randomized controlled trial","volume":"193","author":"Panwar","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.revmed.2019.04.003_bib0355","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/CCM.0000000000002886","article-title":"Oxygen exposure resulting in arterial oxygen tensions above the protocol goal was associated with worse clinical outcomes in acute respiratory distress syndrome","volume":"46","author":"Aggarwal","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.revmed.2019.04.003_bib0360","doi-asserted-by":"crossref","first-page":"R156","DOI":"10.1186\/cc7150","article-title":"Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patients","volume":"12","author":"de Jonge","year":"2008","journal-title":"Crit Care"},{"key":"10.1016\/j.revmed.2019.04.003_bib0365","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1001\/jama.2016.11993","article-title":"Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the oxygen-ICU randomized clinical trial","volume":"316","author":"Girardis","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2019.04.003_bib0370","doi-asserted-by":"crossref","first-page":"c5462","DOI":"10.1136\/bmj.c5462","article-title":"Effect of high flow oxygen on mortality in chronic obstructive pulmonary disease patients in prehospital setting: randomized controlled trial","volume":"341","author":"Austin","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.revmed.2019.04.003_bib0375","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/resp.12620","article-title":"Thoracic Society of Australia and New Zealand oxygen guidelines for acute oxygen use in adults: \u2018Swimming between the flags\u2019","volume":"20","author":"Beasley","year":"2015","journal-title":"Respirology"},{"key":"10.1016\/j.revmed.2019.04.003_bib0380","doi-asserted-by":"crossref","first-page":"k4169","DOI":"10.1136\/bmj.k4169","article-title":"Oxygen therapy for acutely ill medical patients: a clinical practice guideline","volume":"363","author":"Siemieniuk","year":"2018","journal-title":"BMJ"}],"container-title":["La Revue de M\u00e9decine Interne"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866319304370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866319304370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:40:46Z","timestamp":1759336846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0248866319304370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S0248866319304370"],"URL":"https:\/\/doi.org\/10.1016\/j.revmed.2019.04.003","relation":{},"ISSN":["0248-8663"],"issn-type":[{"value":"0248-8663","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Benefits and risks of oxygen therapy during acute medical illness: Just a matter of dose!","name":"articletitle","label":"Article Title"},{"value":"La Revue de M\u00e9decine Interne","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.revmed.2019.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Soci\u00e9t\u00e9 Nationale Fran\u00e7aise de M\u00e9decine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}