{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:03:00Z","timestamp":1782842580329,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"am","delay-in-days":355,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["La Revue de M\u00e9decine Interne"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.revmed.2019.09.001","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T08:02:56Z","timestamp":1569312176000},"page":"826-830","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Un effet ind\u00e9sirable rare de l\u2019amiodarone\u00a0: la neuropathie optique"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5567-354X","authenticated-orcid":false,"given":"R.","family":"Arcani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pellerey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rouby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Gobin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Scapin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Chagny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Arnould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ambrosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gayet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Micallef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Daumas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.revmed.2019.09.001_bib0160","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.jfo.2010.03.017","article-title":"\u0152d\u00e8me papillaire bilat\u00e9ral. Conduite diagnostique","volume":"33","author":"Rougier","year":"2010","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0165","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jfo.2017.02.002","article-title":"\u0152d\u00e8me papillaire bilat\u00e9ral","volume":"40","author":"Rougier","year":"2017","journal-title":"J Fr Ophtalmol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0170","doi-asserted-by":"crossref","first-page":"586","DOI":"10.2174\/1381612823666170124113826","article-title":"An updated review on the most common agents causing toxic optic neuropathies","volume":"23","author":"Wasinska-Borowiec","year":"2017","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.revmed.2019.09.001_bib0175","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0002-9394(99)00016-1","article-title":"Features of amiodarone-induced optic neuropathy","volume":"127","author":"Macaluso","year":"1999","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0180","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archopht.124.5.696","article-title":"Optic neuropathy in patients using amiodarone","volume":"124","author":"Purvin","year":"2006","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0185","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/0002-8703(83)90006-6","article-title":"Amiodarone pharmacokinetics","volume":"106","author":"Holt","year":"1983","journal-title":"Am Heart J"},{"key":"10.1016\/j.revmed.2019.09.001_bib0190","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1161\/01.CIR.67.6.1347","article-title":"Clinical pharmacokinetics and efficacy of amiodarone for refractory tachyarrhythmias","volume":"67","author":"Haffajee","year":"1983","journal-title":"Circulation"},{"key":"10.1016\/j.revmed.2019.09.001_bib0195","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1001\/jama.298.11.1312","article-title":"Prescribing amiodarone: an evidence-based review of clinical indications","volume":"298","author":"Vassallo","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.revmed.2019.09.001_bib0200","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.tcm.2016.03.014","article-title":"Amiodarone and dronedarone: an update","volume":"26","author":"Vamos","year":"2016","journal-title":"Trends Cardiovasc Med"},{"key":"10.1016\/j.revmed.2019.09.001_bib0205","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/0002-8703(85)90238-8","article-title":"Side effects and complications of amiodarone therapy","volume":"109","author":"Raeder","year":"1985","journal-title":"Am Heart J"},{"key":"10.1016\/j.revmed.2019.09.001_bib0210","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1136\/bjo.87.4.420","article-title":"Amiodarone-induced optic neuropathy","volume":"87","author":"Nagra","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0215","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0002-9149(99)00700-6","article-title":"Clinical organ toxicity of antiarrhythmic compounds: ocular and pulmonary manifestations","volume":"84","author":"Pollak","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0220","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2165\/00002018-200326060-00004","article-title":"Potentially significant drug interactions of class III antiarrhythmic drugs","volume":"26","author":"Yamreudeewong","year":"2003","journal-title":"Drug Saf"},{"key":"10.1016\/j.revmed.2019.09.001_bib0225","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0039-6257(97)00118-5","article-title":"Ocular side effects of amiodarone","volume":"42","author":"M\u00e4ntyj\u00e4rvi","year":"1998","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0230","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.revmed.2018.02.017","article-title":"Uv\u00e9ite m\u00e9dicamenteuse et effets ind\u00e9sirables des m\u00e9dicaments en ophtalmologie","volume":"39","author":"Trad","year":"2018","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.revmed.2019.09.001_bib0235","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0025-6196(12)65224-0","article-title":"Optic neuropathy and amiodarone therapy","volume":"62","author":"Feiner","year":"1987","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.revmed.2019.09.001_bib0240","first-page":"25","article-title":"Bilateral optic neuropathy associated with amiodarone therapy","volume":"8","author":"Nazarian","year":"1988","journal-title":"J Clin Neuroophthalmol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0245","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2016-217436","article-title":"Short-term treatment with oral amiodarone resulting in bilateral optic neuropathy and permanent blindness","volume":"2017","author":"Knudsen","year":"2017","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.revmed.2019.09.001_bib0250","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0025-6196(12)64959-3","article-title":"Amiodarone-related optic neuropathy","volume":"63","author":"Gittinger","year":"1988","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.revmed.2019.09.001_bib0255","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1001\/archopht.1987.01060030069028","article-title":"Papillopathy caused by amiodarone","volume":"105","author":"Gittinger","year":"1987","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0260","first-page":"1477","article-title":"The clinical spectrum of amiodarone-associated optic neuropathy","volume":"96","author":"Johnson","year":"2004","journal-title":"J Natl Med Assoc"},{"key":"10.1016\/j.revmed.2019.09.001_bib0265","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.clpt.2003.09.010","article-title":"Monitoring amiodarone's toxicities: recommendations, evidence, and clinical practice","volume":"75","author":"Stelfox","year":"2004","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.revmed.2019.09.001_bib0270","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.ahj.2007.02.010","article-title":"Absence of bilateral vision loss from amiodarone: a randomized trial","volume":"153","author":"Mindel","year":"2007","journal-title":"Am Heart J"},{"key":"10.1016\/j.revmed.2019.09.001_bib0275","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/00019052-200402000-00006","article-title":"Ischemic optic neuropathies","volume":"17","author":"Rucker","year":"2004","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0280","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0002-9394(14)70999-7","article-title":"Incidence of nonarteritic anterior ischemic optic neuropathy","volume":"123","author":"Hattenhauer","year":"1997","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0285","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/01658107.2017.1340961","article-title":"Amiodarone-associated optic neuropathy\u00a0\u2013\u00a0A clinical criteria-based diagnosis?","volume":"42","author":"Fasler","year":"2018","journal-title":"Neuroophthalmol Aeolus Press"},{"key":"10.1016\/j.revmed.2019.09.001_bib0290","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.amjmed.2011.09.020","article-title":"Amiodarone-associated optic neuropathy: a critical review","volume":"125","author":"Passman","year":"2012","journal-title":"Am J Med"},{"key":"10.1016\/j.revmed.2019.09.001_bib0295","first-page":"231","article-title":"Optic nerve ultrastructure following amiodarone therapy","volume":"8","author":"Mansour","year":"1988","journal-title":"J Clin Neuroophthalmol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0300","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/brain\/108.3.753","article-title":"The pathology of amiodarone neurotoxicity. II. Peripheral neuropathy in man","volume":"108","author":"Jacobs","year":"1985","journal-title":"Brain J Neurol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0305","first-page":"105","article-title":"Amiodarone optic neuropathy","volume":"8","author":"Garrett","year":"1988","journal-title":"J Neuroophthalmol"},{"key":"10.1016\/j.revmed.2019.09.001_bib0310","first-page":"75","article-title":"Neuropathies optiques li\u00e9es \u00e0 l\u2019amiodarone\u00a0\u2013\u00a0\u00e0 propos de deux cas","volume":"303","author":"Van Elmbt","year":"2007","journal-title":"Bull Soc Belge Ophtalmol"}],"container-title":["La Revue de M\u00e9decine Interne"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866319306332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866319306332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:41:43Z","timestamp":1759336903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0248866319306332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0248866319306332"],"URL":"https:\/\/doi.org\/10.1016\/j.revmed.2019.09.001","relation":{},"ISSN":["0248-8663"],"issn-type":[{"value":"0248-8663","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Un effet ind\u00e9sirable rare de l\u2019amiodarone\u00a0: la neuropathie optique","name":"articletitle","label":"Article Title"},{"value":"La Revue de M\u00e9decine Interne","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.revmed.2019.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Soci\u00e9t\u00e9 Nationale Fran\u00e7aise de M\u00e9decine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}