{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:56:51Z","timestamp":1772495811919,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:00:00Z","timestamp":1630368000000},"content-version":"am","delay-in-days":426,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["La Revue de M\u00e9decine Interne"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.revmed.2019.12.020","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T08:13:00Z","timestamp":1581581580000},"page":"440-445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characteristics of Systemic Sclerosis patients with positive anti-Th\/To antibodies: About 6 patients and literature review"],"prefix":"10.1016","volume":"41","author":[{"given":"R.","family":"Muller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Benyamine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bertin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-R.","family":"Harl\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Kaplanski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mazodier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Reynaud-Gaubert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Granel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Bardin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.revmed.2019.12.020_bib0220","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1002\/art.39316","article-title":"Interpretation of an extended autoantibody profile in a well-characterized australian systemic sclerosis (scleroderma) cohort using principal components analysis","volume":"67","author":"Patterson","year":"2015","journal-title":"Arthritis Rheumatol Hoboken NJ"},{"issue":"10","key":"10.1016\/j.revmed.2019.12.020_bib0225","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.revmed.2019.05.016","article-title":"Actualit\u00e9s dans la physiopathologie de la scl\u00e9rodermie syst\u00e9mique: vers de nouvelles opportunit\u00e9s th\u00e9rapeutiques","volume":"40","author":"Didier","year":"2019","journal-title":"Rev Med Interne"},{"issue":"Suppl 106(4)","key":"10.1016\/j.revmed.2019.12.020_bib0230","first-page":"98","article-title":"Influence of antibody profile in clinical features and prognosis in a cohort of Spanish patients with systemic sclerosis","volume":"35","author":"Iniesta Arandia","year":"2017","journal-title":"Clin Exp Rheumatol"},{"issue":"2","key":"10.1016\/j.revmed.2019.12.020_bib0235","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/art.38219","article-title":"Prevalence of anti-RNA polymerase III antibodies in systemic sclerosis: New data from a French cohort and a systematic review and meta-analysis","volume":"66","author":"Sobanski","year":"2014","journal-title":"Arthritis Rheumatol Hoboken NJ"},{"issue":"2","key":"10.1016\/j.revmed.2019.12.020_bib0240","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ejim.2010.01.004","article-title":"Low prevalence of anti-RNA polymerase III antibodies in a French scleroderma population: anti-RNA polymerase III scleroderma","volume":"21","author":"Faucher","year":"2010","journal-title":"Eur J Intern Med"},{"issue":"1","key":"10.1016\/j.revmed.2019.12.020_bib0245","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3899\/jrheum.090677","article-title":"Anti-RNA polymerase III antibody prevalence and associated clinical manifestations in a large series of French patients with systemic sclerosis: a cross-sectional study","volume":"37","author":"Meyer","year":"2010","journal-title":"J Rheumatol"},{"issue":"5","key":"10.1016\/j.revmed.2019.12.020_bib0250","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3109\/03009742.2011.569753","article-title":"Anti-RNA polymerase III antibodies are associated with scleroderma renal crisis in a French cohort","volume":"40","author":"Emilie","year":"2011","journal-title":"Scand J Rheumatol"},{"issue":"2","key":"10.1016\/j.revmed.2019.12.020_bib0255","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11926-004-0061-9","article-title":"Antibodies in scleroderma: Direct pathogenicity and phenotypic associations","volume":"6","author":"Chung","year":"2004","journal-title":"Curr Rheumatol Rep"},{"issue":"1","key":"10.1016\/j.revmed.2019.12.020_bib0260","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1346-8138.2009.00762.x","article-title":"Autoantibody profiles in systemic sclerosis: predictive value for clinical evaluation and prognosis","volume":"37","author":"Hamaguchi","year":"2010","journal-title":"J Dermatol"},{"issue":"5","key":"10.1016\/j.revmed.2019.12.020_bib0265","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s10067-012-2145-7","article-title":"Clinical and serological features of systemic sclerosis in a Chinese cohort","volume":"32","author":"Wang","year":"2013","journal-title":"Clin Rheumatol"},{"issue":"6","key":"10.1016\/j.revmed.2019.12.020_bib0270","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1590\/S0365-05962011000600003","article-title":"Autoantibodies in scleroderma and their association with the clinical profile of the disease. A study of 66 patients from southern Brazil","volume":"86","author":"Skare","year":"2011","journal-title":"An Bras Dermatol"},{"issue":"43","key":"10.1016\/j.revmed.2019.12.020_bib0275","doi-asserted-by":"crossref","first-page":"e1728","DOI":"10.1097\/MD.0000000000001728","article-title":"Registry of the Spanish Network for Systemic Sclerosis: Survival, Prognostic Factors, and Causes of Death","volume":"94","author":"Sime\u00f3n-Aznar","year":"2015","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.1016\/j.revmed.2019.12.020_bib0280","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/annrheumdis-2016-210571","article-title":"2016 American College of Rheumatology\/European League Against Rheumatism classification criteria for primary Sj\u00f6gren's syndrome: a consensus and data-driven methodology involving three international patient cohorts","volume":"76","author":"Shiboski","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.revmed.2019.12.020_bib0285","first-page":"211","article-title":"Development of systemic sclerosis in patients with autoimmune hepatitis: an emerging overlap syndrome","volume":"9","author":"Assandri","year":"2016","journal-title":"Gastroenterol Hepatol Bed Bench"},{"issue":"1","key":"10.1016\/j.revmed.2019.12.020_bib0290","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/art.10760","article-title":"A comparison between anti-Th\/To- and anticentromere antibody-positive systemic sclerosis patients with limited cutaneous involvement","volume":"48","author":"Mitri","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.1016\/j.revmed.2019.12.020_bib0295","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1002\/art.1780331210","article-title":"Autoantibody to Th ribonucleoprotein (nucleolar 7-2 RNA protein particle) in patients with systemic sclerosis","volume":"33","author":"Okano","year":"1990","journal-title":"Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.revmed.2019.12.020_bib0300","first-page":"2454","article-title":"Influence of clinical features, serum antinuclear antibodies, and lung function on survival of patients with systemic sclerosis","volume":"28","author":"Jacobsen","year":"2001","journal-title":"J Rheumatol"},{"issue":"6","key":"10.1016\/j.revmed.2019.12.020_bib0305","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/rheumatology\/40.6.683","article-title":"Antibodies to Th\/To ribonucleoprotein in patients with localized scleroderma","volume":"40","author":"Yamane","year":"2001","journal-title":"Rheumatol Oxf Engl"},{"issue":"10","key":"10.1016\/j.revmed.2019.12.020_bib0310","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.3899\/jrheum.100316","article-title":"Anti-Th\/To are common antinucleolar autoantibodies in Italian patients with scleroderma","volume":"37","author":"Ceribelli","year":"2010","journal-title":"J Rheumatol"},{"issue":"7","key":"10.1016\/j.revmed.2019.12.020_bib0315","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.3899\/jrheum.131450","article-title":"Autoantibodies to the Rpp25 component of the Th\/To complex are the most common antibodies in patients with systemic sclerosis without antibodies detectable by widely available commercial tests","volume":"41","author":"Mahler","year":"2014","journal-title":"J Rheumatol"},{"issue":"1","key":"10.1016\/j.revmed.2019.12.020_bib0320","first-page":"9","article-title":"Clinical features of systemic sclerosis and association with antitopoisomerase-1 antibody and centromere pattern of antinuclear antibody","volume":"37","author":"Bertazzi","year":"2012","journal-title":"Acta Reumatol Port"},{"issue":"9","key":"10.1016\/j.revmed.2019.12.020_bib0325","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1136\/ard.61.9.842","article-title":"Differences in autoantibody response to Th\/To between systemic sclerosis and other autoimmune diseases","volume":"61","author":"Kuwana","year":"2002","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.revmed.2019.12.020_bib0330","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.autrev.2012.07.005","article-title":"Diagnostic accuracy and predictive value of extended autoantibody profile in systemic sclerosis","volume":"12","author":"Villalta","year":"2012","journal-title":"Autoimmun Rev"},{"issue":"7","key":"10.1016\/j.revmed.2019.12.020_bib0335","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1093\/rheumatology\/keq446","article-title":"Specific anti-nuclear antibodies in systemic sclerosis patients with and without skin involvement: an extended methodological approach","volume":"50","author":"Van Praet","year":"2011","journal-title":"Rheumatol Oxf Engl"},{"issue":"4","key":"10.1016\/j.revmed.2019.12.020_bib0340","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0889-857X(05)70297-0","article-title":"Antinuclear antibody in systemic sclerosis (scleroderma)","volume":"22","author":"Okano","year":"1996","journal-title":"Rheum Dis Clin North Am"},{"issue":"8","key":"10.1016\/j.revmed.2019.12.020_bib0345","first-page":"1600","article-title":"Anti-th\/to-positivity in a cohort of patients with idiopathic pulmonary fibrosis","volume":"33","author":"Fischer","year":"2006","journal-title":"J Rheumatol"},{"issue":"3","key":"10.1016\/j.revmed.2019.12.020_bib0350","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jaut.2010.06.019","article-title":"Antinuclear antibodies: a contemporary nomenclature using HEp-2 cells","volume":"35","author":"Wiik","year":"2010","journal-title":"J Autoimmun"},{"issue":"9","key":"10.1016\/j.revmed.2019.12.020_bib0355","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1002\/art.1780330917","article-title":"The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays","volume":"33","author":"Kipnis","year":"1990","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.revmed.2019.12.020_bib0360","first-page":"1196","article-title":"Studies of HLA-DR and DQ alleles in systemic sclerosis patients with autoantibodies to RNA polymerases and U3-RNP (fibrillarin)","volume":"27","author":"Falkner","year":"2000","journal-title":"J Rheumatol"},{"issue":"3","key":"10.1016\/j.revmed.2019.12.020_bib0365","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1046\/j.1365-2249.2002.01991.x","article-title":"Autoantibodies against small nucleolar ribonucleoprotein complexes and their clinical associations","volume":"130","author":"Van Eenennaam","year":"2002","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"10.1016\/j.revmed.2019.12.020_bib0370","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.semarthrit.2005.03.005","article-title":"Autoantibodies in systemic sclerosis","volume":"35","author":"Steen","year":"2005","journal-title":"Semin Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.revmed.2019.12.020_bib0375","first-page":"104","article-title":"Disease subsets, antinuclear antibody profile, and clinical features in 127 French and 247 US adult patients with systemic sclerosis","volume":"34","author":"Meyer","year":"2007","journal-title":"J Rheumatol"},{"issue":"3","key":"10.1016\/j.revmed.2019.12.020_bib0380","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2133.2007.08392.x","article-title":"The clinical relevance of serum antinuclear antibodies in Japanese patients with systemic sclerosis","volume":"158","author":"Hamaguchi","year":"2008","journal-title":"Br J Dermatol"},{"issue":"5","key":"10.1016\/j.revmed.2019.12.020_bib0385","doi-asserted-by":"crossref","first-page":"R172","DOI":"10.1186\/ar3495","article-title":"Frequency of disease-associated and other nuclear autoantibodies in patients of the German Network for Systemic Scleroderma: correlation with characteristic clinical features","volume":"13","author":"Mierau","year":"2011","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"10.1016\/j.revmed.2019.12.020_bib0390","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3109\/08916934.2011.592886","article-title":"Distinctive autoantibody profile in Mexican Mestizo systemic sclerosis patients","volume":"44","author":"Rodriguez-Reyna","year":"2011","journal-title":"Autoimmunity"},{"issue":"1","key":"10.1016\/j.revmed.2019.12.020_bib0395","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1756-185X.2011.01688.x","article-title":"South Australian Scleroderma Register: autoantibodies as predictive biomarkers of phenotype and outcome","volume":"15","author":"Graf","year":"2012","journal-title":"Int J Rheum Dis"},{"issue":"8","key":"10.1016\/j.revmed.2019.12.020_bib0400","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1007\/s00296-013-2668-5","article-title":"Systemic sclerosis: demographic, clinical and serological features in 100 Iranian patients","volume":"33","author":"Poormoghim","year":"2013","journal-title":"Rheumatol Int"},{"issue":"3","key":"10.1016\/j.revmed.2019.12.020_bib0405","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.autrev.2012.05.011","article-title":"Autoantibodies in systemic sclerosis","volume":"12","author":"Mehra","year":"2013","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.revmed.2019.12.020_bib0410","doi-asserted-by":"crossref","first-page":"987","DOI":"10.5604\/17322693.1117543","article-title":"Serological profile of patients with systemic sclerosis","volume":"68","author":"Wielosz","year":"2014","journal-title":"Postepy Hig Med Doswiadczalnej Online"},{"issue":"6 Suppl 86","key":"10.1016\/j.revmed.2019.12.020_bib0415","article-title":"Prevalence and clinical profiles of \u00ab\u00a0autoantibody-negative\u00a0\u00bb systemic sclerosis subjects","volume":"32","author":"Hudson","year":"2014","journal-title":"Clin Exp Rheumatol"},{"issue":"11","key":"10.1016\/j.revmed.2019.12.020_bib0420","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1007\/s10067-015-2981-3","article-title":"A cross-sectional study of autoantibody profiles in the Waikato systemic sclerosis cohort, New Zealand","volume":"34","author":"Chang","year":"2015","journal-title":"Clin Rheumatol"},{"issue":"10","key":"10.1016\/j.revmed.2019.12.020_bib0425","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.3899\/jrheum.160106","article-title":"Ethnic differences in autoantibody diversity and hierarchy: more clues from a US cohort of patients with systemic sclerosis","volume":"43","author":"Nandiwada","year":"2016","journal-title":"J Rheumatol"},{"issue":"7","key":"10.1016\/j.revmed.2019.12.020_bib0430","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/08916934.2017.1357699","article-title":"Disease-related autoantibody profile in patients with systemic sclerosis","volume":"50","author":"Liaskos","year":"2017","journal-title":"Autoimmunity"}],"container-title":["La Revue de M\u00e9decine Interne"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866320300084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0248866320300084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:42:50Z","timestamp":1759336970000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0248866320300084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0248866320300084"],"URL":"https:\/\/doi.org\/10.1016\/j.revmed.2019.12.020","relation":{},"ISSN":["0248-8663"],"issn-type":[{"value":"0248-8663","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characteristics of Systemic Sclerosis patients with positive anti-Th\/To antibodies: About 6 patients and literature review","name":"articletitle","label":"Article Title"},{"value":"La Revue de M\u00e9decine Interne","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.revmed.2019.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Soci\u00e9t\u00e9 Nationale Fran\u00e7aise de M\u00e9decine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}