{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:11:08Z","timestamp":1791407468276,"version":"4.3.3"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista de Gastroenterolog\u00eda de M\u00e9xico (English Edition)"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.rgmxen.2022.03.009","type":"journal-article","created":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T06:52:53Z","timestamp":1651387973000},"page":"238-245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inflammatory map of the gastroduodenal mucosa in patients with upper gastrointestinal symptoms. The role of H. pylori infection"],"prefix":"10.1016","volume":"88","author":[{"given":"M.R.","family":"Caballero-Plasencia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Caballero-Mateos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.","family":"Caballero-Plasencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rgmxen.2022.03.009_bib0005","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3109\/00365521.2015.1019918","article-title":"Chronic gastritis","volume":"50","author":"Sipponen","year":"2015","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0010","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.3109\/00365529008997627","article-title":"The occurrence and extent of Helicobacter pylori colonization and antral and body gastritis profiles in an Estonian population sample","volume":"25","author":"Maaroos","year":"1990","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0015","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3109\/00365529008997621","article-title":"Cumulative 10-year risk of symptomatic duodenal and gastric ulcer in patients with or without chronic gastritis. A clinical follow-up study of 454 outpatients","volume":"25","author":"Sipponen","year":"1990","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0020","first-page":"217","article-title":"Peptic ulcer and chronic gastritis: Their relation to age and sex, and to location of ulcer and gastritis","volume":"14","author":"Kekki","year":"1990","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0025","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5056\/jnm18060","article-title":"Role of the duodenum in the pathogenesis of functional dyspepsia: A paradigm shift","volume":"24","author":"Jung","year":"2018","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0030","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1053\/j.gastro.2020.12.016","article-title":"Proton pump inhibitors reduce duodenal eosinophilia, mast cells and permeability in patients with functional dyspepsia","volume":"160","author":"Wauters","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0035","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1053\/j.gastro.2016.02.011","article-title":"Gastroduodenal disorders","volume":"150","author":"Stanghellini","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0040","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1136\/gutjnl-2017-314722","article-title":"Modern diagnosis of GERD: the Lyon consensus","volume":"67","author":"Gyawali","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jcp.25.1.1","article-title":"The histological diagnosis of chronic gastritis in fibreoptic gastroscope biopsy specimens","volume":"25","author":"Whitehead","year":"1972","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000197701","article-title":"The histological classification of duodenitis in fibreoptic biopsy specimens","volume":"13","author":"Whitehead","year":"1975","journal-title":"Digestion"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0055","doi-asserted-by":"crossref","first-page":"530","DOI":"10.17235\/reed.2018.5599\/2018","article-title":"Dyspepsia, functional dyspepsia and Roma IV criteria","volume":"110","author":"Caballero-Mateos","year":"2018","journal-title":"Rev Esp Enferm Dig"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0060","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.cgh.2010.05.031","article-title":"What is the prevalence of clinically significant endoscopic findings in subjects with dyspepsia? Systematic review and meta-analysis","volume":"8","author":"Ford","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0065","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S2468-1253(18)30003-7","article-title":"Epidemiology, clinical characteristics, and associations for symptom-based Rome IV functional dyspepsia in adults in the USA, Canada, and the UK: A cross-sectional population-based study","volume":"3","author":"Aziz","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0070","first-page":"781","article-title":"Epidemiology of dyspepsia in a random Mediterranean population. Prevalence of Helicobacter pylori infection","volume":"92","author":"Caballero-Plasencia","year":"2000","journal-title":"Rev Esp Enferm Dig"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0075","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/BF01600253","article-title":"Helicobacter colonization and histopathological profile of chronic gastritis in patients with or without dyspepsia, mucosal erosion and peptic ulcer: A morphological approach to the study of ulcerogenesis in man","volume":"420","author":"Fiocca","year":"1992","journal-title":"Virchows Archiv A Pathol Anat"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0080","first-page":"8","article-title":"\u00bfExiste alguna relaci\u00f3n entre la sintomatolog\u00eda digestiva y la infecci\u00f3n por H. pylori?","volume":"87","author":"Boixeda","year":"1995","journal-title":"Rev Esp Enferm Dig"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0085","first-page":"292","article-title":"Histopathology of gastro-duodenal biopsies and Helicobacter Pylori infection","volume":"4902","author":"D\u2019costa","year":"2007","journal-title":"BHJ"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0090","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s10620-011-1960-z","article-title":"Impact of Helicobacter pylori infection and microscopic duodenal histopathological changes on Clinical symptoms of patients with functional dyspepsia","volume":"57","author":"Mirbagheri","year":"2012","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0095","first-page":"CD002096","article-title":"Eradication of Helicobacter pylori for non-ulcer dyspepsia","volume":"16","author":"Moayyedi","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0100","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/MCG.0b013e31829f2e25","article-title":"Efficacy of Helicobacter pylori eradication therapy on functional dyspepsia: A meta-analysis of randomized controlled studies with 12-month follow-up","volume":"48","author":"Zhao","year":"2014","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0105","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrgastro.2013.9","article-title":"Helicobacter pylori infection in functional dyspepsia","volume":"10","author":"Suzuki","year":"2013","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0110","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/nmo.12305","article-title":"The gastric accommodation response to meal intake determines the occurrence of transient lower esophageal sphincter relaxations and reflux events in patients with gastro-esophageal reflux disease","volume":"26","author":"Pauwels","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0115","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/apt.15308","article-title":"Duodenal eosinophilia is associated with functional dyspepsia and new onset gastro-oesophageal reflux disease","volume":"50","author":"Ronkainen","year":"2019","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0120","doi-asserted-by":"crossref","first-page":"e12734","DOI":"10.1111\/hel.12734","article-title":"Review: Epidemiology of Helicobacter pylori","volume":"25","author":"Mezmale","year":"2020","journal-title":"Helicobacter"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0125","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/jcp.49.5.377","article-title":"Histology of chronic gastritis with and without duodenitis in patients with Helicobacter pylori infection","volume":"49","author":"Phull","year":"1996","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0130","first-page":"EC01","article-title":"Histomorphological spectrum of duodenal pathology in functional dyspepsia patients","volume":"11","author":"Chaudhari","year":"2017","journal-title":"J Clin Diag Res"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0135","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/j.humpath.2010.04.010","article-title":"Gastric foveolar metaplasia and gastric heterotopia in the duodenum: No evidence of an etiologic role for Helicobacter pylori","volume":"41","author":"Genta","year":"2010","journal-title":"Human Pathology"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0140","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/00365528909093064","article-title":"The clinical relevance of endoscopic and histologic inflammation of gastroduodenal mucosa in dyspepsia of unknown origin","volume":"24","author":"J\u00f6nsson","year":"1989","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0145","doi-asserted-by":"crossref","first-page":"212","DOI":"10.5056\/jnm18176","article-title":"Degranulated eosinophils contain more fine nerve fibers in the duodenal mucosa of patients with functional dyspepsia","volume":"25","author":"Lee","year":"2019","journal-title":"J Neurogastroenterol Motil"},{"key":"10.1016\/j.rgmxen.2022.03.009_bib0150","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1136\/jcp.43.12.981","article-title":"Gastric epithelium in the duodenum: its association with Helicobacter pylori and inflammation","volume":"43","author":"Wyatt","year":"1990","journal-title":"J Clin Pathol"}],"container-title":["Revista de Gastroenterolog\u00eda de M\u00e9xico (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2255534X2200024X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2255534X2200024X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T08:54:24Z","timestamp":1762419264000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2255534X2200024X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S2255534X2200024X"],"URL":"https:\/\/doi.org\/10.1016\/j.rgmxen.2022.03.009","relation":{},"ISSN":["2255-534X"],"issn-type":[{"value":"2255-534X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory map of the gastroduodenal mucosa in patients with upper gastrointestinal symptoms. The role of H. pylori infection","name":"articletitle","label":"Article Title"},{"value":"Revista de Gastroenterolog\u00eda de M\u00e9xico (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rgmxen.2022.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.rgmx.2021.10.001","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Asociaci\u00f3n Mexicana de Gastroenterolog\u00eda. Published by Masson Doyma M\u00e9xico S.A.","name":"copyright","label":"Copyright"}]}}