{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:16:19Z","timestamp":1793646979934,"version":"4.5.1"},"reference-count":16,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T00:00:00Z","timestamp":1684195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista de Gastroenterolog\u00eda de M\u00e9xico (English Edition)"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.rgmxen.2023.05.006","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T11:47:37Z","timestamp":1684756057000},"page":"70-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy and safety of lubiprostone for the treatment of chronic idiopathic constipation: A phase 3, randomized, placebo-controlled study"],"prefix":"10.1016","volume":"89","author":[{"given":"E.","family":"Coss-Adame","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Remes-Troche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Flores Rend\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"Tamayo de la Cuesta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Valdovinos D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rgmxen.2023.05.006_bib0005","unstructured":"National Institute of Diabetes and Digestive and Kidney Diseases. Constipation. US Department of Health and Human Services."},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0010","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1053\/j.gastro.2012.10.028","article-title":"American Gastroenterological Association technical review on constipation","volume":"144","author":"Bharucha","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0015","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000010631","article-title":"Chronic constipation: A review of literature","volume":"97","author":"Forootan","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0020","first-page":"168","article-title":"Consenso mexicano sobre estre\u00f1imiento cr\u00f3nico","volume":"83","author":"Remes-Troche","year":"2018","journal-title":"Rev Gastroenterol M\u00e9x"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0025","first-page":"S55","article-title":"Update on the management of chronic idiopathic constipation","volume":"25","author":"Lacy","year":"2019","journal-title":"Am J Manag Care"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0030","doi-asserted-by":"crossref","first-page":"C178","DOI":"10.1152\/ajpcell.00072.2011","article-title":"Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin","volume":"302","author":"Nighot","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0035","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s10620-011-1702-2","article-title":"Lubiprostone for the treatment of adults with constipation and irritable bowel syndrome","volume":"56","author":"Schey","year":"2011","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0040","doi-asserted-by":"crossref","first-page":"G647","DOI":"10.1152\/ajpgi.00183.2006","article-title":"Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone","volume":"292","author":"Moeser","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0045","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1517\/14740338.2012.708732","article-title":"Safety evaluation of lubiprostone in the treatment of constipation and irritable bowel syndrome","volume":"11","author":"Chamberlain","year":"2012","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0050","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1517\/17425255.2013.876410","article-title":"Lubiprostone: pharmacokinetic, pharmacodynamic, safety and regulatory aspects in the treatment of constipation-predominant irritable bowel syndrome","volume":"10","author":"Raschi","year":"2014","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0055","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1111\/j.1365-2036.2007.03320.x","article-title":"Lubiprostone, a locally acting chloride channel activator, in adult patients with chronic constipation: a double-blind, placebo-controlled, dose-ranging study to evaluate efficacy and safety","volume":"25","author":"Johanson","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0060","unstructured":"World Gastroenterology Organisation Global Guidelines. Constipation: a global perspective. DOI 10.1097\/MCG.0b013e31820fb914."},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0065","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1572-0241.2007.01524.x","article-title":"Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of lubiprostone, a locally-acting type-2 chloride channel activator, in patients with chronic constipation","volume":"103","author":"Johanson","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0070","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1007\/s10620-009-1068-x","article-title":"Efficacy and safety of lubiprostone in patients with chronic constipation","volume":"55","author":"Barish","year":"2010","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0075","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1053\/j.gastro.2005.11.061","article-title":"Functional bowel disorders","volume":"130","author":"Longstreth","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.rgmxen.2023.05.006_bib0080","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1007\/s10620-011-1801-0","article-title":"Long-term safety and effectiveness of lubiprostone, a chloride channel (ClC-2) activator, in patients with chronic idiopathic constipation","volume":"56","author":"Lembo","year":"2011","journal-title":"Dig Dis Sci"}],"container-title":["Revista de Gastroenterolog\u00eda de M\u00e9xico (English Edition)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2255534X23000622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2255534X23000622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T07:03:09Z","timestamp":1718780589000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2255534X23000622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S2255534X23000622"],"URL":"https:\/\/doi.org\/10.1016\/j.rgmxen.2023.05.006","relation":{},"ISSN":["2255-534X"],"issn-type":[{"value":"2255-534X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of lubiprostone for the treatment of chronic idiopathic constipation: A phase 3, randomized, placebo-controlled study","name":"articletitle","label":"Article Title"},{"value":"Revista de Gastroenterolog\u00eda de M\u00e9xico (English Edition)","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rgmxen.2023.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2023 Published by Masson Doyma M\u00e9xico S.A. on behalf of Asociaci\u00f3n Mexicana de Gastroenterolog\u00eda.","name":"copyright","label":"Copyright"}]}}