{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:24:33Z","timestamp":1792607073684,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"1","content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Iberoamericana de Micolog\u00eda"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.riam.2013.09.015","type":"journal-article","created":{"date-parts":[[2013,11,16]],"date-time":"2013-11-16T23:15:20Z","timestamp":1384643720000},"page":"62-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["The immune response against Candida spp. and Sporothrix schenckii"],"prefix":"10.1016","volume":"31","author":[{"given":"Jos\u00e9 A.","family":"Mart\u00ednez-\u00c1lvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"P\u00e9rez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Flores-Carre\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor M.","family":"Mora-Montes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.riam.2013.09.015_bib0005","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1469-0691.2009.02824.x","article-title":"Different virulence levels of the species of Sporothrix in a murine model","volume":"15","author":"Arrillaga-Moncrieff","year":"2009","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.riam.2013.09.015_bib0010","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0171-2985(96)80059-3","article-title":"Tumor necrosis factor (TNF) induction from monocyte\/macrophages by Candida species","volume":"196","author":"Aybay","year":"1996","journal-title":"Immunobiology"},{"key":"10.1016\/j.riam.2013.09.015_bib0015","doi-asserted-by":"crossref","first-page":"940383","DOI":"10.1155\/2010\/940383","article-title":"Normal human gingival epithelial cells sense C. parapsilosis by toll-like receptors and module its pathogenesis through antimicrobial peptides and proinflammatory cytokines","volume":"2010","author":"Bahri","year":"2010","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.riam.2013.09.015_bib0020","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.4049\/jimmunol.1002599","article-title":"Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-b signaling","volume":"186","author":"Bourgeois","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.riam.2013.09.015_bib0025","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1126\/science.1222236","article-title":"Tackling human fungal infections","volume":"336","author":"Brown","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.riam.2013.09.015_bib0030","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1099\/00222615-28-3-173","article-title":"Candidacidal mechanisms of peritoneal macrophages activated with lymphokines or gamma-interferon","volume":"28","author":"Brummer","year":"1989","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.riam.2013.09.015_bib0035","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1023\/A:1006964516334","article-title":"Host organism defense by a peptide-polysaccharide extracted from the fungus Sporothrix schenckii","volume":"144","author":"Carlos","year":"1999","journal-title":"Mycopathologia"},{"key":"10.1016\/j.riam.2013.09.015_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11046-009-9190-z","article-title":"Current research on the immune response to experimental sporotrichosis","volume":"168","author":"Carlos","year":"2009","journal-title":"Mycopathologia"},{"key":"10.1016\/j.riam.2013.09.015_bib0045","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1046\/j.1365-3083.2003.01175.x","article-title":"Sporothrix schenckii lipid inhibits macrophage phagocytosis: involvement of nitric oxide and tumour necrosis factor-\u03b1","volume":"57","author":"Carlos","year":"2003","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.riam.2013.09.015_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0036-46652009000100001","article-title":"Excretion\u2013secretion products and proteases from live Sporothrix schenckii yeast phase: immunological detection and cleavage of human IgG","volume":"51","author":"Da Rosa","year":"2009","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"10.1016\/j.riam.2013.09.015_bib0055","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/13693780801914898","article-title":"Asteroid body in sporotrichosis. Yeast viability and biological significance within the host immune response","volume":"46","author":"Da Rosa","year":"2008","journal-title":"Med Mycol"},{"key":"10.1016\/j.riam.2013.09.015_bib0060","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1365-3083.2011.02636.x","article-title":"Antibodies against Sporothrix schenckii enhance TNF-\u03b1 production and killing by macrophages","volume":"75","author":"de Lima Franco","year":"2012","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.riam.2013.09.015_bib0065","doi-asserted-by":"crossref","first-page":"e32621","DOI":"10.1371\/journal.pone.0032621","article-title":"Development of an in vitro model for the multi-parametric quantification of the cellular interactions between Candida yeasts and phagocytes","volume":"7","author":"Dementhon","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.riam.2013.09.015_bib0070","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12281-012-0109-7","article-title":"Role of the fungal cell wall in pathogenesis and antifungal resistance","volume":"6","author":"D\u00edaz-Jim\u00e9nez","year":"2012","journal-title":"Curr Fungal Infect Rep"},{"key":"10.1016\/j.riam.2013.09.015_bib0075","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2567.2007.02712.x","article-title":"Detrimental role of endogenous nitric oxide in host defence against Sporothrix schenckii","volume":"123","author":"Fernandes","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.riam.2013.09.015_bib0080","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1128\/IAI.00044-11","article-title":"The interaction between Candida krusei and murine macrophages results in multiple outcomes, including intracellular survival and escape from killing","volume":"79","author":"Garc\u00eda-Rodas","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.riam.2013.09.015_bib0085","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrmicro2711","article-title":"Candida albicans morphogenesis and host defence: discriminating invasion from colonization","volume":"10","author":"Gow","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.riam.2013.09.015_bib0090","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.micinf.2012.06.001","article-title":"Phagocytic receptors on macrophages distinguish between different Sporothrix schenckii morphotypes","volume":"14","author":"Guzman-Beltran","year":"2012","journal-title":"Microbes Infect"},{"key":"10.1016\/j.riam.2013.09.015_bib0095","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1099\/00222615-42-4-291","article-title":"Various Candida and Torulopsis species differ in their ability to induce the production of C3, factor B and granulocyte-macrophage colony-stimulating factor (GM-CSF) in human monocyte cultures","volume":"42","author":"H\u00f8g\u00e5sen","year":"1995","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.riam.2013.09.015_bib0100","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1601-0825.2007.01318.x","article-title":"IL-1\u03b1, IL-1ra and IL-8 are differentially induced by Candida in experimental oral candidiasis","volume":"13","author":"Jayatilake","year":"2007","journal-title":"Oral Dis"},{"key":"10.1016\/j.riam.2013.09.015_bib0105","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1128\/IAI.72.9.5073-5079.2004","article-title":"Impaired host defense against Sporothrix schenckii in mice with chronic granulomatous disease","volume":"72","author":"Kajiwara","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.riam.2013.09.015_bib0110","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/cmi.12103","article-title":"The role of galectin-3 in phagocytosis of Candida albicans and Candida parapsilosis by human neutrophils","volume":"15","author":"Linden","year":"2013","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.riam.2013.09.015_bib0115","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3109\/13693780903164566","article-title":"High efficiency opsonin-independent phagocytosis of Candida parapsilosis by human neutrophils","volume":"48","author":"Linden","year":"2010","journal-title":"Med Mycol"},{"key":"10.1016\/j.riam.2013.09.015_bib0120","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fmicb.2011.00243","article-title":"Sporothrix schenckii cell wall peptidorhamnomannans","volume":"2","author":"Lopes-Bezerra","year":"2011","journal-title":"Front Microbiol"},{"key":"10.1016\/j.riam.2013.09.015_bib0125","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2217\/fmb.10.157","article-title":"Sporothrix schenckii complex and sporotrichosis, an emerging health problem","volume":"6","author":"L\u00f3pez-Romero","year":"2011","journal-title":"Future Microbiol"},{"key":"10.1016\/j.riam.2013.09.015_bib0130","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1128\/IAI.62.4.1489-1493.1994","article-title":"Phagocytosis of medically important yeasts by polymorphonuclear leukocytes","volume":"62","author":"Lyman","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.riam.2013.09.015_bib0135","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11046-005-0142-y","article-title":"Influence of Th1\/Th2 cytokines and nitric oxide in murine systemic infection induced by Sporothrix schenckii","volume":"161","author":"Maia","year":"2006","journal-title":"Mycopathologia"},{"key":"10.1016\/j.riam.2013.09.015_bib0140","doi-asserted-by":"crossref","first-page":"e1003315","DOI":"10.1371\/journal.ppat.1003315","article-title":"Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1","volume":"9","author":"Marakalala","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.riam.2013.09.015_bib0145","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.4049\/jimmunol.146.8.2790","article-title":"Mechanisms of host defense against Candida species. II. Biochemical basis for the killing of Candida by mononuclear phagocytes","volume":"146","author":"Marodi","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.riam.2013.09.015_bib0150","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.4049\/jimmunol.146.8.2783","article-title":"Mechanisms of host defense against Candida species. I. Phagocytosis by monocytes and monocyte-derived macrophages","volume":"146","author":"Marodi","year":"1991","journal-title":"J Immunol"},{"key":"10.1016\/j.riam.2013.09.015_bib0155","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1128\/IAI.01282-10","article-title":"Recognition and blocking of innate immunity cells by Candida albicans chitin","volume":"79","author":"Mora-Montes","year":"2011","journal-title":"Infect Immun"},{"key":"10.1016\/j.riam.2013.09.015_bib0160","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2217\/fmb.09.88","article-title":"Protein glycosylation in Candida","volume":"4","author":"Mora-Montes","year":"2009","journal-title":"Future Microbiol"},{"key":"10.1016\/j.riam.2013.09.015_bib0165","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00430-011-0209-y","article-title":"Activation of MAPK\/c-Fos induced responses in oral epithelial cells is specific to Candida albicans and Candida dubliniensis hyphae","volume":"201","author":"Moyes","year":"2012","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.riam.2013.09.015_bib0170","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1471-2180-11-122","article-title":"In vitro interactions of Candida parapsilosis wild type and lipase deficient mutants with human monocyte derived dendritic cells","volume":"11","author":"Nagy","year":"2011","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.riam.2013.09.015_bib0175","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.femsim.2004.08.004","article-title":"Humoral immune response against soluble and fractionate antigens in experimental sporotrichosis","volume":"43","author":"Nascimento","year":"2005","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.riam.2013.09.015_bib0180","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1002\/eji.200838513","article-title":"Passive immunization with monoclonal antibody against a 70-kDa putative adhesin of Sporothrix schenckii induces protection in murine sporotrichosis","volume":"38","author":"Nascimento","year":"2008","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.riam.2013.09.015_bib0185","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3109\/08820139.2012.719982","article-title":"Role of TLR-2 and fungal surface antigens on innate immune response against Sporothrix schenckii","volume":"42","author":"Negrini Tde","year":"2013","journal-title":"Immunol Invest"},{"key":"10.1016\/j.riam.2013.09.015_bib0190","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrmicro1815","article-title":"An integrated model of the recognition of Candida albicans by the innate immune system","volume":"6","author":"Netea","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.riam.2013.09.015_bib0195","doi-asserted-by":"crossref","first-page":"e1000760","DOI":"10.1371\/journal.ppat.1000760","article-title":"A novel pseudopodial component of the dendritic cell anti-fungal response: the fungipod","volume":"6","author":"Neumann","year":"2010","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.riam.2013.09.015_bib0200","doi-asserted-by":"crossref","first-page":"e1001322","DOI":"10.1371\/journal.ppat.1001322","article-title":"Host iron withholding demands siderophore utilization for Candida glabrata to survive macrophage killing","volume":"7","author":"Nevitt","year":"2011","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.riam.2013.09.015_bib0205","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/infdis\/139.2.152","article-title":"Cell-mediated immune responses III sporotrichosis","volume":"139","author":"Plouffe","year":"1979","journal-title":"J Infect Dis"},{"key":"10.1016\/j.riam.2013.09.015_bib0210","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1099\/00222615-41-6-384","article-title":"Interaction of Candida krusei with human neutrophils in vitro","volume":"41","author":"Richardson","year":"1994","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.riam.2013.09.015_bib0215","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/jlb.57.4.651","article-title":"Effects of granulocyte colony-stimulating factor and interferon-gamma on antifungal activity of human polymorphonuclear neutrophils against pseudohyphae of different medically important Candida species","volume":"57","author":"Roilides","year":"1995","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.riam.2013.09.015_bib0220","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1590\/S0074-02762011000200021","article-title":"2D-immunoblotting analysis of Sporothrix schenckii cell wall","volume":"106","author":"Ruiz-Baca","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.riam.2013.09.015_bib0225","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/13693780802165789","article-title":"Isolation and some properties of a glycoprotein of 70kDa (Gp70) from the cell wall of Sporothrix schenckii involved in fungal adherence to dermal extracellular matrix","volume":"47","author":"Ruiz-Baca","year":"2009","journal-title":"Med Mycol"},{"key":"10.1016\/j.riam.2013.09.015_bib0230","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1084\/jem.152.1.85","article-title":"Macrophage microbicidal activity. Correlation between phagocytosis-associated oxidative metabolism and the killing of Candida by macrophages","volume":"152","author":"Sasada","year":"1980","journal-title":"J Exp Med"},{"key":"10.1016\/j.riam.2013.09.015_bib0235","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2567.2009.03118.x","article-title":"Response of macrophage Toll-like receptor 4 to a Sporothrix schenckii lipid extract during experimental sporotrichosis","volume":"128","author":"Sass\u00e1","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.riam.2013.09.015_bib0240","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11046-012-9523-1","article-title":"Immune response against Sporothrix schenckii in TLR-4-deficient mice","volume":"174","author":"Sass\u00e1","year":"2012","journal-title":"Mycopathologia"},{"key":"10.1016\/j.riam.2013.09.015_bib0245","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1128\/IAI.51.1.6-9.1986","article-title":"Activation of the alternative complement pathway by Sporothrix schenckii","volume":"51","author":"Scott","year":"1986","journal-title":"Infect Immun"},{"key":"10.1016\/j.riam.2013.09.015_bib0250","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.4049\/jimmunol.1003730","article-title":"The facultative intracellular pathogen Candida glabrata subverts macrophage cytokine production and phagolysosome maturation","volume":"187","author":"Seider","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.riam.2013.09.015_bib0255","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF00578497","article-title":"Role of cell-mediated immunity in the resistance to experimental sporotrichosis in mice","volume":"120","author":"Shiraishi","year":"1992","journal-title":"Mycopathologia"},{"key":"10.1016\/j.riam.2013.09.015_bib0260","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.4049\/jimmunol.1200185","article-title":"Differential interaction of the two related fungal species Candida albicans and Candida dubliniensis with human neutrophils","volume":"189","author":"Svobodova","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.riam.2013.09.015_bib0265","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1046\/j.1365-280X.1999.00239.x","article-title":"Involvement of CD4+ T cells and macrophages in acquired protection against infection with Sporothrix schenckii in mice","volume":"37","author":"Tachibana","year":"1999","journal-title":"Med Mycol"},{"key":"10.1016\/j.riam.2013.09.015_bib0270","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/BF00509093","article-title":"Complement activation by Sporothrix schenckii","volume":"277","author":"Torinuki","year":"1985","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.riam.2013.09.015_bib0275","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1093\/intimm\/dxl097","article-title":"Differential induction of Th1-prone immunity by human dendritic cells activated with Sporothrix schenckii of cutaneous and visceral origins to determine their different virulence","volume":"18","author":"Uenotsuchi","year":"2006","journal-title":"Int Immunol"},{"key":"10.1016\/j.riam.2013.09.015_bib0280","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1471-2180-8-229","article-title":"Mannose binding lectin plays a crucial role in innate immunity against yeast by enhanced complement activation and enhanced uptake of polymorphonuclear cells","volume":"8","author":"van Asbeck","year":"2008","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.riam.2013.09.015_bib0285","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/00362178585380541","article-title":"In-vitro killing of Candida species by murine immunoeffectors and its relationship to the experimental pathogenicity","volume":"23","author":"Vecchiarelli","year":"1985","journal-title":"Sabouraudia"}],"container-title":["Revista Iberoamericana de Micolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1130140613001125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1130140613001125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T16:04:51Z","timestamp":1688659491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1130140613001125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S1130140613001125"],"URL":"https:\/\/doi.org\/10.1016\/j.riam.2013.09.015","relation":{},"ISSN":["1130-1406"],"issn-type":[{"value":"1130-1406","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The immune response against Candida spp. and Sporothrix schenckii","name":"articletitle","label":"Article Title"},{"value":"Revista Iberoamericana de Micolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.riam.2013.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Revista Iberoamericana de Micolog\u00eda. Published by Elsevier Espa\u00f1a, S.L. All rights reserved.","name":"copyright","label":"Copyright"}]}}