{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:19:05Z","timestamp":1784636345435,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","award":["455745\/2014-5"],"award-info":[{"award-number":["455745\/2014-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista Iberoamericana de Micolog\u00eda"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.riam.2019.06.003","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T18:56:09Z","timestamp":1574276169000},"page":"181-185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Candidemia in a public hospital in Northeastern Brazil: Epidemiological features and risk factors in critically ill patients"],"prefix":"10.1016","volume":"36","author":[{"given":"Renata Baltar","family":"da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rejane Pereira","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia Lemos","family":"Hinrichsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginaldo Gon\u00e7alves","family":"de Lima-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.riam.2019.06.003_bib0150","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1128\/JCM.43.4.1829-1835.2005","article-title":"Epidemiology and predictors of mortality in cases of Candida bloodstream infection: results from population-based surveillance, Barcelona, Spain, from 2002 to 2003","volume":"43","author":"Almirante","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.riam.2019.06.003_bib0155","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1097\/CCM.0b013e318236f297","article-title":"Systemic antifungal therapy in critically ill patients without invasive fungal infection","volume":"40","author":"Azoulay","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.riam.2019.06.003_bib0160","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1590\/S1413-86702006000100008","article-title":"Evaluation of blood stream infections by Candida in three tertiary hospitals in Salvador, Brazil: a case\u2013control study","volume":"10","author":"Barberino","year":"2006","journal-title":"Braz J Infect Dis"},{"key":"10.1016\/j.riam.2019.06.003_bib0165","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/cc9239","article-title":"Bench-to-bedside review: therapeutic management of invasive candidiasis in the intensive care unit","volume":"14","author":"Bassetti","year":"2010","journal-title":"Crit Care"},{"key":"10.1016\/j.riam.2019.06.003_bib0170","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00134-014-3310-z","article-title":"A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality","volume":"40","author":"Bassetti","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.riam.2019.06.003_bib0175","series-title":"Basic and clinical biostatistics","year":"1990"},{"key":"10.1016\/j.riam.2019.06.003_bib0180","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s00134-014-3400-y","article-title":"Prognostic factors and historical trends in the epidemiology of candidemia in critically ill patients: an analysis of five multicenter centers sequentially conducted over a 9-year period","volume":"40","author":"Colombo","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.riam.2019.06.003_bib0185","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1128\/JCM.00773-06","article-title":"Epidemiology of candidemia in Brazil: a nationwide sentinel surveillance of candidemia in eleven medical centers","volume":"44","author":"Colombo","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.riam.2019.06.003_bib0190","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0732-8893(99)00042-5","article-title":"High rate of non-albicans candidemia in Brazilian tertiary care hospitals","volume":"34","author":"Colombo","year":"1999","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.riam.2019.06.003_bib0195","first-page":"113","article-title":"Epidemiology and treatment of hematogenous candidiasis: a Brazilian perspective","volume":"4","author":"Colombo","year":"2000","journal-title":"Braz J Infect Dis"},{"key":"10.1016\/j.riam.2019.06.003_bib0200","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.eimc.2012.09.011","article-title":"Candida: epidemiologia y factores de riesgo para especies no albicans","volume":"31","author":"Cornistein","year":"2013","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1016\/j.riam.2019.06.003_bib0205","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1590\/S0037-86822008000100005","article-title":"Candidemia em um hospital terci\u00e1rio brasileiro: incid\u00eancia, freq\u00fc\u00eancia das diferentes esp\u00e9cies, fatores de risco e suscetibilidade aos antif\u00fangicos","volume":"41","author":"Fran\u00e7a","year":"2008","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1016\/j.riam.2019.06.003_bib0210","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1590\/S1676-24442010000300009","article-title":"Physiopathogenesis, epidemiology and laboratory diagnosis of candidemia","volume":"46","author":"Giolo","year":"2010","journal-title":"J Bras Patol Med Lab"},{"key":"10.1016\/j.riam.2019.06.003_bib0215","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1469-0691.12539","article-title":"Global trends in the distribution of Candida species causing candidemia","volume":"20","author":"Guinea","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.riam.2019.06.003_bib0220","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1590\/S0037-86822008000400014","article-title":"Candidemia in a tertiary hospital in northeastern Brazil","volume":"41","author":"Hinrichsen","year":"2008","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1016\/j.riam.2019.06.003_bib0225","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1590\/S1517-83822009000200021","article-title":"Candida isolates in tertiary hospitals in northeastern Brazil","volume":"40","author":"Hinrichsen","year":"2009","journal-title":"Braz J Microbiol"},{"key":"10.1016\/j.riam.2019.06.003_bib0230","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.3201\/eid2111.150404","article-title":"Uncommon Candida species fungemia in cancer patients, Houston, Texas, USA","volume":"21","author":"Jung","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.riam.2019.06.003_bib0235","doi-asserted-by":"crossref","first-page":"398","DOI":"10.11604\/pamj.2014.19.398.4960","article-title":"A surveillance of nosocomial Candida infections: epidemiology and influences on mortality in intensive care units","volume":"19","author":"Karacaer","year":"2014","journal-title":"Pan Afr Med J"},{"key":"10.1016\/j.riam.2019.06.003_bib0240","first-page":"1","article-title":"Behavior of candidemia in an Intensive Care Unit","volume":"14","author":"Larrondo","year":"2013","journal-title":"Rev Acta M\u00e9dica"},{"key":"10.1016\/j.riam.2019.06.003_bib0245","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1097\/CCM.0b013e31819daa14","article-title":"Usefulness of the \u201cCandida score\u201d for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: a prospective multicenter study","volume":"37","author":"Le\u00f3n","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.riam.2019.06.003_bib0250","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1590\/S0036-46652006000100004","article-title":"Candidemia in a Brazilian hospital: the importance of Candida parapsilosis","volume":"48","author":"Medrano","year":"2006","journal-title":"Rev Inst Med Trop"},{"key":"10.1016\/j.riam.2019.06.003_bib0255","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10096-002-0697-1","article-title":"Risk factors for breakthrough candidemia","volume":"21","author":"Nucci","year":"2002","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.riam.2019.06.003_bib0260","doi-asserted-by":"crossref","first-page":"e59373","DOI":"10.1371\/journal.pone.0059373","article-title":"Epidemiology of candidemia in Latin America: a laboratory-based survey","volume":"8","author":"Nucci","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.riam.2019.06.003_bib0265","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/01.CCM.0000201897.78123.44","article-title":"Invasive candidiasis in the intensive care unit","volume":"34","author":"Ostrosky-Zeichner","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.riam.2019.06.003_bib0270","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0732-8893(02)00423-6","article-title":"Hematogenous infections due to Candida parapsilosis: changing trends in fungemic patients at a comprehensive cancer center during the last four decades","volume":"44","author":"Safdar","year":"2002","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.riam.2019.06.003_bib0275","article-title":"Comportamiento de la candidemia en una unidad de cuidados intensivos","volume":"12","author":"Serafin","year":"2013","journal-title":"Rev Cub Med Int Emerg"},{"key":"10.1016\/j.riam.2019.06.003_bib0280","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11046-015-9872-7","article-title":"Neonatal candidemia caused by Candida haemulonii: case report and review of literature","volume":"180","author":"Silva","year":"2015","journal-title":"Mycopathologia"},{"key":"10.1016\/j.riam.2019.06.003_bib0285","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4067\/S0716-10182011000100008","article-title":"Invasive candidiasis in critically ill adult patient","volume":"28","author":"Tobar","year":"2011","journal-title":"Rev Chil Infectol"},{"key":"10.1016\/j.riam.2019.06.003_bib0290","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1517\/14656566.2013.805204","article-title":"Invasive candidiasis: update on current pharmacotherapy options and future perspectives","volume":"14","author":"Tragiannidis","year":"2013","journal-title":"Expert Opin Pharmacother"}],"container-title":["Revista Iberoamericana de Micolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1130140619300567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1130140619300567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T06:48:15Z","timestamp":1575010095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1130140619300567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S1130140619300567"],"URL":"https:\/\/doi.org\/10.1016\/j.riam.2019.06.003","relation":{},"ISSN":["1130-1406"],"issn-type":[{"value":"1130-1406","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Candidemia in a public hospital in Northeastern Brazil: Epidemiological features and risk factors in critically ill patients","name":"articletitle","label":"Article Title"},{"value":"Revista Iberoamericana de Micolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.riam.2019.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Asociaci\u00f3n Espa\u00f1ola de Micolog\u00eda. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}