{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:50:36Z","timestamp":1766069436647,"version":"3.48.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista de Investigaci\u00f3n Cl\u00ednica"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.ric.2025.100028","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T16:39:39Z","timestamp":1764607179000},"page":"100028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The origins of oral contraception: The role of Mexican scientists in developing the first synthetic oral contraceptive progestin"],"prefix":"10.1016","volume":"77","author":[{"given":"Fernando","family":"Larrea","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Morales-Esponda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayel","family":"Chirinos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"D\u00edaz-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.ric.2025.100028_bib0120","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0039-128X(92)90016-3","article-title":"Steroid research at Syntex: \u201cthe pill\u201d and cortisone","volume":"57","author":"Djerassi","year":"1992","journal-title":"Steroids"},{"issue":"4","key":"10.1016\/j.ric.2025.100028_bib0125","doi-asserted-by":"crossref","first-page":"e202300048","DOI":"10.1002\/tcr.202300048","article-title":"Russell Earl Marker and the beginning of the steroidal pharmaceutical industry","volume":"23","author":"Seeman","year":"2023","journal-title":"Chem Rec"},{"key":"10.1016\/j.ric.2025.100028_bib0130","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0083-6729(08)61100-0","article-title":"Syntheses of cortisone and related steroids","volume":"11","author":"Djerassi","year":"1953","journal-title":"Vitam Horm"},{"issue":"3","key":"10.1016\/j.ric.2025.100028_bib0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032620","article-title":"Advances in the biosynthesis and molecular evolution of steroidal saponins in plants","volume":"24","author":"Li","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.ric.2025.100028_bib0140","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12051021","article-title":"Naturally occurring norsteroids and their design and pharmaceutical application","volume":"12","author":"Dembitsky","year":"2024","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.ric.2025.100028_bib0145","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ajog.2005.02.118","article-title":"Steroids LIV. Synthesis of 19-nor-17alpha-ethynyltestosterone and 19-nor-17alpha-methyltestosterone. 1954","volume":"194","author":"Djerassi","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ric.2025.100028_bib0150","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1021\/acscentsci.5b00066","article-title":"The chemistry of the pill","volume":"1","author":"Gebel Berg","year":"2015","journal-title":"ACS Cent Sci"},{"key":"10.1016\/j.ric.2025.100028_bib0155","first-page":"363","article-title":"An oral contraceptive. A 4-year study of norethindrone","volume":"18","author":"Tyler","year":"1961","journal-title":"Obstet Gynecol"},{"issue":"4460","key":"10.1016\/j.ric.2025.100028_bib0160","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1126\/science.7403868","article-title":"Injectable contraceptive synthesis: an example of international cooperation","volume":"209","author":"Crabbe","year":"1980","journal-title":"Science"},{"key":"10.1016\/j.ric.2025.100028_bib0165","first-page":"1","article-title":"The mother of the pill","volume":"50","author":"Djerassi","year":"1995","journal-title":"Recent Prog Horm Res"},{"issue":"10","key":"10.1016\/j.ric.2025.100028_bib0170","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1021\/ja01202a039","article-title":"Steroidal sapogenins; the biogenesis of steroidal sapogenins in plants","volume":"69","author":"Marker","year":"1947","journal-title":"J Am Chem Soc"},{"issue":"9","key":"10.1016\/j.ric.2025.100028_bib0175","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1210\/endo.142.9.8401","article-title":"A-ring reduced metabolites of 19-nor synthetic progestins as subtype selective agonists for ER alpha","volume":"142","author":"Larrea","year":"2001","journal-title":"Endocrinology"},{"issue":"2\u20133","key":"10.1016\/j.ric.2025.100028_bib0180","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jsbmb.2006.01.005","article-title":"Synthetic 19-nortestosterone derivatives as estrogen receptor alpha subtype-selective ligands induce similar receptor conformational changes and steroid receptor coactivator recruitment than natural estrogens","volume":"99","author":"Garcia-Becerra","year":"2006","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"12","key":"10.1016\/j.ric.2025.100028_bib0185","first-page":"e757","article-title":"Half a century of the oral contraceptive pill: historical review and view to the future","volume":"58","author":"Liao","year":"2012","journal-title":"Can Fam Physician"},{"issue":"3735","key":"10.1016\/j.ric.2025.100028_bib0190","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.153.3735.493","article-title":"Control of conception by hormonal steroids","volume":"153","author":"Pincus","year":"1966","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.ric.2025.100028_bib0195","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1210\/endo-59-6-695","article-title":"Studies of the biological activity of certain 19-nor steroids in female animals","volume":"59","author":"Chang","year":"1956","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.ric.2025.100028_bib0200","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/0002-9378(58)90722-1","article-title":"Fertility control with oral medication","volume":"75","author":"Pincus","year":"1958","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.ric.2025.100028_bib0205","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1749-6632.1958.tb46797.x","article-title":"Effects of certain 19-nor steroids upon reproductive processes","volume":"71","author":"Pincus","year":"1958","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"10.1016\/j.ric.2025.100028_bib0210","first-page":"431","article-title":"Effect of a progestinestrogen combination (Enovid) on pituitary gonadotrophin and ovulation in rats","volume":"27","author":"Husain","year":"1968","journal-title":"Rev Can Biol"},{"issue":"3","key":"10.1016\/j.ric.2025.100028_bib0215","first-page":"217","article-title":"Effects of oral administration of a norethynodrel\u2013mestranol combination (Enovid) in rats","volume":"27","author":"Husain","year":"1968","journal-title":"Rev Can Biol"},{"issue":"3","key":"10.1016\/j.ric.2025.100028_bib0220","first-page":"137","article-title":"Postmedication fertility in female rats treated with a norethynodrel\u2013mestranol combination (Enovid)","volume":"27","author":"Husain","year":"1968","journal-title":"Rev Can Biol"},{"issue":"1","key":"10.1016\/j.ric.2025.100028_bib0225","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0002-9378(58)90555-6","article-title":"Effects of three 19-nor steroids on human ovulation and menstruation","volume":"75","author":"Garcia","year":"1958","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.ric.2025.100028_bib0230","first-page":"1","article-title":"Twenty years of oral contraception","volume":"15","author":"Rice-Wray","year":"1981","journal-title":"IPPF Med Bull"}],"container-title":["Revista de Investigaci\u00f3n Cl\u00ednica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003483762500484X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003483762500484X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:45:49Z","timestamp":1766069149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003483762500484X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S003483762500484X"],"URL":"https:\/\/doi.org\/10.1016\/j.ric.2025.100028","relation":{},"ISSN":["0034-8376"],"issn-type":[{"type":"print","value":"0034-8376"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The origins of oral contraception: The role of Mexican scientists in developing the first synthetic oral contraceptive progestin","name":"articletitle","label":"Article Title"},{"value":"Revista de Investigaci\u00f3n Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ric.2025.100028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubiran.","name":"copyright","label":"Copyright"}],"article-number":"100028"}}