{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:47:12Z","timestamp":1792072032877,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020205","name":"Jiangxi Province Health Commission","doi-asserted-by":"publisher","award":["202210028"],"award-info":[{"award-number":["202210028"]}],"id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20242BAB25443"],"award-info":[{"award-number":["20242BAB25443"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460303"],"award-info":[{"award-number":["82460303"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista de Investigaci\u00f3n Cl\u00ednica"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ric.2026.100052","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:19:56Z","timestamp":1786994396000},"page":"100052","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Silencing of SEPT9 inhibits proliferation and migration of endometriotic stromal cells via suppression of the PI3K\/AKT signaling pathway"],"prefix":"10.1016","volume":"78","author":[{"given":"Qiong","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Yi","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Yao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Meng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kong-Xian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hui","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ric.2026.100052_bib0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2025.103752","article-title":"Endometriosis and autoimmunity","volume":"24","author":"Blanco","year":"2025","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.ric.2026.100052_bib0180","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","article-title":"Endometriosis: etiology, pathobiology, and therapeutic prospects","volume":"184","author":"Saunders","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.ric.2026.100052_bib0185","doi-asserted-by":"crossref","first-page":"1020827","DOI":"10.3389\/fendo.2022.1020827","article-title":"Endometriosis-associated infertility: from pathophysiology to tailored treatment","volume":"13","author":"Bonavina","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.ric.2026.100052_bib0190","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1186\/s12905-021-01500-4","article-title":"Effect of physical activity and exercise on endometriosis-associated symptoms: a systematic review","volume":"21","author":"Tennfjord","year":"2021","journal-title":"BMC Women's Health"},{"key":"10.1016\/j.ric.2026.100052_bib0195","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/uog.24892","article-title":"Strengths and limitations of diagnostic tools for endometriosis and relevance in diagnostic test accuracy research","volume":"60","author":"Pascoal","year":"2022","journal-title":"Ultrasound Obst Gynecol"},{"key":"10.1016\/j.ric.2026.100052_bib0200","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11154-021-09666-w","article-title":"Hormonal treatments for endometriosis: the endocrine background","volume":"23","author":"Vannuccini","year":"2021","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.ric.2026.100052_bib0205","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/2311-8571.393752","article-title":"Examining the effect of hydroalcoholic extract of Dracaena cinnabari on sex hormones and ovarian and uterine tissues of rats","volume":"10","author":"Najafi","year":"2024","journal-title":"World J Tradit Chin Med"},{"key":"10.1016\/j.ric.2026.100052_bib0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2016.05.029","article-title":"Effect of surgery on ovarian reserve in women with endometriomas, endometriosis and controls","volume":"215","author":"Goodman","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ric.2026.100052_bib0215","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1479-828X.2011.01405.x","article-title":"Identification of endometriosis-related genes by representational difference analysis of cDNA","volume":"52","author":"Chen","year":"2012","journal-title":"Aust N Zeal J Obst Gynaecol"},{"key":"10.1016\/j.ric.2026.100052_bib0220","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1515\/BC.2011.073","article-title":"Septin roles in tumorigenesis","volume":"392","author":"Connolly","year":"2011","journal-title":"bchm"},{"key":"10.1016\/j.ric.2026.100052_bib0225","doi-asserted-by":"crossref","DOI":"10.3390\/cells9102287","article-title":"Targeting DNA repair cell cycle, and tumor microenvironment in B cell lymphoma","volume":"9","author":"Br\u00f6ckelmann","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ric.2026.100052_bib0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116091","article-title":"LCN2: versatile players in breast cancer","volume":"171","author":"Bao","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.ric.2026.100052_bib0235","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.7150\/ijbs.25488","article-title":"Simultaneously targeting DNA damage repair pathway and mTORC1\/2 results in small cell lung cancer growth arrest via ER stress-induced apoptosis","volume":"14","author":"Fang","year":"2018","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.ric.2026.100052_bib0240","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3390\/ijms23031328","article-title":"The apoptosis paradox in cancer","volume":"23","author":"Morana","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ric.2026.100052_bib0245","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/s13046-023-02787-x","article-title":"Role of the DEAD-box RNA helicase DDX5 (p68) in cancer DNA repair, immune suppression, cancer metabolic control, virus infection promotion, and human microbiome (microbiota) negative influence","volume":"42","author":"Li","year":"2023","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.ric.2026.100052_bib0250","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1186\/s12885-024-12877-4","article-title":"SEPT9: from pan-cancer to lung squamous cell carcinoma","volume":"24","author":"Wang","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/j.ric.2026.100052_bib0255","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jmoldx.2016.02.005","article-title":"Detection of colorectal cancer using a simplified SEPT9 gene methylation assay is a reliable method for opportunistic screening","volume":"18","author":"Wu","year":"2016","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.ric.2026.100052_bib0260","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/cac2.12478","article-title":"Combining methylated SEPTIN9 and RNF180 plasma markers for diagnosis and early detection of gastric cancer","volume":"43","author":"Nie","year":"2023","journal-title":"Cancer Commun"},{"key":"10.1016\/j.ric.2026.100052_bib0265","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4251\/wjgo.v10.i1.15","article-title":"Advance in plasma SEPT9 gene methylation assay for colorectal cancer early detection","volume":"10","author":"Wang","year":"2018","journal-title":"World J Gastrointest Oncol"},{"key":"10.1016\/j.ric.2026.100052_bib0270","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1460233","article-title":"Comparative analysis of SDC2 and SEPT9 methylation tests in the early detection of colorectal cancer: a systematic review and meta-analysis","volume":"11","author":"Zhang","year":"2024","journal-title":"Front Med"},{"key":"10.1016\/j.ric.2026.100052_bib0275","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s12672-025-02252-5","article-title":"SEPT9 and PAI-1 are immunohistochemical biomarkers of the hepatocellular carcinoma immune microenvironment","volume":"16","author":"Park","year":"2025","journal-title":"Discov Oncol"},{"key":"10.1016\/j.ric.2026.100052_bib0280","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202201686","article-title":"The concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblasts","volume":"7","author":"Hecht","year":"2024","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.ric.2026.100052_bib0285","first-page":"399","article-title":"Circular RNA circSEPT9 is upregulated in endometrial cancer and promotes cell invasion and migration by downregulating miR-186 through methylation","volume":"52","author":"Guo","year":"2022","journal-title":"Ann Clin Lab Sci"},{"key":"10.1016\/j.ric.2026.100052_bib0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109768","article-title":"Down-regulation of SEPT9 inhibits glioma progression through suppressing TGF-\u03b2-induced epithelial-mesenchymal transition (EMT)","volume":"125","author":"Zhang","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.ric.2026.100052_bib0295","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41419-019-1947-9","article-title":"SEPT9_i1 regulates human breast cancer cell motility through cytoskeletal and RhoA\/FAK signaling pathway regulation","volume":"10","author":"Zeng","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.ric.2026.100052_bib0300","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.201912159","article-title":"CDC42EP5\/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion","volume":"219","author":"Farrugia","year":"2020","journal-title":"J Cell Biol"},{"key":"10.1016\/j.ric.2026.100052_bib0305","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13148-019-0719-9","article-title":"Promoter methylation of SEPT9 as a potential biomarker for early detection of cervical cancer and its overexpression predicts radioresistance","volume":"11","author":"Jiao","year":"2019","journal-title":"Clin Epigenet"},{"key":"10.1016\/j.ric.2026.100052_bib0310","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13148-020-00833-5","article-title":"SEPT9_v2, frequently silenced by promoter hypermethylation, exerts anti-tumor functions through inactivation of Wnt\/\u03b2-catenin signaling pathway via miR92b-3p\/FZD10 in nasopharyngeal carcinoma cells","volume":"12","author":"Jiang","year":"2020","journal-title":"Clin Epigenet"},{"key":"10.1016\/j.ric.2026.100052_bib0315","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ebiom.2018.03.029","article-title":"Plasma mSEPT9: a novel circulating cell-free DNA-based epigenetic biomarker to diagnose hepatocellular carcinoma","volume":"30","author":"Oussalah","year":"2018","journal-title":"eBioMedicine"},{"key":"10.1016\/j.ric.2026.100052_bib0320","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1186\/s12967-024-05635-4","article-title":"Predictive nomogram of the clinical outcomes of colorectal cancer based on methylated SEPT9 and intratumoral IL-10+ Tregs infiltration","volume":"22","author":"Sun","year":"2024","journal-title":"J Transl Med"},{"key":"10.1016\/j.ric.2026.100052_bib0325","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cellsig.2008.11.007","article-title":"Up-regulation of SEPT9_v1 stabilizes c-Jun-N-Terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells","volume":"21","author":"Gonzalez","year":"2009","journal-title":"Cell Signal"},{"key":"10.1016\/j.ric.2026.100052_bib0330","doi-asserted-by":"crossref","first-page":"11142","DOI":"10.1074\/jbc.M808348200","article-title":"SEPT9_v1 up-regulates hypoxia-inducible factor 1 by preventing its RACK1-mediated degradation","volume":"284","author":"Amir","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ric.2026.100052_bib0335","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.3390\/cancers14071652","article-title":"PI3K\/AKT signaling tips the balance of cytoskeletal forces for cancer progression","volume":"14","author":"Deng","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.ric.2026.100052_bib0340","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1007\/s10815-022-02638-2","article-title":"LncRNA IGF2-AS promotes endometriosis progression through targeting miR-370-3p\/IGF2 axis and activating PI3K\/AKT\/mTOR signaling pathway","volume":"39","author":"Jin","year":"2022","journal-title":"J Assist Reprod Genet"}],"container-title":["Revista de Investigaci\u00f3n Cl\u00ednica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034837626000197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034837626000197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:06:39Z","timestamp":1792069599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034837626000197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0034837626000197"],"URL":"https:\/\/doi.org\/10.1016\/j.ric.2026.100052","relation":{},"ISSN":["0034-8376"],"issn-type":[{"value":"0034-8376","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Silencing of SEPT9 inhibits proliferation and migration of endometriotic stromal cells via suppression of the PI3K\/AKT signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Revista de Investigaci\u00f3n Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ric.2026.100052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubiran.","name":"copyright","label":"Copyright"}],"article-number":"100052"}}