{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:47:36Z","timestamp":1792072056063,"version":"4.4.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Revista de Investigaci\u00f3n Cl\u00ednica"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ric.2026.100057","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:50:02Z","timestamp":1790337002000},"page":"100057","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomarker-guided immunotherapy vs. standard care in ICU sepsis: A prospective study"],"prefix":"10.1016","volume":"78","author":[{"given":"Hongyi","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ric.2026.100057_bib0115","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3390\/epidemiologia5030032","article-title":"The global burden of sepsis and septic shock","volume":"5","author":"La Via","year":"2024","journal-title":"Epidemiologia"},{"key":"10.1016\/j.ric.2026.100057_bib0120","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s13054-018-2157-z","article-title":"The global burden of sepsis: barriers and potential solutions","volume":"22","author":"Rudd","year":"2018","journal-title":"Crit Care"},{"key":"10.1016\/j.ric.2026.100057_bib0125","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S1473-3099(13)70001-X","article-title":"Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ric.2026.100057_bib0130","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/imr.12499","article-title":"The immune system's role in sepsis progression, resolution, and long-term outcome","volume":"274","author":"Delano","year":"2016","journal-title":"Immunol Rev"},{"key":"10.1016\/j.ric.2026.100057_bib0135","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1007\/s10156-013-0612-y","article-title":"A Phase II study of polyclonal anti-TNF-\u03b1 (AZD9773) in Japanese patients with severe sepsis and\/or septic shock","volume":"19","author":"Aikawa","year":"2013","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.ric.2026.100057_bib0140","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1186\/s13063-017-2231-x","article-title":"Adjunctive use of physostigmine salicylate (Anticholium\u00ae) in perioperative sepsis and septic shock: study protocol for a randomized, double-blind, placebo-controlled, monocentric trial (Anticholium\u00ae per Se)","volume":"18","author":"Zimmermann","year":"2017","journal-title":"Trials"},{"key":"10.1016\/j.ric.2026.100057_bib0145","doi-asserted-by":"crossref","first-page":"1498974","DOI":"10.3389\/fimmu.2024.1498974","article-title":"Time-dependent variation in immunoparalysis biomarkers among patients with sepsis and critical illness","volume":"15","author":"Samuelsen","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.ric.2026.100057_bib0150","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41420-023-01766-7","article-title":"Immune dysregulation in sepsis: experiences, lessons and perspectives","volume":"9","author":"Cao","year":"2023","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.ric.2026.100057_bib0155","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","article-title":"Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease","volume":"32","author":"Iyer","year":"2012","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.ric.2026.100057_bib0160","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.3390\/jcm14072509","article-title":"Neutrophil-to-lymphocyte ratio as a prognostic biomarker for long-term survival in older adults at a mental health care center: a historical cohort analysis","volume":"14","author":"Chmielewski","year":"2025","journal-title":"J Clin Med"},{"key":"10.1016\/j.ric.2026.100057_bib0165","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.3390\/ijms23073636","article-title":"Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases","volume":"23","author":"Buonacera","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.ric.2026.100057_bib0170","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1111\/ajt.16459","article-title":"Interleukin-6 blockade with tocilizumab increases Tregs and reduces T effector cytokines in renal graft inflammation: a randomized controlled trial","volume":"21","author":"Chandran","year":"2021","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ric.2026.100057_bib0175","doi-asserted-by":"crossref","first-page":"1442909","DOI":"10.3389\/fonc.2024.1442909","article-title":"Real-world treatment patterns, biomarker testing, and clinical outcomes of metastatic non-small cell lung cancer patients in the immunotherapy era","volume":"14","author":"Apter","year":"2024","journal-title":"Front Oncol"},{"key":"10.1016\/j.ric.2026.100057_bib0180","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.ric.2026.100057_bib0185","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13054-020-2830-x","article-title":"Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes","volume":"24","author":"Leijte","year":"2020","journal-title":"Crit Care"},{"key":"10.1016\/j.ric.2026.100057_bib0190","doi-asserted-by":"crossref","first-page":"1043968","DOI":"10.3389\/fimmu.2022.1043968","article-title":"Evaluating IL-6 and IL-10 as rapid diagnostic tools for Gram-negative bacteria and as disease severity predictors in pediatric sepsis patients in the intensive care unit","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.ric.2026.100057_bib0195","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0140-6736(21)00676-0","article-title":"Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial","volume":"397","author":"Abani","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ric.2026.100057_bib0200","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13054-014-0731-6","article-title":"The association between the neutrophil-to-lymphocyte ratio and mortality in critical illness: an observational cohort study","volume":"19","author":"Salciccioli","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.ric.2026.100057_bib0205","first-page":"1","article-title":"Prognostic significance of neutrophil-to-lymphocyte ratio in patients with sepsis: a prospective observational study","volume":"2016","author":"Liu","year":"2016","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.ric.2026.100057_bib0210","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1001\/jama.2010.1553","article-title":"Long-term cognitive impairment and functional disability among survivors of severe sepsis","volume":"304","author":"Iwashyna","year":"2010","journal-title":"JAMA"}],"container-title":["Revista de Investigaci\u00f3n Cl\u00ednica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034837626000240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034837626000240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:06:42Z","timestamp":1792069602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034837626000240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0034837626000240"],"URL":"https:\/\/doi.org\/10.1016\/j.ric.2026.100057","relation":{},"ISSN":["0034-8376"],"issn-type":[{"value":"0034-8376","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomarker-guided immunotherapy vs. standard care in ICU sepsis: A prospective study","name":"articletitle","label":"Article Title"},{"value":"Revista de Investigaci\u00f3n Cl\u00ednica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ric.2026.100057","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Espa\u00f1a, S.L.U. on behalf of Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubiran.","name":"copyright","label":"Copyright"}],"article-number":"100057"}}