{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:20:01Z","timestamp":1778545201811,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"MICINN","doi-asserted-by":"publisher","award":["PID2020-117751RB-I00"],"award-info":[{"award-number":["PID2020-117751RB-I00"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005053","name":"CIBER-BBN","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"FEDER","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"ISCIII","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Developmental Disabilities"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.ridd.2024.104751","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T14:03:26Z","timestamp":1716559406000},"page":"104751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["EEG connectivity patterns in response to gaming and learning-based cognitive stimulations in Rett syndrome"],"prefix":"10.1016","volume":"150","author":[{"given":"Ana","family":"Tost","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan F.","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Bachiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leidy-Yanet","family":"Serna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e9s","family":"Medina-Rivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngeles","family":"Garc\u00eda-Cazorla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel \u00c1ngel","family":"Ma\u00f1anas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ridd.2024.104751_bib1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/hbm.20881","article-title":"Drug effect on EEG connectivity assessed by linear and nonlinear couplings","volume":"31","author":"Alonso","year":"2010","journal-title":"Human Brain Mapping"},{"key":"10.1016\/j.ridd.2024.104751_bib2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/B978-1-4557-7051-9.00055-3","article-title":"Alpha rhythm and sleep spindles in a 20-year-old man","author":"Berry","year":"2015","journal-title":"Sleeping Medicine Pearls"},{"issue":"3","key":"10.1016\/j.ridd.2024.104751_bib3","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3390\/electronics9030491","article-title":"The TCTRS project: a holistic approach for telerehabilitation in Rett syndrome","volume":"9","author":"Capr\u00ec","year":"2020","journal-title":"Electronics"},{"issue":"5","key":"10.1016\/j.ridd.2024.104751_bib4","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.clinph.2008.01.013","article-title":"EEG power and coherence in autistic spectrum disorder","volume":"119","author":"Coben","year":"2008","journal-title":"Clinical Neurophysiology"},{"issue":"1","key":"10.1016\/j.ridd.2024.104751_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/0013164482421003","article-title":"Use of the binomial theorem in interpreting results of multiple tests of significance","volume":"42","author":"Cross","year":"1982","journal-title":"Educational and Psychological Measurement"},{"key":"10.1016\/j.ridd.2024.104751_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.2720","article-title":"MEG measured delta waves increase in adolescents after concussion","author":"Davenport","year":"2022","journal-title":"Brain and Behavior"},{"key":"10.1016\/j.ridd.2024.104751_bib7","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0093-934X(82)90065-7","article-title":"Cerebral lateralization in individuals diagnosed as autistic in early childhood","volume":"15","author":"Dawson","year":"1982","journal-title":"Brain and Language"},{"key":"10.1016\/j.ridd.2024.104751_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ridd.2016.01.009","article-title":"Cognitive training modifies frequency EEG bands and neuropsychological measures in Rett syndrome","volume":"53\u201354","author":"Fabio","year":"2016","journal-title":"Research in Developmental Disabilities"},{"issue":"9","key":"10.1016\/j.ridd.2024.104751_bib9","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1089\/cyber.2018.0711","article-title":"Interactive avatar boosts the performances of children with attention deficit hyperactivity disorder in dynamic measures of intelligence","volume":"22","author":"Fabio","year":"2019","journal-title":"Cyberpsychology, Behavior, and Social Networking"},{"issue":"5","key":"10.1016\/j.ridd.2024.104751_bib10","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/mdc3.13465","article-title":"Repeated motor training on attention reaching skills and stereotypies in rett syndrome","volume":"9","author":"Fabio","year":"2022","journal-title":"Movement Disorders Clinical Practice"},{"key":"10.1016\/j.ridd.2024.104751_bib11","doi-asserted-by":"crossref","unstructured":"Fabio, Rosa Angela, Giorgia Pergolizzi, Andrea Nucita, Giancarlo Iannizzotto, and Tindara Capr\u00ec. 2021. The role of a virtual avatar in attention and memory tasks in Rett syndrome.\u201d doi: 10.1186\/s12883\u2013021-02212-w.","DOI":"10.21203\/rs.3.rs-49996\/v1"},{"issue":"5","key":"10.1016\/j.ridd.2024.104751_bib12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/brainsci10050276","article-title":"Effects of combined transcranial direct current stimulation with cognitive training in girls with Rett syndrome","volume":"10","author":"Fabio","year":"2020","journal-title":"Brain Sciences"},{"issue":"1","key":"10.1016\/j.ridd.2024.104751_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hbm.20371","article-title":"Acute modulation of cortical oscillatory activities during short trains of high-frequency repetitive transcranial magnetic stimulation of the human motor cortex: A combined EEG and TMS study","volume":"29","author":"Fuggetta","year":"2008","journal-title":"Human Brain Mapping"},{"issue":"1","key":"10.1016\/j.ridd.2024.104751_bib14","article-title":"Transcranial magnetic stimulation and connectivity mapping: Tools for studying the neural bases of brain disorders","volume":"4","author":"Hampson","year":"2010","journal-title":"Frontiers in Systems Neuroscience"},{"issue":"2","key":"10.1016\/j.ridd.2024.104751_bib15","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.neuroimage.2006.11.042","article-title":"Regional coherence changes in the early stages of Alzheimer\u2019s disease: A combined structural and resting-state functional MRI study","volume":"35","author":"He","year":"2007","journal-title":"NeuroImage"},{"key":"10.1016\/j.ridd.2024.104751_bib16","doi-asserted-by":"crossref","unstructured":"Hendrayana, Yudy, Jajat Darajat, Kusumah Negara, Agus Gumilar, and Martina Lesyiana. 2021. The impact of beta brain waves in improving cognitive function through brain jogging applications, (April). doi: 10.13189\/saj.2020.080713.","DOI":"10.13189\/saj.2020.080713"},{"key":"10.1016\/j.ridd.2024.104751_bib17","doi-asserted-by":"crossref","unstructured":"Iannizzotto, Giancarlo, Andrea Nucita, Rosa Angela Fabio, Tindara Capr\u00ec, and Lucia Lo Bello. 2020. Remote eye-tracking for cognitive telerehabilitation and interactive school tasks in times of COVID-1,\u00a0doi: 10.3390\/info11060296.","DOI":"10.3390\/info11060296"},{"issue":"5","key":"10.1016\/j.ridd.2024.104751_bib18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4103\/0253-7613.70402","article-title":"\u2018Mean \u00b1 SEM\u2019 or \u2018Mean (SD)\u2019?","volume":"42","author":"Jaykaran","year":"2010","journal-title":"Indian Journal of Pharmacology"},{"issue":"5","key":"10.1016\/j.ridd.2024.104751_bib19","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S1388-2457(01)00513-2","article-title":"Mutual information analysis of the EEG in patients with Alzheimer\u2019s disease","volume":"112","author":"Jeong","year":"2001","journal-title":"Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology"},{"issue":"1","key":"10.1016\/j.ridd.2024.104751_bib20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/s12887-018-1304-7","article-title":"Clinical and genetic rett syndrome variants are defined by stable electrophysiological profiles","volume":"18","author":"Keogh","year":"2018","journal-title":"BMC Pediatrics"},{"issue":"2","key":"10.1016\/j.ridd.2024.104751_bib21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.6001\/actamedica.v25i2.3763","article-title":"The impact of music on the bioelectrical oscillations of the brain","volume":"25","author":"Ku\u010dikien\u0117","year":"2018","journal-title":"Acta Medica Lituanica"},{"key":"10.1016\/j.ridd.2024.104751_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2020.107369","article-title":"Disrupted alertness and related functional connectivity in patients with focal impaired awareness seizures in temporal lobe epilepsy","volume":"112","author":"Liu","year":"2020","journal-title":"Epilepsy & Behavior: E&B"},{"issue":"3","key":"10.1016\/j.ridd.2024.104751_bib23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/jir.12902","article-title":"Cognitive stimulation has potential for brain activation in individuals with Rett syndrome","volume":"66","author":"Migliorelli","year":"2022","journal-title":"Journal of Intellectual Disability Research"},{"key":"10.1016\/j.ridd.2024.104751_bib24","doi-asserted-by":"crossref","first-page":"26032","DOI":"10.1088\/1741-2552\/ab8345","article-title":"SGM: A novel time-frequency algorithm based on unsupervised learning improves high-frequency oscillation detection in epilepsy","volume":"17","author":"Migliorelli","year":"2020","journal-title":"Journal Neural Engineering"},{"issue":"6","key":"10.1016\/j.ridd.2024.104751_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsz081","article-title":"Alterations in EEG connectivity in healthy young adults provide an indicator of sleep depth","volume":"42","author":"Migliorelli","year":"2019","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.ridd.2024.104751_bib26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pediatrneurol.2006.10.003","article-title":"Rett syndrome: Clinical and electrophysiologic aspects","volume":"36","author":"Moser","year":"2007","journal-title":"Pediatric Neurology"},{"key":"10.1016\/j.ridd.2024.104751_bib27","doi-asserted-by":"crossref","unstructured":"Murias, Michael, Sara J. Webb, Jessica Greenson, and Geraldine Dawson. 2006. Resting state cortical connectivity reflected in EEG coherence in individuals with Autism.\u201d","DOI":"10.1016\/j.biopsych.2006.11.012"},{"issue":"6","key":"10.1016\/j.ridd.2024.104751_bib28","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/ana.22124","article-title":"Rett syndrome: Revised diagnostic criteria and nomenclature","volume":"68","author":"Neul","year":"2010","journal-title":"Annals of Neurology"},{"issue":"3","key":"10.1016\/j.ridd.2024.104751_bib29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.31887\/DCNS.2012.14.3\/jneul","article-title":"The relationship of Rett syndrome and MECP2 disorders to autism","volume":"14","author":"Neul","year":"2012","journal-title":"Dialogues in Clinical Neuroscience"},{"issue":"5","key":"10.1016\/j.ridd.2024.104751_bib30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1192\/bjp.170.5.411","article-title":"EEG coherence and syndromes in Schizophrenia","volume":"170","author":"Norman","year":"1997","journal-title":"The British Journal of Psychiatry"},{"issue":"6","key":"10.1016\/j.ridd.2024.104751_bib31","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0387-7604(82)80071-5","article-title":"Ontogenic development of EEG-Asymmetry in early infantile autism","volume":"4","author":"Ogawa","year":"1982","journal-title":"Brain & Development"},{"key":"10.1016\/j.ridd.2024.104751_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/156869","article-title":"FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data","volume":"2011","author":"Oostenveld","year":"2011","journal-title":"Computational Intelligence and Neuroscience"},{"issue":"2160","key":"10.1016\/j.ridd.2024.104751_bib33","article-title":"Coupling in complex systems as information transfer across time scales","volume":"377","author":"Palu\u0161","year":"2019","journal-title":"Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences"},{"key":"10.1016\/j.ridd.2024.104751_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/5073078","article-title":"Illness severity, social and cognitive ability, and EEG analysis of ten patients with rett syndrome treated with Mecasermin (Recombinant Human IGF-1)","volume":"2016","author":"Pini","year":"2016","journal-title":"Autism Research and Treatment"},{"issue":"September","key":"10.1016\/j.ridd.2024.104751_bib35","first-page":"1","article-title":"Brain activity correlates with cognitive performance deterioration during sleep deprivation","volume":"13","author":"Posada-quintero","year":"2019"},{"key":"10.1016\/j.ridd.2024.104751_bib36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.clinph.2022.11.010","article-title":"Alpha and gamma EEG coherence during on-task and mind wandering states in Schizophrenia","volume":"146","author":"Prieto-Alc\u00e1ntara","year":"2023","journal-title":"Clinical Neurophysiology"},{"issue":"5","key":"10.1016\/j.ridd.2024.104751_bib37","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/j.clinph.2016.02.008","article-title":"Coherence in children with AD\/HD and excess alpha power in their EEG","volume":"127","author":"Robbie","year":"2016","journal-title":"Clinical Neurophysiology"},{"issue":"20","key":"10.1016\/j.ridd.2024.104751_bib38","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1080\/09638288.2021.1949398","article-title":"Effects of a remotely supervised motor rehabilitation program for individuals with Rett syndrome at home","volume":"44","author":"Romano","year":"2022","journal-title":"Disability and Rehabilitation"},{"issue":"5","key":"10.1016\/j.ridd.2024.104751_bib39","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.clinph.2010.09.008","article-title":"Intrahemispheric, interhemispheric, and distal EEG coherence in Alzheimer\u2019s disease","volume":"122","author":"Sankari","year":"2011","journal-title":"Clinical Neurophysiology"},{"issue":"4","key":"10.1016\/j.ridd.2024.104751_bib40","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrn1650","article-title":"Normal and pathological oscillatory communication in the brain","volume":"6","author":"Schnitzler","year":"2005","journal-title":"Nature Reviews Neuroscience"},{"issue":"7","key":"10.1016\/j.ridd.2024.104751_bib41","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/j.1460-9568.2009.06937.x","article-title":"Modulation of movement-associated cortical activation by transcranial direct current stimulation","volume":"30","author":"Stagg","year":"2009","journal-title":"European Journal of Neuroscience"},{"issue":"8","key":"10.1016\/j.ridd.2024.104751_bib42","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/S1388-2457(02)00151-7","article-title":"The effects of subthreshold 1 Hz repetitive TMS on cortico-cortical and interhemispheric coherence","volume":"113","author":"Strens","year":"2002","journal-title":"Clinical Neurophysiology"},{"key":"10.1016\/j.ridd.2024.104751_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2022.120381","article-title":"Structural and functional changes in the brains of patients with Rett syndrome: a multimodal MRI study","volume":"441","author":"Takeguchi","year":"2022","journal-title":"Journal of the Neurological Sciences"},{"issue":"3","key":"10.1016\/j.ridd.2024.104751_bib44","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/JP9.0000000000000024","article-title":"A note on error bars as a graphical representation of the variability of data in biomedical research: choosing between standard deviation and standard error of the mean","volume":"2","author":"Tang","year":"2019","journal-title":"Journal of Pancreatology"},{"issue":"8","key":"10.1016\/j.ridd.2024.104751_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/e23081030","article-title":"Choosing strategies to deal with artifactual Eeg data in children with cognitive impairment","volume":"23","author":"Tost","year":"2021","journal-title":"Entropy"},{"key":"10.1016\/j.ridd.2024.104751_bib46","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neuroscience.2015.12.036","article-title":"Cortical connectivity and memory performance in cognitive decline: a study via graph theory from EEG data","volume":"316","author":"Vecchio","year":"2016","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.ridd.2024.104751_bib47","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.yebeh.2010.01.024","article-title":"Correlations between neurophysiological, behavioral, and cognitive function in Rett syndrome","volume":"17","author":"Vignoli","year":"2010","journal-title":"Epilepsy & Behavior"},{"issue":"12","key":"10.1016\/j.ridd.2024.104751_bib48","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.tics.2003.10.012","article-title":"Synchronous neural oscillations and cognitive processes","volume":"7","author":"Ward","year":"2003","journal-title":"Trends in Cognitive Sciences"}],"container-title":["Research in Developmental Disabilities"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0891422224000830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0891422224000830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:07:24Z","timestamp":1778544444000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0891422224000830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":48,"alternative-id":["S0891422224000830"],"URL":"https:\/\/doi.org\/10.1016\/j.ridd.2024.104751","relation":{},"ISSN":["0891-4222"],"issn-type":[{"value":"0891-4222","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EEG connectivity patterns in response to gaming and learning-based cognitive stimulations in Rett syndrome","name":"articletitle","label":"Article Title"},{"value":"Research in Developmental Disabilities","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ridd.2024.104751","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104751"}}