{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:17:13Z","timestamp":1754111833771},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine Case Reports"],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/j.rmcr.2019.01.021","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T11:37:34Z","timestamp":1548761854000},"page":"223-226","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["A case of nivolumab-induced isolated adrenocorticotropic hormone (ACTH) deficiency"],"prefix":"10.1016","volume":"26","author":[{"given":"Yozo","family":"Sato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsunori","family":"Hino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Seike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Gemma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmcr.2019.01.021_bib1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ctrv.2017.06.002","article-title":"Endocrine-related adverse events associated with immune checkpoint blockade and expert insights on their management","volume":"58","author":"Sznol","year":"2017","journal-title":"Cancer Treat Rev."},{"issue":"26","key":"10.1016\/j.rmcr.2019.01.021_bib2","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1056\/NEJMoa1200690","article-title":"Safety, activity, and immune correlates of anti-PD-1 antibody in cancer","volume":"366","author":"Topalian","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.rmcr.2019.01.021_bib3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/CCO.0000000000000293","article-title":"Endocrinological side-effects of immune checkpoint inhibitors","volume":"28","author":"Torino","year":"2016","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.rmcr.2019.01.021_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11102-006-0408-5","article-title":"Isolated corticotrophin deficiency","volume":"9","author":"Andrioli","year":"2006","journal-title":"Pituitary"},{"issue":"4","key":"10.1016\/j.rmcr.2019.01.021_bib5","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1158\/1078-0432.CCR-14-2353","article-title":"Systemic high-dose corticosteroid treatment does not improve the outcome of ipilimumab-related hypophysitis: a retrospective cohort study","volume":"21","author":"Min","year":"2015","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.rmcr.2019.01.021_bib6","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1093\/annonc\/mdv383","article-title":"Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies","volume":"26","author":"Naidoo","year":"2015","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.rmcr.2019.01.021_bib7","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/01.cji.0000178913.41256.06","article-title":"Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer","volume":"28","author":"Blansfield","year":"2005","journal-title":"J. Immunother."},{"issue":"2","key":"10.1016\/j.rmcr.2019.01.021_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1507\/endocrj.EJ16-0596","article-title":"Hyponatremia can be a powerful predictor of the development of isolated ACTH deficiency associated with nivolumab treatment","volume":"64","author":"Cho","year":"2017","journal-title":"Endocr. J."},{"key":"10.1016\/j.rmcr.2019.01.021_bib9","series-title":"ASCO Annual Meeting","article-title":"Impact of Immune-Related Adverse Events (irAE) on Overall Survival (OS) in Patients Treated with Immunotherapy for Non-small Cell Lung Cancer (NSCLC)","author":"Owen","year":"2017"},{"key":"10.1016\/j.rmcr.2019.01.021_bib10","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.2169\/internalmedicine.8548-16","article-title":"Isolated adrenocorticotropic hormone deficiency caused by nivolumab in a patient with metastatic lung cancer","volume":"56","author":"Takaya","year":"2017","journal-title":"Intern. Med."},{"key":"10.1016\/j.rmcr.2019.01.021_bib11","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1111\/1346-8138.13532","article-title":"Isolated adrenocorticotropic hormone deficiency possibly caused by nivolumab in a metastatic melanoma patient","volume":"44","author":"Fujimura","year":"2017","journal-title":"J. Dermatol."},{"key":"10.1016\/j.rmcr.2019.01.021_bib12","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1111\/1346-8138.13571","article-title":"Isolated adrenocorticotropic hormone deficiency associated with nivolumab therapy","volume":"44","author":"Narahira","year":"2017","journal-title":"J. Dermatol."},{"key":"10.1016\/j.rmcr.2019.01.021_bib13","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1507\/endocrj.EJ16-0161","article-title":"Nivolumab-induced hypophysitis in a patient with advanced malignant melanoma","volume":"63","author":"Okano","year":"2016","journal-title":"Endocr. J."},{"key":"10.1016\/j.rmcr.2019.01.021_bib14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/1346-8138.13437","article-title":"Case of hypophysitis caused by nivolumab","volume":"44","author":"Ishikawa","year":"2017","journal-title":"J. Dermatol."},{"key":"10.1016\/j.rmcr.2019.01.021_bib15","first-page":"1","article-title":"Isolated ACTH deficiency probably induced by autoimmune-related mechanism evoked with nivolumab","volume":"18","author":"Kitajima","year":"2017","journal-title":"Jpn. J. Clin. Oncol."},{"key":"10.1016\/j.rmcr.2019.01.021_bib16","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2169\/internalmedicine.9074-17","article-title":"Isolated adrenocorticotropin deficiency due to nivolumab induced hypophysitis in a patient with advanced lung adenocarcinoma: a case report and literature review","volume":"57","author":"Nobumasa","year":"2018","journal-title":"Intern. Med."}],"container-title":["Respiratory Medicine Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213007118303770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213007118303770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T03:22:37Z","timestamp":1606274557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213007118303770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":16,"alternative-id":["S2213007118303770"],"URL":"https:\/\/doi.org\/10.1016\/j.rmcr.2019.01.021","relation":{},"ISSN":["2213-0071"],"issn-type":[{"value":"2213-0071","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A case of nivolumab-induced isolated adrenocorticotropic hormone (ACTH) deficiency","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmcr.2019.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}