{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:08:39Z","timestamp":1792728519568,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":167,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine Case Reports"],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/j.rmcr.2020.101135","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T11:57:24Z","timestamp":1592395044000},"page":"101135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Successful treatment of eosinophilic chronic rhinosinusitis and eosinophilic otitis media using the anti-IL-5 receptor monoclonal antibody benralizumab: A case report"],"prefix":"10.1016","volume":"30","author":[{"given":"Hiroki","family":"Kagoshima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Okanoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Taguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koki","family":"Hasebe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.rmcr.2020.101135_bib1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/all.12644","article-title":"Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study","volume":"70","author":"Tokunaga","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.rmcr.2020.101135_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12950-016-0121-8","article-title":"Pathogenesis of eosinophilic chronic rhinosinusitis","volume":"13","author":"Shah","year":"2016","journal-title":"J. Inflamm. (Lond)"},{"issue":"12","key":"10.1016\/j.rmcr.2020.101135_bib3","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s11882-015-0577-2","article-title":"New insights into eosinophilic otitis media","volume":"15","author":"Kanazawa","year":"2015","journal-title":"Curr. Allergy Asthma Rep."},{"issue":"1","key":"10.1016\/j.rmcr.2020.101135_bib4","article-title":"Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper","volume":"10","author":"Hox","year":"2020","journal-title":"Clin. Transl. Allergy"},{"issue":"5","key":"10.1016\/j.rmcr.2020.101135_bib5","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.jaip.2019.03.008","article-title":"Biologics for severe asthma: treatment-specific effects are important in choosing a specific agent","volume":"7","author":"Krings","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.rmcr.2020.101135_bib6","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.2147\/TCRM.S157171","article-title":"Benralizumab, an add-on treatment for severe eosinophilic asthma: evaluation of exacerbations, emergency department visits, lung function, and oral corticosteroid use","volume":"14","author":"Maselli","year":"2018","journal-title":"Therapeut. Clin. Risk Manag."},{"issue":"8","key":"10.1016\/j.rmcr.2020.101135_bib7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s11882-016-0634-5","article-title":"Eosinophil ETosis and DNA traps: a new look at eosinophilic inflammation","volume":"16","author":"Ueki","year":"2016","journal-title":"Curr. Allergy Asthma Rep."},{"issue":"2","key":"10.1016\/j.rmcr.2020.101135_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.alit.2014.12.006","article-title":"Immunopathology of chronic rhinosinusitis","volume":"64","author":"Kato","year":"2015","journal-title":"Allergol. Int."},{"issue":"5","key":"10.1016\/j.rmcr.2020.101135_bib9","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1365-2222.2011.03854.x","article-title":"Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor","volume":"42","author":"Molfino","year":"2012","journal-title":"Clin. Exp. Allergy"},{"issue":"3","key":"10.1016\/j.rmcr.2020.101135_bib10","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1038\/emm.2013.24","article-title":"A genetic effect of IL-5 receptor \u03b1 polymorphism in patients with aspirin-exacerbated respiratory disease","volume":"45","author":"Losol","year":"2013","journal-title":"Exp. Mol. Med."},{"issue":"2","key":"10.1016\/j.rmcr.2020.101135_bib11","doi-asserted-by":"crossref","first-page":"84","DOI":"10.18176\/jiaci.0385","article-title":"Benralizumab: a new approach for the treatment of severe eosinophilic asthma","volume":"29","author":"D\u00e1vila","year":"2019","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"issue":"4","key":"10.1016\/j.rmcr.2020.101135_bib12","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.jaci.2017.05.044","article-title":"Reduced need for surgery in severe nasal polyposis with mepolizumab: randomized trial","volume":"140","author":"Bachert","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.rmcr.2020.101135_bib13","doi-asserted-by":"crossref","first-page":"213","DOI":"10.23822\/EurAnnACI.1764-1489.94","article-title":"Favorable clinical efficacy of mepolizumab on the upper and lower airways in severe eosinophilic asthma: a 48-week pilot study","volume":"51","author":"Kurosawa","year":"2019","journal-title":"Eur. Ann. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.rmcr.2020.101135_bib14","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jaip.2018.08.021","article-title":"Effects of reslizumab on asthma outcomes in a subgroup of eosinophilic asthma patients with self-reported chronic rhinosinusitis with nasal polyps","volume":"7","author":"Weinstein","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"issue":"2","key":"10.1016\/j.rmcr.2020.101135_bib15","doi-asserted-by":"crossref","first-page":"e238","DOI":"10.1097\/MAO.0000000000002493","article-title":"Use of IL-5 inhibitor benralizumab as a novel therapy for eosinophilic otitis media: clinical capsule and review of literature","volume":"41","author":"Chow","year":"2020","journal-title":"Otol. Neurotol."},{"issue":"7","key":"10.1016\/j.rmcr.2020.101135_bib16","article-title":"Rapid effect of benralizumab for hypereosinophilia in a case of severe asthma with eosinophilic chronic rhinosinusitis","volume":"55","author":"Tsurumaki","year":"2019","journal-title":"Medicina (Kaunas)"},{"issue":"2","key":"10.1016\/j.rmcr.2020.101135_bib17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.alit.2020.02.002","article-title":"The roles of IL-5 and anti-IL-5 treatment in eosinophilic diseases: asthma, eosinophilic granulomatosis with polyangiitis, and eosinophilic chronic rhinosinusitis","volume":"69","author":"Nagase","year":"2020","journal-title":"Allergol. Int."},{"key":"10.1016\/j.rmcr.2020.101135_bib18","article-title":"Therapeutic antibodies for nasal polyposis treatment: where are we headed?","author":"Agarwal","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"5","key":"10.1016\/j.rmcr.2020.101135_bib19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/alr.21685","article-title":"Impact of omalizumab therapy on medication requirements for chronic rhinosinusitis","volume":"6","author":"Chandra","year":"2016","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.rmcr.2020.101135_bib20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12948-019-0106-2","article-title":"Recovery of smell sense loss by mepolizumab in a patient allergic to Dermatophagoides and affected by chronic rhinosinusitis with nasal polyps","volume":"17","author":"Cavaliere","year":"2019","journal-title":"Clin. Mol. Allergy"}],"container-title":["Respiratory Medicine Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213007120301921?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213007120301921?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T01:04:40Z","timestamp":1761959080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213007120301921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":20,"alternative-id":["S2213007120301921"],"URL":"https:\/\/doi.org\/10.1016\/j.rmcr.2020.101135","relation":{},"ISSN":["2213-0071"],"issn-type":[{"value":"2213-0071","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Successful treatment of eosinophilic chronic rhinosinusitis and eosinophilic otitis media using the anti-IL-5 receptor monoclonal antibody benralizumab: A case report","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmcr.2020.101135","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101135"}}