{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:30:28Z","timestamp":1791084628971,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":143,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine Case Reports"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.rmcr.2024.102041","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T17:22:39Z","timestamp":1716571359000},"page":"102041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Tezepelumab improved chronic rhinosinusitis with nasal polyps in a Patient with aspirin exacerbated respiratory disease"],"prefix":"10.1016","volume":"50","author":[{"given":"Yuga","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Terada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Nakadegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinako","family":"Masumitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Motobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reeko","family":"Osada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Takayasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nami","family":"Masumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-4569","authenticated-orcid":false,"given":"Naomi","family":"Tsurikisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmcr.2024.102041_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/all.13599","article-title":"B Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper","volume":"74","author":"Kowalski","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.rmcr.2024.102041_bib2","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.3389\/fphar.2020.01147","article-title":"NSAID-exacerbated respiratory disease (NERD): from pathogenesis to improved care","volume":"11","author":"Woo","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.rmcr.2024.102041_bib3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jaci.2022.08.021","article-title":"Updates on immune mechanisms in aspirin-exacerbated respiratory disease","volume":"151","author":"Laidlaw","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmcr.2024.102041_bib4","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.jaci.2005.08.035","article-title":"Aspirin sensitivity and severity of asthma: evidence for irreversible airway obstruction in patients with severe or difficult\u2010to\u2010treat asthma","volume":"116","author":"Mascia","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmcr.2024.102041_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"Epos 2020: European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.rmcr.2024.102041_bib6","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jaci.2014.08.020","article-title":"Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: a meta-analysis of the literature","volume":"135","author":"Rajan","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmcr.2024.102041_bib7","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1042\/CS20190281","article-title":"New insights into the pathophysiology and therapeutic targets of asthma and comorbid chronic rhinosinusitis with or without nasal polyposis","volume":"137","author":"Striz","year":"2023","journal-title":"Clin. Sci."},{"key":"10.1016\/j.rmcr.2024.102041_bib8","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.jaci.2015.10.009","article-title":"Chronic rhinosinusitis pathogenesis","volume":"136","author":"Stevens","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmcr.2024.102041_bib9","doi-asserted-by":"crossref","DOI":"10.1177\/19458924221080260","article-title":"Fractional exhaled nitric oxide as a marker of mucosal inflammation in chronic rhinosinusitis","author":"Olonisakin","year":"2022","journal-title":"Am. J. Rhinol. Allergy 19458924221080260"},{"key":"10.1016\/j.rmcr.2024.102041_bib10","doi-asserted-by":"crossref","first-page":"316","DOI":"10.2500\/aap.2019.40.4241","article-title":"Effect of omalizumab on outcomes in patients with aspirin-exacerbated respiratory disease","volume":"40","author":"Jean","year":"2019","journal-title":"Allergy Asthma Proc."},{"key":"10.1016\/j.rmcr.2024.102041_bib11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jaci.2020.05.032","article-title":"Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials","volume":"146","author":"Gevaert","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmcr.2024.102041_bib12","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jaci.2011.07.056","article-title":"Mepolizumab, a humanized anti\u2010IL\u20105 mAb, as a treatment option for severe nasal polyposis","volume":"128","author":"Gevaert","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmcr.2024.102041_bib13","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.jaci.2021.08.030","article-title":"Efficacy and safety of benralizumab in chronic rhinosinusitis with nasal polyps: a randomized, placebo-controlled trial","volume":"149","author":"Bachert","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmcr.2024.102041_bib14","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1016\/j.jaip.2021.08.004","article-title":"Benralizumab effectiveness in severe eosinophilic asthma with and without chronic rhinosinusitis with nasal polyps: a real-world multicenter study","volume":"9","author":"Nolasco","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.rmcr.2024.102041_bib15","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jaip.2021.09.030","article-title":"Appraisal of the real-world effectiveness of biologic therapies in aspirin-exacerbated respiratory disease","volume":"10","author":"Wangberg","year":"2022","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.rmcr.2024.102041_bib16","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/all.15067","article-title":"Efficacy and safety of dupilumab in patients with uncontrolled severe chronic rhinosinusitis with nasal polyps and a clinical diagnosis of NSAID-ERD: results from two randomized placebo-controlled phase 3 trials","volume":"77","author":"Mullol","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.rmcr.2024.102041_bib17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.5414\/ALX02296E","article-title":"Epithelial immune regulation of inflammatory airway diseases: chronic rhinosinusitis with nasal polyps (CRSwNP)","volume":"6","author":"Klimek","year":"2022","journal-title":"Allergol Select"},{"key":"10.1016\/j.rmcr.2024.102041_bib18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1177\/039463201102400322","article-title":"The expression of TSLP receptor in chronic rhinosinusitis with and without nasal polyps","volume":"24","author":"Boita","year":"2011","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.rmcr.2024.102041_bib19","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jaci.2013.04.005","article-title":"Thymic stromal lymphopoietin activity is increased in nasal polyps of patients with chronic rhinosinusitis","volume":"132","author":"Nagarkar","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.rmcr.2024.102041_bib20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2147\/JAA.S288260","article-title":"Efficacy of tezepelumab in patients with severe, uncontrolled asthma with and without nasal polyposis: a post hoc analysis of the phase 2b pathway study","volume":"14","author":"Emson","year":"2021","journal-title":"J. Asthma Allergy"},{"key":"10.1016\/j.rmcr.2024.102041_bib21","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1358\/dot.2022.58.12.3449205","article-title":"Tezepelumab for asthma","volume":"58","author":"Nolasco","year":"2022","journal-title":"Drugs Today"},{"key":"10.1016\/j.rmcr.2024.102041_bib22","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.3390\/ijms22094369","article-title":"Tezepelumab: a potential new biological therapy for severe refractory asthma","volume":"22","author":"Pelaia","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.rmcr.2024.102041_bib23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0091-6749(80)90143-8","article-title":"Aspirin\u2010sensitive asthma: tolerance to aspirin after positive oral aspirin challenges","volume":"66","author":"Stevenson","year":"1980","journal-title":"J. Allergy Clin. Immunol."},{"issue":"8","key":"10.1016\/j.rmcr.2024.102041_bib24","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/all.12644","article-title":"Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study","volume":"70","author":"Tokunaga","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.rmcr.2024.102041_bib25","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00405-009-1180-8","article-title":"Quality of life in patients with chronic rhinosinusitis: a validation of the Czech version of SNOT-22 questionnaire","volume":"267","author":"Schalek","year":"2010","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"10.1016\/j.rmcr.2024.102041_bib26","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1027\/0838-1925.15.6.246","article-title":"Nasal polyposis in aspirin\u2010hypersensitive patients with asthma (aspirin triad) and aspirin\u2010tolerant patients","volume":"6","author":"Kowalski","year":"2003","journal-title":"Allergy Clin Immunol Int \u2010 J World Allergy Org."},{"key":"10.1016\/j.rmcr.2024.102041_bib27","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1111\/all.15507","article-title":"Updates in biologic therapy for chronic rhinosinusitis with nasal polyps and NSAID-exacerbated respiratory disease","volume":"77","author":"Xu","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.rmcr.2024.102041_bib28","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.anai.2022.01.043","article-title":"Aspirin desensitization and biologics in aspirin-exacerbated respiratory disease: efficacy, tolerability, and patient experience","volume":"128","author":"Mullur","year":"2022","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.rmcr.2024.102041_bib29","first-page":"37","article-title":"Improvement in olfaction in patients with CRSwNP and severe asthma taking anti-IgE and anti-IL-5 biologics: a real-life study","volume":"33","author":"Barroso","year":"2023","journal-title":"J Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.rmcr.2024.102041_bib30","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.3390\/ijms22083969","article-title":"Treatment challenges in severe eosinophilic asthma: differential response to anti-IL-5 and anti-IL-5R therapy","volume":"22","author":"Bakakos","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.rmcr.2024.102041_bib31","doi-asserted-by":"crossref","first-page":"915","DOI":"10.2147\/JAA.S413064","article-title":"Tezepelumab efficacy in patients with severe, uncontrolled asthma with comorbid nasal polyps in NAVIGATOR","volume":"16","author":"Laidlaw","year":"2023","journal-title":"J. Asthma Allergy"},{"key":"10.1016\/j.rmcr.2024.102041_bib32","article-title":"Successful treatment of eosinophilic chronic rhinosinusitis and secretory otitis media in refractory asthma with thymic stromal lymphopoietin (TSLP) receptor monoclonal antibody","volume":"15","author":"Kawashima","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.rmcr.2024.102041_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/falgy.2021.734000","article-title":"Therapeutic options for chronic rhinosinusitis in N-ERD patients","volume":"2","author":"van der Lans","year":"2021","journal-title":"Front Allergy"}],"container-title":["Respiratory Medicine Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213007124000649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213007124000649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T13:33:24Z","timestamp":1720791204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213007124000649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":33,"alternative-id":["S2213007124000649"],"URL":"https:\/\/doi.org\/10.1016\/j.rmcr.2024.102041","relation":{},"ISSN":["2213-0071"],"issn-type":[{"value":"2213-0071","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tezepelumab improved chronic rhinosinusitis with nasal polyps in a Patient with aspirin exacerbated respiratory disease","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine Case Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmcr.2024.102041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102041"}}