{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:54:57Z","timestamp":1789437297189,"version":"build-2803163510"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":3547,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2003,11]]},"DOI":"10.1016\/j.rmed.2003.10.003","type":"journal-article","created":{"date-parts":[[2003,11,20]],"date-time":"2003-11-20T08:04:02Z","timestamp":1069315442000},"page":"S4-S9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"S4","title":["The formulation and evaluation of a CFC-free budesonide pressurised metered dose inhaler"],"prefix":"10.1016","volume":"97","author":[{"given":"D","family":"Ganderton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Meakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Church","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2003.10.003_BIB1","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1183\/09031936.94.07101839","article-title":"Lung deposition of budesonide from Turbuhaler\u00ae is twice that from a pressurised metered dose inhaler P-MDI","volume":"7","author":"Thorsson","year":"1994","journal-title":"Eur Resp J"},{"key":"10.1016\/j.rmed.2003.10.003_BIB2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0378-5173(02)00338-1","article-title":"Deposition and pharmacokinetics of budesonide from the Miat Monodose inhaler, a simple dry powder inhaler","volume":"245","author":"Ball","year":"2002","journal-title":"Int J Pharm"},{"key":"10.1016\/j.rmed.2003.10.003_BIB3","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1053\/rmed.2001.1107","article-title":"A comparison of the lung deposition of budesonide from Easyhaler\u00ae, Turbuhaler\u00ae and a pMDI plus spacer in asthmatic patients","volume":"95","author":"Hirst","year":"2001","journal-title":"Respir Med"},{"key":"10.1016\/j.rmed.2003.10.003_BIB4","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1053\/rmed.2002.1290","article-title":"Effects of 4-week treatment with low-dose budesonide (100\u03bcg BID) from a novel inhaler Airmax\u00ae and from a conventional inhaler on bronchial hyper-responsiveness, lung function and symptoms in patient with mild asthma","volume":"96","author":"Frew","year":"2002","journal-title":"Respir Med"},{"key":"10.1016\/j.rmed.2003.10.003_BIB5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta5260","article-title":"Comparison of the effectiveness of inhaler devices in asthma and chronic airways disease","volume":"5","author":"Brocklebank","year":"2001","journal-title":"Health Technol Assess"},{"issue":"Suppl","key":"10.1016\/j.rmed.2003.10.003_BIB6","first-page":"13","article-title":"Technological development of Airomir\u00ae (salbutamol sulphate in CFC-free system) MDI","volume":"79","author":"Tansey","year":"1995","journal-title":"Br J Clin Prac"},{"issue":"Suppl B","key":"10.1016\/j.rmed.2003.10.003_BIB7","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0954-6111(00)80143-2","article-title":"Pharmaceutical transition to non-CFC pressurized metered dose inhalers","volume":"94","author":"Cripps","year":"2000","journal-title":"Respir Med"},{"key":"10.1016\/j.rmed.2003.10.003_BIB8","doi-asserted-by":"crossref","first-page":"S250","DOI":"10.1016\/S0091-6749(99)70041-2","article-title":"Effect of formulation parameters on hydrofluoroalkane-beclomethasone dipropionate drug disposition in humans","volume":"104","author":"Leach","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.rmed.2003.10.003_BIB9","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1378\/chest.115.2.316","article-title":"Extra-fine corticosteroid aerosols for hydrofluoroalkane-134a metered dose inhalers. Advantages and disadvantages","volume":"115","author":"Tashkin","year":"1999","journal-title":"Chest"},{"issue":"Suppl D","key":"10.1016\/j.rmed.2003.10.003_BIB10","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/S0954-6111(02)80018-X","article-title":"Modulite\u00ae","volume":"96","author":"Ganderton","year":"2002","journal-title":"Respir Med"},{"key":"10.1016\/j.rmed.2003.10.003_BIB11","first-page":"391","article-title":"Biopharmaceutical optimisation of a new CFC-free budesonide pMDI","author":"Acerbi","year":"2002","journal-title":"Respir Drug Deliv VIII"},{"key":"10.1016\/j.rmed.2003.10.003_BIB12","unstructured":"Poli G, Acerbi D, Simonon A, et al. Effect of the actuator orifice diameter on the biodisposition of a new budesonide CFC-free metered dose inhaler formulation. European Respiratory Society Annual Congress 2001 (ERS 2001), Berlin, September 22\u201326, 2001."},{"key":"10.1016\/j.rmed.2003.10.003_BIB13","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1183\/09031936.98.12061340","article-title":"Lung deposition of budesonide from a pressurised metered-dose inhaler attached to a spacer","volume":"12","author":"Thorsson","year":"1998","journal-title":"Eur Respir J"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611103003615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611103003615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:05:42Z","timestamp":1760609142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611103003615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11]]},"references-count":13,"alternative-id":["S0954611103003615"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2003.10.003","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2003,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The formulation and evaluation of a CFC-free budesonide pressurised metered dose inhaler","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2003.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}