{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T17:59:45Z","timestamp":1774115985138,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":2759,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2006,2]]},"DOI":"10.1016\/j.rmed.2005.05.017","type":"journal-article","created":{"date-parts":[[2005,7,6]],"date-time":"2005-07-06T18:02:27Z","timestamp":1120672947000},"page":"273-278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Characterisation of patients with frequent exacerbation of asthma"],"prefix":"10.1016","volume":"100","author":[{"given":"Takeharu","family":"Koga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Oshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Kamimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisamichi","family":"Aizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.rmed.2005.05.017_bib1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1067\/mai.2003.178","article-title":"Inhaled corticosteroids and allergy specialty care reduce emergency hospital use for asthma","volume":"111","author":"Schatz","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.rmed.2005.05.017_bib2","doi-asserted-by":"crossref","unstructured":"American Thoracic Society. Proceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med 2000; 162(6): 2341\u201351.","DOI":"10.1164\/ajrccm.162.6.ats9-00"},{"issue":"2","key":"10.1016\/j.rmed.2005.05.017_bib3","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1183\/09031936.02.02542001","article-title":"Persistent asthma: disease control, resource utilisation and direct costs","volume":"20","author":"Van Ganse","year":"2002","journal-title":"Eur Respir J"},{"issue":"4","key":"10.1016\/j.rmed.2005.05.017_bib4","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1136\/thx.54.4.296","article-title":"Morbidity from asthma in relation to regular treatment: a community based study","volume":"54","author":"Walsh","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2005.05.017_bib5","unstructured":"Asthma GIf (National Heart, Lung and Blood Institute). Global strategy for asthma management and prevention. 2002."},{"issue":"5","key":"10.1016\/j.rmed.2005.05.017_bib6","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1183\/09031936.98.12051209","article-title":"Difficult asthma","volume":"12","author":"Barnes","year":"1998","journal-title":"Eur Respir J"},{"issue":"9","key":"10.1016\/j.rmed.2005.05.017_bib7","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/thorax.58.9.757","article-title":"Increased circulating 92kDa matrix metalloproteinase (MMP-9) activity in exacerbations of asthma","volume":"58","author":"Oshita","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2005.05.017_bib8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1183\/09041950.005s1693","article-title":"Lung volumes and forced ventilatory flows. Report Working Party Standardisation of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society","volume":"16","author":"Quanjer","year":"1993","journal-title":"Eur Respir J Suppl"},{"issue":"8","key":"10.1016\/j.rmed.2005.05.017_bib9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1053\/rmed.2002.1327","article-title":"Expression of bronchodilator response: comparison of four indices","volume":"96","author":"Chhabra","year":"2002","journal-title":"Respir Med"},{"issue":"9","key":"10.1016\/j.rmed.2005.05.017_bib10","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/S0954-6111(99)90102-6","article-title":"Evaluation of bronchodilator response in patients with airway obstruction","volume":"93","author":"Quadrelli","year":"1999","journal-title":"Respir Med"},{"key":"10.1016\/j.rmed.2005.05.017_bib11","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0091-6749(96)80185-0","article-title":"Asthma control versus asthma severity","volume":"98","author":"Cockcroft","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.rmed.2005.05.017_bib12","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1164\/ajrccm.159.4.9806052","article-title":"Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment","volume":"159","author":"Sont","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.rmed.2005.05.017_bib13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1164\/ajrccm.161.1.9802048","article-title":"The relationship between airways inflammation and asthma severity","volume":"161","author":"Louis","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.rmed.2005.05.017_bib14","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1164\/ajrccm.164.5.2011026","article-title":"Factors associated with persistent airflow Limitation in severe asthma","volume":"164","author":"ten Brinke","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.rmed.2005.05.017_bib15","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1378\/chest.101.3.621","article-title":"The fatality-prone asthmatic patient. Follow-up study after near-fatal attacks","volume":"101","author":"Molfino","year":"1992","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.rmed.2005.05.017_bib16","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1067\/mai.2002.122458","article-title":"Chronic sinusitis in severe asthma is related to sputum eosinophilia","volume":"109","author":"ten Brinke","year":"2002","journal-title":"J Allergy Clin Immunol"},{"issue":"2 Pt 2","key":"10.1016\/j.rmed.2005.05.017_bib17","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1164\/ajrccm\/149.2_Pt_2.S9","article-title":"Physiologic measures: pulmonary function tests. Asthma outcome","volume":"149","author":"Enright","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"10.1016\/j.rmed.2005.05.017_bib18","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1164\/rccm.2108009","article-title":"Risk factors for airway remodeling in asthma manifested by a low postbronchodilator FEV1\/vital capacity ratio: a longitudinal population study from childhood to adulthood","volume":"165","author":"Rasmussen","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.rmed.2005.05.017_bib19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/thorax.57.3.242","article-title":"Correlation between the bronchial subepithelial layer and whole airway wall thickness in patients with asthma","volume":"57","author":"Kasahara","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2005.05.017_bib20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1067\/mai.2003.128","article-title":"Airway remodeling in asthma: new insights","volume":"111","author":"Davies","year":"2003","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.rmed.2005.05.017_bib21","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1378\/chest.111.4.852","article-title":"Airways remodeling is a distinctive feature of asthma and is related to severity of disease","volume":"111","author":"Chetta","year":"1997","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.rmed.2005.05.017_bib22","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1164\/ajrccm.163.2.9912091","article-title":"Predictive markers of asthma exacerbations during stepwise dose reduction of inhaled corticosteroid","volume":"163","author":"Leuppi","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.rmed.2005.05.017_bib23","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jaci.2003.08.009","article-title":"Features of airway remodeling and eosinophilic inflammation in chronic rhinosinusitis: is the histopathology similar to asthma?","volume":"112","author":"Ponikau","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.rmed.2005.05.017_bib24","doi-asserted-by":"crossref","unstructured":"European Network for Understanding Mechanisms of Severe Asthma. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. Eur Respir J 2003; 22(3), 470\u20137.","DOI":"10.1183\/09031936.03.00261903"},{"issue":"11","key":"10.1016\/j.rmed.2005.05.017_bib25","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.4049\/jimmunol.156.11.4422","article-title":"Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes","volume":"156","author":"Meagher","year":"1996","journal-title":"J Immunol"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611105002416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611105002416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:16:03Z","timestamp":1760609763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611105002416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,2]]}},"alternative-id":["S0954611105002416"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2005.05.017","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2006,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterisation of patients with frequent exacerbation of asthma","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2005.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}