{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:35:33Z","timestamp":1790415333123,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":2359,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.rmed.2006.05.019","type":"journal-article","created":{"date-parts":[[2006,7,11]],"date-time":"2006-07-11T10:02:05Z","timestamp":1152612125000},"page":"217-222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effects of nebulised iloprost on pulmonary function and gas exchange in severe pulmonary hypertension"],"prefix":"10.1016","volume":"101","author":[{"given":"F.","family":"Reichenberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mainwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Doughty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Fineberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.W.","family":"Morrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pepke-Zaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2006.05.019_bib1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1056\/NEJMoa020204","article-title":"Inhaled iloprost for severe pulmonary hypertension","volume":"347","author":"Olschewski","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rmed.2006.05.019_bib2","first-page":"724","article-title":"Effects of aerosolized prostacyclin in severe pneumonia. Impact of fibrosis","volume":"151","author":"Walmrath","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rmed.2006.05.019_bib3","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1164\/ajrccm.160.2.9810008","article-title":"Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis","volume":"160","author":"Olschewski","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rmed.2006.05.019_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1034\/j.1399-3003.2000.16b15.x","article-title":"Diffusion capacity and haemodynamics in primary and chronic thromboembolic pulmonary hypertension","volume":"16","author":"Steenhuis","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmed.2006.05.019_bib5","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/thorax.57.6.473","article-title":"Peripheral airway obstruction in primary pulmonary hypertension","volume":"57","author":"Meyer","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2006.05.019_bib6","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/sj.bjp.0702392","article-title":"Prostanoid receptors involved in the relaxation of human bronchial preparations","volume":"126","author":"Norel","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.rmed.2006.05.019_bib7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1152\/jappl.1980.49.3.521","article-title":"Reversal of 5HT-induced bronchoconstriction by PGI2: distribution of central and peripheral actions","volume":"49","author":"Spannhake","year":"1980","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.rmed.2006.05.019_bib8","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0091-6749(90)90196-B","article-title":"Effects of prostacyclin on bronchoconstriction and neutropenia induced by inhaled platelet-activating factor in man","volume":"85","author":"Lammers","year":"1990","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.rmed.2006.05.019_bib9","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1152\/jappl.1988.64.4.1567","article-title":"Bronchoconstrictor and antibronchoconstrictor properties of inhaled prostacyclin in asthma","volume":"64","author":"Hardy","year":"1988","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.rmed.2006.05.019_bib10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1183\/09031936.01.17100140","article-title":"Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension","volume":"17","author":"Gessler","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmed.2006.05.019_bib11","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1056\/NEJM200006223422503","article-title":"Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue","volume":"342","author":"Hoeper","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rmed.2006.05.019_bib12","doi-asserted-by":"crossref","first-page":"435","DOI":"10.7326\/0003-4819-132-6-200003210-00003","article-title":"Inhaled iloprost to treat severe pulmonary hypertension","volume":"132","author":"Olschewski","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rmed.2006.05.019_bib13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1183\/09031936.01.17100080","article-title":"Long-term treatment of pulmonary hypertension with aerosolized iloprost","volume":"17","author":"Machherndl","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmed.2006.05.019_bib14","unstructured":"Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. NHBLI\/WHO Workshop Report, National Heart, Lung, and Blood Institute, National Institute of Health; April 2001, NIH Publication 2701."},{"key":"10.1016\/j.rmed.2006.05.019_bib15","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1136\/thx.2003.019349","article-title":"Relationship between peripheral airway dysfunction, airway obstruction, and neutrophilic inflammation in COPD","volume":"59","author":"O\u2019Donnell","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2006.05.019_bib16","doi-asserted-by":"crossref","unstructured":"Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. NEJM 2004.","DOI":"10.1056\/NEJMoa032158"},{"key":"10.1016\/j.rmed.2006.05.019_bib17","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1183\/09031936.01.17406470","article-title":"Oxygen desaturation on the 6-min walk test and mortality in untreated primary pulmonary hypertension","volume":"17","author":"Paciocco","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmed.2006.05.019_bib18","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1164\/ajrccm.152.6.8520796","article-title":"Single-breath carbon monoxide diffusing capacity (transfer factor). Recommendations for a standard technique\u20141995 update","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rmed.2006.05.019_bib19","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1183\/09031936.95.08030492","article-title":"Reference values for residual volume, functional residual capacity and total lung capacity. ATS workshop on lung volume measurements. Official Statement of The European Respiratory Society","volume":"8","author":"Stocks","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmed.2006.05.019_bib20","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1164\/rccm.200110-028PP","article-title":"New treatments for pulmonary arterial hypertension","volume":"165","author":"Hoeper","year":"2002","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611106002824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611106002824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:21:43Z","timestamp":1760610103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611106002824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0954611106002824"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2006.05.019","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of nebulised iloprost on pulmonary function and gas exchange in severe pulmonary hypertension","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2006.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}