{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:08:12Z","timestamp":1793502492119,"version":"4.5.0"},"reference-count":118,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":1904,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1016\/j.rmed.2007.12.007","type":"journal-article","created":{"date-parts":[[2008,1,30]],"date-time":"2008-01-30T10:06:31Z","timestamp":1201687591000},"page":"744-754","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":253,"title":["Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: A meta-analysis"],"prefix":"10.1016","volume":"102","author":[{"given":"Qiu-Li","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-Zhong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shou-Ming","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Jun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2007.12.007_bib1","first-page":"3","article-title":"Report on fourth national epidemiological sampling survey of tuberculosis","volume":"25","year":"2002","journal-title":"Chin J Tuberc Respir Dis"},{"key":"10.1016\/j.rmed.2007.12.007_bib2","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0140-6736(06)68384-0","article-title":"Global epidemiology of tuberculosis","volume":"367","author":"Dye","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2007.12.007_bib3","first-page":"26","article-title":"Pleural tuberculosis","volume":"65","author":"Chakrabarti","year":"2006","journal-title":"Monaldi Arch Chest Dis"},{"key":"10.1016\/j.rmed.2007.12.007_bib4","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1258\/000456303766477011","article-title":"Diagnostic value of adenosine deaminase in tuberculous pleural effusion: a meta-analysis","volume":"40","author":"Goto","year":"2003","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.rmed.2007.12.007_bib5","first-page":"777","article-title":"Adenosine deaminase and interferon gamma measurements for the diagnosis of tuberculous pleurisy: a meta-analysis","volume":"7","author":"Greco","year":"2003","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2007.12.007_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/bmj.326.7379.41","article-title":"Standards for reporting of diagnostic accuracy. Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative","volume":"326","author":"Bossuyt","year":"2003","journal-title":"Br Med J"},{"key":"10.1016\/j.rmed.2007.12.007_bib7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2288-3-25","article-title":"The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews","volume":"3","author":"Whiting","year":"2003","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.rmed.2007.12.007_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2288-2-9","article-title":"Conducting systematic reviews of diagnostic studies: didactic guidelines","volume":"2","author":"Deville","year":"2002","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.rmed.2007.12.007_bib9","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/sim.4780121403","article-title":"Combining independent studies of a diagnostic test into a summary ROC curve: data\u2014analytic approaches and some additional considerations","volume":"12","author":"Moses","year":"1993","journal-title":"Stat Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1067\/mem.2001.114903","article-title":"Diagnosing acute cardiac ischemia in the emergency department: a systematic review of the accuracy and clinical effect of current technologies","volume":"37","author":"Lau","year":"2001","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib11","doi-asserted-by":"crossref","first-page":"667","DOI":"10.7326\/0003-4819-120-8-199404150-00008","article-title":"Guidelines for meta-analyses evaluating diagnostic tests","volume":"120","author":"Irwig","year":"1994","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib12","first-page":"675","article-title":"Meta-analyses of studies of the diagnostic accuracy of laboratory tests: a review of the concepts and methods","volume":"122","author":"Vamvakas","year":"1998","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jclinepi.2003.09.017","article-title":"The conditional relative odds ratio provided less biased results for comparing diagnostic test accuracy in meta-analyses","volume":"57","author":"Suzuki","year":"2004","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.rmed.2007.12.007_bib14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2288-5-20","article-title":"How does study quality affect the results of a diagnostic meta-analysis?","volume":"8","author":"Westwood","year":"2005","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.rmed.2007.12.007_bib15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"Br Med J"},{"key":"10.1016\/j.rmed.2007.12.007_bib16","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1136\/bmj.2.6154.1751-a","article-title":"Adenosine deaminase activity in pleural effusions: an aid to differential diagnosis","volume":"2","author":"Piras","year":"1978","journal-title":"Br Med J"},{"key":"10.1016\/j.rmed.2007.12.007_bib17","first-page":"19","article-title":"The use of adenosine deaminase assays in the diagnosis of tuberculosis","volume":"62","author":"Blake","year":"1982","journal-title":"S Afr Med J"},{"key":"10.1016\/j.rmed.2007.12.007_bib18","first-page":"556","article-title":"Adenosine deaminase estimations in the differentiation of pleural effusions","volume":"62","author":"Maritz","year":"1982","journal-title":"S Afr Med J"},{"key":"10.1016\/j.rmed.2007.12.007_bib19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.0954-6820.1984.tb05011.x","article-title":"Adenosine deaminase in the diagnosis of pleural effusions","volume":"215","author":"Pettersson","year":"1984","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.rmed.2007.12.007_bib20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1378\/chest.87.3.351","article-title":"Carcinomatous and tuberculous pleural effusions. Comparison of tumor markers","volume":"87","author":"Niwa","year":"1985","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib21","first-page":"76","article-title":"Adenosine deaminase activity in pleural fluids\u2014a diagnostic aid in tuberculous pleural effusion","volume":"27","author":"Raj","year":"1985","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"10.1016\/j.rmed.2007.12.007_bib22","first-page":"11","article-title":"Adenosine deaminase activity as a diagnostic index of pleural effusion","volume":"85","author":"Sinha","year":"1987","journal-title":"J Indian Med Assoc"},{"key":"10.1016\/j.rmed.2007.12.007_bib23","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0041-3879(87)90029-8","article-title":"Adenosine deaminase activity in tuberculous pleural effusions: a diagnostic test","volume":"68","author":"Strankinga","year":"1987","journal-title":"Tubercle"},{"key":"10.1016\/j.rmed.2007.12.007_bib24","first-page":"220","article-title":"Adenosine deaminase in pleural fluid\u2014an enzymatic test for tuberculous pleural effusion","volume":"28","author":"Teo","year":"1987","journal-title":"Singapore Med J"},{"key":"10.1016\/j.rmed.2007.12.007_bib25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1378\/chest.93.2.303","article-title":"Diagnostic value of simultaneous determination of pleural adenosine deaminase and pleural lysozyme\/serum lysozyme ratio in pleural effusions","volume":"93","author":"Fontan Bueso","year":"1988","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3904\/kjim.1988.3.2.122","article-title":"C-reactive protein, sialic acid and adenosine deaminase levels in serum and pleural fluid from patients with pleural effusion","volume":"3","author":"Kim","year":"1988","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib27","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1136\/ard.47.5.394","article-title":"Adenosine deaminase activity in rheumatoid pleural effusion","volume":"47","author":"Ocana","year":"1988","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rmed.2007.12.007_bib28","first-page":"122","article-title":"Pleural biopsy and adenosine deaminase enzyme activity in effusions of different aetiologies","volume":"7","author":"Gilhotra","year":"1989","journal-title":"Lung India"},{"key":"10.1016\/j.rmed.2007.12.007_bib29","first-page":"879","article-title":"Diagnostic value of adenosine deaminase and gamma-interferon in tuberculous and malignant pleural effusions","volume":"88","author":"Hsu","year":"1989","journal-title":"Taiwan Yi Xue Hui Za Zhi"},{"key":"10.1016\/j.rmed.2007.12.007_bib30","doi-asserted-by":"crossref","first-page":"478","DOI":"10.2169\/internalmedicine1962.28.478","article-title":"Discrimination of tuberculous from carcinomatous pleural effusion by biochemical markers: adenosine deaminase, lysozyme, fibronectin and carcinoembryonic antigen","volume":"28","author":"Moriwaki","year":"1989","journal-title":"Jpn J Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0009-9120(89)80013-X","article-title":"Adenosine deaminase in body fluids: a useful diagnostic tool in tuberculosis","volume":"22","author":"Segura","year":"1989","journal-title":"Clin Biochem"},{"key":"10.1016\/j.rmed.2007.12.007_bib32","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1378\/chest.97.3.605","article-title":"Serum and pleural adenosine deaminase. Correlation with lymphocytic populations","volume":"97","author":"Baganha","year":"1990","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib33","first-page":"205","article-title":"Efficacy of adenosine deaminase in the diagnosis of pleural effusions","volume":"32","author":"Gupta","year":"1990","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"10.1016\/j.rmed.2007.12.007_bib34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1378\/chest.99.2.355","article-title":"Adenosine deaminase in the diagnosis of tuberculous pleural effusions. A report of 218 patients and review of the literature","volume":"99","author":"Banales","year":"1991","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib35","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1136\/thx.46.2.96","article-title":"Tuberculous pleural effusions: increased culture yield with bedside inoculation of pleural fluid and poor diagnostic value of adenosine deaminase","volume":"46","author":"Maartens","year":"1991","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2007.12.007_bib36","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1378\/chest.99.5.1103","article-title":"Cytokine content in pleural effusion. Comparison between tuberculous and carcinomatous pleurisy","volume":"99","author":"Shimokata","year":"1991","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib37","first-page":"270","article-title":"Poor diagnostic value of adenosine deaminase in pleural, peritoneal and cerebrospinal fluids in tuberculosis","volume":"95","author":"Kaur","year":"1992","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.rmed.2007.12.007_bib38","doi-asserted-by":"crossref","first-page":"752","DOI":"10.2169\/internalmedicine.31.752","article-title":"Simultaneous measurements of adenosine deaminase activity and tuberculostearic acid in pleural effusions for the diagnosis of tuberculous pleuritis","volume":"31","author":"Muranishi","year":"1992","journal-title":"Intern Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib39","first-page":"157","article-title":"Adenosine deaminase in pleural effusions","volume":"40","author":"Nagaraja","year":"1992","journal-title":"J Assoc Physicians India"},{"key":"10.1016\/j.rmed.2007.12.007_bib40","first-page":"123","article-title":"Adenosine deaminase activity in pleural fluid\u2014a diagnostic test of tuberculous pleural effusion","volume":"34","author":"Prasad","year":"1992","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"10.1016\/j.rmed.2007.12.007_bib41","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1378\/chest.103.2.458","article-title":"Diagnosis of tuberculous pleurisy using the biologic parameters adenosine deaminase, lysozyme, and interferon gamma","volume":"103","author":"Valdes","year":"1993","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0954-6111(94)90027-2","article-title":"A comparison study of IFN-gamma, ADA, and CA125 as the diagnostic parameters in tuberculous pleuritis","volume":"88","author":"Aoki","year":"1994","journal-title":"Respir Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib43","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000196327","article-title":"Neopterin, soluble interleukin-2 receptor and adenosine deaminase levels in pleural effusions","volume":"61","author":"Chiang","year":"1994","journal-title":"Respiration"},{"key":"10.1016\/j.rmed.2007.12.007_bib44","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2303.1994.tb00124.x","article-title":"Pleural fluid adenosine deaminase and lymphocyte proportion: clinical usefulness in the diagnosis of tuberculosis","volume":"5","author":"DeOliveira","year":"1994","journal-title":"Cytopathology"},{"key":"10.1016\/j.rmed.2007.12.007_bib45","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/thx.50.6.672","article-title":"Use of adenosine deaminase as a diagnostic tool for tuberculous pleurisy","volume":"50","author":"Burgess","year":"1995","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2007.12.007_bib46","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1164\/ajrccm.152.6.8520765","article-title":"Rapid diagnosis of pleural tuberculosis by polymerase chain reaction","volume":"152","author":"Querol","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib47","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0954-6111(96)90205-X","article-title":"Tumour necrosis factor, interleukin-1 and adenosine deaminase in tuberculous pleural effusion","volume":"90","author":"Orphanidou","year":"1996","journal-title":"Respir Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib48","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0022-2143(96)90182-1","article-title":"Adenosine deaminase isozymes in tuberculous pleural effusion","volume":"127","author":"Shibagaki","year":"1996","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib49","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1183\/09031936.96.09040747","article-title":"Adenosine deaminase (ADA) isoenzyme analysis in pleural effusions: diagnostic role, and relevance to the origin of increased ADA in tuberculous pleurisy","volume":"9","author":"Valdes","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmed.2007.12.007_bib50","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/clinchem\/42.2.218","article-title":"Rapid automated determination of adenosine deaminase and lysozyme for differentiating tuberculous and nontuberculous pleural effusions","volume":"42","author":"Villena","year":"1996","journal-title":"Clin Chem"},{"key":"10.1016\/j.rmed.2007.12.007_bib51","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3904\/kjim.1997.12.2.225","article-title":"Combining ADA, protein and IFN-\u03b3 best allows discrimination between tuberculous and malignant effusion","volume":"12","author":"Kim","year":"1997","journal-title":"Korean J Intern Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0962-8479(97)90013-7","article-title":"Differential diagnosis of tuberculous pleurisy by measurement of cytokine concentrations in pleural effusion","volume":"78","author":"Ogawa","year":"1997","journal-title":"Tuber Lung Dis"},{"key":"10.1016\/j.rmed.2007.12.007_bib53","first-page":"787","article-title":"Diagnostic significance of immunoglobulins and adenosine deaminase in pleural effusion","volume":"47","author":"Ghelani","year":"1999","journal-title":"J Assoc Physicians India"},{"key":"10.1016\/j.rmed.2007.12.007_bib54","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0954-6111(99)90267-6","article-title":"ADA1\/ADAp ratio in pleural tuberculosis: an excellent diagnostic parameter in pleural fluid","volume":"93","author":"Perez-Rodriguez","year":"1999","journal-title":"Respir Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib55","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1378\/chest.116.1.97","article-title":"Diagnostic value of pleural fluid adenosine deaminase in tuberculous pleuritis with reference to HIV coinfection and a Bayesian analysis","volume":"116","author":"Riantawan","year":"1999","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib56","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1378\/chest.118.5.1355","article-title":"Evaluation of polymerase chain reaction, adenosine deaminase, and interferon-gamma in pleural fluid for the differential diagnosis of pleural tuberculosis","volume":"118","author":"Villegas","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib57","first-page":"321","article-title":"Determination of adenosine deaminase activity and its isoenzymes for diagnosis of pleural effusions","volume":"5","author":"Gorguner","year":"2000","journal-title":"Respirology"},{"key":"10.1016\/j.rmed.2007.12.007_bib58","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3346\/jkms.2000.15.3.279","article-title":"Vascular endothelial growth factor in malignant and tuberculous pleural effusions","volume":"15","author":"Lim","year":"2000","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.rmed.2007.12.007_bib59","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1378\/chest.119.6.1737","article-title":"Evaluation of polymerase chain reaction for detection of Mycobacterium tuberculosis in pleural fluid","volume":"119","author":"Nagesh","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib60","first-page":"383","article-title":"Diagnostic role of pleural fluid adenosine deaminase in tuberculous pleural effusion","volume":"32","author":"Reechaipichitkul","year":"2001","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.rmed.2007.12.007_bib61","first-page":"149","article-title":"A prospective study of sensitivity and specificity of adenosine deaminase estimation in the diagnosis of tuberculosis pleural effusion","volume":"43","author":"Sharma","year":"2001","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"10.1016\/j.rmed.2007.12.007_bib62","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1053\/rmed.2001.1103","article-title":"Cytokines in pleural liquid for diagnosis of tuberculous pleurisy","volume":"95","author":"Yamada","year":"2001","journal-title":"Respir Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib63","first-page":"CR708","article-title":"Activity of adenosine deaminase and its isoforms in pleural fluid in tuberculous pleuritis","volume":"8","author":"Andreasyan","year":"2002","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.rmed.2007.12.007_bib64","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1378\/chest.123.3.740","article-title":"Diagnostic significance of interferon-gamma in tuberculous pleural effusions","volume":"123","author":"Aoe","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib65","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1378\/chest.124.3.909","article-title":"Combined use of the polymerase chain reaction and detection of adenosine deaminase activity on pleural fluid improves the rate of diagnosis of pleural tuberculosis","volume":"124","author":"Lima","year":"2003","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib66","first-page":"CR227","article-title":"Differentiating tuberculous from malignant pleural effusions: a scoring model","volume":"9","author":"Porcel","year":"2003","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.rmed.2007.12.007_bib67","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000072008","article-title":"Tumour necrosis factor\u2013alpha in comparison to adenosine deaminase in tuberculous pleuritis","volume":"70","author":"Tahhan","year":"2003","journal-title":"Respiration"},{"key":"10.1016\/j.rmed.2007.12.007_bib68","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cccn.2003.11.016","article-title":"Diagnostic value of pleural fluid adenosine deaminase activity in tuberculous pleurisy","volume":"341","author":"Chen","year":"2004","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.rmed.2007.12.007_bib69","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1590\/S1413-86702004000400007","article-title":"What is the probability of a patient presenting a pleural effusion due to tuberculosis?","volume":"8","author":"Neves","year":"2004","journal-title":"Braz J Infect Dis"},{"key":"10.1016\/j.rmed.2007.12.007_bib70","first-page":"211","article-title":"Diagnostic significance of gamma-interferon in tuberculous pleurisy","volume":"52","author":"Poyraz","year":"2004","journal-title":"Tuberk Toraks"},{"key":"10.1016\/j.rmed.2007.12.007_bib71","first-page":"13","article-title":"Evaluation of cytokines in pleural fluid for the differential diagnosis of tuberculous pleurisy","volume":"29","author":"El-Ansary","year":"2005","journal-title":"Biochim Clin"},{"key":"10.1016\/j.rmed.2007.12.007_bib72","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1159\/000084047","article-title":"Tuberculous effusion: ADA activity correlates with CD4+ cell numbers in the fluid and the pleura","volume":"72","author":"Gaga","year":"2005","journal-title":"Respiration"},{"key":"10.1016\/j.rmed.2007.12.007_bib73","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1086\/432474","article-title":"The clinical utility of polymerase chain reaction for the diagnosis of pleural tuberculosis","volume":"41","author":"Moon","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.rmed.2007.12.007_bib74","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.lab.2004.11.013","article-title":"Evaluation of interferon-\u03b3, interferon-\u03b3-inducing cytokines, and interferon-\u03b3-inducible chemokines in tuberculous pleural effusions","volume":"145","author":"Okamoto","year":"2005","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib75","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/jcla.20054","article-title":"Pleural fluid interferon-gamma and adenosine deaminase levels in tuberculosis pleural effusion: a cost\u2013effectiveness analysis","volume":"19","author":"Sharma","year":"2005","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.rmed.2007.12.007_bib76","first-page":"1040","article-title":"The diagnostic values of serum, pleural fluid and urine neopterin measurements in tuberculous pleurisy","volume":"9","author":"Tozkoparan","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2007.12.007_bib77","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/j.1742-1241.2006.00831.x","article-title":"Diagnostic value of leptin in tuberculous pleural effusions","volume":"60","author":"Celik","year":"2006","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.rmed.2007.12.007_bib78","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.rmed.2006.01.023","article-title":"Level of antibodies against mycobacterial glycolipid in the effusion for diagnosis of tuberculous pleural effusion","volume":"100","author":"Morimoto","year":"2006","journal-title":"Respir Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib79","first-page":"15","article-title":"Adenosine deaminase activity, not diagnostic for tuberculous pleurisy","volume":"71","author":"van Keimpema","year":"1987","journal-title":"Eur J Respir Dis"},{"key":"10.1016\/j.rmed.2007.12.007_bib80","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/1097-0142(19880115)61:2<298::AID-CNCR2820610219>3.0.CO;2-U","article-title":"Tumour markers in pleural effusion diagnosis","volume":"61","author":"Tamura","year":"1988","journal-title":"Cancer"},{"key":"10.1016\/j.rmed.2007.12.007_bib81","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000469134","article-title":"Molecular forms of adenosine deaminase in pleural effusions","volume":"40","author":"Ungerer","year":"1988","journal-title":"Enzyme"},{"key":"10.1016\/j.rmed.2007.12.007_bib82","first-page":"293","article-title":"Diagnosis of tuberculosis in patients with pleural effusion in an area of HIV infection and limited diagnostic facilities","volume":"46","author":"Richter","year":"1994","journal-title":"Trop Geogr Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib83","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1183\/09031936.03.00017103a","article-title":"Diagnostic tools in tuberculous pleurisy: a direct comparative study","volume":"22","author":"Diacon","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmed.2007.12.007_bib84","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1378\/chest.84.1.51","article-title":"Adenosine deaminase in pleural fluids. Test for diagnosis of tuberculous pleural effusion","volume":"84","author":"Ocana","year":"1983","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib85","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0009-9120(89)80013-X","article-title":"Adenosine deaminase in body fluids: a useful diagnostic tool in tuberculosis","volume":"22","author":"Segura","year":"1989","journal-title":"Clin Biochem"},{"key":"10.1016\/j.rmed.2007.12.007_bib86","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1136\/adc.2005.079160","article-title":"Evaluation of polymerase chain reaction and adenosine deaminase assay for the diagnosis of tuberculous effusions in children","volume":"91","author":"Mishra","year":"2006","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.rmed.2007.12.007_bib87","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1378\/chest.86.2.273-a","article-title":"Pleural fluid adenosine deaminase in rheumatoid arthritis and systemic lupus erythematosus","volume":"86","author":"Pettersson","year":"1984","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib88","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0041-3879(86)90008-5","article-title":"Adenosine deaminase activity in the diagnosis of lymphocytic pleural effusions of tuberculous, neoplastic and lymphomatous origin","volume":"67","author":"Ocana","year":"1986","journal-title":"Tubercle"},{"key":"10.1016\/j.rmed.2007.12.007_bib89","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0009-8981(92)90335-N","article-title":"Diagnostic value of adenosine deaminase and lysozyme in tuberculous pleurisy","volume":"209","author":"San Jose","year":"1992","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.rmed.2007.12.007_bib90","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1136\/thx.50.6.600","article-title":"Value of adenosine deaminase in the diagnosis of tuberculous pleural effusions in young patients in a region of high prevalence of tuberculosis","volume":"50","author":"Valdes","year":"1995","journal-title":"Thorax"},{"key":"10.1016\/j.rmed.2007.12.007_bib91","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1378\/chest.109.2.414","article-title":"Combined use of pleural adenosine deaminase with lymphocyte\/neutrophil ratio. Increased specificity for the diagnosis of tuberculous pleuritis","volume":"109","author":"Burgess","year":"1996","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib92","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1378\/chest.90.4.625a","article-title":"High adenosine deaminase activity level in pleural effusion","volume":"90","author":"Perez-Vidal","year":"1986","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib93","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/ard.48.9.789-a","article-title":"Adenosine deaminase activity in rheumatoid pleural effusion","volume":"48","author":"Bonet","year":"1989","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.rmed.2007.12.007_bib94","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1183\/09031936.93.03050586","article-title":"Low value of adenosine deaminase in tuberculous pleural effusions","volume":"3","author":"Querol","year":"1990","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmed.2007.12.007_bib95","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1378\/chest.97.5.1141","article-title":"Elevated levels of soluble interleukin-2 receptors in tuberculous pleural effusions","volume":"97","author":"Ito","year":"1990","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib96","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1378\/chest.99.3.790-a","article-title":"Adenosine deaminase in lymphocytic population","volume":"99","author":"Bovornkitti","year":"1991","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib97","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1378\/chest.102.4.1055","article-title":"Interleukin 6 activity in pleural effusion. Its diagnostic value and thrombopoietic activity","volume":"102","author":"Yokoyama","year":"1992","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib98","first-page":"668","article-title":"Diagnostic value of pleural adenosine deaminase in tuberculous effusions in immunocompromised hosts","volume":"92","author":"Hsu","year":"1993","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.rmed.2007.12.007_bib99","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1378\/chest.106.5.1633","article-title":"Adenosine deaminase in tuberculous pleural effusion","volume":"106","author":"Orriols","year":"1994","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib100","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1378\/chest.109.2.572","article-title":"Similar pleural fluid findings in pleuropulmonary tularemia and tuberculous pleurisy","volume":"109","author":"Pettersson","year":"1996","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib101","first-page":"453","article-title":"Diagnostic methods of primary tuberculous pleural effusion in a region with high prevalence of tuberculosis. A study in Mexican population","volume":"49","author":"Salazar-Lezama","year":"1997","journal-title":"Rev Invest Clin"},{"key":"10.1016\/j.rmed.2007.12.007_bib102","first-page":"831","article-title":"Isoenzymes of adenosine deaminase in pleural effusions: a diagnostic tool?","volume":"2","author":"Carstens","year":"1998","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2007.12.007_bib103","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1001\/archinte.158.18.2017","article-title":"Tuberculous pleurisy. A study of 254 patients","volume":"158","author":"Valdes","year":"1998","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib104","first-page":"868","article-title":"Elevated soluble CD26 levels in patients with tuberculous pleurisy","volume":"5","author":"Oshikawa","year":"2001","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2007.12.007_bib105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.clinbiochem.2004.09.023","article-title":"Role of biochemical tests in the diagnosis of exudative pleural effusions","volume":"38","author":"Ernam","year":"2005","journal-title":"Clin Biochem"},{"key":"10.1016\/j.rmed.2007.12.007_bib106","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1440-1843.2006.00866.x","article-title":"Influence of storage time and temperature on pleural fluid adenosine deaminase determination","volume":"11","author":"Antonangelo","year":"2006","journal-title":"Respirology"},{"key":"10.1016\/j.rmed.2007.12.007_bib107","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1001\/archinte.1990.00390180034005","article-title":"Cytologic and bacteriologic analysis of fluid and pleural biopsy specimens with Cope's needle. Study of 414 patients","volume":"150","author":"Escudero Bueno","year":"1990","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib108","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1378\/chest.91.1.106","article-title":"Tuberculous pleural effusions","volume":"91","author":"Epstein","year":"1987","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib109","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1378\/chest.99.4.883","article-title":"Tuberculous pleural effusion. Twenty-year experience","volume":"99","author":"Seibert","year":"1991","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib110","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00063198-200007000-00002","article-title":"The use of adenosine deaminase and adenosine deaminase isoenzymes in the diagnosis of tuberculous pleuritis","volume":"6","author":"Perez-Rodriguez","year":"2000","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib111","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1440-1843.2005.00689.x","article-title":"Management of tuberculous pleuritis: can we do better?","volume":"10","author":"Wong","year":"2005","journal-title":"Respirology"},{"key":"10.1016\/j.rmed.2007.12.007_bib112","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1378\/chest.125.3.987","article-title":"Comparison of six biological markers for the diagnosis of tuberculous pleuritis","volume":"125","author":"Hiraki","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2007.12.007_bib113","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0895-4356(03)00177-X","article-title":"The diagnostic odds ratio: a single indicator of test performance","volume":"56","author":"Glas","year":"2003","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.rmed.2007.12.007_bib114","series-title":"Systematic reviews in health care. Meta-analysis in context","first-page":"248","article-title":"Systematic reviews of evaluations of diagnostic and screening tests","author":"Deeks","year":"2001"},{"key":"10.1016\/j.rmed.2007.12.007_bib115","series-title":"Users\u2019 guides to the medical literature. A manual for evidence-based clinical practice","first-page":"121","article-title":"Diagnostic tests","author":"Jaeschke","year":"2002"},{"key":"10.1016\/j.rmed.2007.12.007_bib116","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1002\/sim.1091","article-title":"Approaches to heterogeneity in meta-analysis","volume":"20","author":"Petitti","year":"2001","journal-title":"Stat Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib117","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1001\/archinte.158.18.1967","article-title":"Establishing the diagnosis of tuberculous pleuritis","volume":"158","author":"Light","year":"1998","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.rmed.2007.12.007_bib118","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1378\/chest.06-2273","article-title":"Diagnostic value of interferon-\u03b3 in tuberculous pleurisy: a meta-analysis","volume":"131","author":"Jiang","year":"2007","journal-title":"Chest"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611107005069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611107005069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:33:18Z","timestamp":1760610798000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611107005069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":118,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["S0954611107005069"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2007.12.007","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2007.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}