{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T07:07:51Z","timestamp":1773472071549,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1847,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1016\/j.rmed.2008.02.019","type":"journal-article","created":{"date-parts":[[2008,6,25]],"date-time":"2008-06-25T06:09:10Z","timestamp":1214374150000},"page":"1193-1197","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea"],"prefix":"10.1016","volume":"102","author":[{"given":"Ahmet","family":"Ursava\u015f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Karadag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arzu Yilmaztepe","family":"Oral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezgi","family":"Demirdogen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haluk Barbaros","family":"Oral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erc\u00fcment","family":"Ege","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2008.02.019_bib1","series-title":"Diagnostic and coding manual","article-title":"The international classification of sleep disorders","author":"ASDA Diagnostic Classification Steering Committee","year":"1997"},{"key":"10.1016\/j.rmed.2008.02.019_bib2","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1463-1326.2005.00508.x","article-title":"Obesity-related cardiovascular disease: implications of obstructive sleep apnea","volume":"8","author":"Wolk","year":"2006","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.rmed.2008.02.019_bib3","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0140-6736(05)71141-7","article-title":"Long-term cardiovascular outcomes in men with obstructive sleep apnoea\u2013hypopnoea with or without treatment with continuous positive airway pressure: an observational study","volume":"365","author":"Marin","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2008.02.019_bib4","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1056\/NEJMoa043104","article-title":"Obstructive sleep apnea as a risk factor for stroke and death","volume":"353","author":"Yaggi","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rmed.2008.02.019_bib5","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000089814","article-title":"Deleterious effect of sleep breathing disorders on the heart and vascular system","volume":"73","author":"Dincer","year":"2006","journal-title":"Respiration"},{"key":"10.1016\/j.rmed.2008.02.019_bib6","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1172\/JCI8341","article-title":"Pathophysiology role of leptin in obesity related hypertension","volume":"105","author":"Aizawa-Abe","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.rmed.2008.02.019_bib7","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0021-9258(18)53931-4","article-title":"Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP","volume":"268","author":"Werner-Felmayer","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1016\/j.rmed.2008.02.019_bib8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1046\/j.1365-2710.2001.00358.x","article-title":"Neopterin measurement in clinical diagnosis","volume":"26","author":"Berdowska","year":"2001","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.rmed.2008.02.019_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000236491","article-title":"Neopterin, biochemistry and clinical use as a marker for cellular immune reactions","volume":"101","author":"Fuchs","year":"1993","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.rmed.2008.02.019_bib10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/1389200024605082","article-title":"Neopterin as a marker for immune system activation","volume":"3","author":"Murr","year":"2002","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.rmed.2008.02.019_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11325-007-0145-7","article-title":"Reliability and validity studies of the Turkish version of the Epworth Sleepiness Scale","volume":"12","author":"Izci","year":"2008","journal-title":"Sleep Breath"},{"key":"10.1016\/j.rmed.2008.02.019_bib12","series-title":"A manual of standardized terminology techniques and scoring system for sleep stages of human subjects","first-page":"1","year":"1973"},{"key":"10.1016\/j.rmed.2008.02.019_bib13","first-page":"177","article-title":"Neopterin derivatives to activate NF-kappa B","volume":"23","author":"Wirleitner","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.rmed.2008.02.019_bib14","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-kappa B: a pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N Engl J Med"},{"issue":"Suppl. 1","key":"10.1016\/j.rmed.2008.02.019_bib15","first-page":"6","article-title":"Immune response and iron metabolism","volume":"81","author":"Weiss","year":"1998","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.rmed.2008.02.019_bib16","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/S0140-6736(05)62447-6","article-title":"Serum neopterin in acute coronary syndromes","volume":"349","author":"Gupta","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2008.02.019_bib17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0735-1097(97)00172-1","article-title":"Increased neopterin in patients with chronic and acute coronary syndromes","volume":"30","author":"Schumacher","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.rmed.2008.02.019_bib18","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1136\/heart.83.3.346","article-title":"Increased serum neopterin: a marker of coronary artery disease activity in women","volume":"83","author":"Garcia-Moll","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.rmed.2008.02.019_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0002-8703(03)00101-7","article-title":"Neopterin levels in patients with coronary artery disease are independent of Chlamydia pneumoniae seropositivity","volume":"146","author":"Smith","year":"2003","journal-title":"Am Heart J"},{"key":"10.1016\/j.rmed.2008.02.019_bib20","doi-asserted-by":"crossref","first-page":"c134","DOI":"10.1159\/000086684","article-title":"Association between neopterin and carotid intima-media thickness in hemodialysis patients","volume":"101","author":"Erten","year":"2005","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.rmed.2008.02.019_bib21","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/jcu.20093","article-title":"Evaluation of carotid artery wall thickness with high-resolution sonography in obstructive sleep apnea syndrome","volume":"33","author":"Altin","year":"2005","journal-title":"J Clin Ultrasound"},{"key":"10.1016\/j.rmed.2008.02.019_bib22","first-page":"503","article-title":"Increased carotid intima-media thickness and associations with cardiovascular risk factors in obese and overweight children and adolescents","volume":"12","author":"Schiel","year":"2007","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.rmed.2008.02.019_bib23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1007\/s11883-007-0009-4","article-title":"Obesity and inflammation: a new look at an old problem","volume":"9","author":"Mehta","year":"2007","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.rmed.2008.02.019_bib24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.diabet.2007.09.004","article-title":"Adipokines: the missing link between insulin resistance and obesity","volume":"34","author":"Antuna-Puente","year":"2008","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.rmed.2008.02.019_bib25","first-page":"4","article-title":"Recent advances in the relationship between obesity, inflammation, and insulin resistance","volume":"17","author":"Bastard","year":"2006","journal-title":"Eur Cytokine Netw"},{"key":"10.1016\/j.rmed.2008.02.019_bib26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0009-8981(99)00019-4","article-title":"Association between insulin resistance, body mass and neopterin concentrations","volume":"282","author":"Ledochowski","year":"1999","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.rmed.2008.02.019_bib27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1515\/CCLM.2006.055","article-title":"C-reactive protein and neopterin levels in healthy non-obese adults","volume":"44","author":"Bozdemir","year":"2006","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.rmed.2008.02.019_bib28","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1001\/archinte.158.12.1333","article-title":"Obesity without sleep apnea is associated with daytime sleepiness","volume":"158","author":"Vgontzas","year":"1998","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.rmed.2008.02.019_bib29","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1210\/jc.2005-0035","article-title":"Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression","volume":"90","author":"Bixler","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.rmed.2008.02.019_bib30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1389-9457(03)00118-7","article-title":"Sleep disordered breathing may not be an independent risk factor for diabetes, but diabetes may contribute to the occurrence of periodic breathing in sleep","volume":"4","author":"Sanders","year":"2003","journal-title":"Sleep Med"},{"key":"10.1016\/j.rmed.2008.02.019_bib31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.sleep.2006.06.014","article-title":"Obesity, and not obstructive sleep apnea, is responsible for metabolic abnormalities in a cohort with sleep-disordered breathing","volume":"8","author":"Sharma","year":"2007","journal-title":"Sleep Med"},{"key":"10.1016\/j.rmed.2008.02.019_bib32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.sleep.2007.02.004","article-title":"Obesity, and not obstructive sleep apnea, is responsible for increased serum hs-CRP levels in patients with sleep-disordered breathing in Delhi","volume":"9","author":"Sharma","year":"2008","journal-title":"Sleep Med"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611108000954?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611108000954?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:38:11Z","timestamp":1760611091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611108000954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0954611108000954"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2008.02.019","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between serum neopterin, obesity and daytime sleepiness in patients with obstructive sleep apnea","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2008.02.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}