{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:16:47Z","timestamp":1792448207539,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":1539,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.rmed.2008.12.004","type":"journal-article","created":{"date-parts":[[2008,12,31]],"date-time":"2008-12-31T04:39:02Z","timestamp":1230698342000},"page":"700-706","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Bronchial and peripheral airway nitric oxide in primary ciliary dyskinesia and bronchiectasis"],"prefix":"10.1016","volume":"103","author":[{"given":"A.","family":"Shoemark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2008.12.004_bib1","series-title":"Respiratory medicine","first-page":"1445","article-title":"Bronchiectasis","author":"Wilson","year":"2003"},{"issue":"8890","key":"10.1016\/j.rmed.2008.12.004_bib2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0140-6736(94)90931-8","article-title":"Increased nitric oxide in exhaled air of asthmatic patients","volume":"343","author":"Kharitonov","year":"1994","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.rmed.2008.12.004_bib3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1136\/thorax.58.1.68","article-title":"Comparison of exhaled and nasal nitric oxide and exhaled carbon monoxide levels in bronchiectatic patients with and without primary ciliary dyskinesia","volume":"58","author":"Horvath","year":"2003","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.rmed.2008.12.004_bib4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1183\/09031936.03.00305503","article-title":"Nasal nitric oxide measurements for the screening of primary ciliary dyskinesia","volume":"21","author":"Wodehouse","year":"2003","journal-title":"Eur Respir J"},{"issue":"1","key":"10.1016\/j.rmed.2008.12.004_bib5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1136\/thx.2003.017327","article-title":"Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis","volume":"60","author":"Ojoo","year":"2005","journal-title":"Thorax"},{"issue":"7","key":"10.1016\/j.rmed.2008.12.004_bib6","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1136\/thorax.57.7.586","article-title":"Nitric oxide in chronic airway inflammation in children: diagnostic use and pathophysiological significance","volume":"57","author":"Narang","year":"2002","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.rmed.2008.12.004_bib7","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1152\/jappl.1998.85.2.653","article-title":"A two-compartment model of pulmonary nitric oxide exchange dynamics","volume":"85","author":"Tsoukias","year":"1998","journal-title":"J Appl Physiol"},{"issue":"6","key":"10.1016\/j.rmed.2008.12.004_bib8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3109\/07853890008995949","article-title":"Increased bronchial nitric oxide production in patients with asthma measured with a novel method of different exhalation flow rates","volume":"32","author":"Lehtimaki","year":"2000","journal-title":"Ann Med"},{"issue":"3","key":"10.1016\/j.rmed.2008.12.004_bib9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/thx.52.3.260","article-title":"Effects of airway infection by Pseudomonas aeruginosa: a computed tomographic study","volume":"52","author":"Miszkiel","year":"1997","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.rmed.2008.12.004_bib10","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1183\/09031936.98.12061290","article-title":"Exhaled nitric oxide is not elevated in the inflammatory airways diseases of cystic fibrosis and bronchiectasis","volume":"12","author":"Ho","year":"1998","journal-title":"Eur Respir J"},{"issue":"6","key":"10.1016\/j.rmed.2008.12.004_bib11","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.rmed.2006.11.008","article-title":"Aetiology in adult patients with bronchiectasis","volume":"101","author":"Shoemark","year":"2007","journal-title":"Respir Med"},{"issue":"3","key":"10.1016\/j.rmed.2008.12.004_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/1479972308088823","article-title":"Procalcitonin in stable and unstable patients with bronchiectasis","volume":"5","author":"Loebinger","year":"2008","journal-title":"Chron Respir Dis"},{"issue":"2","key":"10.1016\/j.rmed.2008.12.004_bib13","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1164\/ajrccm.152.2.7543345","article-title":"Acute and chronic effects of cigarette smoking on exhaled nitric oxide","volume":"152","author":"Kharitonov","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"issue":"6\u00a0Suppl.","key":"10.1016\/j.rmed.2008.12.004_bib14","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1378\/chest.80.6.865","article-title":"Nasal brushing and measurement of ciliary beat frequency. An in vitro method for evaluating pharmacologic effects on human cilia","volume":"80","author":"Rutland","year":"1981","journal-title":"Chest"},{"issue":"3","key":"10.1016\/j.rmed.2008.12.004_bib15","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/jcp.35.3.357","article-title":"Nasal brushing for the study of ciliary ultrastructure","volume":"35","author":"Rutland","year":"1982","journal-title":"J Clin Pathol"},{"issue":"3","key":"10.1016\/j.rmed.2008.12.004_bib16","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00004728-198206000-00001","article-title":"Computed tomography of bronchiectasis","volume":"6","author":"Naidich","year":"1982","journal-title":"J Comput Assist Tomogr"},{"issue":"1","key":"10.1016\/j.rmed.2008.12.004_bib17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0007-0971(84)90098-6","article-title":"Efficacy of a saccharin test for screening to detect abnormal mucociliary clearance","volume":"78","author":"Stanley","year":"1984","journal-title":"Br J Dis Chest"},{"issue":"8","key":"10.1016\/j.rmed.2008.12.004_bib18","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide","volume":"171","author":"ATS\/ERS","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rmed.2008.12.004_bib19","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/ppul.20670","article-title":"Nitric oxide production in PCD: possible evidence for differential nitric oxide synthase function","volume":"42","author":"Paraskakis","year":"2007","journal-title":"Pediatr Pulmonol"},{"issue":"8","key":"10.1016\/j.rmed.2008.12.004_bib20","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1183\/09031936.94.07081501","article-title":"Primarily nasal origin of exhaled nitric oxide and absence in Kartagener's syndrome","volume":"7","author":"Lundberg","year":"1994","journal-title":"Eur Respir J"},{"issue":"2","key":"10.1016\/j.rmed.2008.12.004_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1034\/j.1399-3003.1999.13b15.x","article-title":"Nasal nitric oxide concentration in paranasal sinus inflammatory diseases","volume":"13","author":"Arnal","year":"1999","journal-title":"Eur Respir J"},{"issue":"6","key":"10.1016\/j.rmed.2008.12.004_bib22","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1183\/09031936.99.13614069","article-title":"Nasal and lower airway level of nitric oxide in children with primary ciliary dyskinesia","volume":"13","author":"Karadag","year":"1999","journal-title":"Eur Respir J"},{"issue":"6","key":"10.1016\/j.rmed.2008.12.004_bib23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/ppul.20202","article-title":"Correlation between cough frequency and airway inflammation in children with primary ciliary dyskinesia","volume":"39","author":"Zihlif","year":"2005","journal-title":"Pediatr Pulmonol"},{"issue":"2","key":"10.1016\/j.rmed.2008.12.004_bib24","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/ppul.20329","article-title":"Impairment of nitric oxide output of conducting airways in primary ciliary dyskinesia","volume":"41","author":"Mahut","year":"2006","journal-title":"Pediatr Pulmonol"},{"issue":"3","key":"10.1016\/j.rmed.2008.12.004_bib25","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1152\/japplphysiol.00950.2003","article-title":"Modeling pulmonary nitric oxide exchange","volume":"96","author":"George","year":"2004","journal-title":"J Appl Physiol"},{"issue":"1","key":"10.1016\/j.rmed.2008.12.004_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1006\/bbrc.1993.1187","article-title":"Modulation of airway epithelial cell ciliary beat frequency by nitric oxide","volume":"191","author":"Jain","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.rmed.2008.12.004_bib27","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1164\/ajrccm.153.2.8564142","article-title":"Expression of nitric oxide synthase in the human nasal mucosa","volume":"153","author":"Furukawa","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.rmed.2008.12.004_bib28","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1177\/44.5.8627003","article-title":"Localization of endothelial NOS at the basal microtubule membrane in ciliated epithelium of rat lung","volume":"44","author":"Xue","year":"1996","journal-title":"J Histochem Cytochem"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095461110800423X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095461110800423X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:48:40Z","timestamp":1760611720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095461110800423X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S095461110800423X"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2008.12.004","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bronchial and peripheral airway nitric oxide in primary ciliary dyskinesia and bronchiectasis","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2008.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}