{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:01:05Z","timestamp":1791223265678,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,8,22]],"date-time":"2013-08-22T00:00:00Z","timestamp":1377129600000},"content-version":"vor","delay-in-days":1574,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.rmed.2009.01.002","type":"journal-article","created":{"date-parts":[[2009,2,8]],"date-time":"2009-02-08T04:20:22Z","timestamp":1234066822000},"page":"661-669","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Pulmonary complications of tumor necrosis factor-targeted therapy"],"prefix":"10.1016","volume":"103","author":[{"given":"Krishna","family":"Thavarajah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa J.","family":"Rhew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjana K.","family":"Yeldandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Kamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.rmed.2009.01.002_bib1","first-page":"5","article-title":"Targeting TNF-alpha: a novel therapeutic approach for asthma","volume":"121","author":"Brightling","year":"2008","journal-title":"The Journal of Allergy and Clinical Immunology"},{"issue":"12","key":"10.1016\/j.rmed.2009.01.002_bib2","first-page":"1267","article-title":"Biological agents for rheumatoid arthritis: targeting both physical function and structural damage","volume":"64","author":"Klinkhoff","year":"2004","journal-title":"Drugs"},{"issue":"6","key":"10.1016\/j.rmed.2009.01.002_bib3","first-page":"932","article-title":"Infliximab: a novel chimeric monoclonal antibody for the treatment of Crohn's disease","volume":"21","author":"Mouser","year":"1999","journal-title":"Clinical Therapeutics"},{"issue":"4","key":"10.1016\/j.rmed.2009.01.002_bib4","first-page":"375","article-title":"Adalimumab (HUMIRA): a review","volume":"2","author":"Scheinfeld","year":"2003","journal-title":"Journal of Drugs in Dermatology"},{"issue":"1","key":"10.1016\/j.rmed.2009.01.002_bib5","first-page":"75","article-title":"Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis","volume":"21","author":"Goldenberg","year":"1999","journal-title":"Clinical Therapeutics"},{"key":"10.1016\/j.rmed.2009.01.002_bib6","unstructured":"Available from: http:\/\/www.accessdata.fda.gov\/scripts\/cder\/drugsatfda\/."},{"issue":"3","key":"10.1016\/j.rmed.2009.01.002_bib7","first-page":"159","article-title":"Tumor necrosis factor antagonists: different kinetics and\/or mechanisms of action may explain differences in the risk for developing granulomatous infection","volume":"36","author":"Furst","year":"2006","journal-title":"Seminars in Arthritis and Rheumatism"},{"issue":"10","key":"10.1016\/j.rmed.2009.01.002_bib8","first-page":"1285","article-title":"The divergent role of tumor necrosis factor receptors in infectious diseases","volume":"2","author":"Schluter","year":"2000","journal-title":"Microbes and Infection\/Institut Pasteur"},{"issue":"3\u20134","key":"10.1016\/j.rmed.2009.01.002_bib9","first-page":"231","article-title":"Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models","volume":"19","author":"Kruglov","year":"2008","journal-title":"Cytokine & Growth Factor Reviews"},{"issue":"5","key":"10.1016\/j.rmed.2009.01.002_bib10","first-page":"847","article-title":"Autoimmune diseases induced by TNF-targeted therapies","volume":"22","author":"Ramos-Casals","year":"2008","journal-title":"Best Practice & Research"},{"issue":"15","key":"10.1016\/j.rmed.2009.01.002_bib11","first-page":"1098","article-title":"Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent","volume":"345","author":"Keane","year":"2001","journal-title":"The New England Journal of Medicine"},{"issue":"9","key":"10.1016\/j.rmed.2009.01.002_bib12","first-page":"1279","article-title":"Histoplasmosis after treatment with anti-tumor necrosis factor-alpha therapy","volume":"167","author":"Wood","year":"2003","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"6","key":"10.1016\/j.rmed.2009.01.002_bib13","first-page":"2395","article-title":"Pulmonary cryptococcosis after initiation of anti-tumor necrosis factor-alpha therapy","volume":"124","author":"Hage","year":"2003","journal-title":"Chest"},{"issue":"10","key":"10.1016\/j.rmed.2009.01.002_bib14","first-page":"685","article-title":"Pulmonary infectious complications associated with anti-TNFalpha therapy (infliximab) for rheumatoid arthritis","volume":"45","author":"Imaizumi","year":"2006","journal-title":"Internal Medicine"},{"issue":"5","key":"10.1016\/j.rmed.2009.01.002_bib15","first-page":"617","article-title":"Serious bacterial infections in patients with rheumatoid arthritis under anti-TNF-alpha therapy","volume":"42","author":"Kroesen","year":"2003","journal-title":"Rheumatology (Oxford, England)"},{"issue":"4","key":"10.1016\/j.rmed.2009.01.002_bib16","first-page":"1125","article-title":"Risk of serious bacterial infections among rheumatoid arthritis patients exposed to tumor necrosis factor alpha antagonists","volume":"56","author":"Curtis","year":"2007","journal-title":"Arthritis and Rheumatism"},{"issue":"5","key":"10.1016\/j.rmed.2009.01.002_bib17","first-page":"1858","article-title":"Lung injury linked to etanercept therapy","volume":"122","author":"Peno-Green","year":"2002","journal-title":"Chest"},{"issue":"4","key":"10.1016\/j.rmed.2009.01.002_bib18","first-page":"618","article-title":"Granulomatous lung disease occurring during etanercept treatment","volume":"53","author":"Phillips","year":"2005","journal-title":"Arthritis and Rheumatism"},{"issue":"5","key":"10.1016\/j.rmed.2009.01.002_bib19","first-page":"651","article-title":"Pulmonary lymphohistiocytic reactions temporally related to etanercept therapy","volume":"18","author":"Yousem","year":"2005","journal-title":"Modern Pathology"},{"issue":"5","key":"10.1016\/j.rmed.2009.01.002_bib20","first-page":"817","article-title":"Development of sarcoidosis during etanercept therapy","volume":"55","author":"Gonzalez-Lopez","year":"2006","journal-title":"Arthritis and Rheumatism"},{"issue":"3","key":"10.1016\/j.rmed.2009.01.002_bib21","first-page":"648","article-title":"Sarcoid-like granulomatous disease following etanercept treatment for RA","volume":"34","author":"Kudrin","year":"2007","journal-title":"The Journal of Rheumatology"},{"issue":"1","key":"10.1016\/j.rmed.2009.01.002_bib22","first-page":"99","article-title":"Pulmonary sarcoidosis in a patient with ankylosing spondylitis treated with infliximab","volume":"25","author":"Almodovar","year":"2007","journal-title":"Clinical and Experimental Rheumatology"},{"issue":"6","key":"10.1016\/j.rmed.2009.01.002_bib23","first-page":"978","article-title":"Pulmonary sarcoidosis developing during infliximab therapy","volume":"55","author":"O'Shea","year":"2006","journal-title":"Arthritis and Rheumatism"},{"issue":"6","key":"10.1016\/j.rmed.2009.01.002_bib24","first-page":"761","article-title":"The rheumatoid nodule","volume":"33","author":"Ziff","year":"1990","journal-title":"Arthritis and Rheumatism"},{"issue":"5","key":"10.1016\/j.rmed.2009.01.002_bib25","first-page":"489","article-title":"Tumour necrosis factor alpha independent disease mechanisms in rheumatoid arthritis: a histopathological study on the effect of infliximab on rheumatoid nodules","volume":"63","author":"Baeten","year":"2004","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"4","key":"10.1016\/j.rmed.2009.01.002_bib26","first-page":"445","article-title":"Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis","volume":"47","author":"Cunnane","year":"2002","journal-title":"Arthritis and Rheumatism"},{"issue":"3","key":"10.1016\/j.rmed.2009.01.002_bib27","first-page":"843","article-title":"Development of rheumatoid nodules during anti-tumor necrosis factor alpha therapy with etanercept","volume":"46","author":"Kekow","year":"2002","journal-title":"Arthritis and Rheumatism"},{"issue":"7","key":"10.1016\/j.rmed.2009.01.002_bib28","first-page":"2077","article-title":"Pulmonary rheumatoid nodules in an etanercept-treated patient","volume":"48","author":"Hubscher","year":"2003","journal-title":"Arthritis and Rheumatism"},{"issue":"7","key":"10.1016\/j.rmed.2009.01.002_bib29","first-page":"1590","article-title":"Etanercept-related extensive pulmonary nodulosis in a patient with rheumatoid arthritis","volume":"34","author":"van Ede","year":"2007","journal-title":"The Journal of Rheumatology"},{"issue":"3","key":"10.1016\/j.rmed.2009.01.002_bib30","first-page":"622","article-title":"Pulmonary complications of infliximab therapy in patients with rheumatoid arthritis","volume":"33","author":"Ostor","year":"2006","journal-title":"The Journal of Rheumatology"},{"issue":"5","key":"10.1016\/j.rmed.2009.01.002_bib31","first-page":"709","article-title":"Terminal diffuse alveolar damage in relation to interstitial pneumonias. An autopsy study","volume":"119","author":"Rice","year":"2003","journal-title":"American Journal of Clinical Pathology"},{"issue":"5","key":"10.1016\/j.rmed.2009.01.002_bib32","first-page":"1151","article-title":"Acute exacerbation of preexisting interstitial lung disease after administration of etanercept for rheumatoid arthritis","volume":"34","author":"Hagiwara","year":"2007","journal-title":"The Journal of Rheumatology"},{"issue":"1","key":"10.1016\/j.rmed.2009.01.002_bib33","first-page":"35","article-title":"Biological and clinical effects of anti-TNFalpha treatment","volume":"7","author":"Valesini","year":"2007","journal-title":"Autoimmunity Reviews"},{"issue":"6","key":"10.1016\/j.rmed.2009.01.002_bib34","first-page":"1189","article-title":"Interstitial pneumonitis associated with infliximab therapy","volume":"33","author":"Villeneuve","year":"2006","journal-title":"The Journal of Rheumatology"},{"issue":"4","key":"10.1016\/j.rmed.2009.01.002_bib35","first-page":"276","article-title":"Severe interstitial pneumonitis associated with infliximab therapy","volume":"33","author":"Chatterjee","year":"2004","journal-title":"Scandinavian Jouranl of Rheumatology"},{"issue":"4","key":"10.1016\/j.rmed.2009.01.002_bib36","first-page":"617","article-title":"Comment on methotrexate pneumonitis after initiation of infliximab therapy for rheumatoid arthritis","volume":"49","author":"Courtney","year":"2003","journal-title":"Arthritis and Rheumatism"},{"issue":"6","key":"10.1016\/j.rmed.2009.01.002_bib37","first-page":"670","article-title":"Methotrexate pneumonitis after initiation of infliximab therapy for rheumatoid arthritis","volume":"47","author":"Kramer","year":"2002","journal-title":"Arthritis and Rheumatism"},{"issue":"4","key":"10.1016\/j.rmed.2009.01.002_bib38","first-page":"242","article-title":"Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases","volume":"86","author":"Ramos-Casals","year":"2007","journal-title":"Medicine (Baltimore)"},{"issue":"9","key":"10.1016\/j.rmed.2009.01.002_bib39","first-page":"764","article-title":"Infliximab-induced SLE-like syndrome involving the lung and pleura","volume":"16","author":"Diri","year":"2007","journal-title":"Lupus"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095461110900002X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S095461110900002X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:50:49Z","timestamp":1760611849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S095461110900002X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S095461110900002X"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2009.01.002","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pulmonary complications of tumor necrosis factor-targeted therapy","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2009.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}