{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:22:54Z","timestamp":1791174174509,"version":"4.1.0"},"reference-count":132,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":1325,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.rmed.2009.07.010","type":"journal-article","created":{"date-parts":[[2009,8,6]],"date-time":"2009-08-06T05:51:28Z","timestamp":1249537888000},"page":"1777-1790","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["Recent advances in the diagnosis and treatment of multidrug-resistant tuberculosis"],"prefix":"10.1016","volume":"103","author":[{"given":"Suhail","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiman","family":"Mokaddas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rmed.2009.07.010_bib1","series-title":"Global tuberculosis control: surveillance, planning and financing","author":"World Health Organization","year":"2008"},{"key":"10.1016\/j.rmed.2009.07.010_bib2","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0140-6736(03)14333-4","article-title":"Tuberculosis","volume":"362","author":"Frieden","year":"2003","journal-title":"Lancet"},{"issue":"Suppl. 1","key":"10.1016\/j.rmed.2009.07.010_bib3","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1086\/518665","article-title":"HIV infection and multidrug-resistant tuberculosis-the perfect storm","volume":"196","author":"Wells","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib4","first-page":"769","article-title":"Streptomycin treatment of pulmonary tuberculosis: a Medical Research Council Investigation","volume":"4582","author":"Medical Research Council","year":"1948","journal-title":"Br Med J"},{"key":"10.1016\/j.rmed.2009.07.010_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0041-3879(85)90040-6","article-title":"The action of antituberculosis drugs in short-course chemotherapy","volume":"66","author":"Mitchison","year":"1985","journal-title":"Tubercle"},{"key":"10.1016\/j.rmed.2009.07.010_bib6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1164\/rccm.200411-1603OE","article-title":"The diagnosis and therapy of tuberculosis during the past 100 years","volume":"171","author":"Mitchison","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib7","first-page":"1","article-title":"Treatment of tuberculosis","volume":"52","year":"2003","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.rmed.2009.07.010_bib8","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1128\/JCM.01780-07","article-title":"Cavitary disease and quantitative sputum bacillary load in cases of pulmonary tuberculosis","volume":"45","author":"Palaci","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib9","series-title":"Anti-tuberculosis drug resistance in the world: fourth Global report","author":"World Health Organization","year":"2008"},{"key":"10.1016\/j.rmed.2009.07.010_bib10","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.3201\/eid0811.020507","article-title":"Rifampin- and multidrug-resistant tuberculosis in Russian civilians and prison inmates: dominance of the Beijing strain family","volume":"8","author":"Drobniewski","year":"2002","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib11","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1378\/chest.113.5.1178","article-title":"Low serum antimycobacterial drug levels in non-HIV-infected tuberculosis patients","volume":"113","author":"Kimerling","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.rmed.2009.07.010_bib12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5144\/0256-4947.2005.150","article-title":"Molecular fingerprinting reveals familial transmission of rifampin-resistant tuberculosis in Kuwait","volume":"25","author":"Mokaddas","year":"2005","journal-title":"Ann Saudi Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib13","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1016\/S0140-6736(06)69863-2","volume":"368","author":"Aziz","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2009.07.010_bib14","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1086\/505877","article-title":"Global incidence of multidrug-resistant tuberculosis","volume":"194","author":"Zignol","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib15","doi-asserted-by":"crossref","first-page":"e292","DOI":"10.1371\/journal.pmed.0040292","article-title":"Randomized trials to optimize treatment of multidrug-resistant tuberculosis","volume":"4","author":"Mitnick","year":"2007","journal-title":"PLoS Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib16","first-page":"301","article-title":"Emergence of Mycobacterium tuberculosis with extensive resistance to second-line drugs-worldwide, 2000\u20132004","volume":"55","author":"Centers for Disease Control and Prevention (CDC)","year":"2006","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.rmed.2009.07.010_bib17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrmicro2048","article-title":"Doomsday postponed? Preventing and reversing epidemics of drug-resistant tuberculosis","volume":"7","author":"Dye","year":"2009","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib18","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/S0140-6736(06)69573-1","article-title":"Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa","volume":"368","author":"Gandhi","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2009.07.010_bib19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/358591a0","article-title":"The catalase\u2013peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis","volume":"358","author":"Zhang","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.rmed.2009.07.010_bib20","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0140-6736(93)90417-F","article-title":"Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis","volume":"341","author":"Telenti","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2009.07.010_bib21","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nm1466","article-title":"Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid","volume":"12","author":"Vilcheze","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1054\/tuld.1998.0002","article-title":"Molecular genetics basis of antimicrobial agent resistance in Mycobacterium tuberculosis: 1998 update","volume":"79","author":"Ramaswamy","year":"1998","journal-title":"Tuber Lung Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib23","first-page":"97","article-title":"Drug resistance in Mycobacterium tuberculosis","volume":"8","author":"Johnson","year":"2006","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.rmed.2009.07.010_bib24","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1128\/AAC.47.4.1241-1250.2003","article-title":"Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis","volume":"47","author":"Ramaswamy","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1089\/107662902760190644","article-title":"Variations in the occurrence of the S315T mutation within the katG gene in isoniazid-resistant clinical Mycobacterium tuberculosis isolates from Kuwait","volume":"8","author":"Abal","year":"2002","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.rmed.2009.07.010_bib26","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1128\/AAC.46.5.1417-1424.2002","article-title":"High prevalence of Ser315Thr substitution among isoniazid-resistant Mycobacterium tuberculosis clinical isolates of from Northwestern Russia, 1996\u20132001","volume":"46","author":"Mokrousov","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib27","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1128\/JCM.41.9.4471-4474.2003","article-title":"Mutations in katG, inhA, and ahpC genes of Brazilian isoniazid-resistant isolates of Mycobacterium tuberculosis","volume":"41","author":"Silva","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib28","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1128\/AAC.00112-06","article-title":"Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis","volume":"50","author":"Hazbon","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib29","first-page":"319","article-title":"Secular trends in susceptibility patterns of Mycobacterium tuberculosis isolates in Kuwait, 1996\u20132005","volume":"12","author":"Mokaddas","year":"2008","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib30","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1128\/JCM.39.2.636-641.2001","article-title":"Analysis for a limited number of gene codons can predict drug resistance of Mycobacterium tuberculosis in a high-incidence community","volume":"39","author":"Van Rie","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib31","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1128\/AAC.46.2.443-450.2002","article-title":"Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India","volume":"46","author":"Siddiqi","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib32","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1093\/jac\/dkm086","article-title":"Molecular characteristics of rifampicin- and isoniazid resistant Mycobacterium tuberculosis isolates from Russian Federation","volume":"59","author":"Afanas'ev","year":"2007","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0732-8893(02)00457-1","article-title":"Characterization of rpoB mutations in rifampin-resistant clinical Mycobacterium tuberculosis isolates from Kuwait and Dubai","volume":"44","author":"Ahmad","year":"2002","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib34","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1365-2672.2008.03815.x","article-title":"Characterization of rpoB mutations associated with rifampin resistance in Mycobacterium tuberculosis from eastern China","volume":"105","author":"Sheng","year":"2008","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1128\/JCM.39.1.107-110.2001","article-title":"Frequency of rpoB mutations inside and outside the cluster I region in rifampin-resistant clinical Mycobacterium tuberculosis isolates","volume":"39","author":"Heep","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ijantimicag.2005.06.009","article-title":"The occurrence of rare rpoB mutations in rifampicin-resistant Mycobacterium tuberculosis isolates from Kuwait","volume":"26","author":"Ahmad","year":"2005","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.rmed.2009.07.010_bib37","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/jac\/42.5.621","article-title":"Relationship between antimycobacterial activities of rifampicin, rifabutin and KRM-1648 and rpoB mutations of Mycobacterium tuberculosis","volume":"42","author":"Yang","year":"1998","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib38","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1469-0691.2004.00917.x","article-title":"In-vitro activity of rifabutin against rifampicin-esistant Mycobacterium tuberculosis isolates with known rpoB mutations","volume":"10","author":"Cavusoglu","year":"2004","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.rmed.2009.07.010_bib39","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nm0696-662","article-title":"Mutations in pncA, a gene encoding pyrazinamidase\/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus","volume":"2","author":"Scorpio","year":"1996","journal-title":"Nat Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib40","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1128\/JCM.00352-07","article-title":"Development and evaluation of a line probe assay for rapid identification of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis strains","volume":"45","author":"Sekiguchi","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib41","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1128\/AAC.44.2.326-336.2000","article-title":"Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis","volume":"44","author":"Ramaswamy","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib42","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nm0597-567","article-title":"The emb operon, a unique gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol","volume":"3","author":"Telenti","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib43","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1128\/AAC.01486-07","article-title":"Transfer of embB codon 306 mutations into clinical Mycobacterium tuberculosis strains alters susceptibility to ethambutol, isoniazid and rifampin","volume":"52","author":"Safi","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib44","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1128\/AAC.01357-08","article-title":"Mutations at embB codon 306 are an important molecular indicator of ethambutol resistance in Mycobacterium tuberculosis","volume":"53","author":"Starks","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tube.2006.05.004","article-title":"Frequency of embB codon 306 mutations in ethambutol-susceptible and -resistant clinical Mycobacterium tuberculosis isolates in Kuwait","volume":"87","author":"Ahmad","year":"2007","journal-title":"Tuberculosis"},{"key":"10.1016\/j.rmed.2009.07.010_bib46","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1128\/AAC.40.4.1024","article-title":"Characterization of rpsL and rrs mutations in streptomycin-resistant Mycobacterium tuberculosis isolates from diverse geographic locations","volume":"40","author":"Sreevatsan","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib47","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1128\/AAC.40.5.1186","article-title":"Characterization of streptomycin resistance mechanisms among Mycobacterium tuberculosis isolates from patients in New York City","volume":"40","author":"Cooksey","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib48","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1128\/AAC.49.8.3192-3197.2005","article-title":"Molecular analysis of cross-resistance to capreomycin, kanamycin, amikacin and viomycin in Mycobacterium tuberculosis","volume":"49","author":"Maus","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib49","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1128\/AAC.49.2.571-577.2005","article-title":"Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis","volume":"49","author":"Maus","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib50","first-page":"128","article-title":"A phase II study of the sterilizing activities of ofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis","volume":"12","author":"Rustomjee","year":"2008","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib51","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S1473-3099(03)00671-6","article-title":"Fluoroquinolones, tuberculosis, and resistance","volume":"3","author":"Ginsburg","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib52","first-page":"228","article-title":"Mutations in the gyrA and gyrB genes of fluoroquinolone-resistant Mycobacterium tuberculosis from TB patients in Thailand","volume":"36","author":"Pitaksajjakul","year":"2005","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"10.1016\/j.rmed.2009.07.010_bib53","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/jac\/dkm061","article-title":"Fluoroquinolones resistance in Mycobacterium tuberculosis isolates: associated genetic mutations and relationship to antimicrobial exposure","volume":"59","author":"Wang","year":"2007","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib54","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1128\/AAC.47.12.3799-3805.2003","article-title":"ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates","volume":"47","author":"Morlock","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib55","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ccm.2005.02.012","article-title":"The diagnosis of tuberculosis","volume":"26","author":"Brodie","year":"2005","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib56","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1183\/09031936.05.00050305","article-title":"Nonconventional and new methods in the diagnosis of tuberculosis: feasibility and applicability in the field","volume":"26","author":"Palomino","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.rmed.2009.07.010_bib57","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10096-005-0039-1","article-title":"Molecular diagnostics in tuberculosis","volume":"24","author":"Cheng","year":"2005","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib58","doi-asserted-by":"crossref","first-page":"140","DOI":"10.7883\/yoken.JJID.2007.140","article-title":"Development and evaluation of a multiplex PCR for rapid detection and differentiation of Mycobacterium tuberculosis complex members from non-tuberculous mycobacteria","volume":"60","author":"Mokaddas","year":"2007","journal-title":"Jap J Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib59","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1128\/JCM.41.9.4418-4420.2003","article-title":"Evaluation of INNO-LiPA MYCOBACTERIA v2: improved reverse hybridization multiple DNA probe assay for mycobacterial identification","volume":"41","author":"Tortoli","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib60","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1128\/JCM.44.2.334-339.2006","article-title":"Evaluation of the new Genotype Mycobacterium assay for identification of mycobacterial species","volume":"44","author":"Russo","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib61","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00284-008-9102-3","article-title":"Species spectrum of nontuberculous mycobacteria causing infections in Kuwait","volume":"56","author":"Mokaddas","year":"2008","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib62","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1128\/JCM.40.2.607-610.2002","article-title":"Evaluation of automated BACTEC MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to four major antituberculous drugs: comparison with the radiometric BACTEC 460TB method and the agar plate method of proportion","volume":"40","author":"Tortoli","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib63","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1128\/JCM.42.3.1109-1114.2004","article-title":"Evaluation of the fully automated BACTEC MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to pyrazinamide, streptomycin, isoniazid, rifampin, and ethambutol and comparison with the radiometric BACTEC 460TB method","volume":"42","author":"Scarparo","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib64","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1128\/JCM.44.1.20-28.2006","article-title":"Current perspective on drug susceptibility testing of Mycobacterium tuberculosis complex: the automated nonradiometric systems","volume":"44","author":"Piersimoni","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib65","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1128\/JCM.44.3.688-692.2006","article-title":"Multicenter laboratory validation of the BACTEC MGIT 960 technique for testing susceptibilities of Mycobacterium tuberculosis to classical second-line and newer antimicrobials","volume":"44","author":"Rusch-Gerdes","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib66","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJMoa055524","article-title":"Microscopic-observation drug-susceptibility assay for the diagnosis of TB","volume":"355","author":"Moore","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib67","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1128\/JCM.01949-06","article-title":"Evaluation of microscopic observation drug susceptibility assay for the detection of multidrug-resistant Mycobacterium tuberculosis","volume":"45","author":"Shiferaw","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib68","first-page":"332","article-title":"Microscopic-observation drug susceptibility assay provides rapid and reliable identification of MDR-TB","volume":"12","author":"Ejigu","year":"2008","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib69","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1469-0691.2007.01698.x","article-title":"Rapid drug resistance detection in Mycobacterium tuberculosis. a review of colourimetric methods","volume":"13","author":"Palomino","year":"2007","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.rmed.2009.07.010_bib70","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1128\/JCM.42.2.871-873.2004","article-title":"Direct colorimetric assay for rapid detection of rifampin-resistant Mycobacterium tuberculosis","volume":"42","author":"Abate","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib71","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/jac\/dkl477","article-title":"Colorimetric redox-indicator methods for the rapid detection of multidrug resistance in Mycobacterium tuberculosis: a systematic review and meta-analysis","volume":"59","author":"Martin","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib72","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1128\/JCM.00691-07","article-title":"Evaluation of direct detection of Mycobacterium tuberculosis rifampin resistance by a nitrate reductase assay applied to sputum samples in Cotonou, Benin","volume":"45","author":"Affolabi","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib73","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1128\/JCM.41.10.4865-4869.2003","article-title":"Photographic and luminometric detection of luciferase reporter phages for susceptibility testing of Mycobacterium tuberculosis isolates","volume":"41","author":"Hazbon","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib74","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tube.2007.08.006","article-title":"Evaluation of semiautomated reporter phage assay for susceptibility testing of Mycobacterium tuberculosis isolates in South Africa","volume":"88","author":"Banaiee","year":"2008","journal-title":"Tuberculosis"},{"key":"10.1016\/j.rmed.2009.07.010_bib75","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1128\/JCM.01332-06","article-title":"Direct detection of Mycobacterium tuberculosis complex DNA and rifampin resistance in clinical specimens from tuberculosis patients by line probe assay","volume":"44","author":"Traore","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib76","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1128\/JCM.00521-07","article-title":"Evaluation of Genotype MTBDR plus assay for rifampin and isoniazid susceptibility testing of Mycobacterium tuberculosis strains and clinical specimens","volume":"45","author":"Hillemann","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib77","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1128\/JCM.00081-09","article-title":"Feasibility of the GenoType MTBDR sl assay for fluoroquinolone, amikacin-capreomycin and ethambutol resistance testing of Mycobacterium tuberculosis strains and clinical specimens","volume":"47","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib78","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.mimet.2004.02.006","article-title":"Multicenter evaluation of reverse line blot assay for detection of drug resistance in Mycobacterium tuberculosis clinical isolates","volume":"57","author":"Mokrousov","year":"2004","journal-title":"J Microbiol Methods"},{"key":"10.1016\/j.rmed.2009.07.010_bib79","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1198-743X.2004.889.x","article-title":"Use of a high-density DNA probe array for detecting mutations involved in rifampicin resistance in Mycobacterium tuberculosis","volume":"10","author":"Sougakoff","year":"2004","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.rmed.2009.07.010_bib80","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/JCM.01821-07","article-title":"Development of multiplex assay for rapid characterization of Mycobacterium tuberculosis","volume":"46","author":"Bergval","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib81","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/infdis\/171.1.240","article-title":"Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase\u2013peroxidase (katG) gene associated with isoniazid resistance","volume":"171","author":"Cockerill","year":"1995","journal-title":"J Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib82","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.mcp.2004.04.001","article-title":"Rapid detection of ethambutol-resistant Mycobacterium tuberculosis strains by PCR-RFLP targeting embB codons 306 and 497 and iniA codon 501 mutations","volume":"18","author":"Ahmad","year":"2004","journal-title":"Mol Cell Probes"},{"key":"10.1016\/j.rmed.2009.07.010_bib83","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ijantimicag.2003.10.004","article-title":"Contribution of AGC to ACC and other mutations at codon 315 of the katG gene in isoniazid-resistant Mycobacterium tuberculosis isolates from the Middle East","volume":"23","author":"Ahmad","year":"2004","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.rmed.2009.07.010_bib84","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10096-008-0584-5","article-title":"Prospective evaluation of pyrosequencing for the rapid detection of isoniazid and rifampin resistance in clinical Mycobacterium tuberculosis isolates","volume":"28","author":"Marttila","year":"2009","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib85","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1128\/JCM.42.4.1585-1589.2004","article-title":"Direct detection of rifampin- and isoniazid-resistant Mycobacterium tuberculosis in auramine-rhodamine-positive sputum specimens by real-time PCR","volume":"42","author":"Ruiz M Torres","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib86","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/jac\/dki132","article-title":"Direct detection in clinical samples of multiple gene mutations causing resistance of Mycobacterium tuberculosis to isoniazid and rifampicin using fluorogenic probes","volume":"55","author":"Espasa","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib87","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1128\/JCM.43.9.4880-4884.2005","volume":"43","author":"Viveiros","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib88","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s10096-008-0548-9","article-title":"Multidrug-resistant tuberculosis: rapid detection of resistance to rifampin and high or low levels of isoniazid in clinical specimens and isolates","volume":"27","author":"Vijdea","year":"2008","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib89","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/jac\/dkn433","article-title":"Rapid genotypic assays to identify drug-resistant Mycobacterium tuberculosis in South Africa","volume":"63","author":"Evans","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib90","first-page":"2928","article-title":"Evaluation of a new line probe assay for rapid identification of gyrA mutations in Mycobacterium tuberculosis","volume":"49","author":"Giannoni","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.rmed.2009.07.010_bib91","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.diagmicrobio.2005.09.014","article-title":"Evaluation of the CombiChip Mycobacteria Drug-Resistance detection DNA chip for identifying mutations associated with resistance to isoniazid and rifampin in Mycobacterium tuberculosis","volume":"54","author":"Kim","year":"2006","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib92","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1016\/S1472-9792(08)70038-6","article-title":"The early bactericidal activity of anti-tuberculosis drugs: a literature review","volume":"88","author":"Donald","year":"2008","journal-title":"Tuberculosis"},{"key":"10.1016\/j.rmed.2009.07.010_bib93","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1093\/jac\/dki148","article-title":"Linezolid for the treatment of multidrug-resistant tuberculosis","volume":"56","author":"Fortun","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib94","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1164\/rccm.200806-892OC","article-title":"Early and extended early bactericidal activity of linezolid in pulmonary tuberculosis","volume":"178","author":"Dietze","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib95","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1001\/jama.283.19.2537","article-title":"Standard short-course chemotherapy for drug-resistant tuberculosis","volume":"283","author":"Espinal","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.rmed.2009.07.010_bib96","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1164\/rccm.200802-240OC","article-title":"Influence of multidrug-resistance on tuberculosis treatment outcomes with standardized regimens","volume":"178","author":"Mak","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib97","doi-asserted-by":"crossref","first-page":"123","DOI":"10.7326\/0003-4819-149-2-200807150-00008","article-title":"Initial drug resistance and tuberculosis treatment outcomes: systematic review and meta-analysis","volume":"149","author":"Lew","year":"2008","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib98","doi-asserted-by":"crossref","first-page":"184","DOI":"10.7326\/0003-4819-117-3-184","article-title":"Clinical presentation and outcome of patients with HIV infection and tuberculosis caused by multiple-drug-resistant bacilli","volume":"117","author":"Fischl","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib99","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1164\/ajrccm.153.1.8542137","article-title":"Outcome of MDR-TB patients, 1983\u20131993: prolonged survival with appropriate therapy","volume":"153","author":"Park","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib100","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1093\/clinids\/21.5.1238","article-title":"Improved outcomes for patients with multidrug-resistant tuberculosis","volume":"21","author":"Turett","year":"1995","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib101","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0140-6736(04)15496-2","article-title":"Programmes and principles in treatment of multidrug-resistant tuberculosis","volume":"363","author":"Mukherjee","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2009.07.010_bib102","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/MCP.0b013e3280f3c0b2","article-title":"The clinical management of drug-resistant tuberculosis","volume":"13","author":"Furin","year":"2007","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib103","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1055\/s-0028-1085702","article-title":"Epidemiology and treatment of multidrug-resistant tuberculosis","volume":"29","author":"Mitnick","year":"2008","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib104","first-page":"1306","article-title":"Providing HIV care for tuberculosis patients in sub-Saharan Africa","volume":"10","author":"Harries","year":"2006","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib105","first-page":"290","article-title":"Representative drug susceptibility patterns for guiding design of retreatment regimens for MDR-TB","volume":"10","author":"Rich","year":"2006","journal-title":"Int J Tuberc Lung Dis"},{"issue":"Suppl. 1","key":"10.1016\/j.rmed.2009.07.010_bib106","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1086\/518656","article-title":"Facing the crises: improving the diagnosis of tuberculosis in the HIV era","volume":"196","author":"Perkins","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib107","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0140-6736(05)17786-1","article-title":"Clinical outcome of individualised treatment of multidrug-resistant tuberculosis in Latvia: a retrospective cohort study","volume":"365","author":"Leimane","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.rmed.2009.07.010_bib108","first-page":"421","article-title":"Retreatment management strategies when first-line tuberculosis therapy fails","volume":"9","author":"Saravia","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib109","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3201\/eid1405.070721","article-title":"Scale-up of multidrug-resistant tuberculosis laboratory services, Peru","volume":"15","author":"Shin","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib110","doi-asserted-by":"crossref","first-page":"650","DOI":"10.7326\/0003-4819-144-9-200605020-00008","article-title":"Time to sputum culture conversion in multidrug-resistant tuberculosis: predictors and relationship to treatment outcome","volume":"144","author":"Holtz","year":"2006","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib111","first-page":"818","article-title":"Acquisition of drug resistance in multidrug-resistant Mycobacterium tuberculosis during directly observed empiric treatment with standardized regimens","volume":"9","author":"Han","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib112","first-page":"432","article-title":"Factors associated with time to sputum smear conversion in active pulmonary tuberculosis","volume":"7","author":"Dominguez-Castellano","year":"2003","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib113","first-page":"402","article-title":"Treatment outcomes in an integrated civilian and prison MDR-TB treatment program in Russia","volume":"10","author":"Shin","year":"2006","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib114","first-page":"585","article-title":"Treatment outcome cohort analysis in an integrated DOTS and DOTS-Plus TB program in Latvia","volume":"11","author":"Riekstina","year":"2007","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib115","first-page":"560","article-title":"Results of a standardised regimen for multidrug-resistant tuberculosis in Bangladesh","volume":"8","author":"Van Deun","year":"2004","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib116","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.3201\/eid1209.051618","article-title":"Multidrug-resistant tuberculosis management in resource-limited settings","volume":"12","author":"Nathanson","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.rmed.2009.07.010_bib117","doi-asserted-by":"crossref","first-page":"e352","DOI":"10.1371\/journal.pmed.0030352","article-title":"Feasibility and cost-effectiveness of treating multidrug-resistant tuberculosis: a cohort study in the Philippines","volume":"3","author":"Tupasi","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib118","series-title":"Guidelines for the programmatic management of drug-resistant tuberculosis","author":"World Health Organization","year":"2006"},{"key":"10.1016\/j.rmed.2009.07.010_bib119","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1055\/s-2004-829503","article-title":"Antimicrobial therapy of tuberculosis: justification for currently recommended treatment regimens","volume":"25","author":"Mitchison","year":"2004","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib120","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1371\/journal.pmed.0040120","article-title":"Why is long-term therapy required to cure tuberculosis","volume":"4","author":"Connolly","year":"2007","journal-title":"PLoS Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib121","doi-asserted-by":"crossref","first-page":"e273","DOI":"10.1371\/journal.pmed.0030273","article-title":"Prospects for advancing tuberculosis control through novel therapies","volume":"3","author":"Salomon","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib122","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1055\/s-0028-1085706","article-title":"Emerging drugs for active tuberculosis","volume":"29","author":"Ginsberg","year":"2008","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib123","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/35016103","article-title":"A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis","volume":"405","author":"Stover","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.rmed.2009.07.010_bib124","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1128\/AAC.00074-08","article-title":"Powerful bactericidal and sterilizing activity of a regimen containing PA-824, moxifloxacin and pyrazinamide in a murine model of tuberculosis","volume":"52","author":"Nueremberger","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib125","doi-asserted-by":"crossref","first-page":"e466","DOI":"10.1371\/journal.pmed.0030466","article-title":"OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice","volume":"3","author":"Matsumoto","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.rmed.2009.07.010_bib126","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1073\/pnas.0508392103","article-title":"Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis","volume":"103","author":"Manjunatha","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.rmed.2009.07.010_bib127","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1126\/science.1106753","article-title":"A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis","volume":"307","author":"Andries","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.rmed.2009.07.010_bib128","doi-asserted-by":"crossref","first-page":"3543","DOI":"10.1128\/AAC.00766-06","article-title":"Combinations of R207910 with drugs used to treat multidrug-resistant tuberculosis have the potential to shorten treatment duration","volume":"50","author":"Lounis","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib129","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1093\/jac\/dki319","article-title":"Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines","volume":"56","author":"Protopopova","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib130","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1128\/AAC.01326-06","article-title":"Drug therapy of experimental TB: improved outcome by combining SQ109, a new diamine antibiotic with existing TB drugs","volume":"51","author":"Nikonenko","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib131","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/jac\/dkn214","article-title":"In vitro and in vivo antimycobacterial acitivities of ketone and amide derivatives of quinoxaline 1,4-di-N-oxide","volume":"62","author":"Villar","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.rmed.2009.07.010_bib132","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1021\/jm900003c","article-title":"Structure-activity relationships for a series of quinoline-based compounds against replicating and nonreplicating","volume":"52","author":"Lilienkampf","year":"2009","journal-title":"J Med Chem"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611109002443?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611109002443?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:53:53Z","timestamp":1760612033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611109002443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":132,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0954611109002443"],"URL":"https:\/\/doi.org\/10.1016\/j.rmed.2009.07.010","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent advances in the diagnosis and treatment of multidrug-resistant tuberculosis","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rmed.2009.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}